LOCUS       NM_007641               2984 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus membrane-spanning 4-domains, subfamily A, member 1
            (Ms4a1), mRNA.
ACCESSION   NM_007641
VERSION     NM_007641.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2984)
  AUTHORS   Jiang,H.C., Park,S.J., Wang,I.H., Bear,D.M., Nowlan,A. and
            Greer,P.L.
  TITLE     CD20/MS4A1 is a mammalian olfactory receptor expressed in a subset
            of olfactory sensory neurons that mediates innate avoidance of
            predators
  JOURNAL   Nat Commun 15 (1), 3360 (2024)
   PUBMED   38637611
  REMARK    GeneRIF: CD20/MS4A1 is a mammalian olfactory receptor expressed in
            a subset of olfactory sensory neurons that mediates innate
            avoidance of predators.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2984)
  AUTHORS   Gruper,Y., Wolff,A.S.B., Glanz,L., Spoutil,F., Marthinussen,M.C.,
            Osickova,A., Herzig,Y., Goldfarb,Y., Aranaz-Novaliches,G.,
            Dobes,J., Kadouri,N., Ben-Nun,O., Binyamin,A., Lavi,B., Givony,T.,
            Khalaila,R., Gome,T., Wald,T., Mrazkova,B., Sochen,C., Besnard,M.,
            Ben-Dor,S., Feldmesser,E., Orlova,E.M., Hegedus,C., Lampe,I.,
            Papp,T., Felszeghy,S., Sedlacek,R., Davidovich,E., Tal,N.,
            Shouval,D.S., Shamir,R., Guillonneau,C., Szondy,Z., Lundin,K.E.A.,
            Osicka,R., Prochazka,J., Husebye,E.S. and Abramson,J.
  TITLE     Autoimmune amelogenesis imperfecta in patients with APS-1 and
            coeliac disease
  JOURNAL   Nature 624 (7992), 653-662 (2023)
   PUBMED   37993717
REFERENCE   3  (bases 1 to 2984)
  AUTHORS   Patel,J., Xun,D., Creswell,K., Kim,D.K., Wu,M., Hwang,J.W.,
            Kim,T.S., Bansal,S., Hong,S.H., Galli,S., Kim,H.J., Deng,C.,
            Byers,S.W. and Lee,M.H.
  TITLE     Loss of RARRES1 function Promotes Follicular Lymphomagenesis and
            Inhibits B cell Differentiation in Mice
  JOURNAL   Int J Biol Sci 18 (7), 2670-2682 (2022)
   PUBMED   35541897
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2984)
  AUTHORS   Liao,J., Luan,Y., Ren,Z., Liu,X., Xue,D., Xu,H., Sun,Z., Yang,K.,
            Peng,H. and Fu,Y.X.
  TITLE     Converting Lymphoma Cells into Potent Antigen-Presenting Cells for
            Interferon-Induced Tumor Regression
  JOURNAL   Cancer Immunol Res 5 (7), 560-570 (2017)
   PUBMED   28533311
  REMARK    GeneRIF: Our findings indicate that anti-CD20-IFNalpha eradicates
            B-cell lymphoma by employing tumor cells as antigen-presenting
            cells to reactivate tumor-infiltrating CD8(+) T cells and
            synergizing with anti-PD-L1 treatment
REFERENCE   5  (bases 1 to 2984)
  AUTHORS   Lykken,J.M., Horikawa,M., Minard-Colin,V., Kamata,M., Miyagaki,T.,
            Poe,J.C. and Tedder,T.F.
  TITLE     Galectin-1 drives lymphoma CD20 immunotherapy resistance:
            validation of a preclinical system to identify resistance
            mechanisms
  JOURNAL   Blood 127 (15), 1886-1895 (2016)
   PUBMED   26888257
  REMARK    GeneRIF: Galectin-1 has a role in driving lymphoma CD20
            immunotherapy resistance in a mouse model
REFERENCE   6  (bases 1 to 2984)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 2984)
  AUTHORS   Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
  TITLE     A linkage map of mouse chromosome 19: definition of comparative
            mapping relationships with human chromosomes 10 and 11 including
            the MEN1 locus
  JOURNAL   Genomics 14 (1), 26-31 (1992)
   PUBMED   1358795
REFERENCE   8  (bases 1 to 2984)
  AUTHORS   Szepetowski,P., Simon,M.P., Grosgeorge,J., Huebner,K., Bastard,C.,
            Evans,G.A., Tsujimoto,Y., Birnbaum,D., Theillet,C. and Gaudray,P.
