LOCUS       NM_025485               1230 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S22 (Mrps22), mRNA.
ACCESSION   NM_025485
VERSION     NM_025485.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1230)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1230)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1230)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1230)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   5  (bases 1 to 1230)
  AUTHORS   Cheong,A., Archambault,D., Degani,R., Iverson,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1230)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1230)
  AUTHORS   Yagi,M., Uchiumi,T., Takazaki,S., Okuno,B., Nomura,M., Yoshida,S.,
            Kanki,T. and Kang,D.
  TITLE     p32/gC1qR is indispensable for fetal development and mitochondrial
            translation: importance of its RNA-binding ability
  JOURNAL   Nucleic Acids Res 40 (19), 9717-9737 (2012)
   PUBMED   22904065
REFERENCE   8  (bases 1 to 1230)
  AUTHORS   Crisponi,L., Uda,M., Deiana,M., Loi,A., Nagaraja,R., Chiappe,F.,
            Schlessinger,D., Cao,A. and Pilia,G.
  TITLE     FOXL2 inactivation by a translocation 171 kb away: analysis of 500
            kb of chromosome 3 for candidate long-range regulatory sequences
  JOURNAL   Genomics 83 (5), 757-764 (2004)
   PUBMED   15081106
REFERENCE   9  (bases 1 to 1230)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   10 (bases 1 to 1230)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moseley,A., Koc,H. and
            Spremulli,L.L.
  TITLE     A proteomics approach to the identification of mammalian
            mitochondrial small subunit ribosomal proteins
  JOURNAL   J Biol Chem 275 (42), 32585-32591 (2000)
   PUBMED   10938081
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ183743.1, AK154600.1 and BE983156.1.
            
            On Jul 11, 2009 this sequence version replaced NM_025485.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051198.1, AK154600.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CJ183743.1         1-19
            20-1211             AK154600.1         1-1192
            1212-1230           BE983156.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1230
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 51.41 cM"
     gene            1..1230
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /note="mitochondrial ribosomal protein S22"
                     /db_xref="GeneID:64655"
                     /db_xref="MGI:MGI:1928137"
     exon            1..207
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1115
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /note="ribosomal protein, mitochondrial, S22; 28S
                     ribosomal protein S22, mitochondrial; MRP-S22; S22mt"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS22"
                     /protein_id="NP_079761.1"
                     /db_xref="CCDS:CCDS23427.1"
                     /db_xref="GeneID:64655"
                     /db_xref="MGI:MGI:1928137"
                     /translation="MAAVRTPLSLWRFQLGSRRARRVCTRATAQRHPDALLATRPQPF
                     EVGQPRRLLSSEAESGSSEVKKPAFMDEEVQRILTKITGLDLQKTFRPAIQPLKPPTY
                     KLMTQAQLEEATRLAVEAAKVRLKMPPVLEERKPINDVLAEDKILEGTETNKYVFTDI
                     SYNIPHRERFIVVREPSGTLRKASWEERDRVIQIYFPKEGRRVLPPVIFKDENLKTMY
                     SQDRHADVLNLCVAQFEPDSAEYIKVHHQTYEDIDRHGKYELLRSTRHFGGMAWYFVN
                     KKKIDGLLIDQIQRDLVDDATSLVQLYHMLHPDGQSAQEAKEQAAEGVDLIKVFAKTE
                     AQRGAYIELALQTYQEIVTSHSAAS"
     exon            208..371
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     exon            372..536
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     exon            537..680
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     exon            681..764
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     exon            765..910
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1019
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1216
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /note="hexamer: ATTAAA"
     polyA_site      1216
                     /gene="Mrps22"
                     /gene_synonym="3100002P07Rik; Rpms22"
                     /note="major polyA site"
ORIGIN      
        1 tctatcgatt ccggcgcaaa gagcgtctgg taatcatggc tgcagtcaga acaccgttgt
       61 cgctgtggag gttccaattg ggctctcggc gagcacggcg ggtctgtact cgggccacag
      121 cccagcgcca ccccgatgct ctgctcgcga cgcggcccca gccattcgag gtggggcagc
      181 ctcgccgcct gctcagctcc gaggcagagt ccggtagctc agaagtcaag aaacctgctt
      241 tcatggatga ggaggtccag aggatcctca ccaagattac aggcctggac ttgcagaaga
      301 ctttcaggcc tgccatacaa ccactgaagc caccaaccta taagttaatg acacaggcac
      361 agttggaaga ggctactaga ctggcagttg aggcagctaa agtacgatta aagatgccac
      421 cagttctgga agaacgaaag ccaataaatg acgtattagc tgaggataag atcttggaag
      481 gaacagaaac aaacaaatat gtgtttactg atatatcata taacatacca catcgggaac
      541 gttttattgt tgttagagaa ccaagtggca cactacgcaa agcttcatgg gaagaacggg
      601 acagagtgat acaaatttat ttcccgaaag aaggtcgtag agttttgcca ccagtaattt
      661 tcaaagatga aaaccttaag accatgtaca gccaagaccg gcatgctgat gtcctcaatc
      721 tctgtgttgc ccagtttgag ccagattccg ctgagtatat caaggttcat catcagacct
      781 atgaagatat agacagacat ggaaaatatg agcttttacg ttcaacaaga cactttggtg
      841 gaatggcttg gtattttgta aataaaaaaa agattgatgg tttgcttatt gatcagatcc
      901 agagagactt ggttgatgat gccaccagcc tggtccagct gtaccacatg ctccatccag
      961 atggccagtc agctcaagag gccaaagagc aggctgctga gggagtcgac ttaattaagg
     1021 tcttcgcaaa aacagaagca cagagaggag catatataga attagcactt caaacttatc
     1081 aagaaatagt taccagtcat tccgcagcat cctgagaaca gttaaaaaca catttcatag
     1141 taatgccctt ccattttggt aatactaagc tgaacattta aaaatcttgg gattaaaagg
     1201 tacttactga cttaaaaaaa aaaaaaaaaa
//
