LOCUS       NM_001082536            4345 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus myocardin related transcription factor A (Mrtfa),
            transcript variant 2, mRNA.
ACCESSION   NM_001082536
VERSION     NM_001082536.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4345)
  AUTHORS   Cao,K., Zhu,Y., Kuai,Y., Chen,B., Zhao,Q. and Yu,W.
  TITLE     Macrophage MKL1 contributes to cardiac fibrosis in a mouse model of
            myocardial infarction
  JOURNAL   Life Sci 356, 123036 (2024)
   PUBMED   39222836
  REMARK    GeneRIF: Macrophage MKL1 contributes to cardiac fibrosis in a mouse
            model of myocardial infarction.
REFERENCE   2  (bases 1 to 4345)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
  REMARK    GeneRIF: The actin-binding protein CAP1 represses
            MRTF-SRF-dependent gene expression in mouse cerebral cortex.
REFERENCE   3  (bases 1 to 4345)
  AUTHORS   Zhou,L.Y., Jin,C.X., Wang,W.X., Song,L., Shin,J.B., Du,T.T. and
            Wu,H.
  TITLE     Differential regulation of hair cell actin cytoskeleton mediated by
            SRF and MRTFB
  JOURNAL   Elife 12, e90155 (2023)
   PUBMED   37982489
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4345)
  AUTHORS   Singh,A.K., Rai,A., Weber,A., Gericke,M., Janssen,K.P., Moser,M.
            and Posern,G.
  TITLE     MRTF-A gain-of-function in mice impairs homeostatic renewal of the
            intestinal epithelium
  JOURNAL   Cell Death Dis 14 (9), 639 (2023)
   PUBMED   37770456
  REMARK    GeneRIF: MRTF-A gain-of-function in mice impairs homeostatic
            renewal of the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4345)
  AUTHORS   Yamamura,Y., Sakai,N., Iwata,Y., Lagares,D., Hara,A., Kitajima,S.,
            Toyama,T., Miyagawa,T., Ogura,H., Sato,K., Oshima,M., Nakagawa,S.,
            Tamai,A., Horikoshi,K., Matsuno,T., Yamamoto,N., Hayashi,D.,
            Toyota,Y., Kaikoi,D., Shimizu,M., Tager,A.M. and Wada,T.
  TITLE     Myocardin-related transcription factor contributes to renal
            fibrosis through the regulation of extracellular microenvironment
            surrounding fibroblasts
  JOURNAL   FASEB J 37 (7), e23005 (2023)
   PUBMED   37289107
REFERENCE   6  (bases 1 to 4345)
  AUTHORS   Lockman,K., Hinson,J.S., Medlin,M.D., Morris,D., Taylor,J.M. and
            Mack,C.P.
  TITLE     Sphingosine 1-phosphate stimulates smooth muscle cell
            differentiation and proliferation by activating separate serum
            response factor co-factors
  JOURNAL   J Biol Chem 279 (41), 42422-42430 (2004)
   PUBMED   15292266
  REMARK    GeneRIF: RhoA-dependent activation of MRTF-A has a role in
            sphingosine 1-phosphate activation of multiple signaling pathways
            in smooth muscle cells
REFERENCE   7  (bases 1 to 4345)
  AUTHORS   Du,K.L., Chen,M., Li,J., Lepore,J.J., Mericko,P. and Parmacek,M.S.
  TITLE     Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals
            and induces smooth muscle cell differentiation from
            undifferentiated embryonic stem cells
  JOURNAL   J Biol Chem 279 (17), 17578-17586 (2004)
   PUBMED   14970199
  REMARK    GeneRIF: MKL1 transduces cytoskeletal signals and induces smooth
            muscle cell differentiation from undifferentiated embryonic stem
            cells
REFERENCE   8  (bases 1 to 4345)
  AUTHORS   Miralles,F., Posern,G., Zaromytidou,A.I. and Treisman,R.
  TITLE     Actin dynamics control SRF activity by regulation of its
            coactivator MAL
  JOURNAL   Cell 113 (3), 329-342 (2003)
   PUBMED   12732141
  REMARK    GeneRIF: Rho-actin signaling regulates the subcellular localization
            of the myocardin-related SRF coactivator MAL
REFERENCE   9  (bases 1 to 4345)
  AUTHORS   Wang,D.Z., Li,S., Hockemeyer,D., Sutherland,L., Wang,Z.,
            Schratt,G., Richardson,J.A., Nordheim,A. and Olson,E.N.
  TITLE     Potentiation of serum response factor activity by a family of
            myocardin-related transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14855-14860 (2002)
   PUBMED   12397177
  REMARK    GeneRIF: interacts with serum response factor and stimulates its
            transcriptional activity
REFERENCE   10 (bases 1 to 4345)
  AUTHORS   Sasazuki,T., Sawada,T., Sakon,S., Kitamura,T., Kishi,T.,
            Okazaki,T., Katano,M., Tanaka,M., Watanabe,M., Yagita,H.,
            Okumura,K. and Nakano,H.
