LOCUS       NM_031870               3048 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus mutS homolog 4 (Msh4), transcript variant 1, mRNA.
ACCESSION   NM_031870
VERSION     NM_031870.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3048)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 3048)
  AUTHORS   Huang,T., Wu,X., Wang,S., Bao,Z., Wan,Y., Wang,Z., Li,M., Yu,X.,
            Lv,Y., Liu,Z., Chen,X., Chan,W.Y., Gao,F., Lu,G., Chen,Z.J. and
            Liu,H.
  TITLE     SPIDR is required for homologous recombination during mammalian
            meiosis
  JOURNAL   Nucleic Acids Res 51 (8), 3855-3868 (2023)
   PUBMED   36938872
REFERENCE   3  (bases 1 to 3048)
  AUTHORS   Li,Y., Wu,Y., Khan,I., Zhou,J., Lu,Y., Ye,J., Liu,J., Xie,X.,
            Hu,C., Jiang,H., Fan,S., Zhang,H., Zhang,Y., Jiang,X., Xu,B., Ma,H.
            and Shi,Q.
  TITLE     M1AP interacts with the mammalian ZZS complex and promotes male
            meiotic recombination
  JOURNAL   EMBO Rep 24 (2), e55778 (2023)
   PUBMED   36440627
REFERENCE   4  (bases 1 to 3048)
  AUTHORS   Tanno,N., Takemoto,K., Takada-Horisawa,Y., Shimada,R., Fujimura,S.,
            Tani,N., Takeda,N., Araki,K. and Ishiguro,K.I.
  TITLE     FBXO47 is essential for preventing the synaptonemal complex from
            premature disassembly in mouse male meiosis
  JOURNAL   iScience 25 (4), 104008 (2022)
   PUBMED   35310947
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3048)
  AUTHORS   Wang,Y., Chen,Y., Chen,J., Wang,L., Nie,L., Long,J., Chang,H.,
            Wu,J., Huang,C. and Lei,M.
  TITLE     The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the
            nuclear envelope
  JOURNAL   Nat Commun 10 (1), 564 (2019)
   PUBMED   30718482
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3048)
  AUTHORS   Hirano,M. and Noda,T.
  TITLE     Genomic organization of the mouse Msh4 gene producing bicistronic,
            chimeric and antisense mRNA
  JOURNAL   Gene 342 (1), 165-177 (2004)
   PUBMED   15527976
  REMARK    GeneRIF: Study suggests that the dynamic interchromosomal
            (intergenic) trans-splicing generates functional diversity of the
            mouse Msh4 gene.
REFERENCE   7  (bases 1 to 3048)
  AUTHORS   Kolas,N.K. and Cohen,P.E.
  TITLE     Novel and diverse functions of the DNA mismatch repair family in
            mammalian meiosis and recombination
  JOURNAL   Cytogenet Genome Res 107 (3-4), 216-231 (2004)
   PUBMED   15467367
  REMARK    Review article
REFERENCE   8  (bases 1 to 3048)
  AUTHORS   Santucci-Darmanin,S., Vidal,F., Scimeca,J.C., Turc-Carel,C. and
            Paquis-Flucklinger,V.
  TITLE     Family of SRY/Sox proteins is involved in the regulation of the
            mouse Msh4 (MutS Homolog 4) gene expression
  JOURNAL   Mol Reprod Dev 60 (2), 172-180 (2001)
   PUBMED   11553915
REFERENCE   9  (bases 1 to 3048)
  AUTHORS   Her,C., Wu,X., Bailey,S.M. and Doggett,N.A.
  TITLE     Mouse MutS homolog 4 is predominantly expressed in testis and
            interacts with MutS homolog 5
  JOURNAL   Mamm Genome 12 (1), 73-76 (2001)
   PUBMED   11178747
REFERENCE   10 (bases 1 to 3048)
  AUTHORS   Kneitz,B., Cohen,P.E., Avdievich,E., Zhu,L., Kane,M.F., Hou,H. Jr.,
            Kolodner,R.D., Kucherlapati,R., Pollard,J.W. and Edelmann,W.
  TITLE     MutS homolog 4 localization to meiotic chromosomes is required for
            chromosome pairing during meiosis in male and female mice
  JOURNAL   Genes Dev 14 (9), 1085-1097 (2000)
   PUBMED   10809667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087184.7.
