LOCUS       NP_084239                432 aa            linear   ROD 30-APR-2024
DEFINITION  small ribosomal subunit protein uS5m [Mus musculus].
ACCESSION   NP_084239
VERSION     NP_084239.1
DBSOURCE    REFSEQ: accession NM_029963.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 432)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 432)
  AUTHORS   Gao,F., Liang,T., Lu,Y.W., Fu,X., Dong,X., Pu,L., Hong,T., Zhou,Y.,
            Zhang,Y., Liu,N., Zhang,F., Liu,J., Malizia,A.P., Yu,H., Zhu,W.,
            Cowan,D.B., Chen,H., Hu,X., Mably,J.D., Wang,J., Wang,D.Z. and
            Chen,J.
  TITLE     A defect in mitochondrial protein translation influences
            mitonuclear communication in the heart
  JOURNAL   Nat Commun 14 (1), 1595 (2023)
   PUBMED   36949106
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 432)
  AUTHORS   Juskeviciene,R., Fritz,A.K., Brilkova,M., Akbergenov,R.,
            Schmitt,K., Rehrauer,H., Laczko,E., Isnard-Petit,P., Thiam,K.,
            Eckert,A., Schacht,J., Wolfer,D.P., Bottger,E.C. and Shcherbakov,D.
  TITLE     Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is
            Intimately Linked to Mitoribosomal Misreading
  JOURNAL   Int J Mol Sci 23 (8), 4384 (2022)
   PUBMED   35457201
  REMARK    GeneRIF: Phenotype of Mrps5-Associated Phylogenetic Polymorphisms
            Is Intimately Linked to Mitoribosomal Misreading.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 432)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   5  (residues 1 to 432)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 432)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   7  (residues 1 to 432)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   8  (residues 1 to 432)
  AUTHORS   Houtkooper,R.H., Mouchiroud,L., Ryu,D., Moullan,N., Katsyuba,E.,
            Knott,G., Williams,R.W. and Auwerx,J.
  TITLE     Mitonuclear protein imbalance as a conserved longevity mechanism
  JOURNAL   Nature 497 (7450), 451-457 (2013)
   PUBMED   23698443
REFERENCE   9  (residues 1 to 432)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (residues 1 to 432)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB049941.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB049941.1, BC021947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.05 cM"
     Protein         1..432
                     /product="small ribosomal subunit protein uS5m"
                     /note="28S ribosomal protein S5, mitochondrial; S5mt;
                     MRP-S5"
                     /calculated_mol_wt=48076
     Region          110..130
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99N87.1)"
     Region          219..374
                     /region_name="rpsE_bact"
                     /note="ribosomal protein S5, bacterial/organelle type;
                     TIGR01021"
                     /db_xref="CDD:130093"
     CDS             1..432
                     /gene="Mrps5"
                     /gene_synonym="1620401I16Rik"
                     /coded_by="NM_029963.2:3..1301"
                     /db_xref="CCDS:CCDS16706.1"
                     /db_xref="GeneID:77721"
                     /db_xref="MGI:MGI:1924971"
ORIGIN      
        1 maaavraagc lpalcslqag hflsrqlsln afpvaatsfl avktalshgs lssretrrnh
       61 cltslshvlq tqccvsspgn wtgqqcrpys fftkltaeel wkgalaetga garkgrgkrt
      121 kkkkrkdlnr gqiigegrsg flwpglnvpl iksgvvqnig qrskeeqqkv eatmveqree
      181 wdrkrkikvk rergwsgntw ggvsigppdp gpngetyedf dtrilevrnv fnmtakegrk
      241 ksvrvlvavg ngngaagfai gkaadrgdaf rkaknraihy lhyieryegh tifhdislrf
      301 krtqirmkkq prgyglrchr aiiticrlig ikdmyarvtg smnmlnltrg lfhglarqet
      361 hqhladkkgl hvvefreecg plpivvasph galskepepe pevpdtkldw qdvkamqglk
      421 rsvwfnlkrp at
//
