LOCUS       NM_001282054            3087 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus mutS homolog 4 (Msh4), transcript variant 2, mRNA.
ACCESSION   NM_001282054
VERSION     NM_001282054.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3087)
  AUTHORS   Ito,M., Yun,Y., Kulkarni,D.S., Lee,S., Sandhu,S., Nunez,B., Hu,L.,
            Lee,K., Lim,N., Hirota,R.M., Prendergast,R., Huang,C., Huang,I. and
            Hunter,N.
  TITLE     Distinct and interdependent functions of three RING proteins
            regulate recombination during mammalian meiosis
  JOURNAL   Proc Natl Acad Sci U S A 122 (2), e2412961121 (2025)
   PUBMED   39761402
REFERENCE   2  (bases 1 to 3087)
  AUTHORS   Huang,T., Wu,X., Wang,S., Bao,Z., Wan,Y., Wang,Z., Li,M., Yu,X.,
            Lv,Y., Liu,Z., Chen,X., Chan,W.Y., Gao,F., Lu,G., Chen,Z.J. and
            Liu,H.
  TITLE     SPIDR is required for homologous recombination during mammalian
            meiosis
  JOURNAL   Nucleic Acids Res 51 (8), 3855-3868 (2023)
   PUBMED   36938872
REFERENCE   3  (bases 1 to 3087)
  AUTHORS   Li,Y., Wu,Y., Khan,I., Zhou,J., Lu,Y., Ye,J., Liu,J., Xie,X.,
            Hu,C., Jiang,H., Fan,S., Zhang,H., Zhang,Y., Jiang,X., Xu,B., Ma,H.
            and Shi,Q.
  TITLE     M1AP interacts with the mammalian ZZS complex and promotes male
            meiotic recombination
  JOURNAL   EMBO Rep 24 (2), e55778 (2023)
   PUBMED   36440627
REFERENCE   4  (bases 1 to 3087)
  AUTHORS   Tanno,N., Takemoto,K., Takada-Horisawa,Y., Shimada,R., Fujimura,S.,
            Tani,N., Takeda,N., Araki,K. and Ishiguro,K.I.
  TITLE     FBXO47 is essential for preventing the synaptonemal complex from
            premature disassembly in mouse male meiosis
  JOURNAL   iScience 25 (4), 104008 (2022)
   PUBMED   35310947
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3087)
  AUTHORS   Wang,Y., Chen,Y., Chen,J., Wang,L., Nie,L., Long,J., Chang,H.,
            Wu,J., Huang,C. and Lei,M.
  TITLE     The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the
            nuclear envelope
  JOURNAL   Nat Commun 10 (1), 564 (2019)
   PUBMED   30718482
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3087)
  AUTHORS   Hirano,M. and Noda,T.
  TITLE     Genomic organization of the mouse Msh4 gene producing bicistronic,
            chimeric and antisense mRNA
  JOURNAL   Gene 342 (1), 165-177 (2004)
   PUBMED   15527976
  REMARK    GeneRIF: Study suggests that the dynamic interchromosomal
            (intergenic) trans-splicing generates functional diversity of the
            mouse Msh4 gene.
REFERENCE   7  (bases 1 to 3087)
  AUTHORS   Kolas,N.K. and Cohen,P.E.
  TITLE     Novel and diverse functions of the DNA mismatch repair family in
            mammalian meiosis and recombination
  JOURNAL   Cytogenet Genome Res 107 (3-4), 216-231 (2004)
   PUBMED   15467367
  REMARK    Review article
REFERENCE   8  (bases 1 to 3087)
  AUTHORS   Santucci-Darmanin,S., Vidal,F., Scimeca,J.C., Turc-Carel,C. and
            Paquis-Flucklinger,V.
  TITLE     Family of SRY/Sox proteins is involved in the regulation of the
            mouse Msh4 (MutS Homolog 4) gene expression
  JOURNAL   Mol Reprod Dev 60 (2), 172-180 (2001)
   PUBMED   11553915
REFERENCE   9  (bases 1 to 3087)
  AUTHORS   Her,C., Wu,X., Bailey,S.M. and Doggett,N.A.
  TITLE     Mouse MutS homolog 4 is predominantly expressed in testis and
            interacts with MutS homolog 5
  JOURNAL   Mamm Genome 12 (1), 73-76 (2001)
   PUBMED   11178747
REFERENCE   10 (bases 1 to 3087)
  AUTHORS   Kneitz,B., Cohen,P.E., Avdievich,E., Zhu,L., Kane,M.F., Hou,H. Jr.,
            Kolodner,R.D., Kucherlapati,R., Pollard,J.W. and Edelmann,W.
  TITLE     MutS homolog 4 localization to meiotic chromosomes is required for
            chromosome pairing during meiosis in male and female mice
  JOURNAL   Genes Dev 14 (9), 1085-1097 (2000)
   PUBMED   10809667
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087184.7.
            
            On Oct 5, 2022 this sequence version replaced NM_001282054.1.
