LOCUS       NM_028722               4593 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus male specific lethal 1 (Msl1), transcript variant 1,
            mRNA.
ACCESSION   NM_028722 XM_915688 XM_923879 XM_923881 XM_923887 XM_923888
VERSION     NM_028722.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4593)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4593)
  AUTHORS   He,Y., Wang,S., Liu,S., Qin,D., Liu,Z., Wang,L., Chen,X. and
            Zhang,L.
  TITLE     MSL1 Promotes Liver Regeneration by Driving Phase Separation of
            STAT3 and Histone H4 and Enhancing Their Acetylation
  JOURNAL   Adv Sci (Weinh) 10 (23), e2301094 (2023)
   PUBMED   37279389
  REMARK    GeneRIF: MSL1 Promotes Liver Regeneration by Driving Phase
            Separation of STAT3 and Histone H4 and Enhancing Their Acetylation.
REFERENCE   3  (bases 1 to 4593)
  AUTHORS   Ye,A., Kim,H. and Kim,J.
  TITLE     PEG3 control on the mammalian MSL complex
  JOURNAL   PLoS One 12 (6), e0178363 (2017)
   PUBMED   28609438
  REMARK    GeneRIF: Data show that complete removal of paternally expressed
            gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1
            (Msl1) and male-specific lethal 3 (Msl3).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4593)
  AUTHORS   Ye,A., He,H. and Kim,J.
  TITLE     PEG3 binds to H19-ICR as a transcriptional repressor
  JOURNAL   Epigenetics 11 (12), 889-900 (2016)
   PUBMED   27824289
REFERENCE   5  (bases 1 to 4593)
  AUTHORS   Dmitriev,R.I., Pestov,N.B., Shakhparonov,M.I. and Okkelman,I.A.
  TITLE     Two distinct nuclear localization signals in mammalian MSL1
            regulate its function
  JOURNAL   J Cell Biochem 115 (11), 1967-1973 (2014)
   PUBMED   24913909
  REMARK    GeneRIF: Studies identi fi ed a novel signal of nuclear
            localization (NLS) in all MSL1 protein isoforms and found that the
            combination of both NLS allows for its intra-nuclear focal
            accumulation and nuclear transport of TTC4 while all MSL1 isoforms
            affect H4K16Ac.
REFERENCE   6  (bases 1 to 4593)
  AUTHORS   Dmitriev,R.I., Okkelman,I.A., Abdulin,R.A., Shakhparonov,M.I. and
            Pestov,N.B.
  TITLE     Nuclear transport of protein TTC4 depends on the cell cycle
  JOURNAL   Cell Tissue Res 336 (3), 521-527 (2009)
   PUBMED   19390865
REFERENCE   7  (bases 1 to 4593)
  AUTHORS   Dmitriev,R.I., Korneenko,T.V., Bessonov,A.A., Shakhparonov,M.I.,
            Modyanov,N.N. and Pestov,N.B.
  TITLE     Characterization of hampin/MSL1 as a node in the nuclear
            interactome
  JOURNAL   Biochem Biophys Res Commun 355 (4), 1051-1057 (2007)
   PUBMED   17335777
  REMARK    GeneRIF: hampin may be linked to diverse regulatory processes in
            the nucleus
REFERENCE   8  (bases 1 to 4593)
  AUTHORS   Dmitriev,R.I., Pestov,N.B., Korneenko,T.V. and Shakhparonov,M.I.
  TITLE     Intracellular location of hampin isoforms
  JOURNAL   Dokl Biochem Biophys 408, 130-132 (2006)
   PUBMED   16913411
REFERENCE   9  (bases 1 to 4593)
  AUTHORS   Dmitriev,R.I., Pestov,N.B., Korneenko,T.V., Gerasimova,A.V.,
            Zhao,Kh., Modianov,N.N., Kostina,M.B. and Shakhparonov,M.I.
  TITLE     [Tissue specificity of alternative splicing products of mouse mRNA
            encoding new protein hampin homologous to the Drosophila MSL-1
            protein]
  JOURNAL   Bioorg Khim 31 (4), 363-371 (2005)
   PUBMED   16119455
  REMARK    GeneRIF: Describes the primary structure of the protein hampin,
            which shares about 26% sequence identity with the Drosophila MSL1
            protein. In mouse, at least five splice isoforms exist, two of
            which have restricted tissue specificity (testes).
REFERENCE   10 (bases 1 to 4593)
  AUTHORS   Marin,I.
  TITLE     Evolution of chromatin-remodeling complexes: comparative genomics
            reveals the ancient origin of 'novel' compensasome genes
  JOURNAL   J Mol Evol 56 (5), 527-539 (2003)
   PUBMED   12698291
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014463.1, BC058629.1 and AL590963.11.