  TITLE     Localization of 11q13 loci with respect to regional chromosomal
            breakpoints
  JOURNAL   Genomics 12 (4), 738-744 (1992)
   PUBMED   1572647
REFERENCE   9  (bases 1 to 2984)
  AUTHORS   Watanabe,T., Sakai,Y., Miyawaki,S., Shimizu,A., Koiwai,O. and
            Ohno,K.
  TITLE     A molecular genetic linkage map of mouse chromosome 19, including
            the lpr, Ly-44, and Tdt genes
  JOURNAL   Biochem Genet 29 (7-8), 325-335 (1991)
   PUBMED   1684099
REFERENCE   10 (bases 1 to 2984)
  AUTHORS   Charmley,P., Nguyen,J., Wei,S. and Gatti,R.A.
  TITLE     Genetic linkage analysis and homology relationships of genes
            located on human chromosome 11q
  JOURNAL   Genomics 10 (3), 608-617 (1991)
   PUBMED   1679745
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK017903.1, AK080148.1 and BE687007.1.
            
            On Jul 21, 2018 this sequence version replaced NM_007641.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156033.1, AK080148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2055              AK017903.1         4-2058
            2056-2838           AK080148.1         2056-2838
            2839-2984           BE687007.1         1-146               c
FEATURES             Location/Qualifiers
     source          1..2984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 8.19 cM"
     gene            1..2984
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /note="membrane-spanning 4-domains, subfamily A, member 1"
                     /db_xref="GeneID:12482"
                     /db_xref="MGI:MGI:88321"
     exon            1..102
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            103..255
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..993
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /note="B-cell differentiation antigen Ly-44; lymphocyte
                     antigen 44; membrane-spanning 4-domains, subfamily A,
                     member 2; CD20 antigen"
                     /codon_start=1
                     /product="B-lymphocyte antigen CD20"
                     /protein_id="NP_031667.1"
                     /db_xref="CCDS:CCDS37923.1"
                     /db_xref="GeneID:12482"
                     /db_xref="MGI:MGI:88321"
                     /translation="MSGPFPAEPTKGPLAMQPAPKVNLKRTSSLVGPTQSFFMRESKA
                     LGAVQIMNGLFHITLGGLLMIPTGVFAPICLSVWYPLWGGIMYIISGSLLAAAAEKTS
                     RKSLVKAKVIMSSLSLFAAISGIILSIMDILNMTLSHFLKMRRLELIQTSKPYVDIYD
                     CEPSNSSEKNSPSTQYCNSIQSVFLGILSAMLISAFFQKLVTAGIVENEWKRMCTRSK
                     SNVVLLSAGEKNEQTIKMKEEIIELSGVSSQPKNEEEIEIIPVQEEEEEEAEINFPAP
                     PQEQESLPVENEIAP"
     exon            256..375
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..435
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            436..672
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            673..774
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /inference="alignment:Splign:2.1.0"
     exon            775..2979
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2035..2040
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /note="hexamer: AATAAA"
     polyA_site      2061
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /note="major polyA site"
     regulatory      2474..2479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /note="hexamer: AATAAA"
     polyA_site      2500
                     /gene="Ms4a1"
                     /gene_synonym="Cd20; Ly-44; Ms4a2"
                     /note="major polyA site"
ORIGIN      
        1 actcatcttc aagtacttga gatagaagag gccaactgat ctcagctgtg agtggctaat
