LOCUS       NP_034960               1358 aa            linear   ROD 27-APR-2025
DEFINITION  DNA mismatch repair protein Msh6 [Mus musculus].
ACCESSION   NP_034960
VERSION     NP_034960.1
DBSOURCE    REFSEQ: accession NM_010830.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1358)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell 188 (6), 1524-1544 (2025)
   PUBMED   39938516
REFERENCE   2  (residues 1 to 1358)
  AUTHORS   Shi,Y., Jiang,J., Cui,Y., Chen,Y., Dong,T., An,H. and Liu,P.
  TITLE     MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A
            to Promote the Metastasis of Glioblastoma Multiforme
  JOURNAL   DNA Cell Biol 40 (1), 93-100 (2021)
   PUBMED   33181035
  REMARK    GeneRIF: MSH6 Aggravates the Hypoxic Microenvironment via
            Regulating HIF1A to Promote the Metastasis of Glioblastoma
            Multiforme.
REFERENCE   3  (residues 1 to 1358)
  AUTHORS   Zanotti,K.J., Maul,R.W., Yang,W. and Gearhart,P.J.
  TITLE     DNA Breaks in Ig V Regions Are Predominantly Single Stranded and
            Are Generated by UNG and MSH6 DNA Repair Pathways
  JOURNAL   J Immunol 202 (5), 1573-1581 (2019)
   PUBMED   30665938
REFERENCE   4  (residues 1 to 1358)
  AUTHORS   Gallego-Llamas,J., Timms,A.E., Pitstick,R., Peters,J., Carlson,G.A.
            and Beier,D.R.
  TITLE     Improvement of ENU Mutagenesis Efficiency Using Serial Injection
            and Mismatch Repair Deficiency Mice
  JOURNAL   PLoS One 11 (7), e0159377 (2016)
   PUBMED   27441645
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1358)
  AUTHORS   Zhao,X.N., Lokanga,R., Allette,K., Gazy,I., Wu,D. and Usdin,K.
  TITLE     A MutSbeta-Dependent Contribution of MutSalpha to Repeat Expansions
            in Fragile X Premutation Mice?
  JOURNAL   PLoS Genet 12 (7), e1006190 (2016)
   PUBMED   27427765
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 1358)
  AUTHORS   Edelmann,W., Yang,K., Umar,A., Heyer,J., Lau,K., Fan,K.,
            Liedtke,W., Cohen,P.E., Kane,M.F., Lipford,J.R., Yu,N.,
            Crouse,G.F., Pollard,J.W., Kunkel,T., Lipkin,M., Kolodner,R. and
            Kucherlapati,R.
  TITLE     Mutation in the mismatch repair gene Msh6 causes cancer
            susceptibility
  JOURNAL   Cell 91 (4), 467-477 (1997)
   PUBMED   9390556
REFERENCE   7  (residues 1 to 1358)
  AUTHORS   Miyaki,M., Konishi,M., Tanaka,K., Kikuchi-Yanoshita,R., Muraoka,M.,
            Yasuno,M., Igari,T., Koike,M., Chiba,M. and Mori,T.
  TITLE     Germline mutation of MSH6 as the cause of hereditary nonpolyposis
            colorectal cancer
  JOURNAL   Nat Genet 17 (3), 271-272 (1997)
   PUBMED   9354786
REFERENCE   8  (residues 1 to 1358)
  AUTHORS   Donohue,P.J., Feng,S.L., Alberts,G.F., Guo,Y., Peifley,K.A.,
            Hsu,D.K. and Winkles,J.A.
  TITLE     Fibroblast growth factor-1 stimulation of quiescent NIH 3T3 cells
            increases G/T mismatch-binding protein expression
  JOURNAL   Biochem J 319 (Pt 1) (Pt 1), 9-12 (1996)
   PUBMED   8870641
REFERENCE   9  (residues 1 to 1358)
  AUTHORS   Corradi,A., Croci,L., Stayton,C.L., Gulisano,M., Boncinelli,E. and
            Consalez,G.G.
  TITLE     cDNA sequence, map, and expression of the murine homolog of GTBP, a
            DNA mismatch repair gene
  JOURNAL   Genomics 36 (2), 288-295 (1996)
   PUBMED   8812455
REFERENCE   10 (residues 1 to 1358)
  AUTHORS   Papadopoulos,N., Nicolaides,N.C., Liu,B., Parsons,R., Lengauer,C.,
            Palombo,F., D'Arrigo,A., Markowitz,S., Willson,J.K., Kinzler,K.W.
            et al.
