LOCUS       NM_001411711            1854 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus musculin (Msc), transcript variant 3, mRNA.
ACCESSION   NM_001411711
VERSION     NM_001411711.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1854)
  AUTHORS   Jin,L., Han,S., Lv,X., Li,X., Zhang,Z., Kuang,H., Chen,Z., Lv,C.A.,
            Peng,W., Yang,Z., Yang,M., Mi,L., Liu,T., Ma,S., Qiu,X., Wang,Q.,
            Pan,X., Shan,P., Feng,Y., Li,J., Wang,F., Xie,L., Zhao,X., Fu,J.F.,
            Lin,J.D. and Meng,Z.X.
  TITLE     The muscle-enriched myokine Musclin impairs beige fat thermogenesis
            and systemic energy homeostasis via Tfr1/PKA signaling in male mice
  JOURNAL   Nat Commun 14 (1), 4257 (2023)
   PUBMED   37468484
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1854)
  AUTHORS   Vanni,A., Carnasciali,A., Mazzoni,A., Russo,E., Farahvachi,P.,
            Gloria,L.D., Ramazzotti,M., Lamacchia,G., Capone,M., Salvati,L.,
            Calosi,L., Bani,D., Liotta,F., Cosmi,L., Amedei,A., Ballerini,C.,
            Maggi,L. and Annunziato,F.
  TITLE     Musculin does not modulate the disease course of Experimental
            Autoimmune Encephalomyelitis and DSS colitis
  JOURNAL   Immunol Lett 255, 21-31 (2023)
   PUBMED   36848960
  REMARK    GeneRIF: Musculin does not modulate the disease course of
            Experimental Autoimmune Encephalomyelitis and DSS colitis.
REFERENCE   3  (bases 1 to 1854)
  AUTHORS   Yu,J., Liu,Y., Zhang,W., Yang,X., Tang,W., Liang,H., Li,S., Gao,W.
            and Yan,J.
  TITLE     Musculin Deficiency Aggravates Colonic Injury and Inflammation in
            Mice with Inflammatory Bowel Disease
  JOURNAL   Inflammation 43 (4), 1455-1463 (2020)
   PUBMED   32239394
  REMARK    GeneRIF: Musculin Deficiency Aggravates Colonic Injury and
            Inflammation in Mice with Inflammatory Bowel Disease.
REFERENCE   4  (bases 1 to 1854)
  AUTHORS   Yahya,I., Boing,M., Pu,Q., Puchert,M., Oedemis,V., Engele,J.,
            Brand-Saberi,B. and Morosan-Puopolo,G.
  TITLE     Cxcr4 and Sdf-1 are critically involved in the formation of facial
            and non-somitic neck muscles
  JOURNAL   Sci Rep 10 (1), 5049 (2020)
   PUBMED   32193486
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1854)
  AUTHORS   Wu,C., Chen,Z., Dardalhon,V., Xiao,S., Thalhamer,T., Liao,M.,
            Madi,A., Franca,R.F., Han,T., Oukka,M. and Kuchroo,V.
  TITLE     The transcription factor musculin promotes the unidirectional
            development of peripheral Treg cells by suppressing the TH2
            transcriptional program
  JOURNAL   Nat Immunol 18 (3), 344-353 (2017)
   PUBMED   28114290
  REMARK    GeneRIF: this study shows that MSC-deficient TGFb-induced Treg
            cells are unable to suppress Th2 cell responses, and that
            MSC-deficient mice spontaneously develop gut and lung inflammation
            with age
REFERENCE   6  (bases 1 to 1854)
  AUTHORS   Eng,S.R., Lanier,J., Fedtsova,N. and Turner,E.E.
  TITLE     Coordinated regulation of gene expression by Brn3a in developing
            sensory ganglia
  JOURNAL   Development 131 (16), 3859-3870 (2004)
   PUBMED   15253936
REFERENCE   7  (bases 1 to 1854)
  AUTHORS   Lu,J.R., Bassel-Duby,R., Hawkins,A., Chang,P., Valdez,R., Wu,H.,
            Gan,L., Shelton,J.M., Richardson,J.A. and Olson,E.N.
  TITLE     Control of facial muscle development by MyoR and capsulin
  JOURNAL   Science 298 (5602), 2378-2381 (2002)
   PUBMED   12493912
  REMARK    GeneRIF: findings identify MyoR and capsulin as unique
            transcription factors for the development of specific head muscles
REFERENCE   8  (bases 1 to 1854)
  AUTHORS   Robb,L., Brodnicki,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.
            and Harvey,R.P.
  TITLE     Assignment of the human helix-loop-helix transcription factor gene
            musculin/activated B-cell factor-1 (MSC) to chromosome 8q21 and its
            mouse homologue (Msc) to the proximal region of chromosome 1
  JOURNAL   Genomics 57 (2), 318-319 (1999)
   PUBMED   10198176
REFERENCE   9  (bases 1 to 1854)
  AUTHORS   Lu,J., Webb,R., Richardson,J.A. and Olson,E.N.
  TITLE     MyoR: a muscle-restricted basic helix-loop-helix transcription
            factor that antagonizes the actions of MyoD
  JOURNAL   Proc Natl Acad Sci U S A 96 (2), 552-557 (1999)
   PUBMED   9892671
REFERENCE   10 (bases 1 to 1854)
  AUTHORS   Robb,L., Hartley,L., Wang,C.C., Harvey,R.P. and Begley,C.G.
