LOCUS       NM_080452               2079 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein S2 (Mrps2), transcript
            variant 1, mRNA.
ACCESSION   NM_080452
VERSION     NM_080452.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2079)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 2079)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 2079)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 2079)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   5  (bases 1 to 2079)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 2079)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK077219.1 and AK051184.1.
            
            On Oct 6, 2009 this sequence version replaced NM_080452.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK051184.1, AK165956.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1118              AK077219.1         170-1287
            1119-2079           AK051184.1         1119-2079
FEATURES             Location/Qualifiers
     source          1..2079
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..2079
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /note="mitochondrial ribosomal protein S2"
                     /db_xref="GeneID:118451"
                     /db_xref="MGI:MGI:2153089"
     exon            1..77
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..910
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /note="isoform 1 is encoded by transcript variant 1; 28S
                     ribosomal protein S2, mitochondrial; S2mt; MRP-S2; small
                     ribosomal subunit protein uS2m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS2m isoform 1"
                     /protein_id="NP_536700.3"
                     /db_xref="CCDS:CCDS15838.1"
                     /db_xref="GeneID:118451"
                     /db_xref="MGI:MGI:2153089"
                     /translation="MAPAPAVLTRLLCAGVRRWPGFLQKAIPGPAEQNGRKVTGAPVP
                     AVSEPQDGDDFQSRILDTPLQHSDFFNVKELFSVKSLFEARVHLGHKAGCRHRFMEPY
                     IFGNRLGQDIIDLDQTALNLQLALNFTAHVAYRKGIILFVSRNRQFSHLIETTAQACG
                     EYAHTRYFKGGLLTNAQLLFGPSVRLPDLIIFLHTLNNVFEPHVAVRDAAKMNIPTVG
                     IVDTNCNPCLITYPIPGNDDSPQAIQLFCKLFRTTINRAKEKRRQMEALHRLQSPKGS
                     EGSGTSPVPDKSHSP"
     exon            78..194
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            195..324
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            325..2079
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2067
                     /gene="Mrps2"
                     /gene_synonym="1500019M10Rik"
                     /note="major polyA site"
ORIGIN      
        1 gagtctctgc aggatctctg tccacgcgcc cgccatggcg cccgctccgg ccgtgctgac
       61 ccggctgctg tgtgcaggtg tgcggcgctg gccaggtttc ctgcagaagg cgatcccggg
      121 ccctgcggag cagaatggta ggaaggtcac gggagccccg gtccccgcag tcagcgagcc
      181 ccaggatggc gacgatttcc agagcaggat cctagatacg ccattacagc attcggattt
      241 cttcaatgtc aaggagctgt tttctgtgaa gagcctcttc gaggcccgag tacacctggg
      301 acataaagct ggttgccgcc ataggtttat ggagccgtac atctttggga accgcctggg
      361 ccaagatatc atcgatctgg atcagacagc cttgaatctc caactggctt tgaacttcac
      421 cgcgcacgtg gcctaccgca agggcatcat tctgtttgtg agccggaatc gtcagttctc
      481 tcacttaatt gagactacag cccaggcctg tggggagtac gcccacaccc gctacttcaa
      541 gggtggcttg ctgactaacg cacaactcct ctttgggcct tcagtccgcc taccagacct
      601 catcatcttt ctgcacacac tcaacaatgt ctttgaaccc catgtggctg tgagggatgc
      661 agccaagatg aacatcccca cagtgggcat tgtggacacc aactgcaacc catgcctcat
      721 cacttaccct atccctggca acgacgactc gccccaagct atccagctct tctgcaagct
      781 cttccggaca accatcaaca gggccaagga gaagaggagg cagatggagg ccctgcatcg
      841 gctgcagagt cccaaggggt ccgagggcag tgggacatct cctgtgcctg ataagagcca
      901 ttccccataa cagaaagccc ttctcccaca ctagatagcc agccctcttc tgagcaggaa
      961 ggtccttgtc caaccctggt ctgtgtcccc actccctgtc ctcagcatca gcaccacagt
     1021 cctatttcct tagatatggc caccccaaag tccaatgatc ttgagctaac ccttatctgt
     1081 ctcttttctg ggaacaaact caggtaaagt acctagtcac atggcctctg gcatccatta
     1141 agacttgaac atagctagcc aagtttccgc ttttcagtta aaattaatcc tccattgtct
     1201 gctaattaat ccttcattct ctgaagaaaa ttccaagcaa aaccaacact gatgtccctc
     1261 aggaccccca gtagttgcct ctagacctgt aaccaggcta agcaggctcc cagagggaag
     1321 ataggaagta tagtccatgc attgtgctgc actactaaag aacttaatga gtttgctaat
     1381 tcattcaagc agaagtctgg ggaatatatg tgggaatgga ttttaaaggt ttggggtaat
     1441 ggaaagaaca taaaactgaa tcaggctgag ttttatggat atgggcttct ctggagctct
     1501 tatgtttaat atggaagctc gcacagtgaa aaaaggtgtc aaaagtttgt tccatgtttg
     1561 gctgaagtat tttttaaaag aacctactga tgggagcaca aaagtccttg agcccacaga
     1621 tcaccaagga aaccaggaat gttaatcaca tagggttgac tccccaaaga aggaaatcca
     1681 tacctgtttc ccacccagag gactgggcgt ggatgttgtt aatgacctgg tgacctttgc
     1741 tatttgtaga gccagacctc acccaaatgc cccctaaatg tttgtcttgg actcttcctt
     1801 cctagacctt tatttttaac ttagtttctc caccaataaa atccatgctt aggggagatg
     1861 tcacaagtat tttataacct gctgacctct acattatctt ggtcagagac cataccagat
     1921 cctaggccct taagctatag gacccatctt tgtggtcggt gtactttgag ctgagtttca
     1981 atgtaattat gcctcttata cccgggattg tattacatca ggaaactttt ccagaattgt
     2041 actattttaa tatatgttta cagtaaacca cctggtgtc
//
