LOCUS       NM_001122667            8281 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus myocardin related transcription factor B (Mrtfb),
            transcript variant 3, mRNA.
ACCESSION   NM_001122667
VERSION     NM_001122667.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8281)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
  REMARK    GeneRIF: The actin-binding protein CAP1 represses
            MRTF-SRF-dependent gene expression in mouse cerebral cortex.
REFERENCE   2  (bases 1 to 8281)
  AUTHORS   Fang,G., Tian,Y., Huang,S., Zhang,X., Liu,Y., Li,Y., Du,J. and
            Gao,S.
  TITLE     KLF15 maintains contractile phenotype of vascular smooth muscle
            cells and prevents thoracic aortic dissection by interacting with
            MRTFB
  JOURNAL   J Biol Chem 300 (5), 107260 (2024)
   PUBMED   38582447
  REMARK    GeneRIF: KLF15 maintains contractile phenotype of vascular smooth
            muscle cells and prevents thoracic aortic dissection by interacting
            with MRTFB.
REFERENCE   3  (bases 1 to 8281)
  AUTHORS   Zhou,L.Y., Jin,C.X., Wang,W.X., Song,L., Shin,J.B., Du,T.T. and
            Wu,H.
  TITLE     Differential regulation of hair cell actin cytoskeleton mediated by
            SRF and MRTFB
  JOURNAL   Elife 12, e90155 (2023)
   PUBMED   37982489
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8281)
  AUTHORS   Mohan,K., Gasparoni,G., Salhab,A., Orlich,M.M., Geffers,R.,
            Hoffmann,S., Adams,R.H., Walter,J. and Nordheim,A.
  TITLE     Age-Associated Changes in Endothelial Transcriptome and Epigenetic
            Landscapes Correlate With Elevated Risk of Cerebral Microbleeds
  JOURNAL   J Am Heart Assoc 12 (17), e031044 (2023)
   PUBMED   37609982
REFERENCE   5  (bases 1 to 8281)
  AUTHORS   Yamamura,Y., Sakai,N., Iwata,Y., Lagares,D., Hara,A., Kitajima,S.,
            Toyama,T., Miyagawa,T., Ogura,H., Sato,K., Oshima,M., Nakagawa,S.,
            Tamai,A., Horikoshi,K., Matsuno,T., Yamamoto,N., Hayashi,D.,
            Toyota,Y., Kaikoi,D., Shimizu,M., Tager,A.M. and Wada,T.
  TITLE     Myocardin-related transcription factor contributes to renal
            fibrosis through the regulation of extracellular microenvironment
            surrounding fibroblasts
  JOURNAL   FASEB J 37 (7), e23005 (2023)
   PUBMED   37289107
REFERENCE   6  (bases 1 to 8281)
  AUTHORS   Li,J., Zhu,X., Chen,M., Cheng,L., Zhou,D., Lu,M.M., Du,K.,
            Epstein,J.A. and Parmacek,M.S.
  TITLE     Myocardin-related transcription factor B is required in cardiac
            neural crest for smooth muscle differentiation and cardiovascular
            development
  JOURNAL   Proc Natl Acad Sci U S A 102 (25), 8916-8921 (2005)
   PUBMED   15951419
  REMARK    GeneRIF: MRTF-B plays a critical role in regulating differentiation
            of cardiac neural crest cells into smooth muscle.
            GeneRIF: Consistent with the pattern of expression, E10.5 and E11.5
            MRTF-B-/- mutants exhibit deformation of aortic arch arteries 3, 4,
            and 6 and severe attenuation of smooth muscle cell differentiation
            in the arch arteries and the aorticopulmonary septum.
REFERENCE   7  (bases 1 to 8281)
  AUTHORS   Kuwahara,K., Barrientos,T., Pipes,G.C., Li,S. and Olson,E.N.
  TITLE     Muscle-specific signaling mechanism that links actin dynamics to
            serum response factor
  JOURNAL   Mol Cell Biol 25 (8), 3173-3181 (2005)
   PUBMED   15798203
REFERENCE   8  (bases 1 to 8281)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 8281)
  AUTHORS   Wang,D.Z., Li,S., Hockemeyer,D., Sutherland,L., Wang,Z.,
            Schratt,G., Richardson,J.A., Nordheim,A. and Olson,E.N.
