LOCUS       NM_145573               1064 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S35 (Mrps35),
            transcript variant 1, mRNA.
ACCESSION   NM_145573 XM_994870 XM_994888 XM_994905
VERSION     NM_145573.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1064)
  AUTHORS   Ha,H.T., Liu,S., Nguyen,X.T., Vo,L.K., Leong,N.C., Nguyen,D.T.,
            Balamurugan,S., Lim,P.Y., Wu,Y., Seong,E., Nguyen,T.Q., Oh,J.,
            Wenk,M.R., Cazenave-Gassiot,A., Yapici,Z., Ong,W.Y., Burmeister,M.
            and Nguyen,L.N.
  TITLE     Lack of SPNS1 results in accumulation of lysolipids and lysosomal
            storage disease in mouse models
  JOURNAL   JCI Insight 9 (8), e175462 (2024)
   PUBMED   38451736
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1064)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1064)
  AUTHORS   Kenny,T.C., Khan,A., Son,Y., Yue,L., Heissel,S., Sharma,A.,
            Pasolli,H.A., Liu,Y., Gamazon,E.R., Alwaseem,H., Hite,R.K. and
            Birsoy,K.
  TITLE     Integrative genetic analysis identifies FLVCR1 as a plasma-membrane
            choline transporter in mammals
  JOURNAL   Cell Metab 35 (6), 1057-1071 (2023)
   PUBMED   37100056
REFERENCE   4  (bases 1 to 1064)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   5  (bases 1 to 1064)
  AUTHORS   Doucet-Beaupre,H., Gilbert,C., Profes,M.S., Chabrat,A., Pacelli,C.,
            Giguere,N., Rioux,V., Charest,J., Deng,Q., Laguna,A., Ericson,J.,
            Perlmann,T., Ang,S.L., Cicchetti,F., Parent,M., Trudeau,L.E. and
            Levesque,M.
  TITLE     Lmx1a and Lmx1b regulate mitochondrial functions and survival of
            adult midbrain dopaminergic neurons
  JOURNAL   Proc Natl Acad Sci U S A 113 (30), E4387-E4396 (2016)
   PUBMED   27407143
REFERENCE   6  (bases 1 to 1064)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   7  (bases 1 to 1064)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153575.5.
            
            On Aug 30, 2022 this sequence version replaced NM_145573.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019964.1, AK077677.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC153575.5         91012-91140
            130-167             AC153575.5         94351-94388
            168-335             AC153575.5         96374-96541
            336-396             AC153575.5         98068-98128
            397-536             AC153575.5         104092-104231
            537-646             AC153575.5         108382-108491
            647-716             AC153575.5         109663-109732
            717-1064            AC153575.5         118794-119141
FEATURES             Location/Qualifiers
     source          1..1064
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 77.7 cM"
     gene            1..1064
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /note="mitochondrial ribosomal protein S35"
                     /db_xref="GeneID:232536"
                     /db_xref="MGI:MGI:2385255"
     exon            1..129
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..986
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mitochondrial ribosomal protein S34; 28S ribosomal protein
                     S35, mitochondrial; S35mt; MRP-S35; small ribosomal
                     subunit protein mS35"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS35 isoform 1"
                     /protein_id="NP_663548.2"
                     /db_xref="CCDS:CCDS51959.1"
                     /db_xref="GeneID:232536"
                     /db_xref="MGI:MGI:2385255"
                     /translation="MAAAALQLRQTLCPGARVLRTFSSVASPAAPRAGPRTASRSERP
                     MRRKALPPRTEKMDTDQDWPSVYPTAAPFKPSAVPLPVRMGYPVKKGVPMAKEGNLEL
                     LKIPNFLHLTPVAIKRHCAALKDFCTEWPAALDSDEKCEEHFPVEIDTADYVSSGPSI
                     RNPKARAVTLRVKLSSLNLDNHAKKKLIKLVGERYCKATDVLTITTDRCPLKRQNCDY
                     AVYLLTVLYHESWKTEDWENSKTEEDMDEYVWAKSSSENSVLQTLLQMRAAESSVAPS
                     REELLGTKEVEDYQKCIVRLKNEGENEASLAQYKESVKRLLNLA"
     exon            130..167
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            168..335
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            336..396
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            397..536
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            537..646
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            647..716
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     exon            717..1064
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /note="hexamer: TATAAA"
     polyA_site      1064
                     /gene="Mrps35"
                     /gene_synonym="MDSO23; MRP-S28; MRPS28"
                     /note="major polyA site"
ORIGIN      
        1 gctccggctc gccgtccttt atcatggcgg ccgccgcgct gcagctgagg cagaccctgt
       61 gcccgggagc gcgcgtcctg cgcaccttct cctcggtcgc cagccccgcg gctccgagag
      121 ccggcccgcg tacggcatcc agaagcgaaa ggccgatgag gagaaaggca ctacctccta
      181 ggacggagaa gatggatact gatcaggact ggcccagtgt ttaccccact gccgcgccgt
      241 ttaaaccctc agctgttcct ctacctgttc gaatgggata cccagtaaag aagggtgtgc
      301 ccatggcgaa ggaagggaat ctagagcttt taaagatccc aaattttctg catttgactc
      361 ctgtggcaat taaaaggcac tgtgcagcat tgaaagattt ctgcactgag tggccagctg
      421 cactcgacag tgatgagaaa tgtgaggagc attttccagt tgagattgat acagcggatt
      481 atgtgtcatc gggaccatct attcgaaacc ccaaagcccg agccgtaacg ttaagggtta
      541 aactttccag tttgaattta gacaatcatg ccaagaaaaa actcattaag cttgtaggag
      601 agcggtactg caaggccacc gatgtgctca ctatcaccac agacagatgc cctttgaagc
      661 ggcagaactg tgactatgca gtgtatcttc tcacagtcct gtaccacgaa tcttggaaaa
      721 ctgaagactg ggaaaacagt aagaccgagg aagacatgga cgagtatgtg tgggcaaaga
      781 gctcctcgga gaacagtgtc cttcagaccc tgctgcagat gagagctgcg gagagcagtg
      841 tggcgccgag cagagaagag ctgctgggga ccaaagaggt cgaggattat cagaagtgta
      901 tcgttcgtct caagaacgag ggggagaacg aggcaagcct cgctcagtac aaggagtctg
      961 tgaagagact gttaaatttg gcgtgaagtc caaactagaa ggcaactgta tcaattttat
     1021 gttgtattta gtcactgatt tgatataaat gggagaatcc ttaa
//
