LOCUS       NM_023514               1445 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S9 (Mrps9), mRNA.
ACCESSION   NM_023514
VERSION     NM_023514.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1445)
  AUTHORS   Jiang,J., Qi,T., Li,L., Pan,Y., Huang,L., Zhu,L., Zhang,D., Ma,X.
            and Qin,Y.
  TITLE     MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway Inhibits
            Neuron Apoptosis and Protects Ischemic Stroke
  JOURNAL   J Mol Neurosci 74 (1), 23 (2024)
   PUBMED   38381220
  REMARK    GeneRIF: MRPS9-Mediated Regulation of the PI3K/Akt/mTOR Pathway
            Inhibits Neuron Apoptosis and Protects Ischemic Stroke.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1445)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 1445)
  AUTHORS   Alvarez-Dominguez,J.R., Zhang,X. and Hu,W.
  TITLE     Widespread and dynamic translational control of red blood cell
            development
  JOURNAL   Blood 129 (5), 619-629 (2017)
   PUBMED   27899360
REFERENCE   4  (bases 1 to 1445)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 1445)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   6  (bases 1 to 1445)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   7  (bases 1 to 1445)
  AUTHORS   Kim,S.C., Sprung,R., Chen,Y., Xu,Y., Ball,H., Pei,J., Cheng,T.,
            Kho,Y., Xiao,H., Xiao,L., Grishin,N.V., White,M., Yang,X.J. and
            Zhao,Y.
  TITLE     Substrate and functional diversity of lysine acetylation revealed
            by a proteomics survey
  JOURNAL   Mol Cell 23 (4), 607-618 (2006)
   PUBMED   16916647
REFERENCE   8  (bases 1 to 1445)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   9  (bases 1 to 1445)
  AUTHORS   Lionikas,A., Blizard,D.A., Gerhard,G.S., Vandenbergh,D.J.,
            Stout,J.T., Vogler,G.P., McClearn,G.E. and Larsson,L.
  TITLE     Genetic determinants of weight of fast- and slow-twitch skeletal
            muscle in 500-day-old mice of the C57BL/6J and DBA/2J lineage
  JOURNAL   Physiol Genomics 21 (2), 184-192 (2005)
   PUBMED   15687484
REFERENCE   10 (bases 1 to 1445)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Koc,H., Moseley,A. and
            Spremulli,L.L.
  TITLE     Identification of four proteins from the small subunit of the
            mammalian mitochondrial ribosome using a proteomics approach
  JOURNAL   Protein Sci 10 (3), 471-481 (2001)
   PUBMED   11344316
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY145802.1, BC116437.2 and BC051936.1.
            
            On Mar 12, 2008 this sequence version replaced NM_023514.3.
            
            Sequence Note: A downstream translational start codon is selected
            for this RefSeq based on its better conservation in mammalian
            species and a strong Kozak signal. An upstream in-frame start codon
            is also present but has a weaker Kozak signal and is only present
            in mouse; use of the upstream start codon would result in a protein
            that is 6 aa longer. Leaky scanning by ribosomes may allow
            translation initiation at the downstream start codon.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK009082.1, SRR1660811.350886.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               BY145802.1         1-162
            163-675             BC116437.2         113-625
            676-1445            BC051936.1         369-1138
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 21.62 cM"
     gene            1..1445
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /note="mitochondrial ribosomal protein S9"
                     /db_xref="GeneID:69527"
                     /db_xref="MGI:MGI:1916777"
     exon            1..194
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1232
