LOCUS       NP_001357720             525 aa            linear   ROD 27-APR-2025
DEFINITION  MSL complex subunit 3 isoform 1 [Mus musculus].
ACCESSION   NP_001357720 XP_006528804
VERSION     NP_001357720.1
DBSOURCE    REFSEQ: accession NM_001370791.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 525)
  AUTHORS   Mitchell,T.A., Lin,J.M., Hicks,S.M., James,J.R., Rangan,P. and
            Forni,P.E.
  TITLE     Loss of function of male-specific lethal 3 (Msl3) does not affect
            spermatogenesis in rodents
  JOURNAL   Dev Dyn 253 (5), 453-466 (2024)
   PUBMED   37847071
  REMARK    GeneRIF: Loss of function of male-specific lethal 3 (Msl3) does not
            affect spermatogenesis in rodents.
REFERENCE   2  (residues 1 to 525)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (residues 1 to 525)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 525)
  AUTHORS   Ye,A., Kim,H. and Kim,J.
  TITLE     PEG3 control on the mammalian MSL complex
  JOURNAL   PLoS One 12 (6), e0178363 (2017)
   PUBMED   28609438
  REMARK    GeneRIF: Data show that complete removal of paternally expressed
            gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1
            (Msl1) and male-specific lethal 3 (Msl3).
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 525)
  AUTHORS   Ye,A., He,H. and Kim,J.
  TITLE     PEG3 binds to H19-ICR as a transcriptional repressor
  JOURNAL   Epigenetics 11 (12), 889-900 (2016)
   PUBMED   27824289
REFERENCE   6  (residues 1 to 525)
  AUTHORS   Chelmicki,T., Dundar,F., Turley,M.J., Khanam,T., Aktas,T.,
            Ramirez,F., Gendrel,A.V., Wright,P.R., Videm,P., Backofen,R.,
            Heard,E., Manke,T. and Akhtar,A.
  TITLE     MOF-associated complexes ensure stem cell identity and Xist
            repression
  JOURNAL   Elife 3, e02024 (2014)
   PUBMED   24842875
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 525)
  AUTHORS   Wolstenholme,J.T., Rissman,E.F. and Bekiranov,S.
  TITLE     Sexual differentiation in the developing mouse brain: contributions
            of sex chromosome genes
  JOURNAL   Genes Brain Behav 12 (2), 166-180 (2013)
   PUBMED   23210685
REFERENCE   8  (residues 1 to 525)
  AUTHORS   Kadlec,J., Hallacli,E., Lipp,M., Holz,H., Sanchez-Weatherby,J.,
            Cusack,S. and Akhtar,A.
  TITLE     Structural basis for MOF and MSL3 recruitment into the dosage
            compensation complex by MSL1
  JOURNAL   Nat Struct Mol Biol 18 (2), 142-149 (2011)
   PUBMED   21217699
  REMARK    GeneRIF: Msl1 interacts with Msl3 as an extended chain forming an
            extensive hydrophobic interface, whereas the Msl1-MOF interface
            involves electrostatic interactions between the HAT domain and a
            long helix of Msl1.
REFERENCE   9  (residues 1 to 525)
  AUTHORS   Cormier,T.A., Prakash,S.K., Magner,D.B., Zoghbi,H.Y. and Van den
            Veyver,I.B.
  TITLE     Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked polydactyly
            (Xpl) and Patchy-fur (Paf) mutant mice
  JOURNAL   Mamm Genome 12 (10), 796-798 (2001)
   PUBMED   11668396
  REMARK    GeneRIF: Analysis of Mid1, Hccs, Arhgap6, and Msl3l1 in X-linked
            polydactyly (Xpl) and Patchy-fur (Paf) mutant mice
REFERENCE   10 (residues 1 to 525)
  AUTHORS   Prakash,S.K., Van den Veyver,I.B., Franco,B., Volta,M., Ballabio,A.
            and Zoghbi,H.Y.
  TITLE     Characterization of a novel chromo domain gene in xp22.3 with
            homology to Drosophila msl-3
  JOURNAL   Genomics 59 (1), 77-84 (1999)
   PUBMED   10395802
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671489.12.
            
            On Jun 2, 2019 this sequence version replaced XP_006528804.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223971.19048.1,
                                           SRR10223969.20183.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..525
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 78.73 cM"
     Protein         1..525
                     /product="MSL complex subunit 3 isoform 1"
                     /note="male-specific lethal-3 protein-like 1;
                     male-specific lethal-3 homolog 1; male-specific lethal 3
                     homolog"
                     /calculated_mol_wt=60161
     Region          15..81
                     /region_name="CBD_MSL3_like"
                     /note="chromo barrel domain of human male-specific lethal
                     complex subunit 3, and similar proteins; cd18983"
                     /db_xref="CDD:350846"
     Site            order(26..27,31..34,54,56..59,63,65..68,70..72,75..76)
                     /site_type="other"
                     /note="putative peptide binding site [polypeptide
                     binding]"
                     /db_xref="CDD:350846"
     Site            order(31,56,59,63)
                     /site_type="other"
                     /note="putative methylated histone tail binding site
                     [chemical binding]"
                     /db_xref="CDD:350846"
     Site            order(53,55..60,62..66)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     Site            order(53,56,60,62,66)
                     /site_type="other"
                     /note="putative RNA binding site [nucleotide binding]"
                     /db_xref="CDD:350846"
     Region          119..148
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Region          166..510
                     /region_name="MRG"
                     /note="pfam05712"
                     /db_xref="CDD:461721"
     Region          294..444
                     /region_name="Required for the histone acetyltransferase
                     activity of the MSL complex.
                     /evidence=ECO:0000250|UniProtKB:Q8N5Y2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Region          302..383
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Site            313
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Site            315
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Site            371
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N5Y2; propagated from
                     UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Site            404
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8N5Y2; propagated from
                     UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Site            409
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Site            411
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVG9.3)"
     Site            415
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q9WVG9.3)"
     CDS             1..525
                     /gene="Msl3"
                     /gene_synonym="Msl31; Msl3l1"
                     /coded_by="NM_001370791.1:44..1621"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS90775.1"
                     /db_xref="GeneID:17692"
                     /db_xref="MGI:MGI:1341851"
ORIGIN      
        1 msasegmkfq fhsgekvlcf epdptkarvl ydakiidvii gkdekgrkip eylihfngwn
       61 rswdrwaaee hvlhdtdenr rlqrklakka iarlrgtgkk krrcrlpgvd svlksvpvke
      121 kskndensvs stchescgek nggikehrqr rikvkakakk kvlslrsrke mdertitidi
      181 pdvlkkqled dcyyinrrkr lvklpcqtni itilesyvkh fainaafsan erprhhhamm
      241 hthmnvhyvp aeknvdlcke mvdglritfd ytlplvllyp yeqtqykrvt sskfflpike
      301 sttttnrsqe elspspplln pstpqstesq pptgepatpk rrkaepealq slrrstrhst
      361 ncdrlsesss spqpkrrqqd tsasmpklfl hlekktpvhs rssspipltp skdgsavfag
      421 fegrrpnein evlswklvpd nyppgdqppp psyiygaqhl lrlfvklpei lgkmsfsekn
      481 lkallkhfdl flrflaeyhd dffpesayva aceahystkn praiy
//
