LOCUS       NP_079712                293 aa            linear   ROD 24-DEC-2024
DEFINITION  methylsterol monooxygenase 1 [Mus musculus].
ACCESSION   NP_079712
VERSION     NP_079712.1
DBSOURCE    REFSEQ: accession NM_025436.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 293)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 293)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 293)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 293)
  AUTHORS   Xin,Y., Li,C., Guo,Y., Xiao,R., Zhang,H. and Zhou,G.
  TITLE     RNA-Seq analysis reveals a negative role of MSMO1 with a synergized
            NSDHL expression during adipogenesis of 3T3-L1
  JOURNAL   Biosci Biotechnol Biochem 83 (4), 641-652 (2019)
   PUBMED   30582412
  REMARK    GeneRIF: The findings indicate that MSMO1 and NSDHL are novel
            modulators of adipogenesis.
REFERENCE   5  (residues 1 to 293)
  AUTHORS   Lowther,K.M., Favero,F., Yang,C.R., Taylor,H.S. and Seli,E.
  TITLE     Embryonic poly(A)-binding protein is required at the preantral
            stage of mouse folliculogenesis for oocyte-somatic communication
  JOURNAL   Biol Reprod 96 (2), 341-351 (2017)
   PUBMED   28203794
REFERENCE   6  (residues 1 to 293)
  AUTHORS   Sisecioglu,M., Budak,H., Geffers,L., Cankaya,M., Ciftci,M.,
            Thaller,C., Eichele,G., Kufrevioglu,O.I. and Ozdemir,H.
  TITLE     A compendium of expression patterns of cholesterol biosynthetic
            enzymes in the mouse embryo
  JOURNAL   J Lipid Res 56 (8), 1551-1559 (2015)
   PUBMED   26108225
REFERENCE   7  (residues 1 to 293)
  AUTHORS   Patra,D., DeLassus,E., Liang,G. and Sandell,L.J.
  TITLE     Cartilage-specific ablation of site-1 protease in mice results in
            the endoplasmic reticulum entrapment of type IIb procollagen and
            down-regulation of cholesterol and lipid homeostasis
  JOURNAL   PLoS One 9 (8), e105674 (2014)
   PUBMED   25147951
  REMARK    Publication Status: Online-Only
REFERENCE   8  (residues 1 to 293)
  AUTHORS   Sukhanova,A., Gorin,A., Serebriiskii,I.G., Gabitova,L., Zheng,H.,
            Restifo,D., Egleston,B.L., Cunningham,D., Bagnyukova,T., Liu,H.,
            Nikonova,A., Adams,G.P., Zhou,Y., Yang,D.H., Mehra,R., Burtness,B.,
            Cai,K.Q., Klein-Szanto,A., Kratz,L.E., Kelley,R.I., Weiner,L.M.,
            Herman,G.E., Golemis,E.A. and Astsaturov,I.
  TITLE     Targeting C4-demethylating genes in the cholesterol pathway
            sensitizes cancer cells to EGF receptor inhibitors via increased
            EGF receptor degradation
  JOURNAL   Cancer Discov 3 (1), 96-111 (2013)
   PUBMED   23125191
  REMARK    GeneRIF: This work identifies a critical role for SC4MOL and NSDHL
            in the regulation of EGFR signaling and endocytic trafficking and
            suggests novel strategies to increase the potency of EGFR
            antagonists in tumors
REFERENCE   9  (residues 1 to 293)
  AUTHORS   Pfister,S., Jones,V.J., Power,M., Truisi,G.L., Khoo,P.L.,
            Steiner,K.A., Kanai-Azuma,M., Kanai,Y., Tam,P.P. and Loebel,D.A.
  TITLE     Sox17-dependent gene expression and early heart and gut development
            in Sox17-deficient mouse embryos
  JOURNAL   Int J Dev Biol 55 (1), 45-58 (2011)
   PUBMED   21305474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005090.1 and AC152168.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005090.1, AK151135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..293
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 32.3 cM"
     Protein         1..293
                     /product="methylsterol monooxygenase 1"
                     /EC_number="1.14.18.9"
                     /note="C-4 methylsterol oxidase; sterol-C4-methyl
                     oxidase-like"
                     /calculated_mol_wt=34641
     Site            55..75
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRA4.1)"
     Site            100..120
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRA4.1)"
     Region          143..274
                     /region_name="FA_hydroxylase"
                     /note="Fatty acid hydroxylase; pfam04116"
                     /db_xref="CDD:397991"
     Region          157..161
                     /region_name="Histidine box-1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRA4.1)"
     Region          170..174
                     /region_name="Histidine box-2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRA4.1)"
     Site            199..219
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRA4.1)"
     Region          249..255
                     /region_name="Histidine box-3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9CRA4.1)"
     CDS             1..293
                     /gene="Msmo1"
                     /gene_synonym="1500001G16Rik; DESP4; ERG25; Sc4mol"
                     /coded_by="NM_025436.3:102..983"
                     /db_xref="CCDS:CCDS22328.1"
                     /db_xref="GeneID:66234"
                     /db_xref="MGI:MGI:1913484"
ORIGIN      
        1 matnksvgvf ssaslaveyv dsllpenplq epfknawvym ldnytkfqia twgslivhea
       61 iyflfslpgf lfqfipymrk ykiqkdkpet fegqwkclkk ilfnhffiql plicgtyyft
      121 effnipydwe rmprwyltla rclgcavied twhyflhrll hhkriykyih kvhhefqapf
      181 gieaeyahpl etlilgtgff igivllcdhv illwawvtir lletidvhsg ydiplnplnl
      241 vpfytgarhh dfhhmnfign yastftwwdk lfgtdaqyha yiekskklgk ksd
//
