LOCUS       NM_010830               4288 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus mutS homolog 6 (Msh6), mRNA.
ACCESSION   NM_010830
VERSION     NM_010830.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4288)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell (2025) In press
   PUBMED   39938516
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4288)
  AUTHORS   Shi,Y., Jiang,J., Cui,Y., Chen,Y., Dong,T., An,H. and Liu,P.
  TITLE     MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A
            to Promote the Metastasis of Glioblastoma Multiforme
  JOURNAL   DNA Cell Biol 40 (1), 93-100 (2021)
   PUBMED   33181035
  REMARK    GeneRIF: MSH6 Aggravates the Hypoxic Microenvironment via
            Regulating HIF1A to Promote the Metastasis of Glioblastoma
            Multiforme.
REFERENCE   3  (bases 1 to 4288)
  AUTHORS   Zanotti,K.J., Maul,R.W., Yang,W. and Gearhart,P.J.
  TITLE     DNA Breaks in Ig V Regions Are Predominantly Single Stranded and
            Are Generated by UNG and MSH6 DNA Repair Pathways
  JOURNAL   J Immunol 202 (5), 1573-1581 (2019)
   PUBMED   30665938
REFERENCE   4  (bases 1 to 4288)
  AUTHORS   Gallego-Llamas,J., Timms,A.E., Pitstick,R., Peters,J., Carlson,G.A.
            and Beier,D.R.
  TITLE     Improvement of ENU Mutagenesis Efficiency Using Serial Injection
            and Mismatch Repair Deficiency Mice
  JOURNAL   PLoS One 11 (7), e0159377 (2016)
   PUBMED   27441645
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4288)
  AUTHORS   Zhao,X.N., Lokanga,R., Allette,K., Gazy,I., Wu,D. and Usdin,K.
  TITLE     A MutSbeta-Dependent Contribution of MutSalpha to Repeat Expansions
            in Fragile X Premutation Mice?
  JOURNAL   PLoS Genet 12 (7), e1006190 (2016)
   PUBMED   27427765
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4288)
  AUTHORS   Edelmann,W., Yang,K., Umar,A., Heyer,J., Lau,K., Fan,K.,
            Liedtke,W., Cohen,P.E., Kane,M.F., Lipford,J.R., Yu,N.,
            Crouse,G.F., Pollard,J.W., Kunkel,T., Lipkin,M., Kolodner,R. and
            Kucherlapati,R.
  TITLE     Mutation in the mismatch repair gene Msh6 causes cancer
            susceptibility
  JOURNAL   Cell 91 (4), 467-477 (1997)
   PUBMED   9390556
REFERENCE   7  (bases 1 to 4288)
  AUTHORS   Miyaki,M., Konishi,M., Tanaka,K., Kikuchi-Yanoshita,R., Muraoka,M.,
            Yasuno,M., Igari,T., Koike,M., Chiba,M. and Mori,T.
  TITLE     Germline mutation of MSH6 as the cause of hereditary nonpolyposis
            colorectal cancer
  JOURNAL   Nat Genet 17 (3), 271-272 (1997)
   PUBMED   9354786
REFERENCE   8  (bases 1 to 4288)
  AUTHORS   Donohue,P.J., Feng,S.L., Alberts,G.F., Guo,Y., Peifley,K.A.,
            Hsu,D.K. and Winkles,J.A.
  TITLE     Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells
            increases G/T mismatch-binding protein expression
  JOURNAL   Biochem J 319 (Pt 1) (Pt 1), 9-12 (1996)
   PUBMED   8870641
REFERENCE   9  (bases 1 to 4288)
  AUTHORS   Corradi,A., Croci,L., Stayton,C.L., Gulisano,M., Boncinelli,E. and
            Consalez,G.G.
  TITLE     cDNA sequence, map, and expression of the murine homolog of GTBP, a
            DNA mismatch repair gene
  JOURNAL   Genomics 36 (2), 288-295 (1996)
   PUBMED   8812455
REFERENCE   10 (bases 1 to 4288)
  AUTHORS   Papadopoulos,N., Nicolaides,N.C., Liu,B., Parsons,R., Lengauer,C.,
            Palombo,F., D'Arrigo,A., Markowitz,S., Willson,J.K., Kinzler,K.W.
            et al.