  TITLE     Potentiation of serum response factor activity by a family of
            myocardin-related transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14855-14860 (2002)
   PUBMED   12397177
  REMARK    GeneRIF: interacts with serum response factor and stimulates its
            transcriptional activity
REFERENCE   10 (bases 1 to 8281)
  AUTHORS   Skarnes,W.C., Auerbach,B.A. and Joyner,A.L.
  TITLE     A gene trap approach in mouse embryonic stem cells: the lacZ
            reported is activated by splicing, reflects endogenous gene
            expression, and is mutagenic in mice
  JOURNAL   Genes Dev 6 (6), 903-918 (1992)
   PUBMED   1592261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160961.3 and AC163640.5.
            
            On May 20, 2009 this sequence version replaced NM_001122667.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-74                AC160961.3         56352-56425         c
            75-135              AC160961.3         47767-47827         c
            136-325             AC163640.5         132855-133044       c
            326-391             AC163640.5         81097-81162         c
            392-447             AC163640.5         79531-79586         c
            448-523             AC163640.5         77823-77898         c
            524-685             AC163640.5         75071-75232         c
            686-864             AC163640.5         73642-73820         c
            865-1002            AC163640.5         64466-64603         c
            1003-1265           AC163640.5         60940-61202         c
            1266-1365           AC163640.5         59247-59346         c
            1366-2397           AC163640.5         57742-58773         c
            2398-2553           AC163640.5         56116-56271         c
            2554-2712           AC163640.5         54019-54177         c
            2713-2850           AC163640.5         53524-53661         c
            2851-2911           AC163640.5         49749-49809         c
            2912-8281           AC163640.5         41897-47266         c
FEATURES             Location/Qualifiers
     source          1..8281
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.24 cM"
     gene            1..8281
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /note="myocardin related transcription factor B"
                     /db_xref="GeneID:239719"
                     /db_xref="MGI:MGI:3050795"
     exon            1..74
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            75..135
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            136..325
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..3447
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /note="isoform 3 is encoded by transcript variant 3;
                     MKL/myocardin-like protein 2; gene trap insertion site
                     4-1; MKL/myocardin-like 2; myocardial related
                     transcription factor B; megakaryoblastic leukemia 2"
                     /codon_start=1
                     /product="myocardin-related transcription factor B isoform
                     3"
                     /protein_id="NP_001116139.1"
                     /db_xref="CCDS:CCDS49768.1"
                     /db_xref="GeneID:239719"
