LOCUS       NM_001013389            2161 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus MRS2 magnesium transporter (Mrs2), mRNA; nuclear gene
            for mitochondrial product.
ACCESSION   NM_001013389 XM_354744
VERSION     NM_001013389.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Powell,D.R., Doree,D.D., Shadoan,M.K., Platt,K.A., Brommage,R.,
            Vogel,P. and Revelli,J.P.
  TITLE     Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and Thin
            When Maintained on a High-Fat Diet
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   38878275
  REMARK    GeneRIF: Mice Lacking Mrs2 Magnesium Transporter are Hypophagic and
            Thin When Maintained on a High-Fat Diet.
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Ponnusamy,T., Velusamy,P. and Shanmughapriya,S.
  TITLE     Mrs2-mediated mitochondrial magnesium uptake is essential for the
            regulation of MCU-mediated mitochondrial Ca2+ uptake and viability
  JOURNAL   Mitochondrion 76, 101877 (2024)
   PUBMED   38599304
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Vishnu,N., Venkatesan,M., Madaris,T.R., Venkateswaran,M.K.,
            Stanley,K., Ramachandran,K., Chidambaram,A., Madesh,A.K., Yang,W.,
            Nair,J., Narkunan,M., Muthukumar,T., Karanam,V., Joseph,L.C.,
            Le,A., Osidele,A., Aslam,M.I., Morrow,J.P., Malicdan,M.C.,
            Stathopulos,P.B. and Madesh,M.
  TITLE     ERMA (TMEM94) is a P-type ATPase transporter for Mg2+ uptake in the
            endoplasmic reticulum
  JOURNAL   Mol Cell 84 (7), 1321-1337 (2024)
   PUBMED   38513662
REFERENCE   4  (bases 1 to 2161)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2161)
  AUTHORS   Madaris,T.R., Venkatesan,M., Maity,S., Stein,M.C., Vishnu,N.,
            Venkateswaran,M.K., Davis,J.G., Ramachandran,K., Uthayabalan,S.,
            Allen,C., Osidele,A., Stanley,K., Bigham,N.P., Bakewell,T.M.,
            Narkunan,M., Le,A., Karanam,V., Li,K., Mhapankar,A., Norton,L.,
            Ross,J., Aslam,M.I., Reeves,W.B., Singh,B.B., Caplan,J.,
            Wilson,J.J., Stathopulos,P.B., Baur,J.A. and Madesh,M.
  TITLE     Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic
            programming in prolonged dietary stress
  JOURNAL   Cell Rep 42 (3), 112155 (2023)
   PUBMED   36857182
  REMARK    GeneRIF: Limiting Mrs2-dependent mitochondrial Mg[2+] uptake
            induces metabolic programming in prolonged dietary stress.
REFERENCE   6  (bases 1 to 2161)
  AUTHORS   Daw,C.C., Ramachandran,K., Enslow,B.T., Maity,S., Bursic,B.,
            Novello,M.J., Rubannelsonkumar,C.S., Mashal,A.H., Ravichandran,J.,
            Bakewell,T.M., Wang,W., Li,K., Madaris,T.R., Shannon,C.E.,
            Norton,L., Kandala,S., Caplan,J., Srikantan,S., Stathopulos,P.B.,
            Reeves,W.B. and Madesh,M.
  TITLE     Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate
            Cellular Metabolism
  JOURNAL   Cell 183 (2), 474-489 (2020)
   PUBMED   33035451
REFERENCE   7  (bases 1 to 2161)
  AUTHORS   Zsurka,G., Gregan,J. and Schweyen,R.J.
  TITLE     The human mitochondrial Mrs2 protein functionally substitutes for
            its yeast homologue, a candidate magnesium transporter
  JOURNAL   Genomics 72 (2), 158-168 (2001)
   PUBMED   11401429
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645533.9, AW456688.1, CA752560.1, BB015377.2 and BU058305.1.
