LOCUS       NM_001370791            5223 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus MSL complex subunit 3 (Msl3), transcript variant 1,
            mRNA.
ACCESSION   NM_001370791 XM_006528741
VERSION     NM_001370791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5223)
  AUTHORS   Mitchell,T.A., Lin,J.M., Hicks,S.M., James,J.R., Rangan,P. and
            Forni,P.E.
  TITLE     Loss of function of male-specific lethal 3 (Msl3) does not affect
            spermatogenesis in rodents
  JOURNAL   Dev Dyn 253 (5), 453-466 (2024)
   PUBMED   37847071
  REMARK    GeneRIF: Loss of function of male-specific lethal 3 (Msl3) does not
            affect spermatogenesis in rodents.
REFERENCE   2  (bases 1 to 5223)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5223)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5223)
  AUTHORS   Ye,A., Kim,H. and Kim,J.
  TITLE     PEG3 control on the mammalian MSL complex
  JOURNAL   PLoS One 12 (6), e0178363 (2017)
   PUBMED   28609438
  REMARK    GeneRIF: Data show that complete removal of paternally expressed
            gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1
            (Msl1) and male-specific lethal 3 (Msl3).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5223)
  AUTHORS   Ye,A., He,H. and Kim,J.
  TITLE     PEG3 binds to H19-ICR as a transcriptional repressor
  JOURNAL   Epigenetics 11 (12), 889-900 (2016)
   PUBMED   27824289
REFERENCE   6  (bases 1 to 5223)
  AUTHORS   Chelmicki,T., Dundar,F., Turley,M.J., Khanam,T., Aktas,T.,
            Ramirez,F., Gendrel,A.V., Wright,P.R., Videm,P., Backofen,R.,
            Heard,E., Manke,T. and Akhtar,A.
  TITLE     MOF-associated complexes ensure stem cell identity and Xist
            repression
  JOURNAL   Elife 3, e02024 (2014)
   PUBMED   24842875
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5223)
  AUTHORS   Wolstenholme,J.T., Rissman,E.F. and Bekiranov,S.
  TITLE     Sexual differentiation in the developing mouse brain: contributions
            of sex chromosome genes
  JOURNAL   Genes Brain Behav 12 (2), 166-180 (2013)
   PUBMED   23210685
REFERENCE   8  (bases 1 to 5223)
  AUTHORS   Kadlec,J., Hallacli,E., Lipp,M., Holz,H., Sanchez-Weatherby,J.,
            Cusack,S. and Akhtar,A.
  TITLE     Structural basis for MOF and MSL3 recruitment into the dosage
            compensation complex by MSL1
  JOURNAL   Nat Struct Mol Biol 18 (2), 142-149 (2011)
   PUBMED   21217699
  REMARK    GeneRIF: Msl1 interacts with Msl3 as an extended chain forming an
            extensive hydrophobic interface, whereas the Msl1-MOF interface
            involves electrostatic interactions between the HAT domain and a
            long helix of Msl1.
REFERENCE   9  (bases 1 to 5223)
  AUTHORS   Cormier,T.A., Prakash,S.K., Magner,D.B., Zoghbi,H.Y. and Van den
            Veyver,I.B.
  TITLE     Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly
            (Xpl) and Patchy-fur (Paf) mutant mice
  JOURNAL   Mamm Genome 12 (10), 796-798 (2001)
   PUBMED   11668396
  REMARK    GeneRIF: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked
            polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
REFERENCE   10 (bases 1 to 5223)
  AUTHORS   Prakash,S.K., Van den Veyver,I.B., Franco,B., Volta,M., Ballabio,A.
            and Zoghbi,H.Y.
  TITLE     Characterization of a novel chromo domain gene in xp22.3 with
            homology to Drosophila msl-3
  JOURNAL   Genomics 59 (1), 77-84 (1999)
   PUBMED   10395802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671489.12.