  TITLE     Identification of a novel transcriptional activator, BSAC, by a
            functional cloning to inhibit tumor necrosis factor-induced cell
            death
  JOURNAL   J Biol Chem 277 (32), 28853-28860 (2002)
   PUBMED   12019265
  REMARK    GeneRIF: BSAC is a novel transcriptional activator with
            antiapoptotic function
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102198.9 and AC141880.3.
            
            On May 16, 2019 this sequence version replaced NM_001082536.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The encoded isoform (2) has
            a longer and distinct N-terminus compared to isoform 1. This
            variant uses a non-AUG translation start codon.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF532597.1, BC050941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               AC102198.9         125644-125873       c
            231-492             AC102198.9         52528-52789         c
            493-558             AC141880.3         62884-62949
            559-614             AC141880.3         81521-81576
            615-690             AC141880.3         84621-84696
            691-852             AC141880.3         85680-85841
            853-1028            AC141880.3         87310-87485
            1029-1178           AC141880.3         87924-88073
            1179-1444           AC141880.3         89759-90024
            1445-1613           AC141880.3         90119-90287
            1614-2609           AC141880.3         91012-92007
            2610-2762           AC141880.3         92327-92479
            2763-2823           AC141880.3         92829-92889
            2824-4345           AC141880.3         94436-95957
FEATURES             Location/Qualifiers
     source          1..4345
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.98 cM"
     gene            1..4345
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /note="myocardin related transcription factor A"
                     /db_xref="GeneID:223701"
                     /db_xref="MGI:MGI:2384495"
     exon            1..230
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            231..492
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            493..558
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            559..614
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            615..690
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            691..852
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1028
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1178
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1444
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1613
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..2609
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2610..2762
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2763..2823
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            2824..4345
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4320..4325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /note="hexamer: AATAAA"
     polyA_site      4345
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /note="major polyA site"
ORIGIN      
        1 gtggctgagt ggagccggcg gcggtcgtgt ctgcggtgtc cccggcggca agaacgaccg
       61 tcccaccctc cccaccccct cgttcccgct cgccacgctc cctcggcttg cgcggacctc
      121 tccctaactt ggtgcagtct gactggtact agaggctcgg gaggatacgt gagcggctgg
      181 caccggagtg gggcgagccg cggagcccgg gccaggaggc gaacgaggcg gttaccatca
      241 cgaaagccaa ggtggatttc tccagtgtgg tgtgcctgcc cccttccgtc attgctgtga
      301 atgggctgga cggaggaggg gctggcgaaa atgacgacga gccagtgctc ctgtctctgt
      361 ctgcggcccc cagcccccag agcgaagctg ttgccaatga actgcaggag ctgtccctgc
      421 agcccgagct gactctaggc ctccatcctg ggaggaaccc caatttacct ccacttagtg
      481 agcggaagaa tgtgctgcag ttgaagctcc agcagcggcg gacccgggag gaactggtga
      541 gccaagggat catgccgcct ttgaaaagcc ccgctgcatt tcatgagcag agaagaagcc
      601 tggagcgggc caggaccgag gactatttga aacggaagat ccgttcccgg cccgagagag
      661 cagagctggt caggatgcac attctggaag agacctcggc tgagccttcg ctccaggcca
      721 agcagctgaa gctgaagaga gccaggctgg ctgatgacct caatgaaaag attgcacaga
      781 ggcctggccc catggagctg gtggagaaga atatcctgcc tgtggagtcc agcctgaagg
      841 aggctatcat tgtgggccag gtaaattacc caaaggtagc agacagttcc tccttcgacg