            
            Transcript Variant: This variant (2) contains alternate exons in
            the 5' UTR, lacks a portion of the 5' coding region, and initiates
            translation at a downstream start codon, compared to variant 1. The
            encoded isoform (2) has a shorter N-terminus than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029837.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN00849374,
                                           SAMN00849383 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC087184.7         90863-90936         c
            75-226              AC087184.7         90373-90524         c
            227-409             AC087184.7         87601-87783         c
            410-567             AC087184.7         83480-83637         c
            568-678             AC087184.7         83020-83130         c
            679-794             AC087184.7         76308-76423         c
            795-968             AC087184.7         74885-75058         c
            969-1141            AC087184.7         73013-73185         c
            1142-1209           AC087184.7         69926-69993         c
            1210-1284           AC087184.7         65554-65628         c
            1285-1349           AC087184.7         64104-64168         c
            1350-1519           AC087184.7         62823-62992         c
            1520-1656           AC087184.7         60852-60988         c
            1657-1760           AC087184.7         59821-59924         c
            1761-1885           AC087184.7         58461-58585         c
            1886-2086           AC087184.7         55759-55959         c
            2087-2205           AC087184.7         53919-54037         c
            2206-2334           AC087184.7         52516-52644         c
            2335-2509           AC087184.7         49534-49708         c
            2510-2598           AC087184.7         47083-47171         c
            2599-3087           AC087184.7         43341-43829         c
FEATURES             Location/Qualifiers
     source          1..3087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 78.7 cM"
     gene            1..3087
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="mutS homolog 4"
                     /db_xref="GeneID:55993"
                     /db_xref="MGI:MGI:1860077"
     exon            1..74
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            75..226
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            227..409
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            410..567
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             496..2790
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="isoform 2 is encoded by transcript variant 2; mutS
                     protein homolog 4; MutS homolog 4 variant theta 1; MutS
                     homolog 4 variant iota 1"
                     /codon_start=1
                     /product="mutS protein homolog 4 isoform 2"
                     /protein_id="NP_001268983.1"
                     /db_xref="CCDS:CCDS80067.1"
                     /db_xref="GeneID:55993"
                     /db_xref="MGI:MGI:1860077"
                     /translation="MASIDLKSPQIMLSQFADNTTYAKVITKLQVLSPLEIIMSNTAC
                     VVGNSTKLFTLITENFKNVNFTTVQRKYFNETKGLEYIEQLCIAEFSSVLMEVQSRYY
                     CLAAAAALLKYVEFIQNSVYAPKSLKIYFQGSEQTAMIDSSSAQNLELLVNNQDYRSN
                     HTLFGVLNYTKTAGGSRRLRSNILEPLVDVETISMRLDCVQELLQDEELFFGLQSVIS
                     RFLDTEQLLSVLVQIPKQDTVNAAESKITNLIYLKHTLELVEPLKVTLKNCSTPLLRA
                     YYGSLEDHRFGLILDKIKTVINDDARYMKGCLNMRTQKCYAVRSNISEFLDIARRTYT
                     EIVDDIAGMIAQLAEKYSLPLRTSFSSSRGFFIQMTTDCAALSSDQLPSEFIKISKVK
                     NSYSFTSADLIKMNERCQESLREIYHMTYMIVCKLLSEIYEHIHCLYKLSDTVSMLDM
                     LLSFAHACTLSDYVRPEFTDTLAIKQGWHPILEKISAEKPVANNTYITEGSNVLIITG
                     PNMSGKSTYLKQIALCQIMAQIGSYVPAEYASFRIAAQIFTRISTDDDIETNSSTFMK
                     EMKEIAYILHNANDKSLILIDELGRGTNTEEGIGISYAVCEHLLSIKAFTLFTTHFLE
                     LCHLDALYLNVENMHFEVQHVKNTSRNKDAILYTYKLSRGLTEEKNYGLKAAEASSLP
                     SSIVLDARDITTQITRQILQNQRSSPEMDRQRAVYHLATRLVQAARNSQLEPDRLRTY
                     LSNLKKKYAGDFPRAVGLPEKTEE"
     exon            568..678
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..794
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            795..968
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1141
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1209
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1284
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1349
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1519
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1656
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1760
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1885
