LOCUS       NP_001076005            1029 aa            linear   ROD 27-APR-2025
DEFINITION  myocardin-related transcription factor A isoform 2 [Mus musculus].
ACCESSION   NP_001076005
VERSION     NP_001076005.2
DBSOURCE    REFSEQ: accession NM_001082536.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1029)
  AUTHORS   Cao,K., Zhu,Y., Kuai,Y., Chen,B., Zhao,Q. and Yu,W.
  TITLE     Macrophage MKL1 contributes to cardiac fibrosis in a mouse model of
            myocardial infarction
  JOURNAL   Life Sci 356, 123036 (2024)
   PUBMED   39222836
  REMARK    GeneRIF: Macrophage MKL1 contributes to cardiac fibrosis in a mouse
            model of myocardial infarction.
REFERENCE   2  (residues 1 to 1029)
  AUTHORS   Khudayberdiev,S., Weiss,K., Heinze,A., Colombaretti,D., Trausch,N.,
            Linne,U. and Rust,M.B.
  TITLE     The actin-binding protein CAP1 represses MRTF-SRF-dependent gene
            expression in mouse cerebral cortex
  JOURNAL   Sci Signal 17 (835), eadj0032 (2024)
   PUBMED   38713765
  REMARK    GeneRIF: The actin-binding protein CAP1 represses
            MRTF-SRF-dependent gene expression in mouse cerebral cortex.
REFERENCE   3  (residues 1 to 1029)
  AUTHORS   Zhou,L.Y., Jin,C.X., Wang,W.X., Song,L., Shin,J.B., Du,T.T. and
            Wu,H.
  TITLE     Differential regulation of hair cell actin cytoskeleton mediated by
            SRF and MRTFB
  JOURNAL   Elife 12, e90155 (2023)
   PUBMED   37982489
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1029)
  AUTHORS   Singh,A.K., Rai,A., Weber,A., Gericke,M., Janssen,K.P., Moser,M.
            and Posern,G.
  TITLE     MRTF-A gain-of-function in mice impairs homeostatic renewal of the
            intestinal epithelium
  JOURNAL   Cell Death Dis 14 (9), 639 (2023)
   PUBMED   37770456
  REMARK    GeneRIF: MRTF-A gain-of-function in mice impairs homeostatic
            renewal of the intestinal epithelium.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1029)
  AUTHORS   Yamamura,Y., Sakai,N., Iwata,Y., Lagares,D., Hara,A., Kitajima,S.,
            Toyama,T., Miyagawa,T., Ogura,H., Sato,K., Oshima,M., Nakagawa,S.,
            Tamai,A., Horikoshi,K., Matsuno,T., Yamamoto,N., Hayashi,D.,
            Toyota,Y., Kaikoi,D., Shimizu,M., Tager,A.M. and Wada,T.
  TITLE     Myocardin-related transcription factor contributes to renal
            fibrosis through the regulation of extracellular microenvironment
            surrounding fibroblasts
  JOURNAL   FASEB J 37 (7), e23005 (2023)
   PUBMED   37289107
REFERENCE   6  (residues 1 to 1029)
  AUTHORS   Lockman,K., Hinson,J.S., Medlin,M.D., Morris,D., Taylor,J.M. and
            Mack,C.P.
  TITLE     Sphingosine 1-phosphate stimulates smooth muscle cell
            differentiation and proliferation by activating separate serum
            response factor co-factors
  JOURNAL   J Biol Chem 279 (41), 42422-42430 (2004)
   PUBMED   15292266
  REMARK    GeneRIF: RhoA-dependent activation of MRTF-A has a role in
            sphingosine 1-phosphate activation of multiple signaling pathways
            in smooth muscle cells
REFERENCE   7  (residues 1 to 1029)
  AUTHORS   Du,K.L., Chen,M., Li,J., Lepore,J.J., Mericko,P. and Parmacek,M.S.
  TITLE     Megakaryoblastic leukemia factor-1 transduces cytoskeletal signals
            and induces smooth muscle cell differentiation from
            undifferentiated embryonic stem cells
  JOURNAL   J Biol Chem 279 (17), 17578-17586 (2004)
   PUBMED   14970199
  REMARK    GeneRIF: MKL1 transduces cytoskeletal signals and induces smooth
            muscle cell differentiation from undifferentiated embryonic stem
            cells
REFERENCE   8  (residues 1 to 1029)
  AUTHORS   Miralles,F., Posern,G., Zaromytidou,A.I. and Treisman,R.
  TITLE     Actin dynamics control SRF activity by regulation of its
            coactivator MAL
  JOURNAL   Cell 113 (3), 329-342 (2003)
   PUBMED   12732141
  REMARK    GeneRIF: Rho-actin signaling regulates the subcellular localization
            of the myocardin-related SRF coactivator MAL
REFERENCE   9  (residues 1 to 1029)
  AUTHORS   Wang,D.Z., Li,S., Hockemeyer,D., Sutherland,L., Wang,Z.,
            Schratt,G., Richardson,J.A., Nordheim,A. and Olson,E.N.
