LOCUS       NM_020597                522 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus beta-microseminoprotein (Msmb), mRNA.
ACCESSION   NM_020597
VERSION     NM_020597.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 522)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 522)
  AUTHORS   Masato,M., Miyata,Y., Kurata,H., Ito,H., Mitsunari,K., Asai,A.,
            Nakamura,Y., Araki,K., Mukae,Y., Matsuda,T., Harada,J., Matsuo,T.,
            Ohba,K. and Sakai,H.
  TITLE     Oral administration of E-type prostanoid (EP) 1 receptor antagonist
            suppresses carcinogenesis and development of prostate cancer via
            upregulation of apoptosis in an animal model
  JOURNAL   Sci Rep 11 (1), 20279 (2021)
   PUBMED   34645904
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 522)
  AUTHORS   Bernichtein,S., Pigat,N., Barry Delongchamps,N., Boutillon,F.,
            Verkarre,V., Camparo,P., Reyes-Gomez,E., Mejean,A., Oudard,S.M.,
            Lepicard,E.M., Viltard,M., Souberbielle,J.C., Friedlander,G.,
            Capiod,T. and Goffin,V.
  TITLE     Vitamin D3 Prevents Calcium-Induced Progression of Early-Stage
            Prostate Tumors by Counteracting TRPC6 and Calcium Sensing Receptor
            Upregulation
  JOURNAL   Cancer Res 77 (2), 355-365 (2017)
   PUBMED   27879271
REFERENCE   4  (bases 1 to 522)
  AUTHORS   Bernichtein,S., Pigat,N., Capiod,T., Boutillon,F., Verkarre,V.,
            Camparo,P., Viltard,M., Mejean,A., Oudard,S., Souberbielle,J.C.,
            Friedlander,G. and Goffin,V.
  TITLE     High milk consumption does not affect prostate tumor progression in
            two mouse models of benign and neoplastic lesions
  JOURNAL   PLoS One 10 (5), e0125423 (2015)
   PUBMED   25938513
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 522)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 522)
  AUTHORS   Wang,I., Yu,T.A., Wu,S.H., Chang,W.C. and Chen,C.
  TITLE     Disulfide pairings and secondary structure of porcine
            beta-microseminoprotein
  JOURNAL   FEBS Lett 541 (1-3), 80-84 (2003)
   PUBMED   12706823
REFERENCE   7  (bases 1 to 522)
  AUTHORS   Thota,A., Karajgikar,M., Duan,W., Gabril,M.Y., Chan,F.L.,
            Wong,Y.C., Sakai,H., Chin,J.L., Moussa,M. and Xuan,J.W.
  TITLE     Mouse PSP94 expression is prostate tissue-specific as demonstrated
            by a comparison of multiple antibodies against recombinant proteins
  JOURNAL   J Cell Biochem 88 (5), 999-1011 (2003)
   PUBMED   12616537
  REMARK    GeneRIF: Establishment and characterization of PSP94 antibodies
            contribute to the potential for PSP94 as a new vector gene for
            prostate cancer gene therapy
REFERENCE   8  (bases 1 to 522)
  AUTHORS   Xuan,J.W., Kwong,J., Chan,F.L., Ricci,M., Imasato,Y., Sakai,H.,
            Fong,G.H., Panchal,C. and Chin,J.L.
  TITLE     cDNA, genomic cloning, and gene expression analysis of mouse PSP94
            (prostate secretory protein of 94 amino acids)
  JOURNAL   DNA Cell Biol 18 (1), 11-26 (1999)
   PUBMED   10025505
REFERENCE   9  (bases 1 to 522)
  AUTHORS   Zambrowicz,B.P., Friedrich,G.A., Buxton,E.C., Lilleberg,S.L.,
            Person,C. and Sands,A.T.
  TITLE     Disruption and sequence identification of 2,000 genes in mouse
            embryonic stem cells
  JOURNAL   Nature 392 (6676), 608-611 (1998)
   PUBMED   9560157
REFERENCE   10 (bases 1 to 522)
  AUTHORS   Ulvsback,M., Spurr,N.K. and Lundwall,A.
  TITLE     Assignment of the human gene for beta-microseminoprotein (MSMB) to
            chromosome 10 and demonstration of related genes in other
            vertebrates
  JOURNAL   Genomics 11 (4), 920-924 (1991)
   PUBMED   1783399
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154532.3.
            
            On Jul 10, 2009 this sequence version replaced NM_020597.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U89840.1, CJ055565.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC154532.3         146731-146782       c
            53-158              AC154532.3         140624-140729       c
            159-261             AC154532.3         138540-138642       c
            262-522             AC154532.3         130478-130738       c
FEATURES             Location/Qualifiers
     source          1..522
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.4 cM"
     gene            1..522
                     /gene="Msmb"
                     /gene_synonym="beta-MSP; PIP; PSP94"
                     /note="beta-microseminoprotein"
                     /db_xref="GeneID:17695"
                     /db_xref="MGI:MGI:97166"
     exon            1..52
                     /gene="Msmb"
                     /gene_synonym="beta-MSP; PIP; PSP94"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..391
                     /gene="Msmb"
                     /gene_synonym="beta-MSP; PIP; PSP94"
                     /note="PSP-94; prostate secreted seminal plasma protein;
                     prostate secretory protein of 94 amino acids;
                     beta-inhibin; prostatic inhibin protein"
                     /codon_start=1
                     /product="beta-microseminoprotein precursor"
                     /protein_id="NP_065622.1"
                     /db_xref="CCDS:CCDS36862.1"
                     /db_xref="GeneID:17695"
                     /db_xref="MGI:MGI:97166"
                     /translation="MEAWLGSLLFLATMVIASKAVCSIENREIFPNQMSDDCMDADGN
                     KHFLNTPWKKNCTWCSCDKTSITCCTNATRPLSYDKDNCDVQFHPENCTYSVVDRKNP
                     GKTCRVDSWTM"
     exon            53..158
                     /gene="Msmb"
                     /gene_synonym="beta-MSP; PIP; PSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            159..261
                     /gene="Msmb"
                     /gene_synonym="beta-MSP; PIP; PSP94"
                     /inference="alignment:Splign:2.1.0"
     exon            262..522
                     /gene="Msmb"
                     /gene_synonym="beta-MSP; PIP; PSP94"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggactttg ctggaggtac ccacctgtaa ggagtcctgc tttgtcacca tggaagcttg
       61 gctgggcagt ctcttattcc ttgctaccat ggtgatagca tccaaagcag tatgttctat
      121 tgaaaatcgt gagatatttc caaatcaaat gtctgatgac tgcatggatg ctgatggtaa
      181 caagcatttc cttaacactc cctggaagaa gaactgcacg tggtgttcat gtgacaaaac
      241 gtcaatcacc tgctgtacca acgctactag gcctttgagc tatgacaaag acaactgtga
      301 tgtacaattc cacccagaga actgcaccta cagtgtggtg gatcggaaga acccagggaa
      361 gacctgtcga gttgacagct ggactatgta aatgtgcttc gtgtgggccc aaaagtggag
      421 taacatttga accttgtatg atttaaattt accaatcata agcttgcaag gaggtgacct
      481 gtaatcccag cactcagaag gcagaggcag catatcttga aa
//
