LOCUS       NM_013516               2759 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 2
            (Ms4a2), transcript variant 1, mRNA.
ACCESSION   NM_013516
VERSION     NM_013516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Loste,A., Clement,M., Delbosc,S., Guedj,K., Senemaud,J.,
            Gaston,A.T., Morvan,M., Even,G., Gautier,G., Eggel,A., Arock,M.,
            Procopio,E., Deschildre,C., Louedec,L., Michel,J.B., Deschamps,L.,
            Castier,Y., Coscas,R., Alsac,J.M., Launay,P., Caligiuri,G.,
            Nicoletti,A. and Le Borgne,M.
  TITLE     Involvement of an IgE/Mast cell/B cell amplification loop in
            abdominal aortic aneurysm progression
  JOURNAL   PLoS One 18 (12), e0295408 (2023)
   PUBMED   38055674
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Florsheim,E.B., Bachtel,N.D., Cullen,J.L., Lima,B.G.C.,
            Godazgar,M., Carvalho,F., Chatain,C.P., Zimmer,M.R., Zhang,C.,
            Gautier,G., Launay,P., Wang,A., Dietrich,M.O. and Medzhitov,R.
  TITLE     Immune sensing of food allergens promotes avoidance behaviour
  JOURNAL   Nature 620 (7974), 643-650 (2023)
   PUBMED   37437602
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Valeri,V., Tonon,S., Vibhushan,S., Gulino,A., Belmonte,B.,
            Adori,M., Karlsson Hedestam,G.B., Gautier,G., Tripodo,C., Blank,U.,
            Mion,F. and Pucillo,C.E.M.
  TITLE     Mast cells crosstalk with B cells in the gut and sustain IgA
            response in the inflamed intestine
  JOURNAL   Eur J Immunol 51 (2), 445-458 (2021)
   PUBMED   32920851
REFERENCE   5  (bases 1 to 2759)
  AUTHORS   Ohmori,S., Ishijima,Y., Numata,S., Takahashi,M., Sekita,M.,
            Sato,T., Chugun,K., Yamamoto,M. and Ohneda,K.
  TITLE     GATA2 and PU.1 Collaborate To Activate the Expression of the Mouse
            Ms4a2 Gene, Encoding FcepsilonRIbeta, through Distinct Mechanisms
  JOURNAL   Mol Cell Biol 39 (22), e00314-19 (2019)
   PUBMED   31501274
  REMARK    GeneRIF: Results suggest that PU.1 and LDB1 play central roles in
            the formation of active chromatin structure whereas GATA2 directly
            activates the Ms4a2 promoter.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2759)
  AUTHORS   Costello,P.S., Turner,M., Walters,A.E., Cunningham,C.N.,
            Bauer,P.H., Downward,J. and Tybulewicz,V.L.
  TITLE     Critical role for the tyrosine kinase Syk in signalling through the
            high affinity IgE receptor of mast cells
  JOURNAL   Oncogene 13 (12), 2595-2605 (1996)
   PUBMED   9000133
REFERENCE   7  (bases 1 to 2759)
  AUTHORS   Li,X., Yin,W., Perez-Jurado,L., Bonadio,J. and Francke,U.
  TITLE     Mapping of human and murine genes for latent TGF-beta binding
            protein-2 (LTBP2)
  JOURNAL   Mamm Genome 6 (1), 42-45 (1995)
   PUBMED   7719025
REFERENCE   8  (bases 1 to 2759)
  AUTHORS   Kuster,H., Zhang,L., Brini,A.T., MacGlashan,D.W. and Kinet,J.P.
  TITLE     The gene and cDNA for the human high affinity immunoglobulin E
            receptor beta chain and expression of the complete human receptor
  JOURNAL   J Biol Chem 267 (18), 12782-12787 (1992)
   PUBMED   1535625
REFERENCE   9  (bases 1 to 2759)
  AUTHORS   Hupp,K., Siwarski,D., Mock,B.A. and Kinet,J.P.
