LOCUS       NM_175001                720 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L22 (Mrpl22),
            transcript variant 1, mRNA.
ACCESSION   NM_175001
VERSION     NM_175001.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 720)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 720)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 720)
  AUTHORS   Cheong,A., Archambault,D., Degani,R., Iverson,E., Tremblay,K.D. and
            Mager,J.
  TITLE     Nuclear-encoded mitochondrial ribosomal proteins are required to
            initiate gastrulation
  JOURNAL   Development 147 (10) (2020)
   PUBMED   32376682
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 720)
  AUTHORS   Vincentz,J.W., Firulli,B.A., Toolan,K.P., Arking,D.E.,
            Sotoodehnia,N., Wan,J., Chen,P.S., de Gier-de Vries,C.,
            Christoffels,V.M., Rubart-von der Lohe,M. and Firulli,A.B.
  TITLE     Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA
            Transcription Factor Binding and Disrupts Conduction System
            Development and Function
  JOURNAL   Circ Res 125 (6), 575-589 (2019)
   PUBMED   31366290
REFERENCE   5  (bases 1 to 720)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   6  (bases 1 to 720)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   7  (bases 1 to 720)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 720)
  AUTHORS   Carninci,P., Waki,K., Shiraki,T., Konno,H., Shibata,K., Itoh,M.,
            Aizawa,K., Arakawa,T., Ishii,Y., Sasaki,D., Bono,H., Kondo,S.,
            Sugahara,Y., Saito,R., Osato,N., Fukuda,S., Sato,K., Watahiki,A.,
            Hirozane-Kishikawa,T., Nakamura,M., Shibata,Y., Yasunishi,A.,
            Kikuchi,N., Yoshiki,A., Kusakabe,M., Gustincich,S., Beisel,K.,
            Pavan,W., Aidinis,V., Nakagawara,A., Held,W.A., Iwata,H., Kono,T.,
            Nakauchi,H., Lyons,P., Wells,C., Hume,D.A., Fagiolini,M.,
            Hensch,T.K., Brinkmeier,M., Camper,S., Hirota,J., Mombaerts,P.,
            Muramatsu,M., Okazaki,Y., Kawai,J. and Hayashizaki,Y.
  TITLE     Targeting a complex transcriptome: the construction of the mouse
            full-length cDNA encyclopedia
  JOURNAL   Genome Res 13 (6B), 1273-1289 (2003)
   PUBMED   12819125
REFERENCE   9  (bases 1 to 720)
  AUTHORS   Goldschmidt-Reisin,S., Kitakawa,M., Herfurth,E.,
            Wittmann-Liebold,B., Grohmann,L. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins. N-terminal amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 273 (52), 34828-34836 (1998)
   PUBMED   9857009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928857.15.
            
            On Mar 19, 2020 this sequence version replaced NM_175001.4.
            
            Transcript Variant: This variant (1) represents the protein-coding
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061191.1, BI110332.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AL928857.15        3573-3622
            51-99               AL928857.15        3703-3751
            100-217             AL928857.15        4942-5059
            218-283             AL928857.15        7186-7251
            284-361             AL928857.15        8041-8118
            362-431             AL928857.15        9126-9195
            432-720             AL928857.15        11187-11475
FEATURES             Location/Qualifiers
     source          1..720
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 35.89 cM"
     gene            1..720
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /note="mitochondrial ribosomal protein L22"
                     /db_xref="GeneID:216767"
                     /db_xref="MGI:MGI:1333794"
     exon            1..50
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..643
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /note="39S ribosomal protein L22, mitochondrial; large
                     ribosomal subunit protein uL22m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL22m precursor"
                     /protein_id="NP_778166.2"
                     /db_xref="CCDS:CCDS24724.1"
                     /db_xref="GeneID:216767"
                     /db_xref="MGI:MGI:1333794"
                     /translation="MAAALLRELGALRVPNLRIWATQTLRVLPPSCIHTSASLDISRK
                     WEKKNKIVYPPQLPGEPRRPAEIYHCRRQIKYSKDKMWYLAKMIRGMSIDQALAQLEF
                     NDKKGAQIIKEVLLEAQDMAVRDHNVEFRSNLHIAESTSGRGQCLKRIRYHGRGRFGI
                     MEKVYCHYFVKLVEGPPPPPEVPKTAVDHAKDYIQQLRSRTIIHTL"
     exon            51..99
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /inference="alignment:Splign:2.1.0"
     exon            100..217
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /inference="alignment:Splign:2.1.0"
     exon            218..283
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /inference="alignment:Splign:2.1.0"
     exon            284..361
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /inference="alignment:Splign:2.1.0"
     exon            362..431
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /inference="alignment:Splign:2.1.0"
     exon            432..720
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      700..705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /note="hexamer: AGTAAA"
     polyA_site      720
                     /gene="Mrpl22"
                     /gene_synonym="E030011D16Rik; HSPC158; L22mt; MRP-L22;
                     MRP-L25; Rpml25"
                     /note="major polyA site"
ORIGIN      
        1 ggaggcttcc gtagggctca gcatggcggc cgcactactg cgagagttgg gtgcactgag
       61 ggtacctaac ctgaggatct gggcaacgca gacgctgcgg gttttacccc cgtcgtgcat
      121 ccacacgagt gcttctcttg acatttctcg caaatgggag aagaagaata agattgttta
      181 cccacctcaa ctgcctggcg aacctcggag accagcggaa atttaccatt gtcggagaca
      241 aataaaatac agcaaggaca agatgtggta cctggcaaag atgatacgag gcatgtccat
      301 tgatcaggct ttggcgcagc tggagttcaa tgataaaaag ggggctcaaa tcattaaaga
      361 ggttctctta gaagcacaag acatggcagt gagagaccat aatgtggaat tcagatccaa
      421 cttacacata gctgagtcta cctcaggccg aggccagtgc ctgaagcgca tccgttacca
      481 tggccgaggt cgctttggca ttatggagaa ggtctattgc cactattttg taaagctggt
      541 ggaaggaccc cctcccccac ccgaagtacc caagacagca gttgaccacg ccaaggacta
      601 tattcagcag cttcgcagcc ggaccatcat ccatactcta tgagatctgt gcaggtcatc
      661 ctggctccac ggtgtatata gcttatgttt attttaaaaa gtaaaaacaa gtgattttta
//
