LOCUS       NM_029963               1448 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S5 (Mrps5), mRNA.
ACCESSION   NM_029963
VERSION     NM_029963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1448)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1448)
  AUTHORS   Gao,F., Liang,T., Lu,Y.W., Fu,X., Dong,X., Pu,L., Hong,T., Zhou,Y.,
            Zhang,Y., Liu,N., Zhang,F., Liu,J., Malizia,A.P., Yu,H., Zhu,W.,
            Cowan,D.B., Chen,H., Hu,X., Mably,J.D., Wang,J., Wang,D.Z. and
            Chen,J.
  TITLE     A defect in mitochondrial protein translation influences
            mitonuclear communication in the heart
  JOURNAL   Nat Commun 14 (1), 1595 (2023)
   PUBMED   36949106
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1448)
  AUTHORS   Juskeviciene,R., Fritz,A.K., Brilkova,M., Akbergenov,R.,
            Schmitt,K., Rehrauer,H., Laczko,E., Isnard-Petit,P., Thiam,K.,
            Eckert,A., Schacht,J., Wolfer,D.P., Bottger,E.C. and Shcherbakov,D.
  TITLE     Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is
            Intimately Linked to Mitoribosomal Misreading
  JOURNAL   Int J Mol Sci 23 (8), 4384 (2022)
   PUBMED   35457201
  REMARK    GeneRIF: Phenotype of Mrps5-Associated Phylogenetic Polymorphisms
            Is Intimately Linked to Mitoribosomal Misreading.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1448)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   5  (bases 1 to 1448)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1448)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   7  (bases 1 to 1448)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   8  (bases 1 to 1448)
  AUTHORS   Houtkooper,R.H., Mouchiroud,L., Ryu,D., Moullan,N., Katsyuba,E.,
            Knott,G., Williams,R.W. and Auwerx,J.
  TITLE     Mitonuclear protein imbalance as a conserved longevity mechanism
  JOURNAL   Nature 497 (7450), 451-457 (2013)
   PUBMED   23698443
REFERENCE   9  (bases 1 to 1448)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1448)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB049941.1.
            
            On Jul 22, 2002 this sequence version replaced NM_029963.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049941.1, BC021947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1448
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.05 cM"
     gene            1..1448
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /note="mitochondrial ribosomal protein S5"
                     /db_xref="GeneID:77721"
                     /db_xref="MGI:MGI:1924971"
     exon            1..60
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             3..1301
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /note="28S ribosomal protein S5, mitochondrial; S5mt;
                     MRP-S5"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS5m"
                     /protein_id="NP_084239.1"
                     /db_xref="CCDS:CCDS16706.1"
                     /db_xref="GeneID:77721"
                     /db_xref="MGI:MGI:1924971"
                     /translation="MAAAVRAAGCLPALCSLQAGHFLSRQLSLNAFPVAATSFLAVKT
                     ALSHGSLSSRETRRNHCLTSLSHVLQTQCCVSSPGNWTGQQCRPYSFFTKLTAEELWK
                     GALAETGAGARKGRGKRTKKKKRKDLNRGQIIGEGRSGFLWPGLNVPLIKSGVVQNIG
                     QRSKEEQQKVEATMVEQREEWDRKRKIKVKRERGWSGNTWGGVSIGPPDPGPNGETYE
                     DFDTRILEVRNVFNMTAKEGRKKSVRVLVAVGNGNGAAGFAIGKAADRGDAFRKAKNR
                     AIHYLHYIERYEGHTIFHDISLRFKRTQIRMKKQPRGYGLRCHRAIITICRLIGIKDM
                     YARVTGSMNMLNLTRGLFHGLARQETHQHLADKKGLHVVEFREECGPLPIVVASPHGA
                     LSKEPEPEPEVPDTKLDWQDVKAMQGLKRSVWFNLKRPAT"
     exon            61..147
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            148..285
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            286..411
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            412..645
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            646..680
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            681..771
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..818
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            819..876
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..939
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1076
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1434
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1406..1411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1434
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcatggcggc ggccgtacgc gctgcaggct gtctccctgc attgtgtagc ttgcaggcag
       61 gtcatttcct gtctaggcaa ctctctttaa acgcctttcc agtagcagcc acttcctttt
      121 tggcagtgaa gacagctctt agccacggct cattgtcatc cagggaaaca aggcgcaacc
      181 actgtctgac cagcttgagc catgtgctac agacacagtg ctgcgtttcc tctcccggca
      241 actggacggg ccagcagtgc cggccctaca gcttcttcac caaactgact gcagaagagc
      301 tctggaaagg cgcattagca gagactggag ctggagcaag aaaaggcaga ggcaaaagaa
      361 caaagaaaaa gaagaggaag gatttgaaca ggggccagat cattggtgaa gggcgctctg
      421 gcttcctgtg gcctggtttg aacgttcctc tgataaaaag tggggtcgtc cagaacatcg
      481 gccagagaag caaagaggag cagcagaagg tggaggccac catggtcgag cagcgagagg
      541 agtgggaccg gaagaggaag atcaaagtta aaagggagcg cggctggagt gggaacacgt
      601 gggggggtgt cagtattggc cccccagacc cgggacccaa tggagaaaca tatgaagact
      661 ttgataccag gattcttgag gtaagaaatg tcttcaatat gacagcaaaa gagggaagaa
      721 agaagtcggt ccgagtcctg gttgctgttg ggaatggaaa tggagctgca ggttttgcta
      781 ttgggaaagc tgctgaccgg ggagacgctt tcagaaaggc aaagaaccga gcgattcatt
      841 atttgcatta catagaacga tacgaaggac atacaatatt ccatgacatt tccctaagat
      901 tcaaaaggac acagatccgg atgaagaaac aacccagagg ttacggcctc cgctgccaca
      961 gggccattat caccatctgc cgcctcatcg gcatcaagga catgtatgcg agggtcaccg
     1021 ggtccatgaa catgctcaac ctcacccggg gcctcttcca tgggcttgcc cgccaggaaa
     1081 cccaccaaca tctggcggat aagaagggtc tccacgtggt ggaattccgg gaggaatgtg
     1141 ggcctctgcc tatcgtggtg gcctccccac atggggcctt gagtaaggag ccggagccgg
     1201 aacctgaggt tcctgatacc aagctggact ggcaggacgt gaaggccatg cagggactga
     1261 agcgctctgt gtggtttaat ttaaagaggc ctgccaccta agcctcccgg aaggccagcc
     1321 cagccagtgc ttgtgctgac agcacccgga ggacacgcca ctctcacttt ttattttaaa
     1381 aaaagtccaa ccttctttgt tttcaaataa ataattatag atttgtctta cagaaaaaaa
     1441 aaaaaaaa
//
