LOCUS       NM_026246               1726 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L49 (Mrpl49), mRNA.
ACCESSION   NM_026246
VERSION     NM_026246.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1726)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 1726)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1726)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 1726)
  AUTHORS   Yoshikawa,T., Piao,Y., Zhong,J., Matoba,R., Carter,M.G., Wang,Y.,
            Goldberg,I. and Ko,M.S.
  TITLE     High-throughput screen for genes predominantly expressed in the ICM
            of mouse blastocysts by whole mount in situ hybridization
  JOURNAL   Gene Expr Patterns 6 (2), 213-224 (2006)
   PUBMED   16325481
REFERENCE   5  (bases 1 to 1726)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 1726)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK150572.1.
            
            On Feb 7, 2019 this sequence version replaced NM_026246.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK150715.1, AK150572.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1726              AK150572.1         2-1727
FEATURES             Location/Qualifiers
     source          1..1726
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..1726
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /note="mitochondrial ribosomal protein L49"
                     /db_xref="GeneID:18120"
                     /db_xref="MGI:MGI:108180"
     exon            1..97
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..520
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /note="neighbor of fau 1; 39S ribosomal protein L49,
                     mitochondrial"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL49"
                     /protein_id="NP_080522.1"
                     /db_xref="CCDS:CCDS29488.1"
                     /db_xref="GeneID:18120"
                     /db_xref="MGI:MGI:108180"
                     /translation="MAAAVLRAALQDWRSCLGRSYGRRKLSQTQGPPDNPGFVESVDE
                     YQFVERLLPPTKIPEPPKHKHYPTPSGWQPPRDPLPSLPYFVRRSRMHNIPVYKEITH
                     GNRQMTLIRKVEGDIWALQKDVEEFLSPLLGKTPITQVNEVTGTLRIKGYFDEQLKAW
                     LLEKGF"
     exon            98..248
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /inference="alignment:Splign:2.1.0"
     exon            249..373
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..1726
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1440..1445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /note="hexamer: ATTAAA"
     polyA_site      1464
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /note="major polyA site"
     regulatory      1688..1693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
                     /note="hexamer: ATTAAA"
     polyA_site      1718
                     /gene="Mrpl49"
                     /gene_synonym="L49mt; MRP-L49; Nof1"
ORIGIN      
        1 actcagttga ggcgccaaga tggcagcagc ggtgttgcga gccgctttgc aggactggag
       61 gagctgcctc ggtcggagct acgggcgacg gaagctgagc cagacccagg ggcctcctga
      121 taaccccggc tttgtggagt ctgtggatga ataccaattt gtggagcgcc tgctcccccc
      181 taccaaaatc ccagagccac caaaacataa acattacccc actcctagtg gttggcagcc
      241 tcccagagat cctcttccca gcttgcccta ctttgttcgt cgctctcgga tgcacaatat
      301 tcctgtctac aaggagatca cacacggcaa ccgacagatg accttgattc ggaaagtgga
      361 aggtgacatc tgggccctac agaaggatgt ggaagaattt ctgagcccac tgctgggaaa
      421 gacacctatc acccaggtta atgaggtgac aggtactctt cgaatcaagg gctactttga
      481 tgagcaactt aaagcctggc ttcttgagaa aggcttctga ggcctgatgg tcagccctgt
      541 ggcagtgctc gcgacagact ggcctccaga gaggaggtgg atttgagtct ctggaatggg
      601 atacaaaaat cagggcttaa gtacttagga tgaaagggct ttgagataag gccttgcttt
      661 cataaagtac aagtagacct gtgtgtccat gtgtccactt gagagctgtc ccaacatggg
      721 aggccatagc aacaatcaag ctatcaaaag cagatattaa ctgctgtata gataatctct
      781 tgtgcattgt gtggaagcat cccctgtcaa tcaaaagctg atggccagtg agctgaggca
      841 ggactagaag gcgggacatc tgacagggag attcaccctg gacttggagg aagcaggatg
      901 tagcaaactg aggagaggaa actcaccagc catgtggcag gcgtagtctc gtttaaatgg
      961 gttaaatggg ttatgaacta gtgggagcaa gtctagttta cggccataag cattgcacat
     1021 acaaatgcgc ctgtaagtca taattcagga actgggctga gcaccagtgg aaaagcctga
     1081 gattacaaac tgctgtccca ttataaactt aatacatttc ctattgtttg ctgttctgga
     1141 agcgaccacc caaccctgtt ctggaggctt cacagcatag acccatcaag gaatcaatcc
     1201 ttgacctaga gctcctgcta taggccgggc gtggtggaag ctatggaaca gaagacagta
     1261 cagcaaaaag acatggacgg gagtggatga gacaagcaat atcttaggtt ctgagtgctg
     1321 tactaggtag ggttggggaa tcaccctgtg acctgtaatc aactatacag gggtgtgaag
     1381 acaaaatgca gacctttcac ttctggcgcc cacctcacca gccacatgtc caacccacca
     1441 ttaaactggc taaacaatgt taaacggtgt tcagaacctg cctaccctgt gtgacctcag
     1501 acctaaggta gctagcggta gcaacctccc agtgctctct agttgctgat ctcagcaccc
     1561 tcatcccagg aaccacaggc cggtccattc ttaggtctgt agactaagag cccagcccta
     1621 ccctaggtga cacgttctac caatcattaa tgcaagtttt tattgagctg tatatacaat
     1681 ttaagctatt aaaatttata caatatttac aaattaaata atcatc
//