  TITLE     Gene mapping of the three subunits of the high affinity FcR for IgE
            to mouse chromosomes 1 and 19
  JOURNAL   J Immunol 143 (11), 3787-3791 (1989)
   PUBMED   2531187
REFERENCE   10 (bases 1 to 2759)
  AUTHORS   Ra,C., Jouvin,M.H. and Kinet,J.P.
  TITLE     Complete structure of the mouse mast cell receptor for IgE (Fc
            epsilon RI) and surface expression of chimeric receptors
            (rat-mouse-human) on transfected cells
  JOURNAL   J Biol Chem 264 (26), 15323-15327 (1989)
   PUBMED   2527850
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK144021.1, BC139323.1,
            AK161121.1 and BY585879.1.
            
            On Feb 1, 2013 this sequence version replaced NM_013516.1.
            
            Summary: This gene encodes a member of the membrane-spanning 4A
            family. The encoded protein is the beta subunit of the high
            affinity IgE receptor and is localized to the membrane. The encoded
            protein is required for full activation of mast cells, including
            the release of histamine. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jan 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05019.1, BC139324.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AK144021.1         2-77
            77-828              BC139323.1         1-752
            829-2756            AK161121.1         465-2392
            2757-2759           BY585879.1         407-409
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.46 cM"
     gene            1..2759
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /note="membrane-spanning 4-domains, subfamily A, member 2"
                     /db_xref="GeneID:14126"
                     /db_xref="MGI:MGI:95495"
     exon            1..160
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..806
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /note="isoform a is encoded by transcript variant 1; high
                     affinity immunoglobulin epsilon receptor subunit beta; fc
                     epsilon receptor I beta-chain; membrane-spanning
                     4-domains, subfamily A, member 1; Fc receptor, IgE, high
                     affinity I, beta polypeptide"
                     /codon_start=1
                     /product="high affinity immunoglobulin epsilon receptor
                     subunit beta isoform a"
                     /protein_id="NP_038544.1"
                     /db_xref="CCDS:CCDS29604.1"
                     /db_xref="GeneID:14126"
                     /db_xref="MGI:MGI:95495"
                     /translation="MDTENRSRADLALPNPQESSSAPDIELLEASPAKAAPPKQTWRT
                     FLKKELEFLGATQILVGLICLCFGTIVCSVLYVSDFDEEVLLLYKLGYPFWGAVLFVL
                     SGFLSIISERKNTLYLVRGSLGANIVSSIAAGTGIAMLILNLTNNFAYMNNCKNVTED
                     DGCFVASFTTELVLMMLFLTILAFCSAVLFTIYRIGQELESKKVPDDRLYEELNVYSP
                     IYSELEDKGETSSPVDS"
     exon            161..260
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..395
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            396..452
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..608
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            609..707
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     exon            708..2759
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2738..2743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /note="hexamer: ATTAAA"
     polyA_site      2759
                     /gene="Ms4a2"
                     /gene_synonym="Fce1b; Fcer1b; fcERI; FcRB; Fcrbeta; Ms4a1"