            
            On Jun 2, 2019 this sequence version replaced XM_006528741.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.19048.1,
                                           SRR10223969.20183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL671489.12        33577-33721         c
            146-228             AL671489.12        32112-32194         c
            229-324             AL671489.12        31644-31739         c
            325-425             AL671489.12        30992-31092         c
            426-517             AL671489.12        30069-30160         c
            518-643             AL671489.12        29339-29464         c
            644-804             AL671489.12        28480-28640         c
            805-963             AL671489.12        26792-26950         c
            964-1226            AL671489.12        23892-24154         c
            1227-1336           AL671489.12        22280-22389         c
            1337-1436           AL671489.12        18464-18563         c
            1437-1521           AL671489.12        16812-16896         c
            1522-5223           AL671489.12        11116-14817         c
FEATURES             Location/Qualifiers
     source          1..5223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.73 cM"
     gene            1..5223
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /note="MSL complex subunit 3"
                     /db_xref="GeneID:17692"
                     /db_xref="MGI:MGI:1341851"
     exon            1..145
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1621
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     male-specific lethal-3 protein-like 1; male-specific
                     lethal-3 homolog 1; male-specific lethal 3 homolog"
                     /codon_start=1
                     /product="MSL complex subunit 3 isoform 1"
                     /protein_id="NP_001357720.1"
                     /db_xref="CCDS:CCDS90775.1"
                     /db_xref="GeneID:17692"
                     /db_xref="MGI:MGI:1341851"
                     /translation="MSASEGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDE
                     KGRKIPEYLIHFNGWNRSWDRWAAEEHVLHDTDENRRLQRKLAKKAIARLRGTGKKKR
                     RCRLPGVDSVLKSVPVKEKSKNDENSVSSTCHESCGEKNGGIKEHRQRRIKVKAKAKK
                     KVLSLRSRKEMDERTITIDIPDVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYV
                     KHFAINAAFSANERPRHHHAMMHTHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLV
                     LLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTG
                     EPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHL
                     EKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRPNEINEVLSWKLVPDNYPPGDQPPP
                     PSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAY
                     VAACEAHYSTKNPRAIY"
     exon            146..228
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            229..324
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            325..425
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            426..517
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..643
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            644..804
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..963
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1226
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1336
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1436