            
            On Jun 8, 2013 this sequence version replaced NM_001013389.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422590.151238.1,
                                           SRR10223971.13224.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL645533.9         60177-60350         c
            175-686             AW456688.1         1-512
            687-1061            CA752560.1         340-714
            1062-1514           BB015377.2         163-615
            1515-2066           BU058305.1         68-619
            2067-2161           AL645533.9         32328-32422         c
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 10.83 cM"
     gene            1..2161
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /note="MRS2 magnesium transporter"
                     /db_xref="GeneID:380836"
                     /db_xref="MGI:MGI:2685748"
     exon            1..236
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            237..310
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            311..347
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            348..460
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            461..634
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            635..765
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            766..882
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            883..1035
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1036..1153
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1267
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..2161
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /note="hexamer: ACTAAA"
     regulatory      1494..1499
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /note="hexamer: ACTAAA"
     polyA_site      1499
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /note="major polyA site"
     polyA_site      1518
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /note="major polyA site"
     polyA_site      1560
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
     polyA_site      1576
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
     regulatory      1961..1966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
                     /note="hexamer: AATAGA"
     polyA_site      1987
                     /gene="Mrs2"
                     /gene_synonym="Gm902; HPT; Mrs2l; RPT"
ORIGIN      
        1 ggtgagccgg ttgacccgag ttccggcatg tcggaccggc gtcctggggc ggcttcccgg
       61 ttgcccgcgc gccatggaat gcctgcgctg cctgcccggg ctgctgcccc gcgccgcgca
      121 gccccggagg gccctgtgga cggcggtcgc gcgcctgagc ctcgctgcct gcggcggccg
      181 cgcgacccct ttgcgctccc ggagcccgaa agcgtcgagc acagcccgcg ctgcaggtga
      241 tgtgctccgg tttagaacct cggatgcctc tcaagccact ttagccagcg tggcccaggt
      301 gtttgctgtg acaaagtttg acaaagaagg aaacgttacc tcttttgaga ggaagaaaac
      361 tgaactatac catgagttag cactccaggc cagagacttg aggtttcagc acgtgatgag
      421 catcactact agaaacaaca ggatcatcat gaggatggag tatttgaagg ctgtgataac
      481 tccagagtgt cttctgatac tagattatcg gaatttaaat ttggagcact ggctgtttcg
      541 ggaactgccc tcacagctgg ctggagaagg tcagctggtc acctacccat taccatttga
      601 gttcagagct attgaagcac tcctgcagta ctggatcagc acccttcggg ggagactaag
      661 cgtcctgcag ccactgatcc tcgagaccct ggatgctcta gtggacccca agcactcgtc
      721 tgtggacaga agcaagctgc atgtcctact ccaaaacggc aaaagtctct ctgagttaga
      781 aacagacatt aaaattttca aagagtcgat tttggagctc ttggatgagg aggagatgct
      841 ggaagaactc tgtctgacca agtggagcga cccacatgtc tttgagaaga gcagcactgg
      901 gatcgaccac gcagaggaga tggagctgct gctggagaac tactaccgct tagcagagga
      961 cctctccaac gaggcgcgcg agcttcgggt cctgattgac gattcgcaga gcattatctt
     1021 catcaaccta gacagccatc gcaatgtgat gatgaggtta aatctccagc tgaccatggg
     1081 aaccttctcc ctttcactct ttggtctgat gggagttgct tttggcatga atttggaatc
     1141 ttcccttgaa gaggaccatc gcgtgttttg gctggttacg gggattatgt ttatgggaag
     1201 tggtctcatc tggaggaggt tgctctcatt ccttggaaga cagctggaag ctcctgtgcc
     1261 ccctgtgatg acctccttac ctaaaaagac ccttctggcc aatagaagga tggacgtgaa
     1321 aaacagcctc aggccggaag gacttggagc aagcaggact atcctggcaa gccgctagca
     1381 gcagcctgac agacaaagat ttgtatactt ctgaagctat tattactttc tggggaaaaa
     1441 agacaactgg tgtttaaatt atgtctgact aaaaatactg tggcattcac aatactaaac
     1501 ttgatcacat cttcagaatt ctttgagact aagaagaggt ttctttgtaa aaggccaaaa
     1561 ccctgtgtcc taccaacttt tgaaatactg tttttatggg ctttttaaag tatagattaa
     1621 tttattgtga ggtagactta tgtagattca gcgtcattct acatatcaag aagagtgcag
     1681 cttcgtgctg aaggagccca gggactggca gagcccatgg ttcctgagca cacagacctc
     1741 acttcctcgc gcagggaggg acccacactc ctagcaggtt ctcactcagg aacgaaagct
     1801 aatggatctg ttagccttgc agcaagctct ggaggagtgt tagaccttcc aggcatttgc
     1861 tctcttttat atataagatg aatgaaagga ggtataattt aatgtcagca tatttggatt
     1921 ccagttaatc aagattctta ctattttttg attagttata aatagaacca tgggagttag
     1981 gtttaaagaa ggagtttgtt tattctctta caattttata gctgttttga tgattgcctg
     2041 ttttaagaga ttgtcctact accccctccc caggagaaaa tgtatacagc cagctaatgt
     2101 gtttgccgac ctctcagaag ttagcagatg ggcttgtcaa acaagaacgt agctaatgca
     2161 a
//
