LOCUS       NM_001356286            2066 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus mesothelin (Msln), transcript variant 1, mRNA.
ACCESSION   NM_001356286 XM_006524650
VERSION     NM_001356286.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2066)
  AUTHORS   Alewine,C.
  TITLE     Macrophages Under the Influence of Tumor Mesothelin Weaken Host
            Defenses against Pancreatic Cancer Metastasis
  JOURNAL   Cancer Res 84 (4), 513-514 (2024)
   PUBMED   38356442
  REMARK    GeneRIF: Macrophages Under the Influence of Tumor Mesothelin Weaken
            Host Defenses against Pancreatic Cancer Metastasis.
REFERENCE   2  (bases 1 to 2066)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   3  (bases 1 to 2066)
  AUTHORS   Jiang,W., Gu,G., Zhang,Y., Song,Y., Shi,M., Wang,G., Li,H., Tao,T.,
            Qin,J., Li,X., Jia,H., Jiao,F., Xu,W. and Huang,X.
  TITLE     Novel mesothelin-targeted chimeric antigen receptor-modified UNKT
            cells are highly effective in inhibiting tumor progression
  JOURNAL   Pharmacol Res 197, 106942 (2023)
   PUBMED   37775021
  REMARK    GeneRIF: Novel mesothelin-targeted chimeric antigen
            receptor-modified UNKT cells are highly effective in inhibiting
            tumor progression.
REFERENCE   4  (bases 1 to 2066)
  AUTHORS   Bajwa,P., Kordylewicz,K., Bilecz,A., Lastra,R.R., Wroblewski,K.,
            Rinkevich,Y., Lengyel,E. and Kenny,H.A.
  TITLE     Cancer-associated mesothelial cell-derived ANGPTL4 and STC1 promote
            the early steps of ovarian cancer metastasis
  JOURNAL   JCI Insight 8 (6), e163019 (2023)
   PUBMED   36795484
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2066)
  AUTHORS   Rollins,M.R., Raynor,J.F., Miller,E.A., Butler,J.Z., Spartz,E.J.,
            Lahr,W.S., You,Y., Burrack,A.L., Moriarity,B.S., Webber,B.R. and
            Stromnes,I.M.
  TITLE     Germline T cell receptor exchange results in physiological T cell
            development and function
  JOURNAL   Nat Commun 14 (1), 528 (2023)
   PUBMED   36726009
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2066)
  AUTHORS   Rump,A., Morikawa,Y., Tanaka,M., Minami,S., Umesaki,N., Takeuchi,M.
            and Miyajima,A.
  TITLE     Binding of ovarian cancer antigen CA125/MUC16 to mesothelin
            mediates cell adhesion
  JOURNAL   J Biol Chem 279 (10), 9190-9198 (2004)
   PUBMED   14676194
  REMARK    GeneRIF: binding of membrane-bound mesothelin to ovarian cancer
            antigen CA125 mediates heterotypic cell adhesion
REFERENCE   7  (bases 1 to 2066)
  AUTHORS   Prieve,M.G. and Moon,R.T.
  TITLE     Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a
            and Wnt-1 in C57mg mouse mammary epithelial cells
  JOURNAL   BMC Dev Biol 3, 2 (2003)
   PUBMED   12697065
REFERENCE   8  (bases 1 to 2066)
  AUTHORS   Yamashita,Y., Yokoyama,M., Kobayashi,E., Takai,S. and Hino,O.
  TITLE     Mapping and determination of the cDNA sequence of the Erc gene
            preferentially expressed in renal cell carcinoma in the Tsc2 gene
            mutant (Eker) rat model
  JOURNAL   Biochem Biophys Res Commun 275 (1), 134-140 (2000)
   PUBMED   10944454
REFERENCE   9  (bases 1 to 2066)
  AUTHORS   Bera,T.K. and Pastan,I.
  TITLE     Mesothelin is not required for normal mouse development or
            reproduction
  JOURNAL   Mol Cell Biol 20 (8), 2902-2906 (2000)
   PUBMED   10733593
REFERENCE   10 (bases 1 to 2066)
  AUTHORS   Kojima,T., Oh-eda,M., Hattori,K., Taniguchi,Y., Tamura,M., Ochi,N.
            and Yamaguchi,N.
  TITLE     Molecular cloning and expression of megakaryocyte potentiating
            factor cDNA
  JOURNAL   J Biol Chem 270 (37), 21984-21990 (1995)
   PUBMED   7665620
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144391.1 and D86370.1.