                     /db_xref="MGI:MGI:3050795"
                     /translation="MDHTGAIDTEEELGPLAHLAPSPQSESVAHEFQELSLQSSQHLP
                     TLNERKNVLQLRLQQRRTREQLVDQGIMPPLKSPAAFHEQIKSLERARTENFLKHKIR
                     SRPDRSELVRMHILEETFAEPSLQATQMKLKRARLADDLNEKIAQRPGPMELVEKNIL
                     PVDSSVKEAIIGVVKEDYPHTHGEFSFDEDSSDALSPDQPASQESQGSAASPSEPKVS
                     ASPPPVTASTPAQFTSVSPAVPEFLKTPLTADQPPTRSTAPVLPTNTVSSAKSGPMLV
                     KQSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPNQKGEKSEPQMDSNYARLLQQQQ
                     LFLQLQILSQQQQQQQQQHYNYQTILPAPIKTDKNSSSGSNSGSSSSMPARRPGPLPS
                     SLDDLKVSELKTELKLRGLPVSGTKPDLIERLKPYQEVTSSNLATGSIVAVSSATIVT
                     SNPEVTVALPVTTLHNAVTSSVSTFKADLALPATSSVPHVENAHSPLPISPSPSEQSS
                     LSTDDTNMTDTFTEIMTMMSPSQLLCSSPLRVVSHDDSLSPSSSTLSTLELDAAEKDR
                     KLQEKEKQIEELKRKLEQEQKLVEVLKMQLEVEKRGQQRPPDPQPSDPPHPFNTSDPK
                     HGSVGSSIKDEASLPDCSSPQQPITVPGHSVGQPISTGSQTLVAKKTVVVKQEVPMAQ
                     AEQQNVVSQFYLSSQGQPPALVAQPQALLTTQTTQLLLPVSIQGSNVTSVQLPVGSLQ
                     LQTPAQGRVQAQPHVAAATQVPAAALPSALTSALPQKQEAFPQHVLGQPQPVRKVFTN
                     SAPNTVLQYQRQPGPTNQQPFVSKTSNPALQSRTAPLAPLQNGPSLASKPSSPPPPQQ
                     FVVQHSLFATPITKTKDPPRYEEAIKQARSTQPALPEVSSVHSQQMDDLFDILIKSGE
                     ISFPIKEEPSPISKMKPVTASITTMPVNTVVSRPPPQVQIAPPVSLEPVNSLSASLEN
                     QLEAFLDGTLPSATDTGPLQNSSEDRESFSLIEDLQNDLLSHSSMLYQSHSPMETSEA
                     QLVSGTPCLSLDLSDSNLDNMEWLDITMPTTSSGLTPLSTTAPSMFSADFLDPQDLPL
                     PWD"
     exon            326..391
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            392..447
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            448..523
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            524..685
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            686..864
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1002
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1265
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1365
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..2397
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            2398..2553
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2712
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2850
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            2851..2911
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..8281
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8255..8260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /note="hexamer: AATAAA"
     polyA_site      8281
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /note="major polyA site"
ORIGIN      
        1 ggcggagcga agtctcgcga gatccggtgg tagctgcggc agcggtggcg gcggcggcgg
       61 cagcggccgg ggaggttcat aattaaggtg ctaaggaaga gaatgtaaga caggaaaata
      121 aatattttta ctgaggctgc gtaaaagagg tgtctcagtg gctggaacac aatggatcac
      181 acaggagcca tagacacaga ggaagagctg gggcctctag cccatcttgc accaagtcct
      241 caaagtgagt ctgtggctca cgaattccag gaactgtctc tacagtccag ccagcactta
      301 cccactctga acgaacggaa aaatgtgctc cagctgaggc tgcaacaaag gaggacaaga
      361 gaacaactag tggaccaggg catcatgcca cctttgaaga gtccagcagc attccatgag
