LOCUS       NM_021718               1282 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 4B
            (Ms4a4b), mRNA.
ACCESSION   NM_021718 XM_001000093 XM_001000112 XM_001000122 XM_001000136
            XM_001000154
VERSION     NM_021718.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1282)
  AUTHORS   Yan Y, Li Z, Zhang GX, Williams MS, Carey GB, Zhang J, Rostami A
            and Xu H.
  TITLE     Anti-MS4a4B treatment abrogates MS4a4B-mediated protection in T
            cells and ameliorates experimental autoimmune encephalomyelitis
  JOURNAL   Apoptosis 18 (9), 1106-1119 (2013)
   PUBMED   23801080
  REMARK    GeneRIF: MS4a4B regulated both T cell proliferation and T cell
            apoptosis.
REFERENCE   2  (bases 1 to 1282)
  AUTHORS   Yan Y, Zhang GX, Williams MS, Carey GB, Li H, Yang J, Rostami A and
            Xu H.
  TITLE     TCR stimulation upregulates MS4a4B expression through induction of
            AP-1 transcription factor during T cell activation
  JOURNAL   Mol Immunol 52 (2), 71-78 (2012)
   PUBMED   22595231
  REMARK    GeneRIF: TCR-stimulation induces transactivation of AP-1
            transcription factor, which subsequently binds to the MS4a4B
            promoter and upregulates expression of MS4a4B in activated T cells.
REFERENCE   3  (bases 1 to 1282)
  AUTHORS   Xu H, Yan Y, Williams MS, Carey GB, Yang J, Li H, Zhang GX and
            Rostami A.
  TITLE     MS4a4B, a CD20 homologue in T cells, inhibits T cell propagation by
            modulation of cell cycle
  JOURNAL   PLoS One 5 (11), e13780 (2010)
   PUBMED   21072172
  REMARK    GeneRIF: Data indicate that MS4a4B negatively regulates T cell
            proliferation, and MS4a4B may serve as a modulator in the
            negative-feedback regulatory loop of activated T cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1282)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   5  (bases 1 to 1282)
  AUTHORS   Howie D, Nolan KF, Daley S, Butterfield E, Adams E, Garcia-Rueda H,
            Thompson C, Saunders NJ, Cobbold SP, Tone Y, Tone M and Waldmann H.
  TITLE     MS4A4B is a GITR-associated membrane adapter, expressed by
            regulatory T cells, which modulates T cell activation
  JOURNAL   J Immunol 183 (7), 4197-4204 (2009)
   PUBMED   19752228
REFERENCE   6  (bases 1 to 1282)
  AUTHORS   Xiao Y, Peperzak V, Keller AM and Borst J.
  TITLE     CD27 instructs CD4+ T cells to provide help for the memory CD8+ T
            cell response after protein immunization
  JOURNAL   J Immunol 181 (2), 1071-1082 (2008)
   PUBMED   18606659
  REMARK    GeneRIF: study identified a molecular imprint of CD27-proficient
            CD4+ T cell help in CD8+ memory T cells in the form of the MS4A4B
            molecule
REFERENCE   7  (bases 1 to 1282)
  AUTHORS   Xu H, Williams MS and Spain LM.
  TITLE     Patterns of expression, membrane localization, and effects of
            ectopic expression suggest a function for MS4a4B, a CD20 homolog in
            Th1 T cells
  JOURNAL   Blood 107 (6), 2400-2408 (2006)
   PUBMED   16293604
  REMARK    GeneRIF: MS4a4B expression is tightly regulated during T-cell
            development and MS4a4B expression promotes Th1 function and/or
            differentiation.
REFERENCE   8  (bases 1 to 1282)
  AUTHORS   Liang Y, Buckley TR, Tu L, Langdon SD and Tedder TF.
  TITLE     Structural organization of the human MS4A gene cluster on
            Chromosome 11q12
  JOURNAL   Immunogenetics 53 (5), 357-368 (2001)
   PUBMED   11486273
REFERENCE   9  (bases 1 to 1282)
  AUTHORS   Liang Y and Tedder TF.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
REFERENCE   10 (bases 1 to 1282)
  AUTHORS   Venkataraman C, Schaefer G and Schindler U.
  TITLE     Cutting edge: Chandra, a novel four-transmembrane domain protein
            differentially expressed in helper type 1 lymphocytes
  JOURNAL   J Immunol 165 (2), 632-636 (2000)
   PUBMED   10878334
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK080934.1, AK138737.1 and AF230640.1.
