LOCUS       NM_001364513            2275 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L3 (Mrpl3), transcript
            variant 3, mRNA.
ACCESSION   NM_001364513
VERSION     NM_001364513.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2275)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2275)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 2275)
  AUTHORS   Cahill,L.S., Cameron,J.M., Winterburn,J., Macos,P., Hoggarth,J.,
            Dzamba,M., Brudno,M., Nutter,L.M.J., Sproule,T.J., Burgess,R.W.,
            Henkelman,R.M. and Sled,J.G.
  TITLE     Structural Variant in Mitochondrial-Associated Gene (MRPL3) Induces
            Adult-Onset Neurodegeneration with Memory Impairment in the Mouse
  JOURNAL   J Neurosci 40 (23), 4576-4585 (2020)
   PUBMED   32341096
  REMARK    GeneRIF: Structural Variant in Mitochondrial-Associated Gene
            (MRPL3) Induces Adult-Onset Neurodegeneration with Memory
            Impairment in the Mouse.
REFERENCE   4  (bases 1 to 2275)
  AUTHORS   Cheong,A., Archambault,D., Degani,R., Iverson,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2275)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   6  (bases 1 to 2275)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   7  (bases 1 to 2275)
  AUTHORS   Yagi,M., Uchiumi,T., Takazaki,S., Okuno,B., Nomura,M., Yoshida,S.,
            Kanki,T. and Kang,D.
  TITLE     p32/gC1qR is indispensable for fetal development and mitochondrial
            translation: importance of its RNA-binding ability
  JOURNAL   Nucleic Acids Res 40 (19), 9717-9737 (2012)
   PUBMED   22904065
REFERENCE   8  (bases 1 to 2275)
  AUTHORS   Sproule,T.J., Sled,J.G., Wentzell,J., Wang,B., Henkelman,R.M.,
            Roopenian,D.C. and Burgess,R.W.
  TITLE     A mouse model of heritable cerebrovascular disease
  JOURNAL   PLoS One 5 (12), e15327 (2010)
   PUBMED   21217823
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2275)
  AUTHORS   Diehl,F., Brown,M.A., van Amerongen,M.J., Novoyatleva,T.,
            Wietelmann,A., Harriss,J., Ferrazzi,F., Bottger,T., Harvey,R.P.,
            Tucker,P.W. and Engel,F.B.
  TITLE     Cardiac deletion of Smyd2 is dispensable for mouse heart
            development
  JOURNAL   PLoS One 5 (3), e9748 (2010)
   PUBMED   20305823
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2275)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008592.1 and AK054185.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.9819.1,
                                           SRR7345562.3347133.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               AK008592.1         31-595
            566-2275            AK054185.1         1-1710
FEATURES             Location/Qualifiers
     source          1..2275
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9"
     gene            1..2275
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /note="mitochondrial ribosomal protein L3"
                     /db_xref="GeneID:94062"
                     /db_xref="MGI:MGI:2137204"
     exon            1..245
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1068
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /note="isoform 3 is encoded by transcript variant 3; 39S
                     ribosomal protein L3, mitochondrial; large ribosomal
                     subunit protein uL3m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL3m isoform 3"
                     /protein_id="NP_001351442.1"
                     /db_xref="CCDS:CCDS90652.1"
                     /db_xref="GeneID:94062"
                     /db_xref="MGI:MGI:2137204"
                     /translation="MPGWRLLAQAGARVLGCGARGLGADPGLERRKNILFFVRNLHSK
                     SSTWWDEHLSEENLSFVKQLVSDENKTQLTSKLNPLKDEPWPLHPWEPGSFRVGLIAL
                     KLGMMPLWTKDGQKHAVTLLQVQDCHVLKYTPKEDHNGKIAALTVGGKTVSRFYKPDS
