LOCUS       NM_026835               1353 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 6D
            (Ms4a6d), mRNA.
ACCESSION   NM_026835 NM_022431
VERSION     NM_026835.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1353)
  AUTHORS   Guo,J., Wang,C., Xiang,Q., Feng,Z., Fei,L., Guo,G., Shang,Y.,
            An,Y., Ruan,Z., Chen,Y. and Huang,X.
  TITLE     MS4A6D Promotes carrageenan-induced footpad swelling in mice
            through enhancing macrophages-derived inflammation
  JOURNAL   Mol Immunol 169, 28-36 (2024)
   PUBMED   38493579
  REMARK    GeneRIF: MS4A6D Promotes carrageenan-induced footpad swelling in
            mice through enhancing macrophages-derived inflammation.
REFERENCE   2  (bases 1 to 1353)
  AUTHORS   Chen,Y., Li,S., Huang,X., Wang,C., Pan,Y., Xiang,Q., Feng,Z.,
            Fei,L., Wu,Y., Ruan,Z., An,Y. and Chen,Y.
  TITLE     Tetraspan MS4A6D is a coreceptor of MHC class II antigen (MHC-II)
            that promotes macrophages-derived inflammation
  JOURNAL   Mol Immunol 160, 121-132 (2023)
   PUBMED   37429063
  REMARK    GeneRIF: Tetraspan MS4A6D is a coreceptor of MHC class II antigen
            (MHC-II) that promotes macrophages-derived inflammation.
REFERENCE   3  (bases 1 to 1353)
  AUTHORS   Huang,X., Feng,Z., Jiang,Y., Li,J., Xiang,Q., Guo,S., Yang,C.,
            Fei,L., Guo,G., Zheng,L., Wu,Y. and Chen,Y.
  TITLE     VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1beta in
            macrophages
  JOURNAL   Sci Adv 5 (1), eaau7426 (2019)
   PUBMED   30662948
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1353)
  AUTHORS   Abdallah,B.M., Ditzel,N., Mahmood,A., Isa,A., Traustadottir,G.A.,
            Schilling,A.F., Ruiz-Hidalgo,M.J., Laborda,J., Amling,M. and
            Kassem,M.
  TITLE     DLK1 is a novel regulator of bone mass that mediates estrogen
            deficiency-induced bone loss in mice
  JOURNAL   J Bone Miner Res 26 (7), 1457-1471 (2011)
   PUBMED   21308776
REFERENCE   5  (bases 1 to 1353)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   6  (bases 1 to 1353)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   7  (bases 1 to 1353)
  AUTHORS   Ishibashi,K., Suzuki,M., Sasaki,S. and Imai,M.
  TITLE     Identification of a new multigene four-transmembrane family (MS4A)
            related to CD20, HTm4 and beta subunit of the high-affinity IgE
            receptor
  JOURNAL   Gene 264 (1), 87-93 (2001)
   PUBMED   11245982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165168.3.
            
            On Mar 1, 2022 this sequence version replaced NM_026835.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018331.1, AK004295.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC165168.3         31659-31771
            114-276             AC165168.3         33137-33299
            277-411             AC165168.3         34481-34615
            412-468             AC165168.3         43524-43580
            469-675             AC165168.3         46249-46455
            676-777             AC165168.3         48380-48481
            778-1353            AC165168.3         49264-49839
FEATURES             Location/Qualifiers
     source          1..1353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.45 cM"
     gene            1..1353
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /note="membrane-spanning 4-domains, subfamily A, member
                     6D"
                     /db_xref="GeneID:68774"
                     /db_xref="MGI:MGI:1916024"
     exon            1..113
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            114..276
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..873
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /note="CD20 antigen-like 8; membrane-spanning 4-domains,
                     subfamily A, member 11"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     6D"
                     /protein_id="NP_081111.1"
                     /db_xref="CCDS:CCDS29603.1"
                     /db_xref="GeneID:68774"
                     /db_xref="MGI:MGI:1916024"
                     /translation="MIPQVVTSETVTVISPNGISFPQTDKPQPSHQSQDSLKKHLKAE
                     IKVMAAIQIMCAVMVLALGIILASVPSNLHFTSVFSILLESGYPFVGALFFAISGILS
                     IVTEKKMTKPLVHSSLALSILSVLSALTGIAILSVSLAALEPALQQCKLAFTQLDTTQ
                     DAYHFFSPEPLNSCFVAKAALTGVFSLMLISSVLELGLAVLTATLWWKQSSSAFSGNV
                     IFLSQNSKNKSSVSSESLCNPTYENILTS"
     exon            277..411
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            412..468
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            469..675
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            676..777
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /inference="alignment:Splign:2.1.0"
     exon            778..1353
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1331..1336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="Ms4a6d"
                     /gene_synonym="1110058E16Rik; Ms4a11"
                     /note="major polyA site"
ORIGIN      
        1 agaacttcac aagaaggaac caaggatcag actgagaaaa cccatagtta aagctcttgg
       61 ggtttctgag agctcagctg gaagtgactg ggtgacaagg cgcacaggct cagccgtgga
      121 agctccatca tgattccaca agtagtgacc agtgagactg tcacagtgat ttcaccaaat
      181 ggaatcagct ttccccaaac agacaaaccc cagccttccc accagagcca agacagcctg
      241 aagaaacatc taaaggctga gatcaaagtg atggcggcaa tccagatcat gtgtgctgtg
      301 atggtgttgg ctctgggaat cattttggca tctgttccct ccaatctaca ctttacctca
      361 gtgttttcca tcctgttaga atctggctac ccatttgtag gagctttgtt ttttgccatc
      421 tctggaattc tgtctattgt cacagagaaa aagatgacta agcctttggt tcacagcagc
      481 ctagccctga gcatcctgag tgtcctctct gctcttacag gcatcgctat tctctctgtc
      541 agtttggctg ctttagagcc tgccttgcag caatgtaagc tggctttcac acaactagac
      601 acaacccaag atgcttatca tttctttagc cctgagccat taaacagctg cttcgtggcc
      661 aaagctgctc tgactggagt cttttcactg atgctaatca gcagtgtgtt ggagcttggc
      721 ctggctgtcc tcactgccac actgtggtgg aaacagagct cctctgcttt ctctgggaat
      781 gtgattttcc tgtctcagaa ctcaaagaat aaatccagtg tatcttcaga gtcactttgt
      841 aaccctacat atgaaaacat attgacttca taagaattaa gtagaggtta tatagcagaa
      901 aaatctgtct ttaacatgat ttagaaaagc catttactgt gtgacaacaa tgcttaatat
      961 cttaatatct taatgtgtgt attggttaat cagcaaccat gaaaaacata ctaactggct
     1021 gggttcagta gcacgctctt gatttggcgt cagtcaaaac acagacctgt aaattccaat
     1081 ttatgtagtg gtcaaagagc cccaattatt ttctcaaaaa actggaagaa tgtttcatag
     1141 gatcatggtg gagccaatgg gcaacagttc ttcttatcct tgtcacttgg ctgcaggagg
     1201 tactgactag ggcctgagat catattctgt gtgcgtggca tggacttcat ggcatctatt
     1261 ttattcataa gcacatgaaa acaagtcatc tcttatgaag tctcaaagag cataaaaaag
     1321 ttagcctcca aataaagtct ttatataatc cca
//
