LOCUS       NM_029017                899 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L47 (Mrpl47), mRNA.
ACCESSION   NM_029017 XM_912441
VERSION     NM_029017.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 899)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 899)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 899)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 899)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 899)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 899)
  AUTHORS   Araki,T., Hayashi,M. and Saruta,T.
  TITLE     Cloning and characterization of a novel gene promoting ureteric bud
            branching in the metanephros
  JOURNAL   Kidney Int 64 (6), 1968-1977 (2003)
   PUBMED   14633119
  REMARK    GeneRIF: Novel molecule in developing kidney that is capable of
            modulating ureteric bud branching and kidney differentiation.
            [Metanephros-derived tubulogenic factor]
REFERENCE   7  (bases 1 to 899)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY013327.1, CX122942.1 and
            AA174956.1.
            
            On Mar 5, 2010 this sequence version replaced NM_029017.1.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. This gene is
            immediately adjacent to the gene for BRG1/brm-associated factor 53A
            (also known as BAF complex 53 kDa subunit protein A in humans) in a
            tail-to-tail orientation. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087953.1, BQ884589.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BY013327.1         1-21
            22-638              CX122942.1         1-617
            639-899             AA174956.1         77-337
FEATURES             Location/Qualifiers
     source          1..899
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3"
     gene            1..899
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /note="mitochondrial ribosomal protein L47"
                     /db_xref="GeneID:74600"
                     /db_xref="MGI:MGI:1921850"
     exon            1..114
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..775
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /note="metanephros-derived tubulogenic factor; 39S
                     ribosomal protein L47, mitochondrial"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL29m"
                     /protein_id="NP_083293.1"
                     /db_xref="CCDS:CCDS17299.1"
                     /db_xref="GeneID:74600"
                     /db_xref="MGI:MGI:1921850"
                     /translation="MAATSLVGICRRASAFLKAACSLVNPKDAAHSGCRSSLSLLHKN
                     TPHVTSFLQCKLLHTTLSRKGLEEFFDDPKNWGEEKVKSGASWTCQQLRNKSNEDLHK
                     LWYVLLKERNMLLTLEQEAKRQRLPMPSPERLEKVVDSMDNVDKVVQEREDALRLLQT
                     GQEKPRPGAWRRDIFGRIVWHKFKQWPIPWYLNKRYNRRRFFAMPYVDRFIRLRIEKH
                     ARIEARKRSLQKKKEKILHAKFPHLSQERKSSSV"
     exon            115..266
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            267..327
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            328..424
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            425..555
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            556..651
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..872
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      851..856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /note="hexamer: AAGAAA"
     polyA_site      872
                     /gene="Mrpl47"
                     /gene_synonym="4833424P18Rik; CGI-204; Gm9859; L47mt;
                     MRP-L47; MTF/L47; NCM1"
                     /note="major polyA site"
ORIGIN      
        1 ggtctccatt agaaacatgg ctgcgaccag tctagtgggt atttgtagaa gagcctcagc
       61 gttcctgaag gcagcttgtt ccctagtaaa tcccaaggac gctgctcact cgggttgcag
      121 gtcttctctt agtttgttac ataagaacac accacatgtc acatcttttc tccagtgtaa
      181 attacttcat accacgttgt caaggaaagg actggaagaa ttttttgatg acccaaagaa
      241 ttggggggaa gaaaaagtca aatctggagc ttcatggacc tgccagcagc tgaggaacaa
      301 aagtaacgaa gacttacata agctttggta tgtccttctg aaggaaagaa acatgcttct
      361 aactctggag caggaggcca agcgacagag gttgccaatg ccaagtccgg agcgcttaga
      421 aaaggtcgtt gattccatgg ataacgtaga taaagttgtc caggagaggg aagatgctct
      481 aaggcttctt cagaccggtc aagaaaagcc cagacccggt gcttggagaa gggacatctt
      541 tggacgaatt gtctggcaca aattcaagca gtggcctata ccttggtacc taaataaaag
      601 atacaacagg aggcggttct tcgcaatgcc ttatgtggat cgctttatca gactaagaat
      661 tgagaaacac gcccgcattg aagcaagaaa gagaagttta cagaaaaaga aagaaaaaat
      721 tctccatgca aagttcccac atctctctca agaacggaaa tcaagtagtg tctaagatga
      781 gacccagaag tctggttcca ttgttcttaa agcctgtgtc ctgacgtgaa tacctgttaa
      841 gcagtttata aagaaatgtt cttgtcaagt gaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
