LOCUS       NM_008628               3081 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus mutS homolog 2 (Msh2), mRNA.
ACCESSION   NM_008628
VERSION     NM_008628.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3081)
  AUTHORS   Wang,N., Zhang,S., Langfelder,P., Ramanathan,L., Gao,F.,
            Plascencia,M., Vaca,R., Gu,X., Deng,L., Dionisio,L.E., Vu,H.,
            Maciejewski,E., Ernst,J., Prasad,B.C., Vogt,T.F., Horvath,S.,
            Aaronson,J.S., Rosinski,J. and Yang,X.W.
  TITLE     Distinct mismatch-repair complex genes set neuronal CAG-repeat
            expansion rate to drive selective pathogenesis in HD mice
  JOURNAL   Cell (2025) In press
   PUBMED   39938516
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3081)
  AUTHORS   Ghobashi,A.H., Lanzloth,R., Ladaika,C.A., Masood,A. and
            O'Hagan,H.M.
  TITLE     Single-Cell Profiling Reveals the Impact of Genetic Alterations on
            the Differentiation of Inflammation-Induced Murine Colon Tumors
  JOURNAL   Cancers (Basel) 16 (11), 2040 (2024)
   PUBMED   38893159
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3081)
  AUTHORS   Mandula,J.K., Sierra-Mondragon,R.A., Jimenez,R.V., Chang,D.,
            Mohamed,E., Chang,S., Vazquez-Martinez,J.A., Cao,Y., Anadon,C.M.,
            Lee,S.B., Das,S., Rocha-Munguba,L., Pham,V.M., Li,R., Tarhini,A.A.,
            Furqan,M., Dalton,W., Churchman,M., Moran-Segura,C.M., Nguyen,J.,
            Perez,B., Kojetin,D.J., Obermayer,A., Yu,X., Chen,A., Shaw,T.I.,
            Conejo-Garcia,J.R. and Rodriguez,P.C.
  TITLE     Jagged2 targeting in lung cancer activates anti-tumor immunity via
            Notch-induced functional reprogramming of tumor-associated
            macrophages
  JOURNAL   Immunity 57 (5), 1124-1140 (2024)
   PUBMED   38636522
REFERENCE   4  (bases 1 to 3081)
  AUTHORS   Westcott,P.M.K., Muyas,F., Hauck,H., Smith,O.C., Sacks,N.J.,
            Ely,Z.A., Jaeger,A.M., Rideout,W.M. 3rd, Zhang,D., Bhutkar,A.,
            Beytagh,M.C., Canner,D.A., Jaramillo,G.C., Bronson,R.T.,
            Naranjo,S., Jin,A., Patten,J.J., Cruz,A.M., Shanahan,S.L.,
            Cortes-Ciriano,I. and Jacks,T.
  TITLE     Mismatch repair deficiency is not sufficient to elicit tumor
            immunogenicity
  JOURNAL   Nat Genet 55 (10), 1686-1695 (2023)
   PUBMED   37709863
REFERENCE   5  (bases 1 to 3081)
  AUTHORS   Song,Y., Kerr,T.D., Sanders,C., Dai,L., Baxter,S.S., Somerville,B.,
            Baugher,R.N., Mellott,S.D., Young,T.B., Lawhorn,H.E., Plona,T.M.,
            Xu,B., Wei,L., Hu,Q., Liu,S., Hutson,A., Karim,B., Burkett,S.,
            Difilippantonio,S., Pinto,L., Gebert,J., Kloor,M., Lipkin,S.M.,
            Sei,S. and Shoemaker,R.H.
  TITLE     Organoids and metastatic orthotopic mouse model for mismatch
            repair-deficient colorectal cancer
  JOURNAL   Front Oncol 13, 1223915 (2023)
   PUBMED   37746286
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3081)
  AUTHORS   Reitmair,A.H., Schmits,R., Ewel,A., Bapat,B., Redston,M., Mitri,A.,
            Waterhouse,P., Mittrucker,H.W., Wakeham,A., Liu,B. et al.