            
            On Oct 5, 2022 this sequence version replaced NM_031870.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF298655.1, AK161474.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-187               AC087184.7         91867-92053         c
            188-370             AC087184.7         87601-87783         c
            371-528             AC087184.7         83480-83637         c
            529-639             AC087184.7         83020-83130         c
            640-755             AC087184.7         76308-76423         c
            756-929             AC087184.7         74885-75058         c
            930-1102            AC087184.7         73013-73185         c
            1103-1170           AC087184.7         69926-69993         c
            1171-1245           AC087184.7         65554-65628         c
            1246-1310           AC087184.7         64104-64168         c
            1311-1480           AC087184.7         62823-62992         c
            1481-1617           AC087184.7         60852-60988         c
            1618-1721           AC087184.7         59821-59924         c
            1722-1846           AC087184.7         58461-58585         c
            1847-2047           AC087184.7         55759-55959         c
            2048-2166           AC087184.7         53919-54037         c
            2167-2295           AC087184.7         52516-52644         c
            2296-2470           AC087184.7         49534-49708         c
            2471-2559           AC087184.7         47083-47171         c
            2560-3048           AC087184.7         43341-43829         c
FEATURES             Location/Qualifiers
     source          1..3048
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 78.7 cM"
     gene            1..3048
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="mutS homolog 4"
                     /db_xref="GeneID:55993"
                     /db_xref="MGI:MGI:1860077"
     exon            1..187
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..2751
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="isoform 1 is encoded by transcript variant 1; mutS
                     protein homolog 4; MutS homolog 4 variant theta 1; MutS
                     homolog 4 variant iota 1"
                     /codon_start=1
                     /product="mutS protein homolog 4 isoform 1"
                     /protein_id="NP_114076.2"
                     /db_xref="CCDS:CCDS38678.1"
                     /db_xref="GeneID:55993"
                     /db_xref="MGI:MGI:1860077"
                     /translation="MLRQEAASLSSSPRWTPSRRDAPCGRTLASASRPSTEGAMADRS
                     SSSSSSPAPASAPGSSFGNKRSYAIHRAASSFPVGTSSSSARDTTYPHTFRTPLSAGN
                     PQRSGHKSWTPQVGYSATSSAVSAHAPSVIVAVVEGRGLARGEIGMASIDLKSPQIML
                     SQFADNTTYAKVITKLQVLSPLEIIMSNTACVVGNSTKLFTLITENFKNVNFTTVQRK
                     YFNETKGLEYIEQLCIAEFSSVLMEVQSRYYCLAAAAALLKYVEFIQNSVYAPKSLKI
                     YFQGSEQTAMIDSSSAQNLELLVNNQDYRSNHTLFGVLNYTKTAGGSRRLRSNILEPL
                     VDVETISMRLDCVQELLQDEELFFGLQSVISRFLDTEQLLSVLVQIPKQDTVNAAESK
                     ITNLIYLKHTLELVEPLKVTLKNCSTPLLRAYYGSLEDHRFGLILDKIKTVINDDARY
                     MKGCLNMRTQKCYAVRSNISEFLDIARRTYTEIVDDIAGMIAQLAEKYSLPLRTSFSS
                     SRGFFIQMTTDCAALSSDQLPSEFIKISKVKNSYSFTSADLIKMNERCQESLREIYHM
                     TYMIVCKLLSEIYEHIHCLYKLSDTVSMLDMLLSFAHACTLSDYVRPEFTDTLAIKQG
                     WHPILEKISAEKPVANNTYITEGSNVLIITGPNMSGKSTYLKQIALCQIMAQIGSYVP
                     AEYASFRIAAQIFTRISTDDDIETNSSTFMKEMKEIAYILHNANDKSLILIDELGRGT
                     NTEEGIGISYAVCEHLLSIKAFTLFTTHFLELCHLDALYLNVENMHFEVQHVKNTSRN
                     KDAILYTYKLSRGLTEEKNYGLKAAEASSLPSSIVLDARDITTQITRQILQNQRSSPE
                     MDRQRAVYHLATRLVQAARNSQLEPDRLRTYLSNLKKKYAGDFPRAVGLPEKTEE"
     exon            188..370
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            371..528
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            529..639
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            640..755
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            756..929
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1102
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1170
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..1245
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1310
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1311..1480
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1617
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1721
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1722..1846
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2047
