LOCUS       NM_001100451            4899 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus MSL complex subunit 2 (Msl2), transcript variant 1,
            mRNA.
ACCESSION   NM_001100451 XM_150227 XM_907909
VERSION     NM_001100451.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4899)
  AUTHORS   Sun,Y., Wiese,M., Hmadi,R., Karayol,R., Seyfferth,J., Martinez
            Greene,J.A., Erdogdu,N.U., Deboutte,W., Arrigoni,L., Holz,H.,
            Renschler,G., Hirsch,N., Foertsch,A., Basilicata,M.F., Stehle,T.,
            Shvedunova,M., Bella,C., Pessoa Rodrigues,C., Schwalb,B.,
            Cramer,P., Manke,T. and Akhtar,A.
  TITLE     MSL2 ensures biallelic gene expression in mammals
  JOURNAL   Nature 624 (7990), 173-181 (2023)
   PUBMED   38030723
  REMARK    GeneRIF: MSL2 ensures biallelic gene expression in mammals.
REFERENCE   2  (bases 1 to 4899)
  AUTHORS   Urra,H., Henriquez,D.R., Canovas,J., Villarroel-Campos,D.,
            Carreras-Sureda,A., Pulgar,E., Molina,E., Hazari,Y.M., Limia,C.M.,
            Alvarez-Rojas,S., Figueroa,R., Vidal,R.L., Rodriguez,D.A.,
            Rivera,C.A., Court,F.A., Couve,A., Qi,L., Chevet,E., Akai,R.,
            Iwawaki,T., Concha,M.L., Glavic,A., Gonzalez-Billault,C. and
            Hetz,C.
  TITLE     IRE1alpha governs cytoskeleton remodelling and cell migration
            through a direct interaction with filamin A
  JOURNAL   Nat Cell Biol 20 (8), 942-953 (2018)
   PUBMED   30013108
  REMARK    Erratum:[Nat Cell Biol. 2018 Oct;20(10):1228. doi:
            10.1038/s41556-018-0186-0.. PMID: 30089843]
REFERENCE   3  (bases 1 to 4899)
  AUTHORS   Ye,A., Kim,H. and Kim,J.
  TITLE     PEG3 control on the mammalian MSL complex
  JOURNAL   PLoS One 12 (6), e0178363 (2017)
   PUBMED   28609438
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4899)
  AUTHORS   Chelmicki,T., Dundar,F., Turley,M.J., Khanam,T., Aktas,T.,
            Ramirez,F., Gendrel,A.V., Wright,P.R., Videm,P., Backofen,R.,
            Heard,E., Manke,T. and Akhtar,A.
  TITLE     MOF-associated complexes ensure stem cell identity and Xist
            repression
  JOURNAL   Elife 3, e02024 (2014)
   PUBMED   24842875
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4899)
  AUTHORS   Lai,Z., Moravcova,S., Canitrot,Y., Andrzejewski,L.P., Walshe,D.M.
            and Rea,S.
  TITLE     Msl2 is a novel component of the vertebrate DNA damage response
  JOURNAL   PLoS One 8 (7), e68549 (2013)
   PUBMED   23874665
  REMARK    GeneRIF: Msl2 is a novel component of the vertebrate DNA damage
            response.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4899)
  AUTHORS   Wolstenholme,J.T., Rissman,E.F. and Bekiranov,S.
  TITLE     Sexual differentiation in the developing mouse brain: contributions
            of sex chromosome genes
  JOURNAL   Genes Brain Behav 12 (2), 166-180 (2013)
   PUBMED   23210685
REFERENCE   7  (bases 1 to 4899)
  AUTHORS   Kruse,J.P. and Gu,W.
  TITLE     MSL2 promotes Mdm2-independent cytoplasmic localization of p53
  JOURNAL   J Biol Chem 284 (5), 3250-3263 (2009)
   PUBMED   19033443
  REMARK    GeneRIF: the MSL2-mediated effect on p53 is Mdm2-independent. Thus,
            our study identifies an important ubiquitin-ligase for modulating
            p53 subcellular localization
REFERENCE   8  (bases 1 to 4899)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   9  (bases 1 to 4899)
  AUTHORS   Marin,I.
