LOCUS       NM_001310331             996 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 4A
            (Ms4a4a), mRNA.
ACCESSION   NM_001310331 XM_006543453 XM_986941
VERSION     NM_001310331.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 996)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 996)
  AUTHORS   Sui,Y. and Zeng,W.
  TITLE     MS4A4A Regulates Arginase 1 Induction during Macrophage
            Polarization and Lung Inflammation in Mice
  JOURNAL   Eur J Immunol 50 (10), 1602-1605 (2020)
   PUBMED   32589266
  REMARK    GeneRIF: MS4A4A Regulates Arginase 1 Induction during Macrophage
            Polarization and Lung Inflammation in Mice.
REFERENCE   3  (bases 1 to 996)
  AUTHORS   Mattiola,I., Tomay,F., De Pizzol,M., Silva-Gomes,R., Savino,B.,
            Gulic,T., Doni,A., Lonardi,S., Astrid Boutet,M., Nerviani,A.,
            Carriero,R., Molgora,M., Stravalaci,M., Morone,D., Shalova,I.N.,
            Lee,Y., Biswas,S.K., Mantovani,G., Sironi,M., Pitzalis,C.,
            Vermi,W., Bottazzi,B., Mantovani,A. and Locati,M.
  TITLE     The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK
            cell-mediated resistance to metastasis
  JOURNAL   Nat Immunol 20 (8), 1012-1022 (2019)
   PUBMED   31263276
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125406.4.
            
            On or before Jul 11, 2015 this sequence version replaced
            XM_986941.4, XM_006543453.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This gene lacks full-length transcript support, and
            therefore this CCDS representation has an inferred exon combination
            based on partial transcript,  RNA-seq alignments and orthologous
            data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR3363658.566907.1,
                                           ERR3363660.548195.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC125406.4         132199-132342       c
            145-304             AC125406.4         128934-129093       c
            305-433             AC125406.4         126378-126506       c
            434-490             AC125406.4         121391-121447       c
            491-649             AC125406.4         119441-119599       c
            650-751             AC125406.4         117468-117569       c
            752-996             AC125406.4         114915-115159       c
FEATURES             Location/Qualifiers
     source          1..996
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.44 cM"
     gene            1..996
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /note="membrane-spanning 4-domains, subfamily A, member
                     4A"
                     /db_xref="GeneID:666907"
                     /db_xref="MGI:MGI:3643932"
     exon            1..144
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /inference="alignment:Splign:2.1.0"
     exon            145..304
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..871
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     4A"
                     /protein_id="NP_001297260.1"
                     /db_xref="CCDS:CCDS79692.1"
                     /db_xref="GeneID:666907"
                     /db_xref="MGI:MGI:3643932"
                     /translation="MLVIQGTEQSALEAGYGAQQNGQPLYVNSHSWKRMTEKFLKGEP
                     KILGIVQIVIAIMNLSIGIMMIIATVSTGEIPPSSVYIGYPIWGSLMFIISGSFSIVA
                     GRRTTKGLVRSSLGLNITSSVFAFSGIVISSLSPGIYSFHVYYCTYRGSSEGCHMTLS
                     ILMGLDIVVVVLSVLEFCIGVSLSAFGCRVMCCNPGGVMIIMPSNPTKAETANPVTLQ
                     SGLMPPEHQERNVPENMH"
     exon            305..433
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /inference="alignment:Splign:2.1.0"
     exon            434..490
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /inference="alignment:Splign:2.1.0"
     exon            491..649
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /inference="alignment:Splign:2.1.0"
     exon            650..751
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /inference="alignment:Splign:2.1.0"
     exon            752..996
                     /gene="Ms4a4a"
                     /gene_synonym="EG666907"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atttagaaaa catactagac ttcagcttta gtcacacatg agctgtgacg ggcaagtcat
       61 tgcatctgaa caaagagccc gaggcacatt cctagagaca gctcctcatc tgacacataa
      121 caggctgtcc agttgagaag gaagcattgt ttctgctgcc atgttagtca tacaaggaac
      181 agaacagagt gcattggaag ctggctatgg ggcacagcag aatggacaac ctttatatgt
      241 gaattcgcat tcatggaaaa gaatgacaga gaagttcttg aagggagaac ccaaaatcct
      301 tgggattgtg cagattgtaa tcgccatcat gaacctcagc ataggaatta tgatgataat
      361 tgccactgtg tcgaccggtg aaataccccc ttcttcagtg tacataggat acccaatttg
      421 ggggtcccta atgtttatta tttcaggatc attttcaatt gtagcaggaa gaagaactac
      481 aaaaggtttg gttcgaagca gcctaggctt gaacattacc agctccgtgt ttgccttctc
      541 ggggatcgta atcagctcac tgagcccagg catttattct ttccatgtat attactgtac
      601 atatagaggt tcatcagaag gctgtcacat gaccttgtcc attttaatgg gtctggatat
      661 tgtggtagtc gttttaagtg tgctggaatt ctgcatagga gtatccctct ctgcctttgg
      721 atgcagggtg atgtgttgta accctggtgg ggtcatgata attatgccat caaatcctac
      781 caaggcagag acagcaaatc ctgtaacact tcaaagtgga ttgatgccac cagaacacca
      841 agagagaaat gttccagaaa atatgcactg attatttatc aagaagcaca catgggaaaa
      901 cacaagaatc cagctctgat gtctgtgtat gcatgcatgt gtgtgtgtgt gtgtgtgtgt
      961 gtgtgtgtgt gtgtatgtgt gtgtgtgagt gtgtgt
//
