LOCUS       NM_133246               1009 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 3
            (Ms4a3), mRNA.
ACCESSION   NM_133246 XM_006526726
VERSION     NM_133246.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1009)
  AUTHORS   Lehtonen,H., Jokela,H., Hofmann,J., Tola,L., Mehmood,A.,
            Ginhoux,F., Becher,B., Greter,M., Yegutkin,G.G., Salmi,M., Gerke,H.
            and Rantakari,P.
  TITLE     Early precursor-derived pituitary gland tissue-resident macrophages
            play a pivotal role in modulating hormonal balance
  JOURNAL   Cell Rep 44 (2), 115227 (2025)
   PUBMED   39841599
REFERENCE   2  (bases 1 to 1009)
  AUTHORS   De Ponti,F.F., Bujko,A., Liu,Z., Collins,P.J., Schuermans,S.,
            Maueroder,C., Amstelveen,S., Thone,T., Martens,L., McKendrick,J.G.,
            Louwe,P.A., Sanchez Cruz,A., Saelens,W., Matchett,K.P.,
            Waller,K.J., Zwicker,C., Buglar-Lamb,A., Vanneste,B.,
            Parmentier,F., Binte Abdul Latib,M., Remmerie,A., Kertesz,L.,
            Kremer,A., Verbeke,J., Ipsen,D.H., Pfister,D.R., Liu,Z.,
            Guilliams,M., Henderson,N.C., Ravichandran,K., Marques,P.E. and
            Scott,C.L.
  TITLE     Spatially restricted and ontogenically distinct hepatic macrophages
            are required for tissue repair
  JOURNAL   Immunity 58 (2), 362-380 (2025)
   PUBMED   39862865
REFERENCE   3  (bases 1 to 1009)
  AUTHORS   Abdelbasset,M., Saron,W.A.A., Ma,D., Rathore,A.P.S., Kozaki,T.,
            Zhong,C., Mantri,C.K., Tan,Y., Tung,C.C., Tey,H.L., Chu,J.J.H.,
            Chen,J., Ng,L.G., Wang,H., Ginhoux,F. and St John,A.L.
  TITLE     Differential contributions of fetal mononuclear phagocytes to Zika
            virus neuroinvasion versus neuroprotection during congenital
            infection
  JOURNAL   Cell 187 (26), 7511-7532 (2024)
   PUBMED   39532096
REFERENCE   4  (bases 1 to 1009)
  AUTHORS   Raquer-McKay,H.M., Maqueda-Alfaro,R.A., Saravanan,S., Arroyo
            Hornero,R., Clausen,B.E., Gottfried-Blackmore,A. and Idoyaga,J.
  TITLE     Monocytes give rise to Langerhans cells that preferentially migrate
            to lymph nodes at steady state
  JOURNAL   Proc Natl Acad Sci U S A 121 (47), e2404927121 (2024)
   PUBMED   39541348
REFERENCE   5  (bases 1 to 1009)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   6  (bases 1 to 1009)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1009)
  AUTHORS   Kutok,J.L., Yang,X., Folkerth,R. and Adra,C.N.
  TITLE     Characterization of the expression of HTm4 (MS4A3), a cell cycle
            regulator, in human peripheral blood cells and normal and malignant
            tissues
  JOURNAL   J Cell Mol Med 15 (1), 86-93 (2011)
   PUBMED   19818099
REFERENCE   8  (bases 1 to 1009)
  AUTHORS   Kutok,J.L., Yang,X., Folkerth,R.D., Imitola,J., Raddassi,K.,
            Yano,Y., Salahuddin,S., Lawitts,J., Imboden,H., Chinami,M.,
            Shirakawa,T., Turner,H., Khoury,S., Sayegh,M.H., Scadden,D. and
            Adra,C.
  TITLE     The cell cycle associated protein, HTm4, is expressed in
            differentiating cells of the hematopoietic and central nervous
            system in mice
  JOURNAL   J Mol Histol 36 (1-2), 77-87 (2005)
   PUBMED   15704002
  REMARK    GeneRIF: Murine HTm4 is predominantly a hematopoietic protein and
            highly expressed in the developing and adult murine nervous system.
REFERENCE   9  (bases 1 to 1009)
  AUTHORS   Hulett,M.D., Pagler,E. and Hornby,J.R.
  TITLE     Cloning and characterization of a mouse homologue of the human
            haematopoietic cell-specific four-transmembrane gene HTm4
  JOURNAL   Immunol Cell Biol 79 (4), 345-349 (2001)
   PUBMED   11488981
REFERENCE   10 (bases 1 to 1009)
  AUTHORS   Liang,Y. and Tedder,T.F.
