LOCUS       NM_001347645            2613 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L58 (Mrpl58),
            transcript variant 2, mRNA.
ACCESSION   NM_001347645 XM_006534064
VERSION     NM_001347645.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2613)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2613)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 2613)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 2613)
  AUTHORS   Feaga,H.A., Quickel,M.D., Hankey-Giblin,P.A. and Keiler,K.C.
  TITLE     Human Cells Require Non-stop Ribosome Rescue Activity in
            Mitochondria
  JOURNAL   PLoS Genet 12 (3), e1005964 (2016)
   PUBMED   27029019
  REMARK    GeneRIF: Because ICT1 is essential in human cells, these results
            suggest that ribosome rescue activity in mitochondria is required
            in humans
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2613)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 2613)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 2613)
  AUTHORS   Handa,Y., Hikawa,Y., Tochio,N., Kogure,H., Inoue,M., Koshiba,S.,
            Guntert,P., Inoue,Y., Kigawa,T., Yokoyama,S. and Nameki,N.
  TITLE     Solution structure of the catalytic domain of the mitochondrial
            protein ICT1 that is essential for cell vitality
  JOURNAL   J Mol Biol 404 (2), 260-273 (2010)
   PUBMED   20869366
  REMARK    GeneRIF: solution structure of the catalytic domain of the ICT1
            protein that lacks an N-terminal mitochondrial targeting signal and
            an unstructured C-terminal basic-residue-rich extension
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB857370.1, CX566707.1, BC079614.1 and AW495606.1.
            
            On Dec 3, 2016 this sequence version replaced XM_006534064.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028523.1, SRR1660815.119275.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BB857370.1         3-16
            15-838              CX566707.1         1-824
            839-2584            BC079614.1         777-2522
            2585-2613           AW495606.1         1-29                c
FEATURES             Location/Qualifiers
     source          1..2613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.84 cM"
     gene            1..2613
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /note="mitochondrial ribosomal protein L58"
                     /db_xref="GeneID:68572"
                     /db_xref="MGI:MGI:1915822"
     exon            1..209
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..644
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /EC_number="3.1.1.29"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; peptidyl-tRNA hydrolase ICT1, mitochondrial;
                     large ribosomal subunit protein mL62; immature colon
                     carcinoma transcript 1 protein homolog; 39S ribosomal
                     protein L58, mitochondrial"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL62 isoform 2
                     precursor"
                     /protein_id="NP_001334574.1"
                     /db_xref="CCDS:CCDS83928.1"
                     /db_xref="GeneID:68572"
                     /db_xref="MGI:MGI:1915822"
                     /translation="MATAWGLRWGLSRTGTLLLAPPARCARRALHRQVDGTTFQSIYS
                     LDKLYPESKGADTAWKVPEHAKQASSYIPLDRLSISYCRSSGPGGQNVNKVNSKAEVR
                     FHLASADWIEEPVRQKIALTHKNKINKAGELVLTSESSRYQFRNLAECLQKIRDMIAE
                     ASQVPKEPSKEDARLQRLRIEKMNRERLRQKRLNSALKTSRRMTMD"
     exon            210..246
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            247..306
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            307..389
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            390..559
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            560..2596
