LOCUS       NP_001116139            1091 aa            linear   ROD 27-APR-2025
DEFINITION  myocardin-related transcription factor B isoform 3 [Mus musculus].
ACCESSION   NP_001116139
VERSION     NP_001116139.1
DBSOURCE    REFSEQ: accession NM_001122667.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1091)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
  REMARK    GeneRIF: The actin-binding protein CAP1 represses
            MRTF-SRF-dependent gene expression in mouse cerebral cortex.
REFERENCE   2  (residues 1 to 1091)
  AUTHORS   Fang,G., Tian,Y., Huang,S., Zhang,X., Liu,Y., Li,Y., Du,J. and
            Gao,S.
  TITLE     KLF15 maintains contractile phenotype of vascular smooth muscle
            cells and prevents thoracic aortic dissection by interacting with
            MRTFB
  JOURNAL   J Biol Chem 300 (5), 107260 (2024)
   PUBMED   38582447
  REMARK    GeneRIF: KLF15 maintains contractile phenotype of vascular smooth
            muscle cells and prevents thoracic aortic dissection by interacting
            with MRTFB.
REFERENCE   3  (residues 1 to 1091)
  AUTHORS   Zhou,L.Y., Jin,C.X., Wang,W.X., Song,L., Shin,J.B., Du,T.T. and
            Wu,H.
  TITLE     Differential regulation of hair cell actin cytoskeleton mediated by
            SRF and MRTFB
  JOURNAL   Elife 12, e90155 (2023)
   PUBMED   37982489
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1091)
  AUTHORS   Mohan,K., Gasparoni,G., Salhab,A., Orlich,M.M., Geffers,R.,
            Hoffmann,S., Adams,R.H., Walter,J. and Nordheim,A.
  TITLE     Age-Associated Changes in Endothelial Transcriptome and Epigenetic
            Landscapes Correlate With Elevated Risk of Cerebral Microbleeds
  JOURNAL   J Am Heart Assoc 12 (17), e031044 (2023)
   PUBMED   37609982
REFERENCE   5  (residues 1 to 1091)
  AUTHORS   Yamamura,Y., Sakai,N., Iwata,Y., Lagares,D., Hara,A., Kitajima,S.,
            Toyama,T., Miyagawa,T., Ogura,H., Sato,K., Oshima,M., Nakagawa,S.,
            Tamai,A., Horikoshi,K., Matsuno,T., Yamamoto,N., Hayashi,D.,
            Toyota,Y., Kaikoi,D., Shimizu,M., Tager,A.M. and Wada,T.
  TITLE     Myocardin-related transcription factor contributes to renal
            fibrosis through the regulation of extracellular microenvironment
            surrounding fibroblasts
  JOURNAL   FASEB J 37 (7), e23005 (2023)
   PUBMED   37289107
REFERENCE   6  (residues 1 to 1091)
  AUTHORS   Li,J., Zhu,X., Chen,M., Cheng,L., Zhou,D., Lu,M.M., Du,K.,
            Epstein,J.A. and Parmacek,M.S.
  TITLE     Myocardin-related transcription factor B is required in cardiac
            neural crest for smooth muscle differentiation and cardiovascular
            development
  JOURNAL   Proc Natl Acad Sci U S A 102 (25), 8916-8921 (2005)
   PUBMED   15951419
  REMARK    GeneRIF: MRTF-B plays a critical role in regulating differentiation
            of cardiac neural crest cells into smooth muscle.
            GeneRIF: Consistent with the pattern of expression, E10.5 and E11.5
            MRTF-B-/- mutants exhibit deformation of aortic arch arteries 3, 4,
            and 6 and severe attenuation of smooth muscle cell differentiation
            in the arch arteries and the aorticopulmonary septum.
REFERENCE   7  (residues 1 to 1091)
  AUTHORS   Kuwahara,K., Barrientos,T., Pipes,G.C., Li,S. and Olson,E.N.
  TITLE     Muscle-specific signaling mechanism that links actin dynamics to
            serum response factor
  JOURNAL   Mol Cell Biol 25 (8), 3173-3181 (2005)
   PUBMED   15798203
REFERENCE   8  (residues 1 to 1091)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 1091)
  AUTHORS   Wang,D.Z., Li,S., Hockemeyer,D., Sutherland,L., Wang,Z.,
            Schratt,G., Richardson,J.A., Nordheim,A. and Olson,E.N.