            
            On Mar 30, 2018 this sequence version replaced NM_028722.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014463.1, BC058629.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AK014463.1         1-253
            254-3186            BC058629.1         1-2933
            3187-4593           AL590963.11        50718-52124         c
FEATURES             Location/Qualifiers
     source          1..4593
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.67 cM"
     gene            1..4593
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /note="male specific lethal 1"
                     /db_xref="GeneID:74026"
                     /db_xref="MGI:MGI:1921276"
     exon            1..1089
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1313
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1696
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1744
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1809
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1877
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1878..2002
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2075
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..4593
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4567..4572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /note="hexamer: AATAAA"
     polyA_site      4588
                     /gene="Msl1"
                     /gene_synonym="2810017F12Rik; 4121402D02Rik;
                     4930463F05Rik; Msl-1"
                     /note="major polyA site"
ORIGIN      
        1 gagctccggg gatgagctcg ggggcggctg ggtgcgagct cctgcctctg cggcgaaggc
       61 gacggtggcg gcagcagagg cggcggcgag gccaccatgg gtcggcggcg ggcctcagct
      121 gcggcctcca cttctccgct cgccggcggg atggcgcccg ggcctcggag aagccgcgtt
      181 agcggaggcc tgcggctgct ctgctgagcc gagcccgcca aactcccctc cccctcctcc
      241 gtcctcgacc ccccgcacct cgccccttcc ccaccccctc ctccgtctcg gtcccccgcg
      301 ctgctccgga ccactatgac catgagatcc gcagtgttca aggcggccgc ggcccctgcc
      361 ggcggcaacc ccgagcagcg actggactac gagcgggctg cggcgctggg cgggcccgag
      421 gacgagtccg gggcggccga agcccatttc ctcccccggc atcgtaagct caaggagccg
      481 gggcccccgc tggcctcttc ccagggcggg agcccctcgc cctctccagc cggctgcggc
      541 ggcggcaagg gccggggctt gttactccca gccggggcgg cccccgggca gcaggaagag
      601 agctggggcg gttcggtgcc cttgccctgt ccgcccccag ctactaaaca agccggcatc
      661 ggcggggagc cagtcgcagc cggcgctggc tgcagccccc ggcccaagta tcaggcggtg
      721 ctgcccattc agacgggctc tatcgtggtg gcggcggcca aagagcctac gccctgggct
      781 ggggacaagg gtggggcggc tcccccagct gccaccgcct cggacccggc gggaccccca
      841 ccactacctc tgcccgggcc accacccctc gcgcccaccg ccactgctgg gaccctggcg
      901 gccagtgagg gcagatggaa gagtataagg aagagccctc tcgggggtgg cggcggctcg
      961 ggagcctcca gtcaggccgc ctgcctcaaa cagatccttc tgctgcaatt ggacctcatc
     1021 gaacagcagc agcagcagtt gcaggccaag gagaaggaga tagaggagct gaagtccgag
     1081 agagatacgc tccttgctcg gattgaacgt atggaaaggc ggatgcagct ggtgaagagg
     1141 gataacgaga aggaaaggca caagctgctc cagggctatg aacctgaaga gagagaggaa
     1201 gcagagttgt ctgagaaaat taaattggag cgccagccgg agctttgcga gacctcccag
     1261 gctctgcctt ccaagccttt ctcatgtggc cggagtggaa agggacacaa aaggaaaacc
     1321 ccatttggaa atacagaaag aaagactcct gttaaaaagc tggctcctga attttcaaaa
     1381 gtcaaaacaa aaactcctaa gcactctccc attaaagagg aaccctgtgg ttccatatca
     1441 gaaactgttt gtaaacgtga attgaggagc caagaaaccc cagaaaagcc ccggtcttca
     1501 gtggataccc caccaagact ctcgactccc caaaagggac ccagcaccca ccccaaggag
     1561 aaagccttct caagtgagat ggaagatttg ccgtaccttt ccaccacaga aatgtatttg
     1621 tgtcgttggc accagcctcc cccatcaccg ttaccattac gggaatcctc tccaaagaag