  TITLE     Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene
            family: sixteen new MS4A family members expressed in human and
            mouse
  JOURNAL   Genomics 72 (2), 119-127 (2001)
   PUBMED   11401424
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK158372.1 and AF321128.1.
            
            On or before Jul 11, 2014 this sequence version replaced
            XM_006526726.1, NM_133246.4.
            
            Summary:This gene encodes a member of the membrane-spanning-four
            (MS4) protein group, that contain a four-transmembrane protein
            structure. This gene is expressed in developing hematopoietic cells
            and has also been observed in some regions of the adult brain.
            Expression of the human ortholog of this gene has also been
            observed in some human cancer cell lines. This protein may play a
            role in cell cycle regulation, and interactions have been
            demonstrated between Ms4a3 and KAP phosphatase. [provided by
            RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF321128.1, AY184359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-649               AK158372.1         2-650
            650-1009            AF321128.1         589-948
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.47 cM"
     gene            1..1009
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /note="membrane-spanning 4-domains, subfamily A, member 3"
                     /db_xref="GeneID:170813"
                     /db_xref="MGI:MGI:2158468"
     exon            1..185
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /inference="alignment:Splign:2.1.0"
     exon            186..295
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..850
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /note="hematopoietic-specific transmembrane protein 4;
                     haematopoietic cell-specific transmembrane-4"
                     /codon_start=1
                     /product="membrane-spanning 4-domains subfamily A member
                     3"
                     /protein_id="NP_573509.1"
                     /db_xref="CCDS:CCDS29605.1"
                     /db_xref="GeneID:170813"
                     /db_xref="MGI:MGI:2158468"
                     /translation="MKPEETGGSVYQPLDESRHVQRGVLQALGAIQILNGILILALGI
                     FLVCLQHVSHHFRHFFFFTFYTGYPLWGAVFFISSGSLTVAAGRNPTRMLMQNSFGIN
                     IASTTIAFVGTVFLSVHLAFNTQAFKGCQSSPSPDVCISLGSSSDGLVSLMLILTLLE
                     LSVTISISAMWCLGNVCGLREAITSPPNSVESGILPEGSDSENLNTQPQASEE"
     exon            296..433
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /inference="alignment:Splign:2.1.0"
     exon            434..490
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /inference="alignment:Splign:2.1.0"
     exon            491..649
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /inference="alignment:Splign:2.1.0"
     exon            650..751
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /inference="alignment:Splign:2.1.0"
     exon            752..1009
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      987..992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /note="hexamer: AATAAA"
     polyA_site      1007
                     /gene="Ms4a3"
                     /gene_synonym="HTm4"
                     /note="major polyA site"
ORIGIN      
        1 aggcagccag caaaaccact tccactggac ttgctgagga attgcacaaa gaagagattc
       61 gttaagcctg aggaggaaga gactgctggt tttgggggac agactctggt ggtcattact
      121 gtctcctctt ctgtaatgag ttggacttgc aggggaagga cttgtcaaat cctgaattct
      181 tcaaggtggt acctcatcag gcagacacat gaagccagag gagactggtg gttctgttta
      241 tcagcccttg gatgagtcac gccatgttca acgaggtgta ctgcaagccc tcggggccat
      301 ccagatcctg aatggaatac tgattctagc tctcggaatt tttctggttt gtttacaaca
      361 cgtgtcccac cacttcaggc atttcttctt cttcaccttc tacacaggct acccactgtg
      421 gggtgctgtg ttttttatca gctcaggatc cttgactgtt gccgcaggga gaaaccccac
      481 acgaatgctg atgcaaaaca gttttgggat aaacattgcc agtactacaa ttgcatttgt
      541 tgggactgtt ttcctttctg tgcatttggc attcaatacc caggctttca agggttgcca
      601 atcttcaccg tcacctgatg tctgcatttc cctgggttcc tcatcagatg gcctggtgtc
      661 tttaatgctg attctcaccc tgctggagct gtccgtgacc atttctatct ctgccatgtg
      721 gtgcttggga aatgtttgtg gtttaagaga ggcaattact tcacctccta attctgtgga
      781 gtcaggaata cttcctgaag gaagtgattc tgagaacctg aacactcagc cccaagcttc
      841 agaagagtga gaacctcatt tgaaaactca gcagaacatg aacagatgaa atgcaatcct
      901 tctgtcatgg aaatattcac aagaaagctg gcatctgtcc caattctctc tcctgtaaat
      961 ccacgagcac ggtctggatc tggatgaata aatatatttc cttaggtga
//