                     /note="major polyA site"
ORIGIN      
        1 ggtattcaga gccaacccat cttaactgcc catccagagc acaccgcatt tctgtgtaac
       61 agtatctttc attcctggat agcccaatta atgaaaaaat ggacacagaa aataggagca
      121 gagcagatct tgctctccca aatccacaag aatcctccag tgcacctgac attgaactct
      181 tggaagcatc tcctgccaaa gcagccccac caaagcagac atggcggaca tttttgaaga
      241 aagagttgga gttcctggga gcaacacaaa ttctggttgg tttgatatgc ctttgttttg
      301 gaacaattgt ctgctccgta ctctatgttt cagactttga tgaagaagtg cttttacttt
      361 ataaactagg ctatccattc tggggtgcag tgctgtttgt tttgtctgga tttttgtcaa
      421 ttatctccga aagaaaaaac acattgtatc tggtgagagg cagcctggga gcaaacattg
      481 tcagtagcat cgctgcaggg acggggatcg ccatgctgat cctcaatctg accaataact
      541 tcgcttatat gaacaactgc aagaatgtaa ccgaagacga cggctgcttt gtggcttctt
      601 tcaccacaga actggtgttg atgatgctgt ttctcaccat cctggccttt tgcagtgctg
      661 tgttgttcac tatctatagg attggacaag agttagaaag taaaaaggtc ccagatgatc
      721 gtctttatga agaattaaat gtgtattcac caatttacag tgagttggaa gacaaagggg
      781 aaacatcttc tccagttgat tcataagaat caggggacca ggacaatctg attcaagtat
      841 aatcttgaaa gttgatcttt ttacaaaatt ctcgcaaaat ttctgtttgt tccacattct
      901 gtcagttttt caattggatt gttctgcaga tgccactctt ttagttatgc tgtatctgat
      961 cttctaaata tctccctttt tgcggatatc attcactcca attttcttgt tttgtgtcac
     1021 aatttcacat acatcttttc tggaaagtca tcaaggaata agttggcttt attgtatgtc
     1081 tactttcatg aacaaaagga agatatggaa gaattaccct gagaatttaa ctaaccttag
     1141 ataatcaggt aatatttggc tcttagttca ttttagaatt ctcaacagct atagttatat
     1201 gtgatatata tccaccatat caagccttct gtatgtattt taacatgata tacacttttc
     1261 tgtgtagata tatttccacc ctcaataata atggggttat tttagagaca taaagctttg
     1321 tgaaaagacg acatcatctg gttgatgagt acattcacct gcacaggtat cgctcagtgg
     1381 tttgccaatt ggtgagtagt aggcaataga gaacattatc aaaccattca gtctagtgag
     1441 atggataggt acattcaggg atactgtgag tatcctttag taagacacat gggaagaatg
     1501 aagaataaac tgatgaagac ttgagctaga aggtagtcaa tgggaatgac aagaaatgat
     1561 tgtgtataac acatgtacgt aaatatctac caaaagttgg tagagattgg catgtttgcc
     1621 tagaatctca gcacaaggcc agcctctgtt acatagtgag ttagaggcca gcctggctat
     1681 atgatatcct acatcaaagg accaaaggag aaattggttc aagttgttaa taccttaaag
     1741 gatagttaaa caaacagcag tttgatatat tcagtgtttg attctttaat aaaactaaat
     1801 gaataacatt gagggggagg gaagcagtaa tgtagaagtc tggatggtgg aagagtagta
     1861 gagacaactt aaaactcagt tttagacttt tgttctgaga tgggtataag agtgatcatt
     1921 aaataaggag ggaagacacc aggagaatta ttttgagata gaactaaggc agtcaaactc
     1981 cacatgccta cacttagaag gggaaagtaa ggatcaaaag tagaaaccct aacaagtcag
     2041 gtaagcatat tacagaacat taaccagcag atgcctatag tggggaaaag ttagacaaag
     2101 cgaaaataat tacccaccag agaccgtgca tgtaggcttg ggaaagacaa gagaaaatag
     2161 caactccaaa tgaatgctaa ctctgaagag ggtgtgggca gaggaccaga acatttgcaa
     2221 aggtgcccag agagcagacc atgaatagaa ggtagtgagg aaaaacaaac aaacaaacaa
     2281 acaaacaccc ccaaaacagc tgagaaaatg attttgttgc tcctattaag atttttaaaa
     2341 gaaacaaaaa gagatgttga aaaatctgtt tgctgggatc agttggtgtg ttctccatgt
     2401 gtccaaggga caggtaactt ttctaaatct tcatgtaagg ctcgcctcat ttacatccgt
     2461 ctctccacac agccatatcc tcaattcaca gttactctat cacggtagta aactgtgcgt
     2521 gtgatctcct tatgtatctt caggcagtgt ttatccagta aatcagagtt atttaacttg
     2581 atatttgtat tagcaaatga agttgaaaga atatgaggga agtcttgagg aagaaaatcg
     2641 atggtggata tgatcatatt tcactgtaca catttgtaaa gttctcagaa ataaagaaaa
     2701 ctcattttaa aaagaaccat gtacattaaa acaattgatt aaatggtgcc aaggacaaa
//
