LOCUS       NM_053164               1061 bp    mRNA    linear   ROD 06-AUG-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L43 (Mrpl43), mRNA.
ACCESSION   NM_053164
VERSION     NM_053164.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Bailey,P.J., Klos,J.M., Andersson,E., Karlen,M., Kallstrom,M.,
            Ponjavic,J., Muhr,J., Lenhard,B., Sandelin,A. and Ericson,J.
  TITLE     A global genomic transcriptional code associated with CNS-expressed
            genes
  JOURNAL   Exp Cell Res 312 (16), 3108-3119 (2006)
   PUBMED   16919269
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Tyynismaa,H., Sembongi,H., Bokori-Brown,M., Granycome,C.,
            Ashley,N., Poulton,J., Jalanko,A., Spelbrink,J.N., Holt,I.J. and
            Suomalainen,A.
  TITLE     Twinkle helicase is essential for mtDNA maintenance and regulates
            mtDNA copy number
  JOURNAL   Hum Mol Genet 13 (24), 3219-3227 (2004)
   PUBMED   15509589
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132957.3.
            
            On Jan 7, 2022 this sequence version replaced NM_053164.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065812.1, AK076204.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC132957.3         113537-113694       c
            159-265             AC132957.3         113336-113442       c
            266-1061            AC132957.3         112418-113213       c
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.19 cM"
     gene            1..1061
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /note="mitochondrial ribosomal protein L43"
                     /db_xref="GeneID:94067"
                     /db_xref="MGI:MGI:2137229"
     exon            1..158
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..507
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /note="39S ribosomal protein L43, mitochondrial; L43mt;
                     MRP-L43; mitochondrial ribosomal protein bMRP36a"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL43"
                     /protein_id="NP_444394.1"
                     /db_xref="CCDS:CCDS38000.1"
                     /db_xref="GeneID:94067"
                     /db_xref="MGI:MGI:2137229"
                     /translation="MTGRGTSSRFLTSVLHNGLGRYVQQLQRLSLSLSRDAPSSRGAR
                     EFVEREVTDFARRNPGVVVYVNPRPCAMPRIVAEYLNGAVREENVNSKSVEEIKSLVQ
                     KLADQSGLDVIRIRKPFHTDNPSIQGQWHPFTNKRTALHGLRPRELRDSAPASMQAQ"
     exon            159..265
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /inference="alignment:Splign:2.1.0"
     exon            266..1061
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      765..770
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /note="hexamer: AATAAT"
     polyA_site      784
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /note="major polyA site"
     polyA_site      1033
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
     regulatory      1037..1042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /note="hexamer: AATAAA"
     regulatory      1044..1049
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
                     /note="hexamer: AAGAAA"
     polyA_site      1056
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
     polyA_site      1061
                     /gene="Mrpl43"
                     /gene_synonym="4930442D21Rik; bMRP36a"
ORIGIN      
        1 ccgcgtcctg gctctctaac cgtagccatg accggtcgcg ggacttcgag ccgctttctg
       61 accagcgtcc tccataatgg gctagggcgt tacgtgcagc agctgcagcg cctcagcctc
      121 agcctcagcc gggatgcgcc ctcgtcccgc ggcgccaggg agttcgtgga acgcgaggtg
      181 accgacttcg cccgacggaa cccaggagtc gtagtatacg tgaacccgcg cccgtgcgcc
      241 atgccacgaa tagtggccga ataccttaat ggggctgtgc gcgaggaaaa cgtcaacagc
      301 aagtcggtgg aggagatcaa gtcgttggtg cagaagctgg cagaccagtc cggcttggat
      361 gtgatccgca tccgcaagcc cttccacacg gacaacccga gcatccaggg ccagtggcac
      421 cccttcacca acaaacggac tgccctccac gggctgcggc ccagagaact ccgggattct
      481 gctccagctt cgatgcaagc acagtaaaga accaggcgct ttggaccgtg agagggatag
      541 gattggttcc tcttttggat ttcaagctca ggccgagtag gtgggtggag cctaccagcc
      601 ggggcgtggc ctgagataaa gaagaacctt ttcctttgcc cacttgtagc taggtgcagt
      661 gaccttgtga ataccctaat tctgattcaa ttggcctcct tgcaagctga gatgtgagaa
      721 gtgtacaaca cttgtacaag gaccgtgttt tctgaaatac gaataataat gacttcaaaa
      781 cacatgaaag agtctggagg ctgtcttctg aaggacacgg gatgccctgt tgctcttgct
      841 ggtatggcat tgggcaaggc accttatatc cgtgtttgtg tgcagtttag gaagttgaag
      901 atgagcctgg cgttggtagt gcataacctt taatcccagc atttggttgg cagaggcaga
      961 tgaatctctg cgtttaaggc cagcttggtc tacagagtga gttccaggac aacccagtct
     1021 caaaaactaa aaatgaaata aaaaagaaaa agaaaactga a
//