  TITLE     Evolution of chromatin-remodeling complexes: comparative genomics
            reveals the ancient origin of 'novel' compensasome genes
  JOURNAL   J Mol Evol 56 (5), 527-539 (2003)
   PUBMED   12698291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC070432.1, BC100371.1, AK035934.1 and BE986573.1.
            
            On May 3, 2013 this sequence version replaced NM_001100451.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1353              BC070432.1         1-1353
            1354-3983           BC100371.1         508-3137
            3984-4882           AK035934.1         2204-3102
            4883-4899           BE986573.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..4899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 53.17 cM"
     gene            1..4899
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="MSL complex subunit 2"
                     /db_xref="GeneID:77853"
                     /db_xref="MGI:MGI:1925103"
     exon            1..659
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /inference="alignment:Splign:2.1.0"
     CDS             518..2251
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /EC_number="2.3.2.27"
                     /note="isoform 1 is encoded by transcript variant 1; ring
                     finger protein 184; MSL2-like 1; male-specific lethal-2
                     homolog 1; male-specific lethal 2-like 1; E3
                     ubiquitin-protein ligase MSL2; male-specific lethal 2
                     homolog; E3 ubiquitin-protein transferase MSL2"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase MSL2 isoform 1"
                     /protein_id="NP_001093921.1"
                     /db_xref="CCDS:CCDS85717.1"
                     /db_xref="GeneID:77853"
                     /db_xref="MGI:MGI:1925103"
                     /translation="MNPVNATALYISASRLVLNYDPGDPKAFTEINRLLPYFRQSLSC
                     CVCGHLLQDPIAPTNSTCQHYVCKTCKGKKMMMKPSCSWCKDYEQFEENKQLSILVNC
                     YKKLCEYITQTTLARDIIEAVDCSSDILALLNDGSLFCEETEKPSDSSFTLCLTHSPL
                     PSTSEPTADPQASLSPMSESTLSIAIGSSVINGLPTYNGLSIDRFGINIPSPEHPNTI
                     DVCNTVDIKTEDLSDNLPPVCDTVATDLCSTGIDICSFSEDIKPGDSLLLSVEEVLRS
                     LETVSNTEVCCPNLQPNLEATVSNGPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPK
                     VAKLNRKRSRSESDSEKVQPLPISTIIRGPTLGASAPVTVKRESKISLQPIATVPNGG
                     TTPKISKTVLLSTKSMKKSHEHGSKKSHSKSKPGILKKDKAVKEKMPSHHFMPGSPTK
                     TVYKKPQEKKGCKCGRATQNPSVLTCRGQRCPCYSNRKACLDCICRGCQNSYMANGEK
                     KLEAFAVPEKALEQTRLTLGINVTSIAVRNASTSTSVINVTGSPVTTFLAASTHDDKS
                     LDEAIDMRFDC"
     exon            660..4889
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2878..2883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="hexamer: AATAAA"
     polyA_site      2900
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="major polyA site"
     regulatory      3959..3964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="hexamer: AGTAAA"
     polyA_site      3976
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="major polyA site"
     regulatory      4463..4468
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="hexamer: AATAAA"
     polyA_site      4482
