LOCUS       NM_010270               1061 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S33 (Mrps33),
            transcript variant 1, mRNA.
ACCESSION   NM_010270
VERSION     NM_010270.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Liu,M.H., Lin,X.L. and Xiao,L.L.
  TITLE     SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3
            inflammasome activation by SCAP-SREBP signaling pathway
  JOURNAL   Tissue Cell 86, 102276 (2024)
   PUBMED   37979395
  REMARK    GeneRIF: SARS-CoV-2 nucleocapsid protein promotes TMAO-induced
            NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Liu,H., Nakagawa,T., Kanematsu,T., Uchida,T. and Tsuji,S.
  TITLE     Isolation of 10 differentially expressed cDNAs in differentiated
            Neuro2a cells induced through controlled expression of the GD3
            synthase gene
  JOURNAL   J Neurochem 72 (5), 1781-1790 (1999)
   PUBMED   10217254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU695761.1, BY296250.1, AK019000.1 and AI841153.1.
            
            On Jan 29, 2005 this sequence version replaced NM_010270.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144131.1, CB840826.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BU695761.1         79-96
            19-49               BY296250.1         14-44
            50-669              AK019000.1         2-621
            670-1061            AI841153.1         6-397               c
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.67 cM"
     gene            1..1061
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="mitochondrial ribosomal protein S33"
                     /db_xref="GeneID:14548"
                     /db_xref="MGI:MGI:1338046"
     exon            1..73
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /inference="alignment:Splign:2.1.0"
     exon            74..314
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..420
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ganglioside-induced differentiation-associated-protein 3;
                     28S ribosomal protein S33, mitochondrial; S33mt; small
                     ribosomal subunit protein mS33"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS33 isoform 1"
                     /protein_id="NP_034400.1"
                     /db_xref="CCDS:CCDS20026.1"
                     /db_xref="GeneID:14548"
                     /db_xref="MGI:MGI:1338046"
                     /translation="MSPLSEYALRMSRLSARIFGEVARSTDSKSMKVVSLFSEQPLAK
                     KKETYDWYPNHNTYFALMGNLRFLGLYRDEHQDFKDEQRRLKKLRGKGKPRKGEGKRA
                     TKKK"
     exon            315..1055
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /inference="alignment:Splign:2.1.0"
     regulatory      651..656
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="major polyA site"
     polyA_site      723
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
     regulatory      1032..1037
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="hexamer: AATAAA"
     polyA_site      1055
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
ORIGIN      
        1 gctctctgga gctgggaagc aagtaaaggg gggcgggcct tccggggacg cgcgtgcgcg
       61 aggtcaggag caggaatcct gttccctact ggtgaagaaa tgtctccgct ttcggagtat
      121 gcactgcgca tgtctcgtct gagtgcccgg atctttggtg aagtggccag gtctactgac
      181 tcaaagtcca tgaaagtggt gagcctgttt agcgagcagc ccttggccaa gaagaaagag
      241 acttatgact ggtatccaaa tcacaacacg tattttgcgc tcatgggcaa cctccgtttc
      301 cttggccttt acagagatga gcatcaggac tttaaggatg agcaacgacg tctaaagaag
      361 ctccgtggga aggggaaacc gaggaaagga gaagggaaga gagctacaaa aaagaaatag
      421 catcagctca tcaagaaagc aaatgccttc ctcagtgact aagaaagtgc atctcattat
      481 cttcccgagt attagaggaa catgacttcc ctcagtagac gccaaccctg tgttcacgtt
      541 ttacttcagt taagctgtga ctggtttctt gaagataata ttctaatcct tcaaaattat
      601 aatgaccttg gttttgtaat ctgaagcata cctaattcta taatggagtg aataaactat
      661 tgttgactga tgtgtttaag attggaatgg ctgttaggat tggagctgga gaacctccct
      721 aaatgaatgt cctgtgcttt ctttattcct ccattgcatc ccgacccaac cctaaccttg
      781 cctctctctg accagtgagc ctttgtattc accattaagc ttgctcttta gaaggtgctt
      841 aactgggatt aaaggttttc tgggacaggg agtattgaat gccttgtgta tacaaggtat
      901 tggagtttag taatagagtg gttaaaaagg aaaaacagtt tttagctcat ggaactttag
      961 gctttgtaga agaggctaat ataaatacat atatatttaa catagttata attgtgttgt
     1021 attacaataa taataaatgc tataaaggga aaaaaaaaaa a
//