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /note="muscle protein 637; 28S ribosomal protein S9,
                     mitochondrial; small ribosomal subunit protein uS9m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS9m precursor"
                     /protein_id="NP_076003.3"
                     /db_xref="CCDS:CCDS14918.1"
                     /db_xref="GeneID:69527"
                     /db_xref="MGI:MGI:1916777"
                     /translation="MAAPCVSCGRVLSLWFTPAVRASLCQRPGYWTASAVGWQTGTRF
                     QLSKLIHTTVVTTKKNVQASRQESYTEDFIKKQIEEFNIGKRHLANMMGEDPETFAEE
                     DIDRAIAYLFPSGLFEKRARPMMKHPEHIFPKQRATQWGEDGRPFHFLFYTGKQSYYS
                     LMHDVYGKVMQLEKHRGPLSASAESRDLIGSRWLIKEELEEMLVEKLSDEDYAQFIRL
                     LEKLLTLPCGPAEEEFVQRFRRSVTIQSKKQLIEPVQYDEQGMAFSTSEGRRKSATAQ
                     AVVYEHGSGKIHVNGVDYLIYFPITQDREQLMFPFHFLDRLERHDVTCTVSGGGRSAQ
                     AGAIRLAMARALCSFVTEDEVEWMRQAGLLTPDPRIRERKKPGQEGARRKFTWKKR"
     exon            195..374
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            375..437
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            438..468
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            469..548
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            549..616
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            617..692
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            693..861
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            862..970
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1140
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1419
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /note="hexamer: AATAAA"
     polyA_site      1419
                     /gene="Mrps9"
                     /gene_synonym="2310002A08Rik; mg637; Mrp-S9; S9mt"
                     /note="major polyA site"
ORIGIN      
        1 tgcgcagtct ccaggctcca cccctttccc ctcccgccag gatgtttctt acggccaaca
       61 tggccgcccc ctgtgtgtcc tgcggccgag tgctttccct ttggttcact cccgctgtta
      121 gagctagcct ctgccagagg cccgggtact ggacagcctc ggcggttggc tggcagacag
      181 ggaccaggtt ccagctatca aagctaatac ataccacagt tgtaacaaca aagaaaaatg
      241 tccaagcctc aagacaggaa tcatatacag aagattttat taaaaagcag attgaagaat
      301 tcaatatagg gaagaggcac ttagccaaca tgatgggaga agacccggaa acttttgctg
      361 aagaggatat tgatagagct attgcttacc tttttccaag tggtttgttt gagaagcgag
      421 ccaggccaat gatgaagcat cctgaacata tttttccaaa acaaagagca acccagtggg
      481 gagaagatgg ccgtccattt cattttctct tctatactgg caaacaatcg tactattcat
      541 taatgcacga cgtgtatgga aaggtcatgc agctggaaaa gcacagaggg ccactgtcgg
      601 caagcgctga gtccagagac ctgattggca gcagatggct gattaaggag gaactagaag
      661 aaatgttagt ggaaaaactg tcagatgaag attatgcaca gttcatccga ctgctcgaga
      721 agctattgac attgccgtgc gggcctgcag aagaagaatt tgtgcagagg ttccgcagaa
      781 gtgtaactat tcaatcaaaa aagcaactga ttgaacccgt gcagtatgac gagcagggca
      841 tggccttcag caccagcgaa ggccggagga agagcgccac ggcacaggcg gtcgtttatg
      901 agcacggaag cgggaagatc cacgtgaacg gagttgatta tctaatttac tttcccatca
      961 cacaggacag agaacagttg atgttccctt tccacttcct ggaccggctg gagagacacg
     1021 atgtgacctg cacagtctcc gggggaggga ggtcagcgca ggcaggcgcc atacgcttgg
     1081 cgatggccag agctttgtgc agcttcgtca ctgaggatga ggtcgagtgg atgagacaag
     1141 ccggactact tacccctgat cctcggatca gagaacggaa gaagccaggc caggagggtg
     1201 ctcgaagaaa gttcacctgg aagaagcgct gaaacttttc ccaggagagc gaggagcaca
     1261 gcgtcttcgt gcctggctca tggtagagca cagtcatgca ctgaccaatg gaggcagcgt
     1321 gtacacatcg tcttgagttt acgttatgac atggtttatt tttagtgcta ttttgttata
     1381 tgattgccat tgaaaataat aaaaagaatg ttggtttcaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaa
//