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="major polyA site"
     polyA_site      4636
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
     regulatory      4871..4876
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
                     /note="hexamer: AGTAAA"
     polyA_site      4889
                     /gene="Msl2"
                     /gene_synonym="E130103E02Rik; Msl2l1; Rnf184"
ORIGIN      
        1 cgggaatccg acgcctgcgc cgtagtcccc accgtcccgc tgcctccgcg acgtcgctgc
       61 gatggagtaa gggccccgcc gtcggaagag aaacgtgtgg accgcttgga ccccaccggg
      121 cccgctcccg tgcgcgccag ctccacccgg aggtgcctcc gcggccggac atgctgctcg
      181 agcgcaggcc gcccgccgag ccgcggggct agagcgaacc cggagcccgt ccggagcacc
      241 cagccgcggc cgtgtcggac gaactcgatc gctgatttcg cttgtctctc tttggtctgc
      301 aagtctcagg gacagaggag gggcgccgag gcccccatgt gtgggaggat tgcttcagct
      361 tcacaaactt gcacggattt tggttgctgc tttggccagg ggttctgctc agatttcttc
      421 cgaattgttt taaattcgcc attgttccct ggctgcttac aaacttggat ccggaatttc
      481 ttttcaaccg ggagccattg gtgtcgaagt gtctgcaatg aacccggtga atgctactgc
      541 tctctacatt tccgcgagcc gcctagtgct caactacgac cccggagacc ccaaggcgtt
      601 tacagagatt aacaggctct tgccttactt ccgacagtcc ctctcgtgct gtgtttgcgg
      661 acatttgctt caagatccta ttgcacccac caactccacc tgccaacact atgtctgcaa
      721 aacttgtaaa ggcaagaaaa tgatgatgaa accttcatgt agctggtgca aagactatga
      781 gcagtttgag gagaacaagc agttaagcat cctagtgaat tgctacaaga aactgtgtga
      841 atatataacc cagacgacac tggcacggga tataatagaa gcagttgact gttcttctga
      901 tattttggct ttgcttaatg acggatcatt gttttgtgag gagaccgaga aaccttcaga
      961 ttcatccttc actctgtgtt tgacacattc ccctttacct tcaacttcag aacccacagc
     1021 tgatcctcaa gctagcttat ctccaatgtc tgagagtacc ctcagcattg ccattggcag
     1081 ttctgttatc aatggtttgc ctacttacaa tgggctttca atagatagat ttggtataaa
     1141 tatcccttca cctgaacatc caaatacaat tgacgtgtgt aatactgttg atataaaaac
     1201 tgaggatctg tctgacaacc tgccacctgt ctgtgacacg gtagccactg acttgtgctc
     1261 cacaggtatt gatatctgta gtttcagtga agatataaaa cccggtgact ctcttttgct
     1321 gagtgttgag gaagtactcc gcagcttaga aactgtttca aatacagaag tttgctgtcc
     1381 taatttgcag ccaaacttgg aagccactgt atccaatgga ccttttttgc agctttcttc
     1441 ccagtctctt agccataatg ttttcatgtc caccagccct gcacttcatg ggttatcatg
     1501 tacagcagca actcccaagg tagcaaagtt gaatcgaaaa cgatccagat ctgaaagtga
     1561 cagtgagaaa gttcagccac ttccaatttc taccattatc cgaggcccaa cactgggggc
     1621 atctgctcct gtgactgtga agcgggaaag caaaatctct cttcaaccta tagcaactgt
     1681 tcccaatgga ggcacgacac ccaagatcag caagactgta cttttatcta ctaaaagcat
     1741 gaaaaagagt catgaacatg gatccaagaa atctcactct aaatccaagc caggtattct
     1801 taaaaaagac aaagcagtaa aggaaaagat gcctagtcat cattttatgc caggaagccc
     1861 taccaagact gtgtacaaaa agccccagga aaagaaagga tgtaaatgtg ggcgtgctac
     1921 tcaaaatcca agtgttctta catgccgcgg ccaacgctgc ccttgctact ctaaccggaa
     1981 agcctgctta gattgtatat gtcgtggctg ccaaaactcc tatatggcca atggggagaa
     2041 gaagctggag gcatttgcgg tgccagaaaa ggccttggag cagaccaggc tcactttggg
     2101 cattaatgtg actagcattg ctgtgcgtaa cgcaagtacc agcaccagtg taattaatgt
     2161 cacagggtcc cctgtaacga catttttggc tgccagtaca catgatgata aaagtttgga
     2221 tgaagctata gatatgagat tcgactgtta aatcagtggg tctttaaacc taccccttgg
