LOCUS       NM_025595               1515 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus mitochondrial ribosomal protein L51 (Mrpl51), mRNA.
ACCESSION   NM_025595
VERSION     NM_025595.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   6  (bases 1 to 1515)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   7  (bases 1 to 1515)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 1515)
  AUTHORS   Wang,N., Wang,L., Le,F., Zhan,Q., Zheng,Y., Ding,G., Chen,X.,
            Sheng,J., Dong,M., Huang,H. and Jin,F.
  TITLE     Altered expression of Armet and Mrlp51 in the oocyte,
            preimplantation embryo, and brain of mice following oocyte in vitro
            maturation but postnatal brain development and cognitive function
            are normal
  JOURNAL   Reproduction 142 (3), 401-408 (2011)
   PUBMED   21730110
  REMARK    GeneRIF: The change in Armet expression lasted while the change of
            Mrpl51 disappeared after birth.
REFERENCE   9  (bases 1 to 1515)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 1515)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC166162.6.
            
            On Apr 29, 2007 this sequence version replaced NM_025595.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK012126.1, BY711314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC166162.6         165521-165754
            235-345             AC166162.6         165837-165947
            346-1515            AC166162.6         166544-167713
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 59.32 cM"
     gene            1..1515
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /note="mitochondrial ribosomal protein L51"
                     /db_xref="GeneID:66493"
                     /db_xref="MGI:MGI:1913743"
     exon            1..234
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..542
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /EC_number="3.6.5.3"
                     /note="mitochondrial ribosomal protein 64; large ribosomal
                     subunit protein mL51; 39S ribosomal protein L51,
                     mitochondrial; L51mt; bMRP64; MRP-L51; bMRP-64"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL51 precursor"
                     /protein_id="NP_079871.1"
                     /db_xref="CCDS:CCDS20545.1"
                     /db_xref="GeneID:66493"
                     /db_xref="MGI:MGI:1913743"
                     /translation="MAGSVPWAASRRLWGWVPSACRSFSLGVPRLAFVRLTLPPPKVV
                     DRWNEKRALFGVYDNIGILGNFEKHPKELIKGPVWLRGWRGNELQRCVRKKKFVGNRM
                     FIEDLHNLNKRISYLYKHFNRHGKYR"
     exon            235..345
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /inference="alignment:Splign:2.1.0"
     exon            346..1515
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      618..623
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /note="hexamer: AATAAA"
     polyA_site      648
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /note="major polyA site"
     polyA_site      785
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
     polyA_site      829
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
     regulatory      1349..1354
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
                     /note="hexamer: AATAAA"
     polyA_site      1373
                     /gene="Mrpl51"
                     /gene_synonym="2610511M02Rik; CDA09; HSPC241; Mrp64"
ORIGIN      
        1 gctacctggg taaggcccaa aatggctcct cttactgtca ctaccgtgtg agtcccgcct
       61 gggactgtaa tctgtgtctt ggctttggaa ttcacacccg ctccccattt ttccggctgg
      121 tttgctgccc ctactgaggc ggacaggcta gagtaatggc agggagtgtc ccttgggcgg
      181 caagtaggag actgtggggc tgggtgccct cggcatgccg aagcttctct ctgggcgtcc
      241 cacggttggc cttcgtaagg ctcactcttc cacctcccaa agtggttgat cgctggaacg
      301 agaagagggc tctgtttggc gtctacgaca acattggaat cctggggaat ttcgagaagc
      361 acccaaaaga actgatcaag ggcccagtat ggcttcgagg ctggagagga aatgaattgc
      421 agcgttgtgt ccgaaagaag aaatttgtgg gaaacaggat gttcattgag gacctgcata
      481 accttaacaa acggatcagc tatctctaca aacactttaa ccgacatggg aagtacagat
      541 aggacgggaa atgtgtcacc ctggagaagg ggaacaggac ttatcccagc aaggagagag
      601 ctttgtgtgc tcgatgtaat aaaaaaatgg ggctcctttg gaatctgata tgcccagtgc
      661 tacatttact catgcactct gacgtctgcc tcgttcctaa gtcacatgat cttttgttac
      721 tattacttac agcccagtta tgcttgtggc ctttataaca atcatttatt gctggcactt
      781 tctgacactg gcacctcgtg taagttttta aagaatttat ttttatttat tttatcttat
      841 ttttttgtaa tcttggagct gaaacccagg gacttgctca ttctagggaa ctctgccact
      901 agccgcccag gcccttggaa gtgtagctgc tatttctaaa gactctgcca ccccaaaatg
      961 aactaggaaa gtgaaattac actttgtact gctcttatca gttataagtt agggaacttg
     1021 tctgagtacc acagcatttc ccatcctctt gaatagggca gttttgtgga ggctgacctt
     1081 gagtcatgcc cagttttatg aagtgttaaa gatcacaccc agtattaccc ctgtgtgtgc
     1141 taccctgttt gctttttttt tttttttagg ggaaaaaaat gtcatttaag aaagatattt
     1201 tagggctggt gagatggcac tgactgctct tctgaaggtc ctgagttcaa atcccagcag
     1261 ccacatggtg gctcacaacc acccataatg agatctgacg ccctcttctg gtgcatctga
     1321 agtcagtcac agtgtactta tttttaataa taaaaaagtc tttgatcatt ggaccagagc
     1381 aagtggagtt gaccagagag agcaaggtca actgaggcag cagaggtcct aaattcaatt
     1441 cccaacaacc acatgaagcc tcacaaccat ctgtacagct acagtgtact cacatacatt
     1501 aaataaatct ttttt
//