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1521
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..5223
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /note="hexamer: AATAAA"
     polyA_site      2376
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /note="major polyA site"
     regulatory      5203..5208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /note="hexamer: AATAAA"
     polyA_site      5223
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
ORIGIN      
        1 actctgcccg ccccggagcc tcgccctccg ccacgatgag caaatgagcg cgagcgaggg
       61 catgaaattt caattccact ctggggagaa agtgctgtgc ttcgagcctg accctaccaa
      121 ggcgcgagtg ctgtacgatg ccaagatcat cgatgttatt atcgggaaag acgaaaaggg
      181 cagaaagatt ccagaatatc tgatacattt taatggttgg aacagaagtt gggatagatg
      241 ggcagctgaa gaacatgtgc tacacgatac agatgaaaac cggagattac agcgcaaatt
      301 ggccaaaaaa gcaatagctc gcctgagagg tacaggaaaa aagaagaggc gctgtaggtt
      361 gcctggtgtc gactctgtct taaaaagcgt gccagttaaa gaaaaatcta aaaatgacga
      421 aaactcagta agcagcacct gtcatgagag ctgtggagaa aagaatggag ggataaaaga
      481 acaccgtcag cgtcgtatta aagtaaaggc taaagcgaaa aaaaaggtat tgtcgctgcg
      541 ttcaagaaag gaaatggatg aaagaacaat cactatagat atccccgatg ttctcaagaa
      601 gcagctagag gatgactgtt actatatcaa caggaggaaa cggttagtga aacttccatg
      661 ccagaccaac atcataacaa ttttggaatc ctatgtgaaa cattttgcta ttaatgcagc
      721 cttttcggcc aatgagaggc ctcgtcacca tcatgccatg atgcacacgc acatgaatgt
      781 gcactacgtc ccagctgaaa agaatgttga cctttgtaag gaaatggtgg atggattacg
      841 aataaccttt gattatacgc tcccattagt gttgctctac ccatatgaac aaacccaata
      901 taaaagggtg acatcgtcaa aattttttct tcctattaag gaaagtacca cgacaactaa
      961 taggagccag gaagagctgt ctcctagccc gcctttgttg aatccatcca caccacagtc
     1021 tacagagagt cagccaccta ctggtgaacc agccaccccc aagaggcgca aagccgagcc
     1081 agaagcactg cagtctctca ggcggtccac aaggcacagc accaattgtg acaggctgtc
     1141 tgagagcagc tcctcccctc agccgaagcg ccggcaacag gacacatctg ccagcatgcc
     1201 gaagctgttt ctgcacttgg aaaagaagac acctgtgcac agcagatcat cttcccccat
     1261 tcctctgact ccaagtaagg atgggagtgc tgtatttgct ggcttcgaag ggagaagacc
     1321 caatgaaatc aatgaggtcc tgtcttggaa acttgtgcct gacaattatc cgccaggaga
     1381 ccagccacct cccccttcgt acatttatgg tgcacagcat ttgctccggt tatttgtgaa
     1441 acttccagaa atccttggga agatgtcctt ctctgagaag aatctgaagg ctttactgaa
     1501 gcactttgat ctctttctga ggtttttagc agaataccat gatgacttct tcccggagtc
     1561 ggcttatgtc gctgcctgtg aggcacacta cagcaccaag aaccccaggg caatttatta
     1621 aacttttgat ggttctgtaa aaacaactgc actatgtggc tttatacttt aggtcccagg
     1681 tgaagtgtta atgagatgct agacctatcc tgggggtact ctgacagaaa caggctctgg
     1741 tttttttttt gagttcgtca cattctatta tttctgttaa gaattatttt ctgagctcac
     1801 catggtggtc cttgcctatg gggagggagt cgatttaatt aattaattca tcattttttt
     1861 aaaaaaaatg tactgattac ttcctgggtg cctgaacata ttccaaagta acactgctac
     1921 acaagctgtg tgtgctagca ggctaaaaac agccatagct gtcttcatag ggatatgtcc
     1981 atgaacgtat acttaggtta aacattattc tggtagacag cgcaggtggt tgttagcaag
     2041 gaccatactg tttgattact tgttaatgtt aaacaaaaat ggttttgaaa actgttttct
     2101 gttcaacaga tcttagtcag tgcttggaag ccgcaaagca ctctcaaagt atttctgagg
     2161 gaattgatat gggtggcaaa agagaactta cagctatgca ttgcttgtag cagttccctt
     2221 tctcagaaac attatttttg ttgctctaaa taaagcattg cctgtcttgt ttgagatttt
     2281 acagccatac tctgctatgt aatgttatag ttccttttct atgaaatgtt attttgggtg
     2341 atctaaataa agctttgcca gttttgtttg aaagaagcaa gaggagtttt gctctggcct
