LOCUS       NM_001355759             483 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S21 (Mrps21),
            transcript variant 2, mRNA.
ACCESSION   NM_001355759 XM_006501879
VERSION     NM_001355759.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 483)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 483)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 483)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 483)
  AUTHORS   Gopisetty,G. and Thangarajan,R.
  TITLE     Mammalian mitochondrial ribosomal small subunit (MRPS) genes: A
            putative role in human disease
  JOURNAL   Gene 589 (1), 27-35 (2016)
   PUBMED   27170550
  REMARK    Review article
REFERENCE   5  (bases 1 to 483)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   6  (bases 1 to 483)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   7  (bases 1 to 483)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 483)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 483)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092855.39, AK008265.1 and AC093317.22.
            
            On Sep 27, 2017 this sequence version replaced XM_006501879.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BY294820.1, CK788747.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC092855.39        48421-48437         c
            18-463              AK008265.1         3-448
            464-483             AC093317.22        8811-8830
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 41.36 cM"
     gene            1..483
                     /gene="Mrps21"
                     /gene_synonym="1810031B19Rik; S21mt"
                     /note="mitochondrial ribosomal protein S21"
                     /db_xref="GeneID:66292"
                     /db_xref="MGI:MGI:1913542"
     exon            1..62
                     /gene="Mrps21"
                     /gene_synonym="1810031B19Rik; S21mt"
                     /inference="alignment:Splign:2.1.0"
     exon            63..184
                     /gene="Mrps21"
                     /gene_synonym="1810031B19Rik; S21mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..365
                     /gene="Mrps21"
                     /gene_synonym="1810031B19Rik; S21mt"
                     /EC_number="3.6.5.3"
                     /note="28S ribosomal protein S21, mitochondrial"
                     /codon_start=1
                     /product="small ribosomal subunit protein bS21m"
                     /protein_id="NP_001342688.1"
                     /db_xref="CCDS:CCDS38550.1"
                     /db_xref="GeneID:66292"
                     /db_xref="MGI:MGI:1913542"
                     /translation="MAKHLKFIARTVMVQEGNVEGAYRTLNRILTTDGLTEVISRRRY
                     YEKPCRRRQRESYETCRRIYNMEMARKINFLMRKNRADPWLGC"
     exon            185..483
                     /gene="Mrps21"
                     /gene_synonym="1810031B19Rik; S21mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      442..447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps21"
                     /gene_synonym="1810031B19Rik; S21mt"
                     /note="hexamer: AATAAA"
     polyA_site      471
                     /gene="Mrps21"
                     /gene_synonym="1810031B19Rik; S21mt"
                     /note="major polyA site"
ORIGIN      
        1 gggactccgt agcttccgct tccggtccgc agagacccgg agtccgaatt cagaggcccc
       61 agtctgtagt cccggaagaa tgaagattta aatacgaggc catggctaaa catctgaagt
      121 tcattgccag gacagtgatg gttcaggagg ggaacgtgga aggtgcctac cggaccctga
      181 acagaatcct caccacggat gggcttaccg aagtcataag tcgacgacgc tactatgaga
      241 agccttgccg ccgccgccag cgggagagct atgaaacatg ccggaggatc tacaacatgg
      301 aaatggctcg aaagattaac ttcttgatgc gaaagaaccg tgcagacccg tggctgggct
      361 gctgaggctt ggggctaggc acccacacac ccatgtccaa ctcctttctt tatccagcca
      421 agttctgtta cttttctcta taataaaaac tccatcacag gtgaacaaga aggcttggac
      481 ata
//