  TITLE     Potentiation of serum response factor activity by a family of
            myocardin-related transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14855-14860 (2002)
   PUBMED   12397177
  REMARK    GeneRIF: interacts with serum response factor and stimulates its
            transcriptional activity
REFERENCE   10 (residues 1 to 1091)
  AUTHORS   Skarnes,W.C., Auerbach,B.A. and Joyner,A.L.
  TITLE     A gene trap approach in mouse embryonic stem cells: the lacZ
            reported is activated by splicing, reflects endogenous gene
            expression, and is mutagenic in mice
  JOURNAL   Genes Dev 6 (6), 903-918 (1992)
   PUBMED   1592261
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160961.3 and AC163640.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849381,
                              SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1091
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 9.24 cM"
     Protein         1..1091
                     /product="myocardin-related transcription factor B isoform
                     3"
                     /note="MKL/myocardin-like protein 2; gene trap insertion
                     site 4-1; MKL/myocardin-like 2; myocardial related
                     transcription factor B; megakaryoblastic leukemia 2"
                     /calculated_mol_wt=118420
     Region          52..76
                     /region_name="RPEL"
                     /note="RPEL repeat; cl29414"
                     /db_xref="CDD:475195"
     Region          96..119
                     /region_name="RPEL"
                     /note="RPEL repeat; pfam02755"
                     /db_xref="CDD:460677"
     Region          139..164
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     Region          <197..321
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          394..427
                     /region_name="SAP"
                     /note="SAP domain; pfam02037"
                     /db_xref="CDD:460424"
     Region          562..>597
                     /region_name="DUF2130"
                     /note="Uncharacterized protein conserved in bacteria
                     (DUF2130); pfam09903"
                     /db_xref="CDD:430914"
     CDS             1..1091
                     /gene="Mrtfb"
                     /gene_synonym="Gt4-1; mKIAA1243; Mkl2; MRTF-B; SOLOIST"
                     /coded_by="NM_001122667.2:172..3447"
                     /note="isoform 3 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS49768.1"
                     /db_xref="GeneID:239719"
                     /db_xref="MGI:MGI:3050795"
ORIGIN      
        1 mdhtgaidte eelgplahla pspqsesvah efqelslqss qhlptlnerk nvlqlrlqqr
       61 rtreqlvdqg impplkspaa fheqiksler artenflkhk irsrpdrsel vrmhileetf
      121 aepslqatqm klkrarladd lnekiaqrpg pmelveknil pvdssvkeai igvvkedyph
      181 thgefsfded ssdalspdqp asqesqgsaa spsepkvsas pppvtastpa qftsvspavp
      241 eflktpltad qpptrstapv lptntvssak sgpmlvkqsh pknpndkhrs kkckdpkprv
      301 kklkyhqyip pnqkgeksep qmdsnyarll qqqqlflqlq ilsqqqqqqq qqhynyqtil
      361 papiktdkns ssgsnsgsss smparrpgpl psslddlkvs elktelklrg lpvsgtkpdl
      421 ierlkpyqev tssnlatgsi vavssativt snpevtvalp vttlhnavts svstfkadla
      481 lpatssvphv enahsplpis pspseqssls tddtnmtdtf teimtmmsps qllcssplrv
      541 vshddslsps sstlstleld aaekdrklqe kekqieelkr kleqeqklve vlkmqlevek
      601 rgqqrppdpq psdpphpfnt sdpkhgsvgs sikdeaslpd csspqqpitv pghsvgqpis
      661 tgsqtlvakk tvvvkqevpm aqaeqqnvvs qfylssqgqp palvaqpqal lttqttqlll
      721 pvsiqgsnvt svqlpvgslq lqtpaqgrvq aqphvaaatq vpaaalpsal tsalpqkqea
      781 fpqhvlgqpq pvrkvftnsa pntvlqyqrq pgptnqqpfv sktsnpalqs rtaplaplqn
      841 gpslaskpss ppppqqfvvq hslfatpitk tkdppryeea ikqarstqpa lpevssvhsq
      901 qmddlfdili ksgeisfpik eepspiskmk pvtasittmp vntvvsrppp qvqiappvsl
      961 epvnslsasl enqleafldg tlpsatdtgp lqnssedres fsliedlqnd llshssmlyq
     1021 shspmetsea qlvsgtpcls ldlsdsnldn mewlditmpt tssgltplst tapsmfsadf
     1081 ldpqdlplpw d
//