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2086
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2087..2205
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2334
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2509
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2598
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..3087
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2845..2850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="hexamer: ATTAAA"
     polyA_site      2871
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="major polyA site"
     regulatory      2943..2948
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="hexamer: AATAAA"
     polyA_site      2975
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
     regulatory      3063..3068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
                     /note="hexamer: AATAAA"
     polyA_site      3087
                     /gene="Msh4"
                     /gene_synonym="4930485C04Rik; mMsh4"
ORIGIN      
        1 ctcttctggt ctccggtgca cagacatgca tactggcaaa acacccgtac acttaggtga
       61 aaaagtcctt cagggcaatc tctgtggtag gaaggccctg tgccctgatt gttagatggg
      121 taacaagctt ggatctggac tctgttgcat gactgtacag caggcgctct taaccgctga
      181 gccgcatctc caacatctta acttttaagt ttttcttaga gataaggttc atcatttgga
      241 aacaaaagat cttatgctat acacagagct gcatccagtt ttcctgttgg tacaagctca
      301 tcttctgcac gagataccac ttacccacat acatttagaa ctccgttatc tgctggaaat
      361 ccccagagat cagggcataa aagttggaca ccacaagtag gatattcagc cacatcctct
      421 gcggtgtctg cacacgcccc atcagtcatt gtagcggtgg tggaaggaag agggctggcc
      481 agaggcgaga taggaatggc aagcattgat ttaaaaagcc cacagattat gttgtcacag
      541 tttgcagaca atacaacata tgcaaaggtg atcactaaac tccaagtttt atcacctttg
      601 gaaataataa tgtcaaatac tgcttgtgtt gtgggaaatt caaccaagtt atttactctg
      661 atcacagaaa attttaagaa cgttaatttc actacagtcc aaaggaaata cttcaacgaa
      721 acaaagggct tagagtacat tgagcagttg tgcatagctg agttcagttc tgtgctaatg
      781 gaggtgcagt ccaggtatta ctgccttgca gctgctgcag ctttattaaa gtatgtcgaa
      841 ttcattcaga attcagtgta tgcacccaaa tcgctaaaga tttatttcca aggtagtgag
      901 cagacagcca tgatagattc atcatcggcc caaaacctgg agttgttagt taataaccag
      961 gactacagga gtaatcacac tctcttcggt gttttaaatt acaccaagac tgcgggaggg
     1021 agccgaaggc tgcgctccaa catcctggag cctctggttg atgtggagac gatcagcatg
     1081 cggctggact gtgtccagga gctgctgcag gacgaggagc tcttctttgg actccagtca
     1141 gtcatatcaa gattcctgga tacggagcag ctgctttctg ttttagttca aatcccaaag
     1201 caagacacgg ttaacgcagc tgaatcaaag ataacaaatt tgatctatct gaagcataca
     1261 ttggaacttg tggagccttt aaaggtcacc ttaaagaact gtagcacacc cctattaaga
     1321 gcttactatg gctccttgga agaccatagg tttgggctaa tacttgataa gattaaaaca
     1381 gtgataaatg atgatgcaag gtacatgaag ggctgcctga acatgcggac tcagaagtgc
     1441 tatgcagtgc gctctaacat cagtgagttc ctggacatag ccaggaggac atacacagag
     1501 atagtggacg acatagcagg aatgatagca cagctcgcag agaagtacag tcttccccta
     1561 cggaccagct tcagctcctc acgggggttc ttcatccaga tgaccacaga ctgcgctgca
     1621 ctctccagtg accagcttcc ttcggagttt attaagattt ctaaagtgaa aaactcatat
     1681 agctttacat cagcagattt aattaaaatg aatgaaagat gccaagagtc tttgcgagaa
     1741 atctatcaca tgacctacat gatagtgtgc aaactgctca gtgagatcta cgagcacatc
     1801 cactgcttgt acaagctctc tgacacggtg tccatgctgg atatgctgct gtcgtttgcg
     1861 catgcctgta ctctttctga ctacgttcga ccagagttta ctgacacttt agcaatcaaa
     1921 caaggatggc atcccattct tgaaaaaata tctgcagaga aacctgtcgc caacaatacc
     1981 tacattacag aagggagtaa tgttctaatc attactggac caaatatgag cggaaagtcc
     2041 acgtacttaa agcagattgc actttgtcag atcatggccc agatcggctc ctatgtccca
     2101 gcagaatacg cctcctttag gattgctgca cagatcttta cgagaatcag tactgatgat
     2161 gatattgaaa caaactcatc aacgtttatg aaagaaatga aagagatagc atatattctc
     2221 cataatgcta atgacaagtc actcatatta attgacgagc ttggcagagg cactaataca
     2281 gaagaaggga ttggaatttc ttatgctgtc tgtgagcacc tgcttagcat aaaggcattt
     2341 acactcttca ctacccattt cctggaacta tgccatctag atgccctgta tcttaatgta
     2401 gaaaacatgc attttgaagt tcagcatgtg aagaatacct caagaaataa agatgcaatt
     2461 ttgtatactt acaaactttc caggggactc acagaagaaa agaactatgg attaaaagct
     2521 gcagaggcct cctcacttcc gtcatcgatt gtcttggatg ccagagacat cacaacacaa
     2581 attacaaggc aaattttgca aaatcaaagg agttcccctg agatggatag acagagagct
     2641 gtgtaccatc ttgccacaag gcttgtccag gccgcccgaa actctcagtt ggagccagac
     2701 aggttacgga catacctgag taacctcaag aagaaatatg caggggactt tcccagggct
     2761 gtgggccttc cagagaagac tgaggagtga ccagtacacg gtgtgcacag gggttgcaac
     2821 ttagttgctc agctttatgt tttaattaaa aattatagta tattaacctc agaatggtca
     2881 cctactatga attctagatg gaaaatattc attggaatag cttcaaaagg gacaaatttt
     2941 taaataaaag tttttgttag aaaaataata cagtattcac tgtgaagtca gactaagttt
     3001 gtagtttgct attaagtgta tgtttagaag gttaacagaa gtattctagc ttaaaaatat
     3061 ataataaaga ataggtctga aaaggtt
//
