LOCUS       NM_001010930             945 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S33 (Mrps33),
            transcript variant 2, mRNA.
ACCESSION   NM_001010930
VERSION     NM_001010930.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 945)
  AUTHORS   Liu,M.H., Lin,X.L. and Xiao,L.L.
  TITLE     SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3
            inflammasome activation by SCAP-SREBP signaling pathway
  JOURNAL   Tissue Cell 86, 102276 (2024)
   PUBMED   37979395
  REMARK    GeneRIF: SARS-CoV-2 nucleocapsid protein promotes TMAO-induced
            NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
REFERENCE   2  (bases 1 to 945)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 945)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 945)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   5  (bases 1 to 945)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
REFERENCE   6  (bases 1 to 945)
  AUTHORS   Liu,H., Nakagawa,T., Kanematsu,T., Uchida,T. and Tsuji,S.
  TITLE     Isolation of 10 differentially expressed cDNAs in differentiated
            Neuro2a cells induced through controlled expression of the GD3
            synthase gene
  JOURNAL   J Neurochem 72 (5), 1781-1790 (1999)
   PUBMED   10217254
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU695761.1, BY296250.1, BC028645.1 and AI841153.1.
            
            Transcript Variant: This variant (2) lacks a segment in the coding
            region, as compared to variant 1. The encoded isoform 2 has a
            shorter and distinct C-terminus.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CB337944.1, CF356278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BU695761.1         79-96
            19-58               BY296250.1         14-53
            59-554              BC028645.1         1-496
            555-945             AI841153.1         6-396               c
FEATURES             Location/Qualifiers
     source          1..945
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.67 cM"
     gene            1..945
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="mitochondrial ribosomal protein S33"
                     /db_xref="GeneID:14548"
                     /db_xref="MGI:MGI:1338046"
     exon            1..73
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /inference="alignment:Splign:2.1.0"
     exon            74..198
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..204
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ganglioside-induced differentiation-associated-protein 3;
                     28S ribosomal protein S33, mitochondrial; S33mt; small
                     ribosomal subunit protein mS33"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS33 isoform 2"
                     /protein_id="NP_001010930.1"
                     /db_xref="CCDS:CCDS39464.1"
                     /db_xref="GeneID:14548"
                     /db_xref="MGI:MGI:1338046"
                     /translation="MSPLSEYALRMSRLSARIFGEVARSTDSKSMKVR"
     exon            199..939
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /inference="alignment:Splign:2.1.0"
     regulatory      535..540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="hexamer: AATAAA"
     polyA_site      563
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="major polyA site"
     polyA_site      607
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
     regulatory      916..921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
                     /note="hexamer: AATAAA"
     polyA_site      939
                     /gene="Mrps33"
                     /gene_synonym="CGI-139; Gdap3; MRP-S33; PTD003"
ORIGIN      
        1 gctctctgga gctgggaagc aagtaaaggg gggcgggcct tccggggacg cgcgtgcgcg
       61 aggtcaggag caggaatcct gttccctact ggtgaagaaa tgtctccgct ttcggagtat
      121 gcactgcgca tgtctcgtct gagtgcccgg atctttggtg aagtggccag gtctactgac
      181 tcaaagtcca tgaaagtgag atgagcatca ggactttaag gatgagcaac gacgtctaaa
      241 gaagctccgt gggaagggga aaccgaggaa aggagaaggg aagagagcta caaaaaagaa
      301 atagcatcag ctcatcaaga aagcaaatgc cttcctcagt gactaagaaa gtgcatctca
      361 ttatcttccc gagtattaga ggaacatgac ttccctcagt agacgccaac cctgtgttca
      421 cgttttactt cagttaagct gtgactggtt tcttgaagat aatattctaa tccttcaaaa
      481 ttataatgac cttggttttg taatctgaag catacctaat tctataatgg agtgaataaa
      541 ctattgttga ctgatgtgtt taagattgga atggctgtta ggattggagc tggagaacct
      601 ccctaaatga atgtcctgtg ctttctttat tcctccattg catcccgacc caaccctaac
      661 cttgcctctc tctgaccagt gagcctttgt attcaccatt aagcttgctc tttagaaggt
      721 gcttaactgg gattaaaggt tttctgggac agggagtatt gaatgccttg tgtatacaag
      781 gtattggagt ttagtaatag agtggttaaa aaggaaaaac agtttttagc tcatggaact
      841 ttaggctttg tagaagaggc taatataaat acatatatat ttaacatagt tataattgtg
      901 ttgtattaca ataataataa atgctataaa gggaaaaaaa aaaaa
//