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2166
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2295
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2470
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2559
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..3048
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2806..2811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="hexamer: ATTAAA"
     polyA_site      2832
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="major polyA site"
     regulatory      2904..2909
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="hexamer: AATAAA"
     polyA_site      2936
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
     regulatory      3024..3029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="hexamer: AATAAA"
     polyA_site      3048
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
ORIGIN      
        1 agaaaggccg gagagatgct gaggcaggag gctgcatcgc tttccagttc cccacgctgg
       61 acgccgtcgc ggagggatgc cccatgcggg aggaccctgg cctccgcgtc caggccgagt
      121 acggaaggcg ccatggccga caggagcagc agcagcagca gcagtccggc gccggcgtcc
      181 gcgccaggtt catcatttgg aaacaaaaga tcttatgcta tacacagagc tgcatccagt
      241 tttcctgttg gtacaagctc atcttctgca cgagatacca cttacccaca tacatttaga
      301 actccgttat ctgctggaaa tccccagaga tcagggcata aaagttggac accacaagta
      361 ggatattcag ccacatcctc tgcggtgtct gcacacgccc catcagtcat tgtagcggtg
      421 gtggaaggaa gagggctggc cagaggcgag ataggaatgg caagcattga tttaaaaagc
      481 ccacagatta tgttgtcaca gtttgcagac aatacaacat atgcaaaggt gatcactaaa
      541 ctccaagttt tatcaccttt ggaaataata atgtcaaata ctgcttgtgt tgtgggaaat
      601 tcaaccaagt tatttactct gatcacagaa aattttaaga acgttaattt cactacagtc
      661 caaaggaaat acttcaacga aacaaagggc ttagagtaca ttgagcagtt gtgcatagct
      721 gagttcagtt ctgtgctaat ggaggtgcag tccaggtatt actgccttgc agctgctgca
      781 gctttattaa agtatgtcga attcattcag aattcagtgt atgcacccaa atcgctaaag
      841 atttatttcc aaggtagtga gcagacagcc atgatagatt catcatcggc ccaaaacctg
      901 gagttgttag ttaataacca ggactacagg agtaatcaca ctctcttcgg tgttttaaat
      961 tacaccaaga ctgcgggagg gagccgaagg ctgcgctcca acatcctgga gcctctggtt
     1021 gatgtggaga cgatcagcat gcggctggac tgtgtccagg agctgctgca ggacgaggag
     1081 ctcttctttg gactccagtc agtcatatca agattcctgg atacggagca gctgctttct
     1141 gttttagttc aaatcccaaa gcaagacacg gttaacgcag ctgaatcaaa gataacaaat
     1201 ttgatctatc tgaagcatac attggaactt gtggagcctt taaaggtcac cttaaagaac
     1261 tgtagcacac ccctattaag agcttactat ggctccttgg aagaccatag gtttgggcta
     1321 atacttgata agattaaaac agtgataaat gatgatgcaa ggtacatgaa gggctgcctg
     1381 aacatgcgga ctcagaagtg ctatgcagtg cgctctaaca tcagtgagtt cctggacata
     1441 gccaggagga catacacaga gatagtggac gacatagcag gaatgatagc acagctcgca
     1501 gagaagtaca gtcttcccct acggaccagc ttcagctcct cacgggggtt cttcatccag
     1561 atgaccacag actgcgctgc actctccagt gaccagcttc cttcggagtt tattaagatt
     1621 tctaaagtga aaaactcata tagctttaca tcagcagatt taattaaaat gaatgaaaga
     1681 tgccaagagt ctttgcgaga aatctatcac atgacctaca tgatagtgtg caaactgctc
     1741 agtgagatct acgagcacat ccactgcttg tacaagctct ctgacacggt gtccatgctg
     1801 gatatgctgc tgtcgtttgc gcatgcctgt actctttctg actacgttcg accagagttt
     1861 actgacactt tagcaatcaa acaaggatgg catcccattc ttgaaaaaat atctgcagag
     1921 aaacctgtcg ccaacaatac ctacattaca gaagggagta atgttctaat cattactgga
     1981 ccaaatatga gcggaaagtc cacgtactta aagcagattg cactttgtca gatcatggcc
     2041 cagatcggct cctatgtccc agcagaatac gcctccttta ggattgctgc acagatcttt
     2101 acgagaatca gtactgatga tgatattgaa acaaactcat caacgtttat gaaagaaatg
     2161 aaagagatag catatattct ccataatgct aatgacaagt cactcatatt aattgacgag
     2221 cttggcagag gcactaatac agaagaaggg attggaattt cttatgctgt ctgtgagcac
     2281 ctgcttagca taaaggcatt tacactcttc actacccatt tcctggaact atgccatcta
     2341 gatgccctgt atcttaatgt agaaaacatg cattttgaag ttcagcatgt gaagaatacc
     2401 tcaagaaata aagatgcaat tttgtatact tacaaacttt ccaggggact cacagaagaa
     2461 aagaactatg gattaaaagc tgcagaggcc tcctcacttc cgtcatcgat tgtcttggat
     2521 gccagagaca tcacaacaca aattacaagg caaattttgc aaaatcaaag gagttcccct
     2581 gagatggata gacagagagc tgtgtaccat cttgccacaa ggcttgtcca ggccgcccga
     2641 aactctcagt tggagccaga caggttacgg acatacctga gtaacctcaa gaagaaatat
     2701 gcaggggact ttcccagggc tgtgggcctt ccagagaaga ctgaggagtg accagtacac
     2761 ggtgtgcaca ggggttgcaa cttagttgct cagctttatg ttttaattaa aaattatagt
     2821 atattaacct cagaatggtc acctactatg aattctagat ggaaaatatt cattggaata
     2881 gcttcaaaag ggacaaattt ttaaataaaa gtttttgtta gaaaaataat acagtattca
     2941 ctgtgaagtc agactaagtt tgtagtttgc tattaagtgt atgtttagaa ggttaacaga
     3001 agtattctag cttaaaaata tataataaag aataggtctg aaaaggtt
//