  TITLE     Potentiation of serum response factor activity by a family of
            myocardin-related transcription factors
  JOURNAL   Proc Natl Acad Sci U S A 99 (23), 14855-14860 (2002)
   PUBMED   12397177
  REMARK    GeneRIF: interacts with serum response factor and stimulates its
            transcriptional activity
REFERENCE   10 (residues 1 to 1029)
  AUTHORS   Sasazuki,T., Sawada,T., Sakon,S., Kitamura,T., Kishi,T.,
            Okazaki,T., Katano,M., Tanaka,M., Watanabe,M., Yagita,H.,
            Okumura,K. and Nakano,H.
  TITLE     Identification of a novel transcriptional activator, BSAC, by a
            functional cloning to inhibit tumor necrosis factor-induced cell
            death
  JOURNAL   J Biol Chem 277 (32), 28853-28860 (2002)
   PUBMED   12019265
  REMARK    GeneRIF: BSAC is a novel transcriptional activator with
            antiapoptotic function
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102198.9 and AC141880.3.
            
            On May 16, 2019 this sequence version replaced NP_001076005.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The encoded isoform (2) has
            a longer and distinct N-terminus compared to isoform 1. This
            variant uses a non-AUG translation start codon.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF532597.1, BC050941.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            non-AUG initiation codon :: inferred from conservation
            RefSeq Select criteria   :: based on conservation, expression,
                                        longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1029
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.98 cM"
     Protein         1..1029
                     /product="myocardin-related transcription factor A isoform
                     2"
                     /note="basic SAP and coiled-coil domains;
                     MKL/myocardin-like protein 1; basic SAP coiled-coil
                     transcription activator; megakaryoblastic leukemia
                     (translocation) 1 homolog; megakaryocytic acute leukemia
                     protein homolog; MKL (megakaryoblastic
                     leukemia)/myocardin-like 1; myocardial related
                     transcription factor A"
                     /calculated_mol_wt=108963
     Region          81..105
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     Region          124..149
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     Region          168..193
                     /region_name="RPEL"
                     /note="Repeat in Drosophila CG10860, human KIAA0680 and C.
                     elegans F26H9.2; smart00707"
                     /db_xref="CDD:128947"
     Region          450..483
                     /region_name="SAP"
                     /note="SAP domain; pfam02037"
                     /db_xref="CDD:460424"
     CDS             1..1029
                     /gene="Mrtfa"
                     /gene_synonym="AMKL; Bsac; Mal; Mkl1; Mrtf-A"
                     /coded_by="NM_001082536.2:252..3341"
                     /note="isoform 2 is encoded by transcript variant 2;
                     non-AUG (GUG) translation initiation codon"
                     /db_xref="CCDS:CCDS49674.2"
                     /db_xref="GeneID:223701"
                     /db_xref="MGI:MGI:2384495"
ORIGIN      
        1 mdfssvvclp psviavngld gggagendde pvllslsaap spqseavane lqelslqpel
       61 tlglhpgrnp nlpplserkn vlqlklqqrr treelvsqgi mpplkspaaf heqrrslera
      121 rtedylkrki rsrperaelv rmhileetsa epslqakqlk lkrarladdl nekiaqrpgp
      181 melveknilp vesslkeaii vgqvnypkva dsssfdedss dalspeqpas hesqgsvpsp
      241 lesrvsdplp satsisptqv lsqlpmapdp getlflaeqp plppapllpp slangsivpt
      301 akpaptlikq sqpksaseks qrskkakelk pkvkklkyhq yippdqkqdk gapamdssya
      361 kilqqqqlfl qlqilnqqqq qqqqqhynyq ailpappkps aetpgssapt psrslstsss
      421 pssgtpgpsg larqsstala akpgalpanl ddmkvaelkq elklrslpvs gtktelierl
      481 rayqdqvspa pgapkapatt svlskagevv vafpaallst gsalvtagla paemvvatvt
      541 sngmvkfgst gstppvsptp sersllstgd enstpgdafg emvtspltql tlqasplqiv
      601 keegaraasc clspgarael egldkdqmlq ekdkqieelt rmlqqkqqlv ellrlqleqq
      661 kraqqpapas spvkresgfs scqlscqpqg sahafgsglv vpttnhgdtq apapesppvv
      721 vkqeagppep dlapssqlll gsqgtsflkr vspptlvtds tgthliltvt nksadgpglp
      781 agspqqplsq pgspapgppa qmdlehppqp pfatptsllk keppgyeetv tqqpkqqeng
      841 sssqhmddlf diliqsgeis adfkeppslp gkeksppaaa aygppltpqp splselpqaa
      901 pppgsptlpg rledflesst glplltsghe gpeplslidd lhsqmlsssa ildhppspmd
      961 tselhfapep ssgmgldlav ghldsmdwle lssggpvlsl aplstaapsl fsmdfldghd
     1021 lqlhwdscl
//