  TITLE     MSH2 deficient mice are viable and susceptible to lymphoid tumours
  JOURNAL   Nat Genet 11 (1), 64-70 (1995)
   PUBMED   7550317
REFERENCE   7  (bases 1 to 3081)
  AUTHORS   de Wind,N., Dekker,M., Berns,A., Radman,M. and te Riele,H.
  TITLE     Inactivation of the mouse Msh2 gene results in mismatch repair
            deficiency, methylation tolerance, hyperrecombination, and
            predisposition to cancer
  JOURNAL   Cell 82 (2), 321-330 (1995)
   PUBMED   7628020
REFERENCE   8  (bases 1 to 3081)
  AUTHORS   Varlet,I., Pallard,C., Radman,M., Moreau,J. and de Wind,N.
  TITLE     Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch
            repair genes
  JOURNAL   Nucleic Acids Res 22 (25), 5723-5728 (1994)
   PUBMED   7838728
REFERENCE   9  (bases 1 to 3081)
  AUTHORS   Kolodner,R.D., Hall,N.R., Lipford,J., Kane,M.F., Rao,M.R.,
            Morrison,P., Wirth,L., Finan,P.J., Burn,J. and Chapman,P.
  TITLE     Structure of the human MSH2 locus and analysis of two Muir-Torre
            kindreds for msh2 mutations
  JOURNAL   Genomics 24 (3), 516-526 (1994)
   PUBMED   7713503
  REMARK    Erratum:[Genomics 1995 Aug 10;28(3):613]
REFERENCE   10 (bases 1 to 3081)
  AUTHORS   Fishel,R., Lescoe,M.K., Rao,M.R., Copeland,N.G., Jenkins,N.A.,
            Garber,J., Kane,M. and Kolodner,R.
  TITLE     The human mutator gene homolog MSH2 and its association with
            hereditary nonpolyposis colon cancer
  JOURNAL   Cell 75 (5), 1027-1038 (1993)
   PUBMED   8252616
  REMARK    Erratum:[Cell. 1994 Apr 8;77(1):1 p following 166. PMID: 8156592]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163652.3.
            
            On Jul 13, 2018 this sequence version replaced NM_008628.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC047117.1, X81143.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               AC163652.3         65521-65795         c
            276-430             AC163652.3         59965-60119         c
            431-709             AC163652.3         58249-58527         c
            710-856             AC163652.3         55650-55796         c
            857-1006            AC163652.3         52741-52890         c
            1007-1140           AC163652.3         51898-52031         c
            1141-1340           AC163652.3         49186-49385         c
            1341-1450           AC163652.3         41723-41832         c
            1451-1574           AC163652.3         31022-31145         c
            1575-1725           AC163652.3         29725-29875         c
            1726-1823           AC163652.3         25601-25698         c
            1824-2069           AC163652.3         20627-20872         c
            2070-2274           AC163652.3         19522-19726         c
            2275-2522           AC163652.3         18792-19039         c
            2523-2698           AC163652.3         17269-17444         c
            2699-3081           AC163652.3         14614-14996         c
FEATURES             Location/Qualifiers
     source          1..3081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 57.87 cM"
     gene            1..3081
                     /gene="Msh2"
                     /note="mutS homolog 2"
                     /db_xref="GeneID:17685"
                     /db_xref="MGI:MGI:101816"
     exon            1..275
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..2872
                     /gene="Msh2"
