LOCUS       NM_027836               1336 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 7
            (Ms4a7), transcript variant 1, mRNA.
ACCESSION   NM_027836
VERSION     NM_027836.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1336)
  AUTHORS   Srivastava,N., Hu,H., Peterson,O.J., Vomund,A.N., Stremska,M.,
            Zaman,M., Giri,S., Li,T., Lichti,C.F., Zakharov,P.N., Zhang,B.,
            Abumrad,N.A., Chen,Y.G., Ravichandran,K.S., Unanue,E.R. and Wan,X.
  TITLE     CXCL16-dependent scavenging of oxidized lipids by islet macrophages
            promotes differentiation of pathogenic CD8+ T cells in diabetic
            autoimmunity
  JOURNAL   Immunity (2024) In press
   PUBMED   38754432
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 1336)
  AUTHORS   Zhou,L., Qiu,X., Meng,Z., Liu,T., Chen,Z., Zhang,P., Kuang,H.,
            Pan,T., Lu,Y., Qi,L., Olson,D.P., Xu,X.Z.S., Chen,Y.E., Li,S. and
            Lin,J.D.
  TITLE     Hepatic danger signaling triggers TREM2+ macrophage induction and
            drives steatohepatitis via MS4A7-dependent inflammasome activation
  JOURNAL   Sci Transl Med 16 (738), eadk1866 (2024)
   PUBMED   38478630
  REMARK    GeneRIF: Hepatic danger signaling triggers TREM2[+] macrophage
            induction and drives steatohepatitis via MS4A7-dependent
            inflammasome activation.
REFERENCE   3  (bases 1 to 1336)
  AUTHORS   Lopez-Tello,J. and Sferruzzi-Perri,A.N.
  TITLE     Characterization of placental endocrine function and fetal brain
            development in a mouse model of small for gestational age
  JOURNAL   Front Endocrinol (Lausanne) 14, 1116770 (2023)
   PUBMED   36843585
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1336)
  AUTHORS   Rosin,J.M., Sinha,S., Biernaskie,J. and Kurrasch,D.M.
  TITLE     A subpopulation of embryonic microglia respond to maternal stress
            and influence nearby neural progenitors
  JOURNAL   Dev Cell 56 (9), 1326-1345 (2021)
   PUBMED   33887203
REFERENCE   5  (bases 1 to 1336)
  AUTHORS   Hammond,T.R., Dufort,C., Dissing-Olesen,L., Giera,S., Young,A.,
            Wysoker,A., Walker,A.J., Gergits,F., Segel,M., Nemesh,J.,
            Marsh,S.E., Saunders,A., Macosko,E., Ginhoux,F., Chen,J.,
            Franklin,R.J.M., Piao,X., McCarroll,S.A. and Stevens,B.
  TITLE     Single-Cell RNA Sequencing of Microglia throughout the Mouse
            Lifespan and in the Injured Brain Reveals Complex Cell-State
            Changes
  JOURNAL   Immunity 50 (1), 253-271 (2019)
   PUBMED   30471926
REFERENCE   6  (bases 1 to 1336)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   7  (bases 1 to 1336)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046559.1, AK151261.1, AK079888.1 and AC134839.3.
            
            On Feb 7, 2013 this sequence version replaced NM_027836.5.
