LOCUS       NM_024227               1080 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L28 (Mrpl28), mRNA.
ACCESSION   NM_024227
VERSION     NM_024227.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1080)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 1080)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1080)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 1080)
  AUTHORS   Lin,C., Theodorides,M.L., McDaniel,A.H., Tordoff,M.G., Zhang,Q.,
            Li,X., Bosak,N., Bachmanov,A.A. and Reed,D.R.
  TITLE     QTL analysis of dietary obesity in C57BL/6byj X 129P3/J F2 mice:
            diet- and sex-dependent effects
  JOURNAL   PLoS One 8 (7), e68776 (2013)
   PUBMED   23922663
  REMARK    Publication Status: Online-Only
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY138937.1, AK163190.1 and
            AI849911.1.
            
            On Mar 5, 2010 this sequence version replaced NM_024227.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005797.1, AK163190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY138937.1         2-18
            18-1063             AK163190.1         1-1046
            1064-1080           AI849911.1         1-17                c
FEATURES             Location/Qualifiers
     source          1..1080
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 13.07 cM"
     gene            1..1080
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /note="mitochondrial ribosomal protein L28"
                     /db_xref="GeneID:68611"
                     /db_xref="MGI:MGI:1915861"
     exon            1..347
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..833
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /note="39S ribosomal protein L28, mitochondrial"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL28m"
                     /protein_id="NP_077189.2"
                     /db_xref="CCDS:CCDS37509.1"
                     /db_xref="GeneID:68611"
                     /db_xref="MGI:MGI:1915861"
                     /translation="MPLHRYPVHLWQKLRLRQGICARLPAHFLRSLEEERTPTPVHYK
                     PHGTKFKINPKNGQRERVEDVPIPVHYPPESQQGLWGGEGLILGYRYANNDKLSKRVK
                     KVWKPQLFTRELYSEILDKKFTVTVTMRTLDLIDEAYGFDFYILKTPKEDLGSKFGMD
                     LKRGMLLRLARQDPHLHPENPERRAAIYDKYRSFVIPEAEAEWVGLTLEEALEKQRLL
                     EEKDPVPLFKVYVEELVQRLQEQVLSRPAVVQKRAGDHA"
     exon            348..500
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /inference="alignment:Splign:2.1.0"
     exon            501..635
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /inference="alignment:Splign:2.1.0"
     exon            636..722
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /inference="alignment:Splign:2.1.0"
     exon            723..1065
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1040..1045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /note="hexamer: AGTAAA"
     polyA_site      1065
                     /gene="Mrpl28"
                     /gene_synonym="1110015G04Rik; L28mt; MAAT1; MRP-L28; p15"
                     /note="major polyA site"
ORIGIN      
        1 gacgctattc cggttccggg aggcgcgggc gcgctctcct agaagtagag ggtcgcgcga
       61 tgccgctgca caggtatcct gtgcacctgt ggcagaagct gcggctgcgg cagggcatct
      121 gtgcgcgctt gcccgcccac ttcttgcgct cactggaaga agaacggacg ccgaccccgg
      181 tacactacaa acctcacggg accaagttca agatcaaccc caagaatggg cagcgcgagc
      241 gcgttgagga cgtacccatt ccagttcact accctccaga gtcccagcag ggactgtggg
      301 gtggagaggg cttgatttta ggctacagat acgccaacaa cgacaagctc tccaagaggg
      361 tgaagaaggt gtggaagcca cagctgttca ctcgggagct ttacagtgaa atcctggaca
      421 agaagttcac cgtgactgtg accatgagga ccctggatct catcgatgag gcctatggat
      481 ttgacttcta tattctcaag acccctaagg aggacctggg ctccaagttt ggcatggacc
      541 tgaagcgagg gatgctgctg aggcttgctc gccaggaccc ccatctccac cctgagaacc
      601 ctgagcggag agcagccatc tatgacaagt acaggagctt tgtcatcccc gaggcagagg
      661 ccgagtgggt tggcctgacg ctggaggagg ccctggagaa acagaggctt ctggaggaaa
      721 aggaccctgt acccctgttc aaggtctacg tagaggagct ggtccagcgg cttcaggagc
      781 aggttctgtc caggcccgca gtggtgcaga agagagccgg tgaccacgcc tgagcactgg
      841 gctcagcctc ccctgtgggc agtgggcgaa ccccacttgg catgtgccga gcacacagtt
      901 cctgtggtag acttttcaga gaacccttct gtgccaggac tcgtggaagc ctggagcgga
      961 gcagatgcct gtccaagctg gtcaagtcct tctagttctt gggctgaaat aagtaacagt
     1021 ctgaggcagc ctgcgccaca gtaaagtgtg ttggtttgct tggaaaaaaa aaaaaaaaaa
//