  TITLE     musculin: a murine basic helix-loop-helix transcription factor gene
            expressed in embryonic skeletal muscle
  JOURNAL   Mech Dev 76 (1-2), 197-201 (1998)
   PUBMED   9767165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115876.18.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12282455.6198358.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-874               AC115876.18        153958-154831       c
            875-1854            AC115876.18        152185-153164       c
FEATURES             Location/Qualifiers
     source          1..1854
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 4.5 cM"
     gene            1..1854
                     /gene="Msc"
                     /gene_synonym="bHLHa22; MyoR"
                     /note="musculin"
                     /db_xref="GeneID:17681"
                     /db_xref="MGI:MGI:1333884"
     exon            1..874
                     /gene="Msc"
                     /gene_synonym="bHLHa22; MyoR"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..961
                     /gene="Msc"
                     /gene_synonym="bHLHa22; MyoR"
                     /note="isoform 3 is encoded by transcript variant 3;
                     myogenic repressor"
                     /codon_start=1
                     /product="musculin isoform 3"
                     /protein_id="NP_001398640.1"
                     /db_xref="GeneID:17681"
                     /db_xref="MGI:MGI:1333884"
                     /translation="MSTGSVSDPEDSEMRGLQRVYPAPASKRPPLLRMERGYGSPSDI
                     SSAEEEDGEEEPGSLGAAGGCKRKRLRGADAGGAGGRAGGAGKKPLPPKGSAAECKQS
                     QRNAANARERARMRVLSKAFSRLKTSLPWVPPDTKLSKLDTLRLASSYIAHLRQLLQE
                     DRYEDSYVHPVNLVGMLRSRPGDSSPERYPGPGLARPQTKSQEGRFLEPVTWPFVVSG
                     RPDSDSKDVSAANRLCGTSA"
     exon            875..1854
                     /gene="Msc"
                     /gene_synonym="bHLHa22; MyoR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Msc"
                     /gene_synonym="bHLHa22; MyoR"
                     /note="hexamer: AATAAA"
     polyA_site      1854
                     /gene="Msc"
                     /gene_synonym="bHLHa22; MyoR"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgtac ttttggatcc ggagtcaagt tcagcagagc cctgggctac agggtcagca
       61 gcagatcgcg cccactccag gcgcccagct cacaggggag cctcagtgcg gaggcaagcc
      121 ctggtctctg gtcctcccct gggctctccc acaccccatc ctctgtcaga gagaagaagc
      181 cagagaaagc gagactggcc ggggaggaga aaggcgcgcg cgcgtgggcg ccggggaata
      241 ggcgatgtcc accggctcgg tgagtgaccc cgaagactcg gagatgaggg ggctgcagag
      301 ggtctacccg gccccggcct ccaagaggcc gcccctgctc cgcatggagc gcggttacgg
      361 ctcgcccagc gacatttctt ctgcggaaga ggaggacggt gaagaggagc ccggctccct
      421 gggagccgcg ggaggatgca agaggaagcg gctccgtggg gctgacgctg gcggcgcagg
      481 tggccgcgca ggcggtgcgg ggaagaagcc gctcccgcct aagggctcgg ccgcagagtg
      541 caagcagtcg cagcggaatg cggccaacgc ccgcgaacgc gcccggatgc gcgtgctgag
      601 caaagccttc tccagactga agaccagcct gccctgggtg ccgcccgaca ccaagctttc
      661 caaactggac acgctgcgcc tggcttccag ctacatcgcg cacctgcgcc agctgctgca
      721 ggaggaccgc tacgaggaca gctatgtgca ccctgtgaac ctggtaggga tgctgcgctc
      781 gaggccgggg gacagcagcc cagagcgcta cccgggccca gggctggctc ggccccagac
      841 gaagagccaa gaggggaggt ttctggaacc agtgacgtgg ccattcgtgg tctctggacg
      901 cccagactct gacagcaaag acgtttctgc agccaacagg ctttgtggaa cttccgctta
      961 gagggacagg gcagttagat ggattgtggt aaacgcaaag gactgggcca aggaagtccc
     1021 actggattct ggaccttctc ctttccctgg gcctgtgaac aagacaggag acaagtgtgg
     1081 tttgccctcc tggagcgcag gtggccatgg gtgccccaaa tcagtgcaaa cttctgtaac
     1141 caaagaaagc ccagtttcag gggaagaata cgtggaccag gtaaaaacct agggctttag
     1201 ctctgatcac aaccccctgc ctgctatctg agtccagtgc agaaacgggt tggttttgaa
     1261 gctaatcttg attgccttgt ggttgatggc aaggtcctgc acagccaggt ccttctgtga
     1321 ccgtggatga gagctgtttc ccagcactag aaagaaggcc ggcattagag ctcttcgggg
     1381 gcctgtcact aagggcagtg ttgctacaga cagtggcata ctcttcctgg gcaggacatg
     1441 ttgaggtgga gacattaact ccaggtgctg gttttgctcg aaatctctgc agactggggt
     1501 tcatttcctg agttccctcc tctgtttaat cagtgttggg tctccattca gtgagtgcag
     1561 cttgtttatg gggtctcagc tccttcccac ccacactgtc ccctatttgg ggacatgtgc
     1621 ttcacccctc taattgtctc accctgccac agcatagcct tctgtggggt tcctggtctt
     1681 tcagggatgt actattcttc ctggtccaag gactgtgtgt ggtgggtggc tggggctagg
     1741 gctggtctct attatactgg tttctaccca gtacatggtg cttagtggtc ctggcaatgc
     1801 tgcactatca tggtaactaa catatgtaaa taaatttatt ttttatggac aaaa
//