                     /note="mutS protein homolog 2"
                     /codon_start=1
                     /product="DNA mismatch repair protein Msh2"
                     /protein_id="NP_032654.1"
                     /db_xref="CCDS:CCDS29019.1"
                     /db_xref="GeneID:17685"
                     /db_xref="MGI:MGI:101816"
                     /translation="MAVQPKETLQLEGAAEAGFVRFFEGMPEKPSTTVRLFDRGDFYT
                     AHGEDALLAAREVFKTQGVIKYMGPAGSKTLQSVVLSKMNFESFVKDLLLVRQYRVEV
                     YKNKAGNKASKENEWYLAFKASPGNLSQFEDILFGNNDMSASVGVMGIKMAVVDGQRH
                     VGVGYVDSTQRKLGLCEFPENDQFSNLEALLIQIGPKECVLPGGETTGDMGKLRQVIQ
                     RGGILITERKRADFSTKDIYQDLNRLLKGKKGEQINSAALPEMENQVAVSSLSAVIKF
                     LELLSDDSNFGQFELATFDFSQYMKLDMAAVRALNLFQGSVEDTTGSQSLAALLNKCK
                     TAQGQRLVNQWIKQPLMDRNRIEERLNLVEAFVEDSELRQSLQEDLLRRFPDLNRLAK
                     KFQRQAANLQDCYRLYQGINQLPSVIQALEKYEGRHQALLLAVFVTPLIDLRSDFSKF
                     QEMIETTLDMDQVENHEFLVKPSFDPNLSELREVMDGLEKKMQSTLINAARGLGLDPG
                     KQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSELSSLNEEYTKN
                     KGEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAHLDAIVSFAHVSNAAPVPYVRPVI
                     LEKGKGRIILKASRHACVEVQDEVAFIPNDVHFEKDKQMFHIITGPNMGGKSTYIRQT
                     GVIVLMAQIGCFVPCESAEVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSAT
                     KDSLIIIDELGRGTSTYDGFGLAWAISDYIATKIGAFCMFATHFHELTALANQIPTVN
                     NLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPRHVIACAKQKALELEEFQN
                     IGTSLGCDEAEPAAKRRCLEREQGEKIILEFLSKVKQVPFTAMSEESISAKLKQLKAE
                     VVAKNNSFVNEIISRIKAPAP"
     exon            276..430
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            431..709
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            710..856
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1006
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1140
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1340
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1450
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1574
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1725
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1823
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1824..2069
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2274
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2275..2522
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2698
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     exon            2699..3081
                     /gene="Msh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3061..3066
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msh2"
                     /note="hexamer: AATAAA"
     polyA_site      3081
                     /gene="Msh2"
                     /note="major polyA site"
ORIGIN      
        1 aaacgacgcg gccagcgcag ggtcgctctg tgctctagtg gtgttggtgt ggagcggctc
       61 ggaaatggcg gtgcagccta aggagacgct gcagttggaa ggcgcggccg aggcgggctt
      121 cgtgcgcttc tttgagggca tgccggagaa gccgagcacc acggtgcgcc tcttcgaccg
      181 cggcgacttt tacacggcgc acggagagga cgcgctgctg gcggcccgcg aggtgttcaa
      241 gacccagggc gtgatcaagt acatggggcc ggcagggagt aagaccctgc agagtgttgt
      301 gcttagcaag atgaactttg agtctttcgt gaaagatctt cttctggttc gccagtatcg