            
            Transcript Variant: This variant (1) uses an alternate 5' exon
            structure, differs in the 5' UTR and uses a downstream start codon
            compared to variant 3. It encodes isoform a which is shorter than
            isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151261.1, AK149890.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AK046559.1         2-31
            31-175              AK151261.1         2-146
            176-176             AK079888.1         417-417
            177-962             AK151261.1         148-933
            963-1062            AK079888.1         1204-1303
            1063-1063           AC134839.3         18430-18430
            1064-1336           AK079888.1         1305-1577
FEATURES             Location/Qualifiers
     source          1..1336
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.43 cM"
     gene            1..1336
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /note="membrane-spanning 4-domains, subfamily A, member 7"
                     /db_xref="GeneID:109225"
                     /db_xref="MGI:MGI:1918846"
     exon            1..140
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /inference="alignment:Splign:2.1.0"
     exon            141..300
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..858
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /note="isoform a is encoded by transcript variant 1"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member 7
                     isoform a"
                     /protein_id="NP_082112.3"
                     /db_xref="CCDS:CCDS29598.1"
                     /db_xref="GeneID:109225"
                     /db_xref="MGI:MGI:1918846"
                     /translation="MRLQLGTKNIGWDCFPKDIIIHKREKTGHTYEKEDDLLIGVPSE
                     ATVLGTIQLLCALILASFGGILVSASYFNPEVSTTLISGYLFIGSLCFAIAGILSIIS
                     EKISTKPFALSSLASNVASSVVAVIGLFLFTYCLIALGSAFPHCNSEKKFLSLLSYLK
                     SHHWKNEDKNCYLAYVGAMSALGMMLLFTVLEVFLAGYSSIFWWKQVYSNKPGGTFFL
                     PQSQDHTQLVKSNLLQ"
     exon            301..426
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /inference="alignment:Splign:2.1.0"
     exon            427..483
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /inference="alignment:Splign:2.1.0"
     exon            484..690
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /inference="alignment:Splign:2.1.0"
     exon            691..792
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /inference="alignment:Splign:2.1.0"
     exon            793..1336
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      951..956
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /note="hexamer: AATAAA"
     polyA_site      969
                     /gene="Ms4a7"
                     /gene_synonym="9130422I10Rik; A430103C15Rik; CD20l4;
                     CFFMA"
                     /note="major polyA site"
ORIGIN      
        1 acacaaaatg actgagtgtc aaaggcagac agtgcaactt ctggaggaaa cagctggtaa
       61 gaggttgagt ctgagttctc ccaggagcag agtgagcagg cccaggagct gcagcacaca
      121 ggacagggct gtgaggacag catccctggc accatgcgtc tacagcttgg caccaagaac
      181 attgggtggg actgctttcc aaaggacatc attatccaca aaagagagaa aactggacat
      241 acatatgaaa aagaagatga cctgctgatt ggagtgccta gtgaagccac agttcttgga
      301 accatccagc tactatgtgc cctgatactt gcaagctttg ggggcatttt ggtgtcagct
      361 tcctacttca acccagaagt ttccaccact ttgatatctg gatacctgtt tattggatcc
      421 ctctgttttg ccattgctgg aattctctcc attatctctg aaaaaatctc aaccaaaccc
      481 tttgcactga gcagcctggc ctccaatgta gcaagctctg ttgttgccgt cattggcctc
      541 ttcctcttca cctattgtct gatagccctg gggagtgctt tcccacactg taactcagaa
      601 aagaaattcc tgtccttatt gtcttacttg aaatcccacc attggaagaa tgaagacaag
      661 aactgttacc tggcttatgt cggtgctatg agtgctctgg ggatgatgct tctcttcact
      721 gtgctggagg ttttcctagc tggatacagt tctatctttt ggtggaagca agtctactcc
      781 aacaaacctg ggggtacatt tttcttgcct caatcacaag atcataccca acttgttaaa
      841 agcaatttgt tgcaataatg gatatgaaat acaaaagaag aaagaagaaa tctgttgctc
      901 acagcagagt acagctagac ttgcctgaaa tctcagcttt ggtagatcct aataaacatc
      961 tgaagaaaag ctctcctgtc atactttcaa tgagtcactt catttccatt gaaaatcatt
     1021 tcctaaagtc cgagtcagca aaattccctg attccacatt ccacaatgac cacaaacttt
     1081 atcaacttcc ccaaatagag tgaacagaca gtgtttcatc tgtctgatgc tagatgagaa
     1141 agcatgtact ccttctgggg tggaagctga cagggtcatg tggctaggta aggtctttct
     1201 ctgcattgct tgcacaatcc tttgcttaaa tattagactt tacacattcc aagaacattt
     1261 gagatccttt gaaaatatga cagcctgtac aaggtcctgg gtttgatact acagcaataa
     1321 aaagatataa taaatc
//
