LOCUS       NM_022430               1116 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 8A
            (Ms4a8a), mRNA.
ACCESSION   NM_022430 XM_355186
VERSION     NM_022430.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1116)
  AUTHORS   Michel,J., Schonhaar,K., Schledzewski,K., Gkaniatsou,C., Sticht,C.,
            Kellert,B., Lasitschka,F., Geraud,C., Goerdt,S. and Schmieder,A.
  TITLE     Identification of the novel differentiation marker MS4A8B and its
            murine homolog MS4A8A in colonic epithelial cells lost during
            neoplastic transformation in human colon
  JOURNAL   Cell Death Dis 4 (1), e469 (2013)
   PUBMED   23348583
  REMARK    GeneRIF: MS4A8A is a novel differentiation marker of the intestinal
            epithelium that supports the maintenance of a physiological barrier
            function in the gut by modulating the transcriptome and by
            conferring an increased resistance to reactive oxygen species.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1116)
  AUTHORS   Dike,S., Balija,V.S., Nascimento,L.U., Xuan,Z., Ou,J., Zutavern,T.,
            Palmer,L.E., Hannon,G., Zhang,M.Q. and McCombie,W.R.
  TITLE     The mouse genome: experimental examination of gene predictions and
            transcriptional start sites
  JOURNAL   Genome Res 14 (12), 2424-2429 (2004)
   PUBMED   15574821
REFERENCE   3  (bases 1 to 1116)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   4  (bases 1 to 1116)
  AUTHORS   Ishibashi,K., Suzuki,M., Sasaki,S. and Imai,M.
  TITLE     Identification of a new multigene four-transmembrane family (MS4A)
            related to CD20, HTm4 and beta subunit of the high-affinity IgE
            receptor
  JOURNAL   Gene 264 (1), 87-93 (2001)
   PUBMED   11245982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV305829.1, AK008099.1 and AB026044.1.
            
            On Jan 5, 2007 this sequence version replaced NM_022430.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042719.1, AK008099.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               CV305829.1         1-219
            220-900             AK008099.1         159-839
            901-1116            AB026044.1         851-1066
FEATURES             Location/Qualifiers
     source          1..1116
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 7.62 cM"
     gene            1..1116
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /note="membrane-spanning 4-domains, subfamily A, member
                     8A"
                     /db_xref="GeneID:64381"
                     /db_xref="MGI:MGI:1927657"
     exon            1..120
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..880
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /note="MS4a8B protein; CD20 antigen-like 5"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     8"
                     /protein_id="NP_071875.2"
                     /db_xref="CCDS:CCDS37921.1"
                     /db_xref="GeneID:64381"
                     /db_xref="MGI:MGI:1927657"
                     /translation="MNRPTAQGAVNLSGSKFSTAKSWEPEQERLTWQPGTVSMNTVTS
                     PGPMANSVYVVAPPNSYPVVPGTVPQMPIYPSNQPQVHVISGHLPGLVPAMTEPPAQR
                     VLKKGQVLGAIQILIGLVHIGLGSIMITNLFSHYTPVSLYGGFPFWGGIWFIISGSLS
                     VAAETQPNSPCLLNGSVGLNIFSAICSAVGIMLFITDISISSGYIYPSYYPYQENLGV
                     RTGVAISSVLLIFCLLELSIASVSSHFGCQVACCHYNNPGVVIPNVYAANPVVIPEPP
                     NPIPSYSEVVQDSR"
     exon            121..340
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /inference="alignment:Splign:2.1.0"
     exon            341..463
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /inference="alignment:Splign:2.1.0"
     exon            464..523
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /inference="alignment:Splign:2.1.0"
     exon            524..661
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /inference="alignment:Splign:2.1.0"
     exon            662..775
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1082
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1062..1067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /note="hexamer: AATAAA"
     polyA_site      1082
                     /gene="Ms4a8a"
                     /gene_synonym="2010004L09Rik; CD20L5; Ms4a8"
                     /note="major polyA site"
ORIGIN      
        1 attctaaatg aatcgcccaa ctgcacaggg tgcagtcaat ctctcgggga gtaagttttc
       61 tacagcaaag agttgggaac cggagcaaga gagacttact tggcaaccgg gcacagtaag
      121 catgaataca gtaacttcac cgggccccat ggccaattct gtatatgtgg tggcaccgcc
      181 caacagttat cctgtggtcc caggaaccgt gcctcagatg cctatttatc ccagcaatca
      241 gcctcaagtc catgtgattt ctggtcatct gcctggtttg gtgccagcta tgaccgaacc
      301 gcctgcccag agagtcttga aaaagggaca agtcctaggg gccatccaga tcctgatcgg
      361 cctggtgcac atcggcctgg gctccatcat gatcaccaac ctcttcagcc actatacacc
      421 tgtctccctc tatggaggtt tccccttctg gggaggcatc tggtttatca tttcaggatc
      481 tctctcagtg gcggcagaaa ctcagcccaa ttcaccttgc ctgctgaatg gcagtgtggg
      541 cttgaacatc ttcagcgcca tctgttctgc ggtgggcatc atgctcttca tcacagacat
      601 cagtatctca tcaggataca tctaccctag ctactaccct taccaggaga acttgggtgt
      661 gagaacaggc gtggctattt ctagtgtgct actcatcttc tgcctcttgg agctcagcat
      721 tgcaagtgtg tcctcccact ttggctgcca agtggcctgt tgtcactaca acaatccagg
      781 tgtggtcatt ccaaatgtct atgcagcaaa cccagtggtc atcccagaac caccaaaccc
      841 aataccaagt tattccgaag tagttcaaga ctccagataa gtgaacctga agattctaga
      901 gaccaagtga catcctctcc tacctagact cctataaacc aagttcttcc tttcctgacg
      961 aagggtaaat atctttcttg tggcctaaat tatagactct tgcttcaact caccctggaa
     1021 aaatctctat taaaacgaga tgggagattg aaatggattc aaataaagat gctctagcag
     1081 gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaa
//
