LOCUS       NM_026729                770 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L58 (Mrpl58),
            transcript variant 1, mRNA.
ACCESSION   NM_026729
VERSION     NM_026729.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 770)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 770)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 770)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 770)
  AUTHORS   Feaga,H.A., Quickel,M.D., Hankey-Giblin,P.A. and Keiler,K.C.
  TITLE     Human Cells Require Non-stop Ribosome Rescue Activity in
            Mitochondria
  JOURNAL   PLoS Genet 12 (3), e1005964 (2016)
   PUBMED   27029019
  REMARK    GeneRIF: Because ICT1 is essential in human cells, these results
            suggest that ribosome rescue activity in mitochondria is required
            in humans
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 770)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 770)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 770)
  AUTHORS   Handa,Y., Hikawa,Y., Tochio,N., Kogure,H., Inoue,M., Koshiba,S.,
            Guntert,P., Inoue,Y., Kigawa,T., Yokoyama,S. and Nameki,N.
  TITLE     Solution structure of the catalytic domain of the mitochondrial
            protein ICT1 that is essential for cell vitality
  JOURNAL   J Mol Biol 404 (2), 260-273 (2010)
   PUBMED   20869366
  REMARK    GeneRIF: solution structure of the catalytic domain of the ICT1
            protein that lacks an N-terminal mitochondrial targeting signal and
            an unstructured C-terminal basic-residue-rich extension
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY137982.1, AK003192.1 and AW456161.1.
            
            On Mar 19, 2018 this sequence version replaced NM_026729.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD776020.1, AK003192.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BY137982.1         2-15
            15-748              AK003192.1         1-734
            749-770             AW456161.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..770
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..770
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /note="mitochondrial ribosomal protein L58"
                     /db_xref="GeneID:68572"
                     /db_xref="MGI:MGI:1915822"
     exon            1..122
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..557
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /EC_number="3.1.1.29"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peptidyl-tRNA hydrolase ICT1, mitochondrial; large
                     ribosomal subunit protein mL62; immature colon carcinoma
                     transcript 1 protein homolog; 39S ribosomal protein L58,
                     mitochondrial"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL62 isoform 1"
                     /protein_id="NP_081005.1"
                     /db_xref="CCDS:CCDS25632.1"
                     /db_xref="GeneID:68572"
                     /db_xref="MGI:MGI:1915822"
                     /translation="MATAWGLRWGLSRTGTLLLAPPARCARRALHRQEHAKQASSYIP
                     LDRLSISYCRSSGPGGQNVNKVNSKAEVRFHLASADWIEEPVRQKIALTHKNKINKAG
                     ELVLTSESSRYQFRNLAECLQKIRDMIAEASQVPKEPSKEDARLQRLRIEKMNRERLR
                     QKRLNSALKTSRRMTMD"
     exon            123..159
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            160..219
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            220..302
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            303..472
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            473..754
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      734..739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /note="hexamer: AATAAA"
     polyA_site      754
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /note="major polyA site"
ORIGIN      
        1 ggaagcggtc ctgggaggtg aacatggcga ccgcctgggg cctacgctgg ggcctgagcc
       61 gaactggaac gttgttgctc gcgccgcccg cgcgctgtgc tcgccgggct ctgcacagac
      121 aggagcatgc aaaacaagcc agcagttaca tccctctgga tcggttaagc atatcttact
      181 gtcggagcag cggtcctggt gggcagaatg tgaacaaagt gaattccaag gctgaagtaa
      241 ggtttcactt ggccagtgca gactggattg aggagcccgt gcgccagaag attgccctca
      301 cgcataaaaa taagatcaac aaggcaggag agctggtact tacctctgag agcagccggt
      361 atcagttccg caatctggca gaatgcctac agaaaattcg agacatgatt gccgaggcca
      421 gccaggtacc caaagagcca tccaaggaag atgctcggct tcagagactc aggattgaaa
      481 agatgaatcg ggaaaggcta cgacagaaaa gactaaactc tgccctaaag accagcagga
      541 ggatgactat ggactgaagt cggccctccc tgctggcata gacctgagtg ccagtgcagc
      601 tcagcagagc actgacacac acaggagact tttctcgatt aaccgccctg cccgagcagc
      661 gttcctttgg agggaggctg cagatcatcc agggctgccc cttccgttat ccacctcatg
      721 aatcactggc tgcaataaac atcgaagcac aggaaaaaaa aaaaaaaaaa
//