            
            On Sep 19, 2006 this sequence version replaced NM_021718.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF230640.1, AK138737.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                AK080934.1         2-29
            29-1256             AK138737.1         2-1229
            1257-1282           AF230640.1         1213-1238
FEATURES             Location/Qualifiers
     source          1..1282
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.44 cM"
     gene            1..1282
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /note="membrane-spanning 4-domains, subfamily A, member
                     4B"
                     /db_xref="GeneID:60361"
                     /db_xref="MGI:MGI:1913083"
     exon            1..103
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /inference="alignment:Splign:2.1.0"
     exon            104..263
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..809
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /note="lymphocyte antigen 116"
                     /codon_start=1
                     /product="membrane-spanning 4-domains, subfamily A, member
                     4B"
                     /protein_id="NP_068364.1"
                     /db_xref="CCDS:CCDS29600.1"
                     /db_xref="GeneID:60361"
                     /db_xref="MGI:MGI:1913083"
                     /translation="MQGQEQTTMAVVPGVAVPSKNSVMTSQMWNEKKEKFLKGEPKVL
                     GVLQVMIAIINLSLGIIILTTLFSELPTSVMLMVPIWGSIMFIVSGSLSIAAGVTPTK
                     CLIVASLTLNTITSVLAATASIMGVVSVAVGSQFPFRYNYTITKGLDVLMLIFNMLEF
                     CLAVSVSAFGCEASCCNSREVLVVLPSNPVETVMAPPMTLQPLLPSEHQGTNVPGNVY
                     KNHPGEIV"
     exon            264..383
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /inference="alignment:Splign:2.1.0"
     exon            384..440
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /inference="alignment:Splign:2.1.0"
     exon            441..566
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /inference="alignment:Splign:2.1.0"
     exon            567..668
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /inference="alignment:Splign:2.1.0"
     exon            669..1259
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1239..1244
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /note="putative"
     polyA_site      1256
                     /gene="Ms4a4b"
                     /gene_synonym="Chandra; Ly116"
                     /note="putative"
ORIGIN      
        1 aacagtctgc tatctacaaa ggtgaatcag agtcctgtga gaacacacaa gcaaagcttc
       61 tcctggaata aatcagctga catctgatcc tttccattgt ctgtactgtt tctgctgctc
      121 tggaaaccat gcaaggacag gaacagacca ccatggcagt ggttcctgga gttgctgtgc
      181 cttcaaagaa ttctgttatg acatcacaaa tgtggaatga gaagaaagag aaattcttga
      241 agggggaacc caaagtcctt ggggttttac aagtgatgat tgctatcata aacctcagct
      301 taggaataat aattttgaca actttatttt ctgaactacc cacttcagtg atgttaatgg
      361 tcccaatttg gggatcaata atgttcattg tctccggatc cctgtccatt gcagcaggag
      421 tgacacctac aaaatgcctg atcgttgcca gtctaactct gaacactatc acctctgtgt
      481 tggctgcaac tgcaagcata atgggtgtag tcagtgtggc tgtgggttca cagtttccgt
      541 ttcggtataa ttatacaatc accaagggtt tggatgtttt gatgttaatt ttcaatatgc
      601 tagaattctg ccttgctgtg tccgtctctg catttggatg tgaagcttcc tgttgtaact
      661 cccgtgaggt tcttgtagtg ctaccatcaa atcctgttga gacagtgatg gcacccccaa
      721 tgacacttca accattgcta ccatcagaac accaagggac caatgttcca ggaaatgtgt
      781 acaagaacca cccaggagaa atagtctaat tttgatgtgt gtgtgtgtgt atttccctag
      841 gatattaaca cttcattgca ctggcttttg aggtgaatat tagatttact gtaagtatgt
      901 aagtcaagca cttattaggt caacaacact tcaacatatt atattcattg tatgtacaag
      961 gggcaatgaa tttgcaaaga tgttttgaaa gcaaacagaa aaaaaaaaaa aacaaccaaa
     1021 caaaagacct cttagtgaaa tgaggtctct ttgcaaagac taaaaaactg gagttcacat
     1081 ttttgggggt ggggggggct tttgctaaat aagtagattt agatgctttt gatcaagtac
     1141 aaactcataa agtatgtaag aaattactaa tgataggaac caattttaat ctcatatgta
     1201 acatagtgta taatttaata gatctggtaa aaatttataa taaagagaaa tgcctgaaaa
     1261 aaaaaaaaaa aaaaaaaaaa aa
//