  TITLE     Mutations of GTBP in genetically unstable cells
  JOURNAL   Science 268 (5219), 1915-1917 (1995)
   PUBMED   7604266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN458717.1 and BC051634.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051634.1, AK088259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1358
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.87 cM"
     Protein         1..1358
                     /product="DNA mismatch repair protein Msh6"
                     /note="p160; mutS-alpha 160 kDa subunit; g/T
                     mismatch-binding protein; mutS protein homolog 6"
                     /calculated_mol_wt=150954
     Region          1..87
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54276.3)"
     Site            14
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            38
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            40
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            67
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Region          90..193
                     /region_name="PWWP_MSH6"
                     /note="PWWP domain found in DNA mismatch repair protein
                     MSH6 and similar proteins; cd05837"
                     /db_xref="CDD:438962"
     Site            91
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            order(103,106,133)
                     /site_type="other"
                     /note="putative methyl-histone binding site [polypeptide
                     binding]"
                     /db_xref="CDD:438962"
     Site            104..107
                     /site_type="other"
                     /note="PWWP sequence motif"
                     /db_xref="CDD:438962"
     Site            137
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Region          197..360
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P54276.3)"
     Site            200
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            219
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Region          220..349
                     /region_name="SEEEED"
                     /note="Serine-rich region of AP3B1, clathrin-adaptor
                     complex; pfam14797"
                     /db_xref="CDD:434218"
     Site            227
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            252
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            254
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            256
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            261
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            269
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            274
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            275
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            279
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            280
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Region          406..1327
                     /region_name="MutS"
                     /note="DNA mismatch repair ATPase MutS [Replication,
                     recombination and repair]; COG0249"
                     /db_xref="CDD:440019"
     Site            487
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            503
                     /site_type="acetylation"
                     /note="N6-acetyllysine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            827
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            932
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     Site            1007
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P52701; propagated from
                     UniProtKB/Swiss-Prot (P54276.3)"
     CDS             1..1358
                     /gene="Msh6"
                     /gene_synonym="GTBP; Gtmbp"
                     /coded_by="NM_010830.2:100..4176"
                     /db_xref="CCDS:CCDS29021.1"
                     /db_xref="GeneID:17688"
                     /db_xref="MGI:MGI:1343961"
ORIGIN      
        1 msrqstlysf fpkspalgdt kkaaaeasrq gaaasgasas rggdaawsea epgsrsaavs
       61 asspeakdln gglrrasssa qavppsscdf spgdlvwakm egypwwpclv ynhpfdgtfi
      121 rkkgksvrvh vqffddsptr gwvskrmlkp ytgskskeaq kgghfyssks eilramqrad
      181 ealskdtaer lqlavcdeps epeeeeetev heaylsdkse ednyneseee aqpsvqgprr
      241 ssrqvkkrrv isdsesdigg sdvefkpdtk qegssddass gvgdsdsedl gtfgkgapkr
      301 kramvaqggl rrkslkketg sakratpils etkstlsafs apqnsesqth vsgggndssg
      361 ptvwyhetle wlkpekrrde hrrrpdhpef npttlyvpee flnsctpgmr kwwqlksqnf
      421 dlvifykvgk fyelyhmdav igvselglif mkgnwahsgf peiafgrfsd slvqkgykva
      481 rveqtetpem mearcrkmah vskfdrvvrr eicriitkgt qtysvldgdp senysrylls
      541 lkekeeetsg htrvygvcfv dtslgkffig qfsddrhcsr frtlvahypp vqilfekgnl
      601 stetktvlkg slssclqegl ipgsqfwdat ktlrtllegg yftgngdsst vlplvlkgmt
      661 sesdsvgltp geeselalsa lggivfylkk clidqellsm anfeeyfpld sdtvstvkpg
      721 avftkasqrm vldavtlnnl eiflngtngs tegtllerld tchtpfgkrl lkqwlcaplc
      781 spsaisdrld avedlmavpd kvtevadllk klpdlerlls kihnvgsplk sqnhpdsrai
      841 myeettyskk kiidflsale gfkvmckvsg lleevaggft sktlkqvvtl qskspkgrfp
      901 dltaelqrwd tafdhekark tglitpkagf dsdydqalad ireneqslle yldkqrsrlg
      961 cksivywgig rnryqleipe nfatrnlpee yelkstkkgc krywtktiek klanlinaee
     1021 rrdtslkdcm rrlfcnfdkn hkdwqsavec iavldvllcl anysqggdgp mcrpeivlpg
     1081 edthpflefk gsrhpcitkt ffgddfipnd iligceeeae ehgkaycvlv tgpnmggkst
     1141 lirqagllav maqlgcyvpa ekcrltpvdr vftrlgasdr imsgestffv elsetasilr
     1201 hatahslvlv delgrgtatf dgtaianavv kelaetikcr tlfsthyhsl vedysksvcv
     1261 rlghmacmve necedpsqet itflykfikg acpksygfna arlanlpeev iqkghrkare
     1321 fermnqslql frevclatek ptingeaihr llalingl
//