      901 aggacagcag cgatgccctg tctcctgagc agcctgccag ccatgagtcc cagggttcag
      961 tgccatcacc cttggagtcc cgagtcagtg atccactgcc cagtgccacc tccatatcac
     1021 ccactcaggt tctttctcaa ctcccaatgg ctccggatcc tggagagacg ctttttctgg
     1081 cagagcagcc tcctctgcct cccgcacctc tgctgccccc aagcctagcc aatggaagca
     1141 tcgtccccac tgccaagcct gctcccacac tcatcaagca aagccaaccc aagtctgcca
     1201 gcgagaaatc acagcgcagc aagaaggcca aggagctgaa gccaaaggtg aagaagctca
     1261 agtaccacca gtacatcccc ccggaccaga agcaggacaa gggggcgccc gccatggact
     1321 cctcctatgc caagatcctg cagcagcagc agctcttcct gcagctgcag atcctcaacc
     1381 agcagcagca gcagcagcag caacagcact acaactacca ggccatcctg cctgcccctc
     1441 ccaagccctc ggctgagact cctggaagca gtgcccctac cccatcacgc agcctctcca
     1501 ccagtagcag ccccagctca ggcaccccag ggcccagcgg gctggcacgc cagagcagca
     1561 ccgcactagc tgccaaacca ggagccctgc cagccaacct ggatgacatg aaggtggcag
     1621 agctgaagca agaactgaag ttgcggtccc ttcccgtctc aggcaccaag acagagctga
     1681 tagaacgcct gcgtgcctac caagaccaag tcagcccagc tccaggagcc cccaaggccc
     1741 ctgccaccac ctctgtgctg tccaaggctg gtgaggtagt ggtcgccttc cctgcggccc
     1801 tgctaagcac agggtcagct cttgtaacag caggccttgc accagctgag atggtggtgg
     1861 ccacagtaac cagcaatggc atggtgaagt ttggcagcac aggctccaca ccccccgtgt
     1921 ctcccacccc ttcagagcgc tcactgctca gcacgggtga tgagaattcc acacctgggg
     1981 atgcctttgg tgaaatggtg acatcgccgc tgacacagct caccctgcag gcctccccac
     2041 tgcagatcgt gaaggaggag ggtgcccgtg ctgcgtcctg ctgtctaagc cctggtgctc
     2101 gggctgagct ggagggactg gacaaggacc agatgctgca ggagaaggac aagcagattg
     2161 aggagctgac ccgaatgctc caacagaagc agcagctggt tgagctgctg cggctacagc
     2221 tggagcagca gaagcgggcc cagcagccag ccccagccag cagccctgtg aagagggaaa
     2281 gtggtttctc cagttgccag ctgagctgcc agccccaggg ctctgcccat gcttttggct
     2341 ctggcctagt ggttcccact accaaccatg gagacactca ggccccagcg ccagagtccc
     2401 cacctgtggt ggtgaagcag gaagctgggc cacctgagcc agatctggcc cccagctccc
     2461 agctgctctt gggctcccag ggcaccagct tcctcaagag ggtcagccct cctaccctgg
     2521 tcactgactc tacagggact cacctcatcc tcactgtgac caataagagt gctgatggcc
     2581 ctggcttgcc tgcagggagc ccccagcagc ccttgtccca gcctggttct ccagcccctg
     2641 gtccacctgc ccagatggac ctggagcacc cacctcagcc tccgtttgca acccccacat
     2701 ctctgctgaa gaaggagccc cctggttatg aagagactgt gacccagcag cctaagcagc
     2761 aggaaaatgg ctcctccagt cagcacatgg atgatctgtt tgatattctt attcagagtg
     2821 gagagatttc agcagatttc aaagagccac catccctacc aggcaaggaa aagtcacctc
     2881 cagcagcagc agcgtatggg cctccattga caccacaacc ctcgcctttg agtgaactcc
     2941 cccaagctgc tcctccacca ggttccccca ccctcccagg gcgccttgaa gacttcctgg
     3001 agagcagcac agggctgccc ctgctgacaa gtgggcacga gggaccagaa cccctttccc
     3061 tcattgatga cctccacagc cagatgctga gcagctccgc catcctggac caccccccat
     3121 cacccatgga cacctctgaa ttgcactttg ctcctgagcc cagcagtggt atgggcctgg
     3181 acctggctgt tggccacctg gacagcatgg actggctgga gctgtcgtct ggtggccctg
     3241 tgctcagcct ggctcccctc agcactgcag cccccagcct cttctcgatg gacttcctgg
     3301 atggacacga cttgcagctc cactgggatt cctgcttgta gccctctgac tccagacatg
     3361 cgctagggaa gggtcagagg ttggggagcc acacaaccat acccagtgta cgctcctgtg
     3421 actgtgagcc tcgacaatca cagtccctag gggctgcagc agaaacccta tacttggctc
     3481 aggctcactg tgggcagtgg gcataagctg tcaagaaaca aatctgggcc cattctgagg
     3541 ttttgggagg ctggccagag ccagttcaat tcgacctcct tttctgaggt cagaggtgca
     3601 catctgggtg aagttttttg cctaggtggg cttatagtca acccgccttc caggtccttc
     3661 actgcaagga agaaactagc caggcctcta ctcacccatt ccctatttta gccagtccca
     3721 ggacccggca ctatgccatt tcagtcttgg tgtatagtat aaccactggt ggcaaaagtc
     3781 tgtatagatg tatatacctc tatattatta tatatcaact tacatatata catatatttt
     3841 taggggtggt gggaaatggg tgtggttacc tccacatgct ttcacaacgt aaaaagcctg
     3901 gagggctgtt tggggcttga tacaggatca ttgtgagaag tgtgctatat gacccagtat
     3961 ccaacctggc atgcagctgc ccaggcccac cccacacatg tatgtaacat gtagacacct
     4021 gccattgcct cctacacgcc accctgccct gcttcctggc tcctgagtgc cacaagggca
     4081 gaggtgcctc ctgtcctccg ccagcaactc tccactcacc cacattccgt cccacctccc
     4141 cactgcatcc accctggcct gggagtggga gtggggtggg tcccaatgca tctgctgggg
     4201 gctgagaggt accttctgcc catcaccagc cttgttctgt gctgactcaa tgcagagaag
     4261 ggatagagcc atcaaaagca gtgctggggc aaaggcggaa agctgtgtga actttttaaa
     4321 ataaaacaaa aacactgact tgcca
//