                     RLEFYRDLGLPPKQIHKIFHVTDNAVIKPGTPLYAAHFRPGQYVDVTAKTIGKGFQGV
                     MKRWGFKGQPASHGQTKTHRRPGAISTGDIARVWPGTKMPGRMGNQNRTVYGLKVWRV
                     NTKHNIIYVNGSVPGHKNCLVKVCTAVC"
     exon            246..430
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     exon            431..522
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     exon            523..621
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     exon            622..721
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     exon            722..782
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     exon            783..891
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     exon            892..969
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2275
                     /gene="Mrpl3"
                     /gene_synonym="2010320L16Rik; 5930422H18Rik; dcr; L3mt"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcttttcctc cgcggagggc attggcggac aaacggcgtg actgctgtcc caggcctact
       61 acgaactcct ggggtttggg ttggggactt gctgaaagct ccgcggcggc gcggcgggag
      121 gtgtcgcgag ccgagccctg cccggccact tccatgccgg gttggaggct gctggcgcag
      181 gctggcgccc gggtgctggg ctgtggcgcc agaggcctag gtgctgaccc cggcttagag
      241 agaagaaaga atatcttgtt ctttgttaga aatctccaca gcaagagtag tacttggtgg
      301 gatgaacatc tttctgaaga aaatctctcc tttgttaagc aactggtctc cgatgaaaat
      361 aaaacccagc tgacaagtaa actgaatccc ttgaaagatg agccgtggcc tttacatccc
      421 tgggaaccag gttctttcag agttggcctc atcgccctga agctaggcat gatgccttta
      481 tggaccaagg atggtcaaaa gcatgcagtc acattactac aggtacaaga ctgtcatgtg
      541 ttaaaataca ctcccaagga agaccataat ggaaaaatcg cagccctgac agtgggcggg
      601 aaaaccgtgt cacgcttcta taaacctgac tctagattgg aattttaccg agatcttgga
      661 ctgccaccaa aacagataca taaaatcttt catgtgacag ataacgctgt aattaagcca
      721 gggacccctc tttatgcagc tcactttcgc cctggacagt atgtggatgt cacagccaaa
      781 actattggta aaggttttca gggcgtcatg aaaagatggg gatttaaagg ccaacctgct
      841 tctcatggtc aaacaaagac ccacaggaga cctggcgcta tctcaactgg ggatattgcc
      901 agagtctggc ctggaactaa aatgcccggg cgaatgggaa accaaaacag gacagtgtat
      961 ggactgaaag tgtggagagt gaacaccaag cacaacataa tctatgtcaa tggctctgtg
     1021 cctggacata aaaattgctt agtaaaggta tgtacggctg tctgctaaag gtgcgtacaa
     1081 ttctcctcct cgttgcccgg tcctttccat gaattctctc cgctcgctcg ctcgctcgct
     1141 cgctctgttc tgcagcttct aaagaagcgc ctctgctgcc gcgtgccctg ccccggctct
     1201 ctttgtagga gcgtctcaga aacaacaaaa gccgcgctgg aaataatacg ctgcacactg
     1261 gagccaggag tccagcagtc tgtggcaaag aaggcttcag ggaggggagc cattgcccag
     1321 tgtccctcat ctgtctttcc agaaatttgg ggaaagaata agaagtgctg aagtggaggc
     1381 cagggtctta ctgacatgcc actcagtcac acctgcctcc ccaaacacct gctgtccttg
     1441 tcagaactaa agagaaaggg aaaagggaaa taagactaac gtgtagacca gatagactga
     1501 ggtaaagcct gggcgcttcc gaggatctgc cgtgtgagtg ggctcatagc tgaggtgagc
     1561 ccgtcgctga tgccccagca gaaacaaata gagaccacag tgtgagctgt atacttacta
     1621 cattagatgt gttcatttat actgggaaca gcatcagagc tttgagacgg gaaaccctca
     1681 ggtatggtgg atacataaaa gtgatgagaa gtcactactt gcatcctatg tgacaatgtt
     1741 tatcagatta gcacacagtt ttcttatagg gtgttttcct agttaaagct gagcctaagg
     1801 ttgggcattg gagaaaacgg aatgtgatgg ttccctgggc agcgtcttgg ccacttcccg
     1861 atcaattgta atgaggggca ttaaaataga actcttttta tatacttagt tgttcctaac
     1921 agctgctgac taattttgac taaattattt atttctcatt gttaaaatga accagcccta
     1981 ttttattgtt tatgtaagtg tatttttttt tctctgaatt gagtctacag aagctttgag
     2041 gatcccaata ttatccaaaa ctaaagttca gcatcttgga tcttatcagc acctctgcta
     2101 agggacatct gctgtgaatc cagacataat ctgaaagttt tcaggccata aaatgttctc
     2161 agagcttctg taaacacttg tgggtttctt tctcttgttt ttgctgaatg tcgtcattct
     2221 gtctttaact tctcagttag aatgctcctt gccaaatata agctactttc tttaa
//