     2401 ttcctggttc tttttactgc agggcaacta gtcgggtaac ctcttcactc ccaacttttg
     2461 tttccatttg tttgcccctt gtacgttttt gtccttccct ttttggtttg gcctctctgt
     2521 gcatcgtgac tattagtagt tatgagaagt caccgtgact ctgtgccaac ttgtggctgg
     2581 tctgtgggtc ctgataggtc aaatgcagat ctacccttcc ccaagttggc cagctgatgt
     2641 gatctgtagt catcctttta atcctcctct ctatttctcc ctctctctct ctctctctct
     2701 ctctctctct ttctctattt ctttctctcg ctgtctctct ctctctctcc tctatggttt
     2761 agagagctct aaaggcctgg aaaggatacc gaagccatga aagcattaga taaagcactt
     2821 ctcttactgt ttagctcagt tgactttaat ttccgaaggc cactggtcat gaacaacagg
     2881 agcctcaagg acttttgact caaatggtcc cattaaagtg ccttgtgcat cactgactac
     2941 taagattcac tacctccaga tcagctaaag aaggcatctt cccttctgca tttgtttagt
     3001 tgcttacaca gattcaggtt ggtgggaact gattggaacg gccttcacgt tcttggtagg
     3061 tgtgattttt aattttaatt gtcaatgtaa tggattgaga atcactgtgg aaacacactt
     3121 ctgggtgtgt ctatgatact gtttcagaaa agtttgaact gaagaggaaa gacccgtctt
     3181 gactatggcc atcaccattc cgtggactgg gatctcagac ccagtgaaaa gaagaaatta
     3241 agtagtatct cagaattcac ctttctctgc ttcctgacaa cattaccaat gggttcatgt
     3301 tcctgctgcc atgcttctct gccatgaggg actggaccat caaactggga ggcaaaataa
     3361 acccttttct caggtatttt ctcacagcaa ccacaaaagt ggctcataat ggaacattgg
     3421 tgttgagaag tggggctgtt gtggctaagc ctgaccatgt gggacatagg catttggaac
     3481 tggtttatag ctgagagttt ggaactttga gctagagaag ccttagagtg ctataaatag
     3541 agtttagtag gctattctgg tggtgttttg gaaaactaga atgccaagac aaacgtggat
     3601 agtggagatc tggctcacag gggtttggag agaaaaagag tattgaaaat tgagctacag
     3661 gccatttgtg tgataacctg gcaaaaaaat ctggtatcag gccatgccat tagtgccatg
     3721 tcctaggaac tggagtgagg ctagattcta aagcagtgga ctcattccct tggtggaaga
     3781 aatctgaaga aagcttagcg ttcaggctgt gtaatgttta ctgactactg ctgtcatcca
     3841 ggtctccagt gagaaatagc acaaatgaga caaaagaaga cagatgtgtc agtttggcgg
     3901 gggaagggat ggatttaaag gtgtaggcaa ggcagatcca gagaaagcag cagtacttgt
     3961 taaaagacat tagcaacatt aaagagaaac cttgtgctct gtattagata ttagtgaagg
     4021 ttccttaaag ataagacctc acccccaaaa accccctatt ttgtcaaaat atgaattcat
     4081 ttgaaaggag aaatcgtaaa gtgctgatgg tgttttctgc ttcttgaaag cagttaccta
     4141 ggaaaacctt tccccatggt tggcacacag gccaatatac ttgtaggcta agggacccag
     4201 gtcacagcag aactttgtag tatcactccc atggtacagg tgtgaaagat gtaggtgtgg
     4261 aggagtcatg gagacttgca ctagagttcc agaaagcact gagaccaggc aatgtgtcgc
     4321 ttggttggag tctctgtaaa ctagccctga gaggctacta tgtgaacatg ttaaagtgaa
     4381 gtctaagttg cagtatggat cccaggatgt tgaaggtacc agaactgtgg gtcatcgcct
     4441 gaggaaagcc ccatgcatgg agccgtgtca gccccagaga gaagttgctg caaatggcag
     4501 cgctggagat ctgggactac ccaagccctt ggaaatccat aggagtccat catgagctcc
     4561 agatgcgggc catagagctg caggatctga tgtttgccct gctgggtgtc ggtctttctt
     4621 tggacacacc cttgcttgct gtaattccca ctcttcctgt tgggaatggg agtttttctt
     4681 ctttgccatt gtttattgag acattgttag ttgtttttga ttttatagat gttcacaaat
     4741 aagagattgc cttgagtctc agagaagaca ttgaactgct taacactgct gggactgcta
     4801 aagactatgg agagttttag agagggacta aatgtatttt gaattgtgag atgaaaatga
     4861 gaatttgggg gccagaggtg gaatgctatg gtgtagtggt gtgtttgggt gtcaggttgg
     4921 ctggggtaga ctagagatgc ttgattttga ttattaactt gggtggaatc agaatcaccc
     4981 tggaaacatg cctttggata tgtctctatg aagtttaact gaagagggaa gacccaccct
     5041 aaatgtggat gacactattt taggacttgg ggtcttaaac tgaatgaaaa ggacaaagtg
     5101 agcggaaaat caaaattcgt ctctctttgc ttcctaactg tcagtcttgc tgccgtgact
     5161 tcccctacca tatggaatgc ttctcttcaa actgtaagcc aaaataaatg tttcctccct
     5221 taa
//