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      821..826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /note="hexamer: AATAAA"
     polyA_site      841
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /note="major polyA site"
     regulatory      1679..1684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
                     /note="hexamer: AATATA"
     polyA_site      1705
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
     polyA_site      2596
                     /gene="Mrpl58"
                     /gene_synonym="1110001A02Rik; 1110002E03Rik; Ict1;
                     MRP-L58"
ORIGIN      
        1 ggaagcggtc ctgggaggtg aacatggcga ccgcctgggg cctacgctgg ggcctgagcc
       61 gaactggaac gttgttgctc gcgccgcccg cgcgctgtgc tcgccgggct ctgcacagac
      121 aggtagacgg caccacgttc cagagcatct acagcctgga caagctgtac cccgagtcca
      181 agggcgcgga taccgcctgg aaggtcccgg agcatgcaaa acaagccagc agttacatcc
      241 ctctggatcg gttaagcata tcttactgtc ggagcagcgg tcctggtggg cagaatgtga
      301 acaaagtgaa ttccaaggct gaagtaaggt ttcacttggc cagtgcagac tggattgagg
      361 agcccgtgcg ccagaagatt gccctcacgc ataaaaataa gatcaacaag gcaggagagc
      421 tggtacttac ctctgagagc agccggtatc agttccgcaa tctggcagaa tgcctacaga
      481 aaattcgaga catgattgcc gaggccagcc aggtacccaa agagccatcc aaggaagatg
      541 ctcggcttca gagactcagg attgaaaaga tgaatcggga aaggctacga cagaaaagac
      601 taaactctgc cctaaagacc agcaggagga tgactatgga ctgaagtcgg ccctccctgc
      661 tggcatagac ctgagtgcca gtgcagctca gcagagcact gacacacaca ggagactttt
      721 ctcgattaac cgccctgccc gagcagcgtt cctttggagg gaggctgcag atcatccagg
      781 gctgcccctt ccgttatcca cctcatgaat cactggctgc aataaacatc gaagcacagg
      841 agcctgtttc cagtgagagc tttgcacagg gctcttacct ttgggtctaa gcccacctta
      901 tagttagcac atacagcaac agaggattgt gagtccgtcc acaaggagca cacagttagg
      961 agggccgaga tgggtgagca gacatttgag ctggaccttc agaaagacaa actgaacaca
     1021 gtgggctggg gggaagctgg gtggcaggag gaaacaggga agtcagggac gcctaatggc
     1081 agattgtgta ggagactttt gagaagtgta ccgggcaggt agacacatag agccccaaaa
     1141 tccattgagc tccattccca ggccagaagt cccgggatta tttacttaca tatatagtgg
     1201 gtggatgtat gtgtgccaca cgcacacaga ggttagagag caactagcag tcacctcttc
     1261 ctccctgcgg atagaactca agtctcaggc ttaagggcaa atatcttcac ctgcccagcc
     1321 atttcactct ctctagttta tttagtatca ggtgaggtat gcatgtctgg aggtcagaga
     1381 acaactcctg ggcatcagtt cttgtcctcc atcatgtagg tcccaaggac caatcaggct
     1441 tggccacaag cacctataac tgctgagccg tatcagcagc ccctgaaggt tgtttattat
     1501 acaccccaac ccccaaatgt atctattttt aaaaccaaaa atgaaggcca gagaaagaac
     1561 ctcgctgtcc acactgccac gagttagatc cctggtacct acacggtaga gagaactgac
     1621 tcaggagagg tggtttctga cctccacaag ctccatgaag catccatgtg cacacacaaa
     1681 tataacttaa gttttcttaa tcaaataagc tttgccctgg tcagtttccc ggagaccaga
     1741 atttggattc cacattagcc tgaaaattga gtaccattag tgtcaagcaa agtcagttat
     1801 ctataggagg taaagcattg tgttgggtgg catgaaaatg tggtaaattt gctttgtcat
     1861 tttattctgc tccagggttc tgccatgcaa gagaatccag gcctaaaatg taaacctcca
     1921 agctgatgag ctgtcactgg acttgggtgg gggtttataa caattatttc cactattaat
     1981 cttgttagca gttccccagg tcattgctga tcctggccgc tcctccttca cagcttccta
     2041 caattgtcca atctccacat tgctccaaat gctttcaaac ttcagcttta gctccaagca
     2101 tggtccccac tgccccaccc cccacccccg ttgcagtgaa gtcagcattg agaaacagag
     2161 caggaaattg ttaggattaa ctacagggac caattattcc acacggacaa gccatttact
     2221 aaacaaatgc ttcctgtgct cagttacata gttgcataca ccacacatac ctcctttcaa
     2281 gcctcagccc tttcccagaa cctctacacc taccacgaag ccattgctaa gctatacctc
     2341 ccagactgct cagcgcttcc agccctccgg gtctttttta aagtgcgttt taacactaca
     2401 ataccaagat agctgtctct tttggtttgt ccttttcctc tcttcctgct cttttgacgc
     2461 ccgccctccg gtgtattgtg tatttgcaaa gtacatacgt agtgtctgaa tgtttctatc
     2521 gttactggaa ggatcgggaa gattttcagt gcacatgttt caatactgtc aatattatga
     2581 ctgatacttg tcgcccaaaa aaaaaaaaaa aaa
//