       61 ttggccctta agccttggag ccttggagcc ttggagaccc aggcgtttga aaactcaatg
      121 agtggacctt tcccagcaga gcctacaaaa ggtcccctcg ccatgcaacc tgctccaaaa
      181 gtgaacctca aaaggacatc ttcactggtg ggccccacac aaagcttctt catgagggaa
      241 tcaaaggctt tgggggctgt ccaaatcatg aatggcctct tccatattac cctgggggga
      301 ctgctgatga tccccacagg ggtcttcgca cccatctgtt tgagtgtatg gtaccctctc
      361 tggggaggca ttatgtacat tatttcagga tcactcctgg cagctgcagc agaaaaaacc
      421 tccaggaaga gtttggtcaa agcaaaagtg ataatgagct ctctaagcct ctttgctgcc
      481 atttctggaa taattctttc aatcatggac atacttaaca tgacactttc tcatttttta
      541 aaaatgagaa gactggagct tattcaaact tccaagccgt atgttgatat ctacgactgt
      601 gaaccatcta attcctcaga gaaaaactcc ccatctacac agtactgtaa cagcattcag
      661 tctgtgttct tgggcattct gtcggcgatg ctgatctctg ccttcttcca gaaacttgtg
      721 acagctggta ttgtggagaa tgagtggaaa agaatgtgta ccagatccaa atctaatgtg
      781 gttctgctgt cagctggaga aaaaaatgag cagacgatta aaatgaaaga agaaatcatt
      841 gagctaagtg gagtatcttc ccaaccaaag aatgaagagg aaattgaaat tattccagtg
      901 caggaggaag aagaagaaga agcagaaata aattttccag cacctcccca agagcaggaa
      961 tccttgccag tggaaaatga gatcgctcct taaactcttt tcttttctaa gcattattgt
     1021 ttagagagct tccaagacac atagttaccc tcatctcttg tggccttcca caatctattc
     1081 tccatatttt cacagcttaa ctttgcatag agaagccaca tctagctctc cttcacattt
     1141 gaagaatgca gtgattataa aagattgtct tttgccttgc ttagggagtc ttacactggc
     1201 agaaacgctg aagaatccaa ttctcattca ccttttcctt ggatgtgtgt ctcagtagtg
     1261 gtaatggttt ttccgcattt cctccatcag cagttacagc agagggaaaa gacacatgac
     1321 tgttctgttc atctctgaac tctctgactc cttcttcatg tttggtggag tcccttttgc
     1381 atgattgtct taaagaatat gagagaaatt gtttaatgag aattgtttta ataatgagag
     1441 aaaatgagac acctatatgc ctgtggggaa ggcacaaaat atggcatgtt cttcaagctt
     1501 ctgtgtccca cttgggaagc tgtgaaaggc ctagtcctaa gtctgtctct gtacaaaaag
     1561 catagcttac acataagcaa gtttcatgtc ttaactttgc ccatctccag tttcttggct
     1621 tctggtcaca tcgtttatgt atttgtattc tttagtcaag agaaaaaaga atggtgagac
     1681 agaaatgtaa tgggttccca gatctcaaat cctaagcaac agctgtgctt tgagattctt
     1741 tccaaatggc agagtagttt atttggtctt tcatgattca cagaaaaaaa acaaaaaaac
     1801 aaaaaacaaa aaacctatca ctattttgta atttagttga atgtaagaag caagccaaga
     1861 tattcaataa tagttgtggg gacttgagtc aaacccagct cttcaaattc tagaaatgtt
     1921 tgaaataacc aaattatcta tgcccatatg cctgtataag ctatatcaaa gtatatactt
     1981 tgtgagcaat gtgctgaatc acaaaagagt cagaattgga tttgacacca tatgaataaa
     2041 gacacccaga atcttacatc atttggaaaa ctagtcgtga cattaatatg caattagctg
     2101 gaaagttata agatgcacca caaacacatc ttatatgcac tataaattac cacacaaaga
     2161 tcatgcttaa aaacaacaca gttaaaatcc taaatctcag gccaccatac tttcccaccc
     2221 ctgttcctga gcagggatgc tagcacctga cctagaaaca ctgttagcct aaaaagatct
     2281 caccatagcc tatcattcag ataccatgac aagtctgctt ctaggcatta tgggtatatg
     2341 aacagcttaa gtttcactcc ttggaatatt tctattttat tagaggctac cggtgggagt
     2401 tatttcctgt tattacaaag aaactggaag tagcaccttt tccctgtgtg gtcttcaaaa
     2461 caagctctaa gtaaataaaa ctttgtgtca gtgcctgcaa tggatactcc accttggatg
     2521 tttctttctt ctccataaca tcaaacaatg ggatgcttct gccacataat actaacctgt
     2581 gtttgaatag tggcacatcc agtcatattg agctattcct acctatctga cacatgctcc
     2641 caaggagttt actcatccag taggtcttta ctaagttctg cccacttaca agccacagca
     2701 cgattctcca tatccattct tctccataga aggtacccta agctaaagaa gataccgcta
     2761 tgcctggaga ggatggggag gtgggaggag gagtgtcaag ctgaaaagtt ttaaatgcag
     2821 tattcaattt gaaaagtttc ccctctctga aattcatttc cttaatgatt ttacattagt
     2881 catcgtcaga ttctcaaata attagtcttt accaatttct catgactagg agataatttt
     2941 agtgtctatt taaaaagaat aaaagttctt gtgagcctca aaaa
//