      421 cagataaaaa gcctggagcg agccagaact gagaattttc tgaagcacaa gatccggagc
      481 cgcccagacc gctctgagct tgtcaggatg catattttag aagaaacgtt tgcagagcca
      541 tctcttcagg ccacacagat gaagctgaag agagctcggc tggcagatga cctgaacgag
      601 aagattgctc aaaggcctgg tcccatggag ctggtggaga agaacatcct tcctgtggat
      661 tcgagtgtca aggaagcgat tataggtgtg gtgaaggagg actatcctca cactcatggc
      721 gagttctcat ttgatgaaga tagcagtgat gctttgtctc cagaccagcc agcgagccag
      781 gagtctcagg gctcagctgc atcccccagt gagccaaaag tcagtgcctc gccacctcct
      841 gtgactgcaa gcactccagc ccagtttacc tcagtgtccc cagcagttcc tgaattcttg
      901 aaaacccctc taactgcaga ccagcctccc acaaggtcta cagctcccgt gctccctaca
      961 aacactgtgt cctcagcgaa gtctggccca atgctggtga agcaaagcca tcccaagaat
     1021 ccaaacgaca aacaccgtag caaaaaatgc aaagatccga aaccgcgagt gaagaagctt
     1081 aagtaccacc agtacattcc acccaaccag aagggggaga agagcgagcc acagatggac
     1141 tccaactatg cccgcctgct ccagcagcag cagctcttcc tacagctgca gatcctgagc
     1201 cagcagcagc agcaacagca gcagcagcac tacaactacc agaccatcct acctgcaccc
     1261 atcaaaactg acaagaacag cagcagcggc agtaacagcg gcagtagcag cagcatgccg
     1321 gcgaggaggc caggaccgct gccctccagc ttggatgact taaaggtgtc agagctgaag
     1381 acagaactca aactgagggg tctgccagtg tcaggaacta aaccagacct cattgaacgc
     1441 ctgaaaccct accaggaagt gaccagtagt aaccttgcca ctggcagtat tgtggcagtg
     1501 tcatcagcaa ccattgtcac cagtaaccca gaggtcacag tggcactgcc agtcacaaca
     1561 ctgcataatg ctgtaacaag ctctgtgtcc actttcaagg cagacttggc acttcctgca
     1621 accagcagtg tgccccatgt tgaaaatgcc cactctcctc tgcccatctc cccatcaccc
     1681 tctgagcagt ccagtctcag taccgatgac acaaacatga cagacacctt cacagagatc
     1741 atgactatga tgtcaccttc ccagttgttg tgttcatctc ccctgagggt ggtgagccat
     1801 gatgacagcc tgagcccttc cagtagcacc ctgtctactc tagaactgga tgctgctgag
     1861 aaggaccgca aacttcagga gaaggagaaa cagattgaag aactgaagag gaaactggaa
     1921 caagaacaga agcttgtgga ggtcctcaag atgcagcttg aggtggaaaa acgtgggcag
     1981 cagcgaccac cagaccctca gcccagtgat cccccacatc cctttaatac atcagatcct
     2041 aaacatggca gtgttgggtc ctccatcaag gatgaggcct cactccctga ctgctccagc
     2101 ccccagcagc ccatcacagt gcctggccac tctgtaggcc agcccatctc cacgggtagc
     2161 cagacccttg ttgccaaaaa gactgtggtc gtcaagcaag aggtccccat ggcccaagca
     2221 gagcagcaga acgttgtctc gcagttctac cttagttccc agggacagcc acctgccctt
     2281 gttgctcagc ctcaggcctt actgaccaca cagacaactc agctgctgct gccagtgtcc
     2341 atccagggct caaatgttac ttcagtgcaa ctcccagtag gcagccttca actccagacc
     2401 ccagcacaag gaagagtcca ggctcagcct catgtagctg ctgccacaca ggttccagct
     2461 gcagccctgc cctcagcctt gacctcagca ctgcctcaga agcaggaagc cttcccacag
     2521 cacgtgttgg gccagcctca gccagtcaga aaggtcttca caaactcggc accaaacaca
     2581 gttcttcagt atcagaggca gcctggccca acgaaccagc agccctttgt cagtaagacc
     2641 tctaaccctg ctcttcaatc cagaactgcc ccacttgcac ccctgcaaaa tggacccagc
     2701 ctagccagca agcctagctc accaccccca ccccagcagt ttgttgttca gcactctttg
     2761 tttgcaaccc caatcacgaa gacaaaagat ccacctcgat atgaggaagc catcaagcag
     2821 gcacgtagca cacagccagc ccttccagag gtttccagtg tgcacagtca gcagatggac
     2881 gacctcttcg acatcctcat aaagagtgga gagatttcct tcccaataaa agaagagcct
     2941 tctccaattt ccaagatgaa accagtgaca gccagcatca ccacaatgcc agtcaatacc
     3001 gtggtctctc gaccaccgcc ccaggtccaa atagcaccac ctgtatcctt agaacctgtg