     2281 taggaaatag ctacagtttt acggcagcta tggttctgtt ggtttaactt gccggagctc
     2341 ctgcatatag atcacttgta tcaagtgttt tcattgctaa gttatatgtg ttagtgtcgg
     2401 ggaaatagtt tgcagataat ggaggagtaa ccctacaact atatgttctt agttcttaca
     2461 gaacctcata gtttgagaac aaatgctgat gcaactgatt tatacaaaat gaactttggc
     2521 aaggaaataa caataacctc attgtttatg gtcatgcttt gtgcataatc aaagttgatg
     2581 attaaaatgt aaggaagtgg tatcagtcag tccataaaga ttgcgctaat ttttttgtga
     2641 aaaagtagcc attagtttat caggagactt tgtgctgcct tcaaatgccg cactgatatt
     2701 tctcctgttg aaaagctgat gtgtccagct caacctttgt gctgacataa taccatttct
     2761 gatcatgaaa attggctact ggcgtgtatg tagcagttct taaatcagca gtattatgaa
     2821 agaaaatttc cccctcatta gaatgtttaa gaaatctgtc ttttaaaaaa gtgaacaaat
     2881 aaattccatc agaccacaaa tgttaagctg tttatgcttt aaatatttat gagttcagcc
     2941 ctcctttcta gttatctgat ttacttctat gagaaaatcc taagtccttt cactttgagc
     3001 aatgttctat ttggtaaata aagtgaagag ctgttttatt ctgaatataa ctgaatttat
     3061 atagttcatg acagaatttt taaaaaatat aaaaataatc taaaaattgg gttttattta
     3121 aatgaattct ggaataatgc cccaaatgtg cccagactta tgcattatac ttattgccat
     3181 tgacaacttc ttttttattt atttcctatt tgccacgggc tttaccttga atatgctcct
     3241 ttttttcctt ttctttcttt tcttttttct tttttagggt gctgttcaaa atgaaggctt
     3301 cttcatcaag gcctttagtg aagcctgggc atttaggtct aaagctcgga ggatcttctt
     3361 tagatgctct tgcatgtaaa gcacaaactg tttcagttta atgtacttcc tcctactaac
     3421 tttatgggga agataaacat tctgttgatg ggaggtccta gtcagttgct tgagagagca
     3481 cagcccaggt taaacaagga ctgactaggt gtagagagaa ccttgtgatt tcaaagagtt
     3541 gctgctttgg cagtgcttgt tctaagaaaa atactgctag ggaagttcca acttctactg
     3601 cactcaacat ctagtgagat ctgatgtgtt gaagttgttt tggtttggca cacagcatgt
     3661 tcaatgatgg ttactcgcct cacaaagaca tggagaagaa tcctttggac acagcagatg
     3721 acacctcctg ttttgtagtg tatcctggtg tcattttctg gggatgtggt caggtagttg
     3781 ttttgttgtt gtcattgggc tttttaaaaa aacaaaaaaa taccaaaaaa attttttggt
     3841 ctctttgggt ggggcggggg tgggctaaag ccataggaag gaaatgtgat gtatgtgtcc
     3901 agtatgtacg attttgtttt tgttttgcaa gaagagttga actatttttg ataacaagag
     3961 taaatggtgg aaaatgcttc ttagttgtct tgtctttatt tgcttaccaa gttttggaat
     4021 tttatttaaa tctttaaatg atagcagtgt cttatgaaac atgtatttac ctgaactttg
     4081 taacagtttt tgtgttgaac catattccct gctatataat cgtgtaaatc tgttttttat
     4141 tcactaatga tcactgcaga aatgactaga aatgagattg tacacatgga taattaggct
     4201 atattttgca aatctcccaa actttcctag tatcttaaaa ttcatggagt acctaattgc
     4261 ttcccaaatt tgatcacttt gtttcttgat gcatgggagg tcggcaatat agacaaagtg
     4321 gacattagta tgtgagggcc ttgattgatc tgtaatattg ccaatgatga attcaggttg
     4381 tttttagcac aagtttctct tttttatgct ggtattctca ctgccacatt tttggaaacc
     4441 tgtattacac cttaaatcta tcaataaatg atagttttct aattctatgt tgtagaatac
     4501 tgaggagttt gggatagcat gttttgaatg gtctgtatta gccgggggaa aagaacttta
     4561 ttacagtgcc ttggtttttt atattgtttt tctttatgat gtgtggattt ttaaaaaagt
     4621 aatgttgaca aatgaattag ctgtgaattt attgaagtaa ctggacttct ccatcaggat
     4681 atgaaattac taaacaagaa aaactgcatt taaattggta tatcatgaat aatctgagtc
     4741 cttgccatta gagagttaaa ctttttcttt ttggttagat ttgttgagtg tatattttct
     4801 ttatgaagtc ctagggtaaa ggctctctgt aattgctttc ttaaaaaaaa tgataacctt
     4861 actgaagaaa agtaaaaatg ttaaacaaaa aaaaaaaaa
//