     1681 gaggagactg tagcaaggtg tctgatgcca tcaagtgttg caggagaaac ttcagtcttg
     1741 gctgttcctt cttggaggga ccactcagta gagcctctaa gggacccaaa tccttcagac
     1801 attttggaga acctggatga cagtgtattt tcaaagaggc atgcaaaact ggagctagac
     1861 gagaagagga gaaaacgatg ggatattcag aggatcaggg aacaaagaat tttacagcga
     1921 ctgcagctca gaatgtataa aaagaaagga attcaggaat ctgagcctga ggttacctca
     1981 tttttccctg agccagatga tgttgaaagt ttgctgatta cccccttctt gcctgttgta
     2041 gcatttggac ggccattgcc aaaattagct ccacagaact ttgaactacc ctggttggat
     2101 gagcgaagcc gttgcaggtt ggagatccag aagaagcaca cacctcaccg gacctgtagg
     2161 aagtagctgt gctggcggta gcctgtcttc agatagttgt agcatgctgt tccgagagaa
     2221 tagcagagac ctgtatgtgt gacctgtgcc ctcatgtctg ttatcattca ctggtaatgc
     2281 ctttccatcc tccctttata ttagttttgt tttctttact ctgatttcac aaaacaaaca
     2341 gaagaaagct cttgcgttgg ctgattgtga attaggggtt actggagcgg cttttcccat
     2401 tttggggaga tgagcttgag ctcgtcctat agggggagac ttgggggtcc caggggccac
     2461 ttgtaactca cctgcctgcc taacggggta aagggctctt cattagcgtg tctaagatgg
     2521 agcaaccctt cctgtaggag ctgtgcctgc cctgaccccg tgcctccctg gtgcgccttc
     2581 tgaatagtgt gggtgtagta ggtttcaccg tgaactttag ggcccgagga atagcatgaa
     2641 gtaatgaagc aagacattcc tcagaggggg aaactgcaga gttttacctg aaagtttgtt
     2701 ctctttaaac tgctctgtga cagtggcatg tgggaggaga cgtgcagctg gttcactttc
     2761 ttagttgatg ggtaactgaa gttccttccc acccccaaca aagaagatgt ttagaaaaga
     2821 gattgggagt gtaagtttcc aactagttaa cagtgctaaa ccgatagagc tctcatttgg
     2881 ggatggcatg ccagagtctg tagagatgtc tctgtcatgt cacttttcaa ggattcctta
     2941 gtggggcttg atcctattag ccaaactttt ggtggtgagg tagagatttg gggtggggcc
     3001 gggggtaggg tatggaagga tatgcttcct ctgcctggca gatgtctaca gcttgaaaca
     3061 aacagttgta cctaatgaac tttattcgtt tagtgaaaat agatttatac acgaaccatc
     3121 ttgtttccca tctcctgccc ttgttttgtt actgaaaaga taaaaaagaa aaaaaaaaaa
     3181 aaaaaagaaa aaagaaaaaa aaatcaggac agcactccca ggccactttg gtctcagtgt
     3241 aagatccctg ttaactatct ggaagagaaa tggagccgag gcctgtgggc ttctggatag
     3301 gagttgcctt tcactagcct tcaggactat tgtataaaaa caagttgggg tctaatctct
     3361 agaagggtag ggctcttatc cttgaagaga acatggcccc aaattattag cacttttaga
     3421 ggagaagcca aggtatgtag ggtgtgtggt tggcccatct gctgagcatg cgagaatggc
     3481 attgccactg tgggaagaga cgttctcagg ggcctcccac tgctaaagct tttttgagac
     3541 gttatcttgc tccctgggtt tgactttgaa aggaattatt ccagcagtcc atgtagtgtt
     3601 cttggatgat cttgctgctc ttaattctcc tttgtatgtg tgtgtgtgtg tgtgtgtgtg
     3661 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg gctctgggtt ttcacttgta actccatctg
     3721 cttaggagcg tggtctctct gtgacagaag ctgccataaa ccacctcagc gaggatgtag
     3781 agagaaaggg gacttctccg ctaggggctc tcatctcaca ccttagggat ggggatatag
     3841 ctagaaagat tgggccagat tgttgttgtt gttgttgttg ttgttgtttt aatgaggcca
     3901 actgtttagt gctcctactc tgacctgtgt tgtttcttta taacatgctc ctcaaaaata
     3961 ataacctcaa tcagttgtct ctttacttcg tttcttgatc cctctcagtt tcttcttgac
     4021 aacgagattt gtcagattcc taatttgggt atgggttaac agatttaacc accaggtttc
     4081 tgccctacac agaggagtcc tcagatcctg tttttgctag actgagagga atccatgagg
     4141 tgctatctgg caggactgaa gtggattcta ttgctttggt tctcctttcc ctgaggacct
     4201 actatttggt tatgtcctct cctagatgtc ctttggtttg gggatgctga ggaggctggg
     4261 gtgagagcac agtgaggagc gtggggagtc acctgcttcc cctccgtggg gtacaacact
     4321 gtgagattca gtcttcagca gaaagagagg ccctgcactt ctctgaaaac atagttcctt
     4381 attctttctt taacaaagtt taagctagtg ttaataaatt aaaagagaaa ttgcttgtct
     4441 ctccacctca gctttatttt atgcccgttt catatcgttg tctgtgctgt aattcatact
     4501 tttgatacca tttctgatgt gtaaagtcgg ctgtcttgta aatatcttat aaagagttca
     4561 attgtaaata aactattgtg gccgttaact ttt
//
