LOCUS       NM_023260                914 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S34 (Mrps34), mRNA.
ACCESSION   NM_023260
VERSION     NM_023260.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 914)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 914)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 914)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 914)
  AUTHORS   Richman,T.R., Ermer,J.A., Davies,S.M., Perks,K.L., Viola,H.M.,
            Shearwood,A.M., Hool,L.C., Rackham,O. and Filipovska,A.
  TITLE     Mutation in MRPS34 compromises protein synthesis and causes
            mitochondrial dysfunction
  JOURNAL   PLoS Genet 11 (3), e1005089 (2015)
   PUBMED   25816300
  REMARK    GeneRIF: The Mrps34 mutation causes tissue-specific molecular
            changes that result in heterogeneous pathology involving
            alterations in fractional shortening of the heart and pronounced
            liver dysfunction that is exacerbated with age
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 914)
  AUTHORS   Kargul,G.J., Nagaraja,R., Shimada,T., Grahovac,M.J., Lim,M.K.,
            Nakashima,H., Waeltz,P., Ma,P., Chen,E., Schlessinger,D. and
            Ko,M.S.
  TITLE     Eleven densely clustered genes, six of them novel, in 176 kb of
            mouse t-complex DNA
  JOURNAL   Genome Res 10 (7), 916-923 (2000)
   PUBMED   10899141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA794791.1, AK002285.1 and AC166102.2.
            
            On Jan 17, 2019 this sequence version replaced NM_023260.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024336.1, AK002285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AA794791.1         1-27
            28-840              AK002285.1         2-814
            841-841             AC166102.2         46122-46122         c
            842-914             AK002285.1         816-888
FEATURES             Location/Qualifiers
     source          1..914
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.53 cM"
     gene            1..914
                     /gene="Mrps34"
                     /gene_synonym="0610007F04Rik; 5330430D13Rik; Tce2"
                     /note="mitochondrial ribosomal protein S34"
                     /db_xref="GeneID:79044"
                     /db_xref="MGI:MGI:1930188"
     exon            1..369
                     /gene="Mrps34"
                     /gene_synonym="0610007F04Rik; 5330430D13Rik; Tce2"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..705
                     /gene="Mrps34"
                     /gene_synonym="0610007F04Rik; 5330430D13Rik; Tce2"
                     /note="28S ribosomal protein S34, mitochondrial; S34mt;
                     MRP-S34; T-complex expressed gene 2 protein"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS34"
                     /protein_id="NP_075749.1"
                     /db_xref="CCDS:CCDS28502.1"
                     /db_xref="GeneID:79044"
                     /db_xref="MGI:MGI:1930188"
                     /translation="MARKKVRPRLIAELARRVRALREQRNQPRDSQLYALDYETLTRP
                     HSGRRLPVRAWADVRRESRLLQLLARLPLFGLGRLVTRKSWLWQHDEPCYWRLTRVRP
                     DYTAQNLDHGRAWGILTFKGKSEDTAREIEQVMYHDWRLVPKHEEEAFTAFTAKPEDR
                     LNSVPYPPLLRAMILAERQKNGDTSVQEPLLNLERTRMRPWDYPAKQETKGRAKGTPV
                     "
     exon            370..412
                     /gene="Mrps34"
                     /gene_synonym="0610007F04Rik; 5330430D13Rik; Tce2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..914
                     /gene="Mrps34"
                     /gene_synonym="0610007F04Rik; 5330430D13Rik; Tce2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      894..899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps34"
                     /gene_synonym="0610007F04Rik; 5330430D13Rik; Tce2"
                     /note="hexamer: AATAAA"
     polyA_site      914
                     /gene="Mrps34"
                     /gene_synonym="0610007F04Rik; 5330430D13Rik; Tce2"
                     /note="major polyA site"
ORIGIN      
        1 cgggagagct cctgaagcgc agatttcctg tggagtaagg acactgacat ggcgcggaag
       61 aaagtaagac cccggctgat cgctgagctg gctcgccgcg tgcgcgcctt gcgcgagcag
      121 cggaaccagc cgcgagattc gcagctctac gccctagact acgagacgct gacccggccg
      181 cactccggtc gccggctgcc ggtacgcgcc tgggccgacg tgcgtcgcga gagccgcctc
      241 ctacagctgc tcgcccgcct ccccttgttc ggcctgggcc gtctggttac ccgcaagtcc
      301 tggctgtggc agcacgacga gccatgctac tggcgcctca cgcgtgtgag gcccgactac
      361 acggcgcaga acttggacca cgggagggcc tggggcatcc tgactttcaa agggaagagt
      421 gaggatacgg ctcgggaaat cgagcaagtc atgtaccacg attggcgttt ggtacccaag
      481 cacgaggagg aggccttcac tgcgttcact gcgaaaccag aggacagatt gaattctgtc
      541 ccctatccac ctctgctgcg agccatgatc ctcgctgaac ggcagaaaaa cggggatacc
      601 agcgtccagg agccgctcct gaacctggag aggactcgaa tgcgcccctg ggactaccct
      661 gcaaaacagg agacgaaagg gagggccaag ggcaccccag tctaactgcc aggactggca
      721 gagaggtcct gtgagtcatt tgatggacga gtgcctttga ctgtgctaga tcttcacttc
      781 ggtggcgagt tatatcctac agccctgaca catcaggcaa tgaataatgg ggcagatgac
      841 aggctgcttg gtgtcatttt caggcgggcc cctctctgat tcctcggtct ggaaataaac
      901 gccaggaaac agcc
//