      361 agttgaagtt tataagaata aagctggaaa taaggcgtct aaggagaatg agtggtatct
      421 ggcatttaag gcttctcccg gcaatctttc tcagtttgaa gacatcctgt ttggtaacaa
      481 tgacatgtca gcttccgttg gcgttatggg tattaaaatg gccgtggttg atggtcaaag
      541 acatgttgga gttgggtatg tggattccac ccagaggaag ctaggcttgt gtgagttccc
      601 cgagaatgat cagttctcca atctcgaggc tcttctgatt cagattggac caaaggaatg
      661 cgttttacca ggaggagaga ctactggaga catggggaaa ctgaggcagg ttatccagag
      721 aggagggatt ctgatcacag aaagaaagag agccgacttt tccactaaag acatttatca
      781 ggatctcaac cggttactga aaggcaaaaa aggagaacag ataaatagtg ctgccctacc
      841 agagatggag aatcaggttg cagtttcatc actatctgca gtaatcaagt ttttagaact
      901 cttatcagac gattcaaatt ttgggcagtt tgaactggcc acttttgact tcagccagta
      961 catgaagttg gacatggcag cagttagagc cctcaacctt ttccagggtt ctgttgaaga
     1021 caccactggc tctcagtctc tggccgcatt attgaataaa tgcaaaactg ctcaaggaca
     1081 aagattggtt aaccagtgga tcaagcagcc gctcatggat aggaacagga tagaggagag
     1141 gttaaattta gtggaagctt ttgtcgagga ttcagaactg aggcagagtt tacaggagga
     1201 tttgcttcgc cggtttccag accttaaccg gcttgccaag aaattccaga gacaagcagc
     1261 gaatttacaa gactgttacc gactgtatca gggtattaac cagctcccca gcgtcatcca
     1321 ggctctggag aaatacgaag gaagacacca ggcactgttg ttggcagttt ttgtgactcc
     1381 tcttattgat cttcgttctg atttttcaaa atttcaagaa atgatagaaa caactttaga
     1441 tatggatcag gtggaaaacc acgagttcct tgtaaaacct tcatttgatc ctaacctgag
     1501 tgaactaaga gaagtcatgg atggcctgga gaagaagatg cagtccacct taataaatgc
     1561 agcccggggg ctcggattgg atcctggcaa acagattaaa ttggactcca gtgcacagtt
     1621 tggatattat ttccgtgtaa cctgcaagga agagaaagtg cttcgcaaca acaagaactt
     1681 cagcacagtg gacatccaga agaatggcgt gaagtttacc aacagtgaat tgtcctcttt
     1741 aaatgaagaa tatactaaga acaaaggcga gtatgaagag gcccaggatg ccattgttaa
     1801 agaaattgtc aatatttcct caggctacgt agagccaatg cagacgctca acgatgtgct
     1861 ggctcactta gacgccattg ttagcttcgc tcatgtgtca aacgcagcac ccgttcctta
     1921 tgtacgacca gtcatcttgg agaaaggaaa agggagaatt atattgaaag cctccaggca
     1981 tgcttgtgtt gaagttcaag atgaagttgc atttattcca aatgacgtgc actttgaaaa
     2041 agataaacag atgttccaca tcattactgg tcccaatatg ggaggtaaat caacatacat
     2101 tcgtcagacc ggggtgattg tactcatggc ccaaatcggg tgttttgtgc cctgtgagtc
     2161 ggcagaagtg tccattgtgg attgcatcct tgctcgagtc ggggctggtg acagtcaact
     2221 gaaaggcgtc tccacattca tggctgaaat gctggagact gcttccatcc tcaggtcagc
     2281 aaccaaagac tccttaataa tcattgatga gctgggaaga ggaacctcta cctatgatgg
     2341 atttgggtta gcatgggcta tatcagatta cattgcaacg aagattggtg ccttttgcat
     2401 gtttgccacc cattttcatg aacttactgc tttggccaac caaataccaa ctgttaataa
     2461 tctacatgtc acagcgctca ctactgagga gaccctaact atgctttacc aagtgaaaaa
     2521 aggtgtctgt gatcagagtt tcgggattca cgtggctgag ctcgctaact tcccgaggca
     2581 cgtgatagcg tgcgccaagc agaaggctct agagcttgaa gaatttcaga acattggaac
     2641 ctcgctggga tgtgacgaag ccgagccggc tgcaaagaga cgctgcctgg aaagagagca
     2701 aggtgagaaa attattctgg agttcctgtc gaaggtcaag caggtgccct ttactgccat
     2761 gtcggaggag agcatctccg cgaagctgaa gcaactgaaa gccgaggtgg tcgcaaagaa
     2821 caacagcttc gtaaacgaga tcatttcacg gataaaggct ccggctccgt gaggggacag
     2881 tgggtgggcg tgcacggggg agctcacctt tactgtgtgc tgttctgggt agtgctcccc
     2941 actggaacct ggcctagcag catccggaag tgtttagtga tgcttgaaaa cattaccgtc
     3001 tgtagctggg tgctgtttaa atggggacgg gcaactgtga gcactatgct gaattttata
     3061 aataaaatca tgtagtttgt a
//