  TITLE     Mutations of GTBP in genetically unstable cells
  JOURNAL   Science 268 (5219), 1915-1917 (1995)
   PUBMED   7604266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN458717.1 and BC051634.1.
            
            On Apr 18, 2009 this sequence version replaced NM_010830.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051634.1, AK088259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-578               CN458717.1         13-590
            579-4288            BC051634.1         534-4243
FEATURES             Location/Qualifiers
     source          1..4288
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.87 cM"
     gene            1..4288
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /note="mutS homolog 6"
                     /db_xref="GeneID:17688"
                     /db_xref="MGI:MGI:1343961"
     exon            1..356
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..4176
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /note="p160; mutS-alpha 160 kDa subunit; g/T
                     mismatch-binding protein; mutS protein homolog 6"
                     /codon_start=1
                     /product="DNA mismatch repair protein Msh6"
                     /protein_id="NP_034960.1"
                     /db_xref="CCDS:CCDS29021.1"
                     /db_xref="GeneID:17688"
                     /db_xref="MGI:MGI:1343961"
                     /translation="MSRQSTLYSFFPKSPALGDTKKAAAEASRQGAAASGASASRGGD
                     AAWSEAEPGSRSAAVSASSPEAKDLNGGLRRASSSAQAVPPSSCDFSPGDLVWAKMEG
                     YPWWPCLVYNHPFDGTFIRKKGKSVRVHVQFFDDSPTRGWVSKRMLKPYTGSKSKEAQ
                     KGGHFYSSKSEILRAMQRADEALSKDTAERLQLAVCDEPSEPEEEEETEVHEAYLSDK
                     SEEDNYNESEEEAQPSVQGPRRSSRQVKKRRVISDSESDIGGSDVEFKPDTKQEGSSD
                     DASSGVGDSDSEDLGTFGKGAPKRKRAMVAQGGLRRKSLKKETGSAKRATPILSETKS
                     TLSAFSAPQNSESQTHVSGGGNDSSGPTVWYHETLEWLKPEKRRDEHRRRPDHPEFNP
                     TTLYVPEEFLNSCTPGMRKWWQLKSQNFDLVIFYKVGKFYELYHMDAVIGVSELGLIF
                     MKGNWAHSGFPEIAFGRFSDSLVQKGYKVARVEQTETPEMMEARCRKMAHVSKFDRVV
                     RREICRIITKGTQTYSVLDGDPSENYSRYLLSLKEKEEETSGHTRVYGVCFVDTSLGK
                     FFIGQFSDDRHCSRFRTLVAHYPPVQILFEKGNLSTETKTVLKGSLSSCLQEGLIPGS
                     QFWDATKTLRTLLEGGYFTGNGDSSTVLPLVLKGMTSESDSVGLTPGEESELALSALG
                     GIVFYLKKCLIDQELLSMANFEEYFPLDSDTVSTVKPGAVFTKASQRMVLDAVTLNNL
                     EIFLNGTNGSTEGTLLERLDTCHTPFGKRLLKQWLCAPLCSPSAISDRLDAVEDLMAV
                     PDKVTEVADLLKKLPDLERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFL
                     SALEGFKVMCKVSGLLEEVAGGFTSKTLKQVVTLQSKSPKGRFPDLTAELQRWDTAFD
                     HEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLDKQRSRLGCKSIVYWGIGRN
                     RYQLEIPENFATRNLPEEYELKSTKKGCKRYWTKTIEKKLANLINAEERRDTSLKDCM
                     RRLFCNFDKNHKDWQSAVECIAVLDVLLCLANYSQGGDGPMCRPEIVLPGEDTHPFLE
                     FKGSRHPCITKTFFGDDFIPNDILIGCEEEAEEHGKAYCVLVTGPNMGGKSTLIRQAG
                     LLAVMAQLGCYVPAEKCRLTPVDRVFTRLGASDRIMSGESTFFVELSETASILRHATA
                     HSLVLVDELGRGTATFDGTAIANAVVKELAETIKCRTLFSTHYHSLVEDYSKSVCVRL
                     GHMACMVENECEDPSQETITFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKARE
                     FERMNQSLQLFREVCLATEKPTINGEAIHRLLALINGL"
     exon            357..556
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            557..726
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            727..3262
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3531
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3532..3649
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3650..3739
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3894
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            3895..4094
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     exon            4095..4263
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4239..4244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /note="hexamer: AATAAA"
     polyA_site      4263
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /note="major polyA site"
ORIGIN      
        1 gcgcctcctc ccgactttcc cgccagcggc ggccgcgcgg tggatgcgat ccttgtaggc
       61 gctcggagcc gtggcccggt ctgcccgtca gccttcatca tgtcccgaca aagcaccttg
      121 tacagcttct tccccaagtc cccggcactc ggcgacacca agaaggccgc ggccgaggcc
      181 tcacgccaag gtgccgctgc ctctggagcc tccgcttccc gcggcgggga tgcggcctgg
      241 agcgaggctg aacccgggtc ccggtccgcg gcggtatccg cctcgtcgcc ggaggcaaag
      301 gatctcaacg gagggctgcg gagggcctcc tcctccgcgc aggccgtgcc tcccagttct
      361 tgtgacttct caccaggtga tttggtttgg gctaagatgg aaggttaccc ctggtggcct
      421 tgcctagttt ataatcatcc ctttgatgga acgttcatcc ggaagaaagg gaaatctgtc
      481 cgtgttcatg tacagttctt tgatgacagc ccaacaaggg gctgggttag caaaaggatg
      541 ttaaagccat atacaggttc aaagtcaaag gaagcccaaa agggaggtca tttctacagt
      601 tcaaagtctg agatactcag agcaatgcaa cgtgcagatg aggccttaag taaagacacg
      661 gctgagaggc tgcagctggc agtgtgtgat gagccttcag agccggagga ggaggaggag
      721 acagaggtgc atgaggctta tttatctgat aagagtgaag aggataatta caacgagagt
      781 gaagaagaag cacagcccag tgttcagggg cctaggcgaa gcagccggca agtcaagaag
      841 cgacgggtca tctcagactc ggagagtgac attggtggct ctgatgtaga attcaagcca
      901 gacactaagc aggaaggaag cagtgatgac gcgagcagtg gagttgggga cagcgatagt
      961 gaggacctag gcacctttgg caaaggcgct ccaaagcgga agagagccat ggttgctcag
     1021 ggtggactta gaaggaaaag tctgaagaag gaaacaggct cagccaaacg agcaactccc
     1081 attctctcag aaaccaagag taccttgagc gctttttctg cccctcagaa ttctgaatcc
     1141 cagacccacg tcagtggagg aggtaacgac agtagtggac ccactgtttg gtatcacgaa
     1201 actttagaat ggcttaagcc agaaaagaga agagatgagc acaggagacg ccccgatcac
     1261 cctgaattta accccaccac actgtatgtg cctgaagagt tcctcaattc ttgtacccca
     1321 gggatgagga agtggtggca gctcaagtct cagaactttg acctcgtcat cttttataag
     1381 gtggggaagt tttatgagtt gtatcacatg gatgctgtta ttggagtcag tgagctgggg
     1441 ctgatattca tgaagggcaa ctgggcccat tctggttttc cagagattgc gtttggccgg
     1501 ttctcggatt ccttggtgca gaagggctat aaggtagcac gagtggagca gaccgagact
     1561 ccagaaatga tggaggcgcg atgtcggaaa atggcacacg tgtccaagtt tgatagagtg
     1621 gtgagaaggg agatttgcag gatcattacc aagggcacac agacctacag tgtgctggat
     1681 ggtgatccct ctgagaacta cagtaggtat cttcttagcc tcaaagagaa ggaggaagag