            
            On Sep 28, 2017 this sequence version replaced XM_006524650.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144391.1, SRR13948564.1580897.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2044              AK144391.1         2-2045
            2045-2066           D86370.1           2114-2135
FEATURES             Location/Qualifiers
     source          1..2066
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.85 cM"
     gene            1..2066
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /note="mesothelin"
                     /db_xref="GeneID:56047"
                     /db_xref="MGI:MGI:1888992"
     exon            1..36
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            37..127
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..1917
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1; megakaryocyte potentiating factor;
                     pre-pro-megakaryocyte-potentiating factor"
                     /codon_start=1
                     /product="mesothelin isoform 1 preproprotein"
                     /protein_id="NP_001343215.1"
                     /db_xref="CCDS:CCDS28526.1"
                     /db_xref="GeneID:56047"
                     /db_xref="MGI:MGI:1888992"
                     /translation="MALPTARPLLGSCGSPICSRSFLLLLLSLGWIPRLQTQTTKTSQ
                     EATLLHAVNGAADFASLPTGLFLGLTCEEVSDLSMEQAKGLAMAVRQKNITLRGHQLR
                     CLARRLPRHLTDEELNALPLDLLLFLNPAMFPGQQACAHFFSLISKANVDVLPRRSLE
                     RQRLLMEALKCQGVYGFQVSEADVRALGGLACDLPGKFVARSSEVLLPWLAGCQGPLD
                     QSQEKAVREVLRSGRTQYGPPSKWSVSTLDALQSLVAVLDESIVQSIPKDVKAEWLQH
                     ISRDPSRLGSKLTVIHPRFRRDAEQKACPPGKEPYKVDEDLIFYQNWELEACVDGTML
                     ARQMDLVNEIPFTYEQLSIFKHKLDKTYPQGYPESLIQQLGHFFRYVSPEDIHQWNVT
                     SPDTVKTLLKVSKGQKMNAQAIALVACYLRGGGQLDEDMVKALGDIPLSYLCDFSPQD
                     LHSVPSSVMWLVGPQDLDKCSQRHLGLLYQKACSAFQNVSGLEYFEKIKTFLGGASVK
                     DLRALSQHNVSMDIATFKRLQVDSLVGLSVAEVQKLLGPNIVDLKTEEDKSPVRDWLF
                     RQHQKDLDRLGLGLQGGIPNGYLVLDFNVREAFSSRASLLGPGFVLIWIPALLPALRL
                     S"
     exon            128..171
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            172..218
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            219..339
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            340..425
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            426..555
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            556..749
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            750..840
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            841..940
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1119
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1275
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1418
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1546
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1641
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1828
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2046
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /note="hexamer: AATAAA"
     polyA_site      2046
                     /gene="Msln"
                     /gene_synonym="MPF"
                     /note="major polyA site"
ORIGIN      
        1 cagtgtggag agtctgccta gtagacacta ctgcagacca tggccttgcc aacagctcga
       61 cccctgctgg ggtcctgtgg aagtcccatc tgcagccgaa gcttcctact gcttctcctt
      121 agtcttgggt ggataccacg tctgcagacc cagactacaa agacaagcca ggaggccaca
      181 ctcctccatg ctgtgaacgg tgccgctgac tttgccagtc tccccacagg cctctttctt
      241 ggcctcacat gtgaggaggt atctgacctg agcatggaac aagccaaggg gctggctatg
      301 gctgtaagac agaagaacat tacactccgg ggacatcagc tgcgttgtct ggcacgtcgc
      361 cttcctaggc acctcaccga cgaggaactg aatgctcttc cactggacct gctgctcttc
      421 ctcaacccag ccatgtttcc agggcaacag gcttgtgccc acttcttctc cctcatctct
      481 aaagccaatg tggatgtact cccacggagg tctctggagc gccagaggct gctgatggag
      541 gctctgaagt gccagggcgt gtatggattt caagtgagtg aggcagatgt gcgggctctc
      601 ggaggcctgg cctgtgacct gcctgggaaa tttgtggcca gatcttccga agttctcctc
      661 ccctggctgg caggatgcca aggacccctg gaccagagcc aggaaaaggc agtcagggag
      721 gttctgagga gtggaagaac ccaatatggc cccccatcga agtggtcagt ctccaccctg
      781 gatgccctgc agagcttggt agcagtgttg gatgagtcca tcgtccagag catccccaag
      841 gatgtcaaag ctgaatggct gcaacacatc tccagagacc cctccaggct ggggtctaag
      901 ctgaccgtca tacacccaag gttccgacgg gatgcagaac agaaagcctg ccctccaggg
      961 aaggagccct acaaggtgga tgaagacctc atcttctacc agaattggga gctggaggct
     1021 tgtgtagatg gcaccatgct ggccagacaa atggaccttg tgaacgagat tcccttcacc
     1081 tatgagcagc tcagtatctt taagcacaaa ctggacaaga cctacccaca aggctatcct
     1141 gagtccctga tccagcagct gggtcacttc ttcagatatg ttagccctga agacatccac
     1201 cagtggaatg tgacctcacc agacacagtg aaaactctgc tcaaagtcag caaaggacaa
     1261 aagatgaatg ctcaggcgat tgccttggtc gcctgctatc ttcggggagg aggccagctg
     1321 gacgaggata tggtaaaagc cctgggcgac atcccgttaa gctatctatg tgacttcagc
     1381 ccccaggatc tgcactcggt accctccagt gtcatgtggc tggttgggcc ccaagacctg
     1441 gacaagtgca gccagaggca tctgggtctc ctctaccaga aggcctgctc agccttccag
     1501 aatgtgagcg gcctagaata ctttgagaaa atcaagacat tcctgggtgg ggcctccgtg
     1561 aaggacctgc gggccctcag ccagcacaat gtgagcatgg acatagccac tttcaagagg
     1621 ctgcaggtgg attccctggt ggggctgagt gtggctgagg tacagaaact tctggggcca
     1681 aacattgtgg acctgaagac cgaggaggat aaaagccctg tccgtgactg gctgttccgg
     1741 cagcatcaga aagacctaga caggctgggt ttgggacttc agggtggcat ccccaatggc
     1801 tacctggtcc tggacttcaa tgtccgagag gccttctcca gcagagcctc actccttggg
     1861 ccaggatttg tattaatatg gattccagct ctgctcccag ctttaaggct gagctgagac
     1921 caccaccctg caaggctcct ggtcccagct ctactggggc cctcttgacc aggagtgggt
     1981 accaggggtc attgccaaag tttgaggact cttgaactca ataaacagtg gcatatgctc
     2041 ccttgaaaaa aaaaaaaaaa aaaaaa
//