     3061 aacagtttat ctgccagctt agagaaccag ctagaagcct tcttggatgg cactttgccc
     3121 tcggccactg acactggccc actgcagaac agcagtgaag atagagagtc tttctctctg
     3181 atcgaggatc tgcagaacga cttgctgagt cattccagca tgctgtacca gtctcactct
     3241 cccatggaga cctctgaggc ccagttggtg tcagggaccc cctgtctatc tcttgacctg
     3301 tcagactcca acctggacaa catggagtgg ctagacatta ccatgcccac cacatcctcc
     3361 gggctcactc cactgagtac cactgcgcca agcatgttct ctgctgattt tctggaccca
     3421 caggacctgc cgctgccatg ggactaaggt cacaggtctc ttgtttcaga gctcgtgaga
     3481 tttggaaaca tggaaacaaa cctgagaggc cagtgtttat agctggagcc atagctgcac
     3541 tgtcgaagtc aaaatacatt gtcacagaca aaaaggaagg ccacagcctg gaagccaagt
     3601 gtgagagact ccacagagac agttgtatgc agagcccttg tgaaatgcct tagctaaagc
     3661 caaaggtcag gaaatggcac taggctctgg tcatcagcca ccttttatcc tctgtggtca
     3721 cctcgtggcc ctaataagag gcaagcagct caacttgaaa caccaggcca cccacaaggg
     3781 agggagggga agagccactg cacatgtgct ccttagagtg gcctacggca gatcaatagc
     3841 aaggtcagag gcacctgagc actctgggca gccagcagca gcttccagcc agaggctttg
     3901 agtcccactt tgaaatctgc gtgattgtgt gatgtcatag gtcattttgt gaatttggga
     3961 atcaaaatga tgaacaacct tttaccatca acacatgtct acaagatact gtcacacaag
     4021 agcccagtgt attgagtcca gatacattga tagtgctgca gcttccccag tggccttggg
     4081 tgaatgaggt tgattctcct gtgatgttag acattggaat gtgctttgac cttgtgacct
     4141 ctacagtctt tggtagagta aaaagatggc gtcgactggt cctacttgta ataagtcaga
     4201 tatctctaga gtactgagcc acacagtgtc tccatctttg aagacttgcc gacagactct
     4261 ctcaggtgac catgcccatc tcaaagaacc aaaaaaaggc ttcagcatga aattccttct
     4321 caacctaatg agttaatgga aggtgtgggc cttgagcaca ggttagacca accccctgtc
     4381 accagctccc tggttctcat tgcataggct tgtaactgcc tgctctcaag tctaaaccta
     4441 aaaactggag gttttattcc tctttttccc cttgatccgt aacagaaaag ttatgtttat
     4501 caagtgattt aagaattgtt taagatgcca actgccacag attttccaca actcttgatc
     4561 tagtgattta gttattgaca aattgtaaat aactgaccag agtatggaat ttttattcag
     4621 tgacagccct tatcctatcc ccttcccatc ccctttaacc tgagccaggt gggcttccta
     4681 catcaatcca catgtctctt ccacagcaca tccaggcagt atcctgaccc atcatctaga
     4741 gagaacctta atcatttctg aggaggtttt accccagtga tcaaaatggt cccttttcct
     4801 ggctttaacc tctggcaaac agcgctctct caactgaagc ttggcattct ggtgggcagg
     4861 gcccactgag ctcaggtaat cctcttgttt agaatctggt aggtcagtat tgggaggcac
     4921 caacactagg gtagctggat cctgtcatct gaccaggcct cctgaggttg gctctgctgc
     4981 aactgaggac ctgggaaggc gtgctccccg tggcaatgcc agctctaggt ttgggtggag
     5041 agctttagtc ctttctctac agctttgagt gtccacttaa agtagtatca agtatcagtg
     5101 ggtttctcaa agcccataat tactattagt gtgtttcctc ctgtagaaaa gttgtgagta
     5161 aagacaacat tctagccctc aagtcccttc tattgctttt taagttattt tgaagcttgc
     5221 cacaggaaag acaatctcca aacacagtgg atacagagga ggtcatctca gttgttcatg
     5281 tgcccatccc atccagcctt cagtcccatt tcttaagaag gcaaggggcc tccagccagt
     5341 ggcttcacag ccaactccct cacagcattc cttgccctag tcccctggct tgagcatcct
     5401 gtaggtacat gtgacaccag tgacgtgagc gacacttgat agacctctcg cacatgttct
     5461 ggacaaatgt gggcatcttt cccataggct cacatcaatg tgtcatgacc aaagaccgct
     5521 ctataaaaag gcctcttgac ctagtcccag accgcagtga gtgcattgga aatggtgtgt
     5581 atctgaagac gaatttgttg tttaaagtta gtttcaggcc agcaagatga ctcagcagat
     5641 caggcctgcc aacaagcctg agaggctgag cttgagccct agagcccatg tggtagaagg