     1741 acttctggtc acactcgtgt gtatggtgtt tgctttgtgg acacttcact gggcaagttt
     1801 ttcatcggcc agttttcgga tgaccgccac tgttccagat ttaggacgct agtggctcac
     1861 tatcctccag tacaaatttt gttcgagaaa ggaaatctct caacagagac caaaactgtc
     1921 ctaaagggtt cactgtcatc ttgtcttcag gaaggtctca taccaggttc ccaattttgg
     1981 gatgccacta agaccttgcg aacactcctt gaaggagggt actttactgg aaatggagac
     2041 agtagtacag tgctgcctct ggtgcttaaa ggaatgacct cggagtcaga ttctgttggg
     2101 ttgacaccag gcgaggagag tgaattggct ctctctgctc taggtggtat tgttttctac
     2161 ctcaaaaaat gcctgattga tcaggagctt ctgtcaatgg ctaattttga agagtatttc
     2221 cctttggatt ctgacacggt cagcacagta aaacctgggg ctgtctttac taaagccagt
     2281 cagcggatgg tgctagacgc agtgacatta aacaacctgg agattttcct gaatgggaca
     2341 aatggctcta ctgaagggac cctgctagag agattggata cttgccatac gccctttggc
     2401 aagcggctct taaaacagtg gctctgtgcc cccctctgca gcccttctgc catcagtgac
     2461 cgtctagatg cggtggaaga tctgatggcc gtgcctgaca aggtcactga agttgcagac
     2521 ctcttaaaga agctgccaga ccttgagagg ctactgagta agattcataa tgttgggtct
     2581 cccctgaaga gccagaacca tccagacagc agggctataa tgtacgaaga aacgacatac
     2641 agcaaaaaga agatcattga ttttctctct gctctagaag gattcaaagt aatgtgtaaa
     2701 gtctcagggc ttctggagga ggtcgcgggt ggttttacgt ccaaaaccct caagcaggtt
     2761 gttactctgc agtcaaaaag tcctaaaggc cgctttcctg acctgactgc agaactgcag
     2821 cgatgggaca cagcctttga ccatgagaag gctcggaaga ccggactcat cactccaaaa
     2881 gcagggtttg actctgatta tgaccaagca cttgctgaca tcagagagaa tgaacagagc
     2941 ctcctggagt acttagacaa acagcgcagt cggcttggct gtaagagcat agtctactgg
     3001 ggaatcggta ggaaccgtta ccagttagag attccagaga atttcgctac ccgtaatcta
     3061 cctgaagaat atgagctgaa atctactaaa aaaggctgta aacgatactg gaccaaaacg
     3121 attgagaaga aattagctaa tcttattaat gctgaagaac gcagggacac atccttaaag
     3181 gactgcatgc ggcgcttgtt ctgtaacttc gacaagaacc acaaggactg gcagtctgct
     3241 gtagagtgca ttgcagtgtt ggatgtctta ctgtgcctgg ctaactacag tcaaggagga
     3301 gatggtccta tgtgtcgccc agaaattgtg ttaccaggag aagacacaca tcccttctta
     3361 gagtttaaag ggtcacgaca tccctgcatt acaaagactt tttttggaga cgattttatt
     3421 cctaacgaca ttctaatagg ctgcgaggaa gaagcagagg aacatggcaa agcctattgt
     3481 gtgcttgtga ctggaccaaa tatggggggc aagtctacac tcataagaca ggctggtctg
     3541 ttggctgtga tggcccagct gggttgttac gtacctgctg agaagtgcag gctcacacca
     3601 gttgacagag tgtttactag gcttggtgcc tcagatagaa taatgtcagg agaaagcaca
     3661 ttttttgttg agttgagtga aactgctagc atactcaggc atgcaacagc acattctttg
     3721 gtacttgtgg atgaattagg aagaggcacc gcaacttttg atgggacagc gatagccaat
     3781 gcggttgtta aagaacttgc tgaaaccata aagtgtcgaa cactgttttc tacacactat
     3841 cattcattag tagaagatta ttctaaaagt gtttgtgtgc gcctaggaca tatggcatgc
     3901 atggtagaaa atgaatgtga ggaccccagc caggagacta ttactttcct ctataaattc
     3961 attaagggag cttgtcctaa gagctatggc tttaatgcag caaggcttgc taatctcccg
     4021 gaggaggtta ttcagaaggg acacagaaag gcaagagaat ttgagaggat gaatcagtca
     4081 ttacagctat ttcgggaagt ttgtctggct actgaaaagc cgactataaa cggtgaagct
     4141 atccataggc tgctggcctt gattaacgga ttgtagacta cattggaagc tgagctgact
     4201 tttgaaaaag gtggtaaatt cagacaacat tatgatctaa taaactttat ttttaaaaaa
     4261 tgaaaaaaaa aaaaaaaaaa aaaaaaaa
//
