LOCUS       NM_025302               1047 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L2 (Mrpl2), transcript
            variant 1, mRNA.
ACCESSION   NM_025302
VERSION     NM_025302.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1047)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 1047)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1047)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 1047)
  AUTHORS   O'Brien,T.W., Fiesler,S.E., Denslow,N.D., Thiede,B.,
            Wittmann-Liebold,B., Mougey,E.B., Sylvester,J.E. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins (2). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 274 (51), 36043-36051 (1999)
   PUBMED   10593885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY343877.1, AK009521.1 and AI837821.1.
            
            On Oct 24, 2015 this sequence version replaced NM_025302.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC027762.1, AK009521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               BY343877.1         2-132
            132-1028            AK009521.1         107-1003
            1029-1047           AI837821.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..1047
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..1047
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /note="mitochondrial ribosomal protein L2"
                     /db_xref="GeneID:27398"
                     /db_xref="MGI:MGI:1351622"
     exon            1..170
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..995
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 39S ribosomal protein L2, mitochondrial;
                     ribosomal protein, mitochondrial, L14; large ribosomal
                     subunit protein uL2m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL2m isoform 1
                     precursor"
                     /protein_id="NP_079578.1"
                     /db_xref="CCDS:CCDS37638.1"
                     /db_xref="GeneID:27398"
                     /db_xref="MGI:MGI:1351622"
                     /translation="MALCALTSALRSLSLASAAITARVPTLLPAAQIQSNVLLQLPPA
                     LVSPSYRPVHMSADRSAKFVSWKSRTKYTVKPVKMRKSGGRDHTGRIRVHGIGGGHKQ
                     NYRMIDFLRFRPEKEKAPEPFEEKVVVVRYDPCRSADIALVAGGSRKRWIIATENMKA
                     GDTILNSNHIGRMAVAAQEGDAHPLGALPVGTLINNVESEPGRGAQYIRAAGTCGVLL
                     RKVNGTAIIQLPSKRQMQVLESCTATVGRVSNVNHNQRVIGKAGRNRWLGKRPNSGLW
                     QRKGGWAGRKIRPLPPMKSYVKLPSAAAQN"
     exon            171..339
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /inference="alignment:Splign:2.1.0"
     exon            340..481
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /inference="alignment:Splign:2.1.0"
     exon            482..597
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /inference="alignment:Splign:2.1.0"
     exon            598..708
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /inference="alignment:Splign:2.1.0"
     exon            709..782
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /inference="alignment:Splign:2.1.0"
     exon            783..1031
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1010..1015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /note="hexamer: AATAAA"
     polyA_site      1031
                     /gene="Mrpl2"
                     /gene_synonym="CGI-22; L2mt; MRP-L14; MRP-L2; Rpml14"
                     /note="major polyA site"
ORIGIN      
        1 ggaacgtcat cccagagcgc caggctctgg atgaaggtaa aagcgagcac ggcgcggagg
       61 agcccggccg gcccatggcg ctgtgtgcgc tgacgagtgc tctgcgctct ttgagcctgg
      121 catccgcggc cattaccgcc cgggttccga ctctgctccc tgctgcccag atacagagca
      181 atgtcctcct tcagctgccc cctgccttgg tgtcgccctc ttaccgccca gtgcatatgt
      241 ctgcggaccg cagtgccaag tttgtgtcct ggaagagtcg taccaagtac acagttaaac
      301 cagtgaagat gaggaagtct gggggtcgag accatacagg ccgcatccga gtgcatggta
      361 tcggtggagg ccacaaacag aattatcgca tgattgactt tctacggttc cggccagaaa
      421 aggaaaaggc accagaaccg tttgaggaga aggttgtggt agtccgctat gatccttgta
      481 ggtctgcaga catagctctg gttgctgggg gtagccggaa gcgctggatc attgccacgg
      541 aaaacatgaa ggctggagat acaatcctga actctaatca cataggcagg atggcagtgg
      601 ccgcccagga gggggatgca catccacttg gggcgctgcc tgtggggacc ctcatcaaca
      661 acgtagagag cgagcctggc cggggagccc agtatatccg agctgcaggg acatgcggtg
      721 tgctgcttcg gaaggtgaac gggacagcca ttatccagct gccctcgaag aggcaaatgc
      781 aggtgctgga gtcatgcact gcaactgtag gccgagtatc caacgttaac cataaccagc
      841 gggtcatcgg caaggcagga aggaaccgct ggctgggcaa gaggcctaac agtgggctgt
      901 ggcaacgcaa gggaggctgg gccggccgaa agattcggcc actaccaccc atgaagagtt
      961 atgtgaagct gccctccgct gctgcccaaa actgattgcc ctggactcta ataaaatgtc
     1021 tcttgttttt aaaaaaaaaa aaaaaaa
//