     5701 gcagaactga cccccgaaag ttgtgctctt atctctatat acagagacac ctgcaaatag
     5761 gtatacagtt atttcacagt cattaaaaca caggtcagag agcccattaa gttcccactt
     5821 gcatgtacag ggtacacgtg tagtgtaggc ttctgtttgt atcacattgc caagaaaatt
     5881 cctcttagaa gcctggagtg tcgcagtaga gtccaacccc agtctccctc ttctgcagca
     5941 tccacagtgt ggtggtgtca actttacttt ctgaggcaca gactgccagt tgtcttactg
     6001 tggtaggagg agtggaaata attacaccgt ggcttctaga aagctgatgt ggctgtgaaa
     6061 tttcagcaag gcctctctca gaagcctctg aggctgcggc agtactcact caggcatcca
     6121 ttcagcacac aggcacacag cactcatgca acttttcgct cacatatcat ctccgttcat
     6181 ttcacccaga tattttctaa gacttagact ttcttttcaa aagctccatg gttctttgac
     6241 cacgtgctat gccttactcc agaaagccag gtcagctctg cagagtccgg gaaatgggac
     6301 agtgttgtca ccctgcgcac tcggtcagcg acgggtgggt aagagggtca ccagagtgga
     6361 ctggagcctc aagagccact tttccaggca gcaaggctgt tctcatagtt actgtagtag
     6421 tctgtgcagt gacagctgag gaggcagctg tccctccagg cagggcagcc attttacttt
     6481 cccacagcag acctggctct gggaagtggc caagaggaga cccatcttat ctacaccctg
     6541 aactgttccc acagtggcca gttgcagaag ttctttctgg tagaaggctg gggactccat
     6601 taccactagg atttgcagag aaagctgaga gtggctgttg aattctgcca gcagagcaac
     6661 caggtcaggg ccagcaaagt caagcagcct cgccggcctc tgtccatcac atcacacaac
     6721 acacacaaca ctggggatat taagtacaca gggacccact gctgcagagg accattaacc
     6781 ctaggctgtc ccggcattct aactggaagg cagggcaggt ttatcaggga acacagcttg
     6841 tgctcacagg agtgtttgga gagcatcatc ctgaacattc agctaattgt aaaagatctc
     6901 tgtcaaaact ggaaagtagc agttctgatc tagtcatttt tgtttcctgg ttcaaacctt
     6961 tcgatctctt tttttttttt tttttttttt ggtttttcaa gacagggttt ctctgtgtag
     7021 ccctggctgt cctggaactc actttgtaga ccaggctggc ctcaaactca gaaatccgcc
     7081 tgcctctgcc tcccgagtgc tgggattaaa ggtgtgcgcc accacgcctg gctcaaacct
     7141 tcgatctctt tttcattttc atttaaacag tctctgggct ctgtttttat ttgtccggtg
     7201 actgggagag agcaggttgt cccccccccc caagtgtccc tgtgtcttta gttacagcct
     7261 acggttcaaa aagctgcacg tgtttacaag aagctcttac cctccactca ggccgccggc
     7321 tctggggggg cggacgtgtc ccaagcttgt gacagcagct tggcaatctc agatccacga
     7381 ggtgctgtct ggaatcatgg gaggcactgg cagtgaaagg aaggctttac gccaaggccc
     7441 aagacaaagc tttagcagtg ggcagactca ctggaaagcc gcccagttct cttacctcta
     7501 cttcctgctg tgagggaccc acccaccgac agaagaggaa gggttaggaa agggtttgga
     7561 tccatcaaaa gtacttgacc tcaagaaacc attagtaatc caaaatgttt aaaggaacca
     7621 aaggcatcgc caggtatttg ccaaaagcag ccacttttaa attttgagac tgtgttctca
     7681 agtcagaccc caaaaggttc catctaaggt tataatttcc acagagatgt agatatttct
     7741 tacttgtttt cctgtaaaat agcatagagc tgtttgttgg tttaagaata acattcttgg
     7801 tagcaacgct gaattatttt cttgtttgtc aaggttagtt atctgttgct tgcaatggac
     7861 acgcaggtgt ttttcttctt ttcatcttca cataatgtct tagcatctca cttcctgaca
     7921 agaagggaga aaacaccagt ggcagcaacc atgcctgctg aagcacttgt taatgaacag
     7981 aaaatcatgg cagtcggggg tccattcgtg tgttgccttt atgttgtttt taaaagacaa
     8041 accatgatgc ctttgtactt gctgtttgca cccctgactc gattctgtac tgtgtctgaa
     8101 tgccatacgt ttgcacttgt actgtacata ggcgatgcag actgtatttt tatatgtgtg
     8161 cgcatttatc attggatctt ttgtacatag tggcagtatt gtagctgatc gggaaatgtt
     8221 tgatatctca gcaattttgc atttttgtgt ctcaaataaa aaacattttg atgtaccatg
     8281 a
//
