LOCUS       NM_025301               6712 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L17 (Mrpl17), mRNA.
ACCESSION   NM_025301
VERSION     NM_025301.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6712)
  AUTHORS   He,X.D., Taylor,L.F., Miao,X., Shi,Y., Lin,X., Yang,Z., Liu,X.,
            Miao,Y.L., Alfandari,D., Cui,W., Tremblay,K.D. and Mager,J.
  TITLE     Overlapping peri-implantation phenotypes of ZNHIT1 and ZNHIT2
            despite distinct functions during early mouse developmentdagger
  JOURNAL   Biol Reprod 111 (5), 1017-1029 (2024)
   PUBMED   39194072
REFERENCE   2  (bases 1 to 6712)
  AUTHORS   He,X.D., Phillips,S., Hioki,K., Majhi,P.D., Babbitt,C.,
            Tremblay,K.D., Pobezinsky,L.A. and Mager,J.
  TITLE     TATA-binding associated factors have distinct roles during early
            mammalian development
  JOURNAL   Dev Biol 511, 53-62 (2024)
   PUBMED   38593904
REFERENCE   3  (bases 1 to 6712)
  AUTHORS   Srinivasan,S., He,X., Mirza,S. and Mager,J.
  TITLE     Exosome complex components 1 and 2 are vital for early mammalian
            development
  JOURNAL   Gene Expr Patterns 51, 119346 (2024)
   PUBMED   37940010
REFERENCE   4  (bases 1 to 6712)
  AUTHORS   Bell,C.J., Gupta,N., Tremblay,K.D. and Mager,J.
  TITLE     Borcs6 is required for endo-lysosomal degradation during early
            development
  JOURNAL   Mol Reprod Dev 89 (8), 337-350 (2022)
   PUBMED   35726782
REFERENCE   5  (bases 1 to 6712)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   6  (bases 1 to 6712)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   7  (bases 1 to 6712)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   8  (bases 1 to 6712)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 6712)
  AUTHORS   O'Brien,T.W., Fiesler,S.E., Denslow,N.D., Thiede,B.,
            Wittmann-Liebold,B., Mougey,E.B., Sylvester,J.E. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins (2). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 274 (51), 36043-36051 (1999)
   PUBMED   10593885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY098205.1, AK007828.1, AK147957.1 and AC121823.3.
            
            On Jan 14, 2006 this sequence version replaced NM_025301.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147957.1, AK144092.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BY098205.1         13-32
            21-66               AK007828.1         2-47
            67-2592             AK147957.1         2-2527
            2593-6712           AC121823.3         58667-62786
FEATURES             Location/Qualifiers
     source          1..6712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 55.98 cM"
     gene            1..6712
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="mitochondrial ribosomal protein L17"
                     /db_xref="GeneID:27397"
                     /db_xref="MGI:MGI:1351608"
     exon            1..280
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..637
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="39S ribosomal protein L17, mitochondrial; L17mt;
                     MRP-L17; ribosomal protein, mitochondrial, L26; large
                     ribosomal subunit protein bL17m"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL17m precursor"
                     /protein_id="NP_079577.1"
                     /db_xref="CCDS:CCDS21662.1"
                     /db_xref="GeneID:27397"
                     /db_xref="MGI:MGI:1351608"
                     /translation="MRLSLAAAISHGRVYRRLGLGPESRIHLLRNLLTGLVRHERIEA
                     TWARADEMRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFKVLAPRFQGQNG
                     NYTRMLQIPNRKEQDRAKMAVIEYKGNYLPPLPLPHRDSNLTLLNQLLLGLQQDLHHN
                     QDASLHSSCTVQTPKT"
     exon            281..349
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /inference="alignment:Splign:2.1.0"
     exon            350..6712
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      808..813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="hexamer: AATATA"
     polyA_site      814
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="major polyA site"
     regulatory      888..893
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="hexamer: AGTAAA"
     polyA_site      913
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="major polyA site"
     regulatory      1157..1162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="hexamer: ATTAAA"
     polyA_site      1176
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="major polyA site"
     polyA_site      1730
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="hexamer: ACTAAA"
     polyA_site      2076
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
     regulatory      3775..3780
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="hexamer: AACAAG"
     polyA_site      3802
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
     regulatory      3971..3976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
                     /note="hexamer: GATAAA"
     polyA_site      3995
                     /gene="Mrpl17"
                     /gene_synonym="MRP-L26; Rpml26"
ORIGIN      
        1 ctctgagacg tgcctccgcc cctctgctcc ccctctcccc gcgcgcgcac acacagctcg
       61 gagtttccct ttccgggccc ccgagaggag gggctgaggt gagagcatga ggttgtcgct
      121 ggctgccgct atctcccacg gccgcgtcta ccgccgcctg ggcctgggtc cggagtcccg
      181 catccatctg ctgcggaact tgctcacggg cctagttcgc cacgaacgca tcgaggcgac
      241 atgggcacgc gcggacgaga tgaggggcta cgcggagaag ctcatcgatt atggaaagct
      301 gggcgacacc aacgaacgag ccatgcgtat ggctgacttc tggctcacag agaaggactt
      361 gatcccaaag ctgtttaaag tgctagcgcc tcggttccaa ggtcagaatg ggaactacac
      421 aagaatgcta cagatcccga atcggaagga gcaagatcgg gccaagatgg cggtgataga
      481 atataaaggg aactacctcc ctcccctgcc tctgcctcac agagacagca accttactct
      541 cctaaaccag ctgctcctgg gactgcagca ggacctgcac cataaccagg acgcaagcct
      601 ccacagctcc tgtacagttc aaacaccaaa gacttaactg gagctggaga gtggtgcata
      661 ggtgtggtgc ccgtgttcgt gggtcttgga gctcgtgtag tgtgtgaggc ctggaagtag
      721 cattgtaaag ccccctcata atgagaccca gacctccctg ctgactcaca cgatcctctt
      781 tgcacagaag ataaaagtct taatatgaat ataagatatt gactttcttg tccttcccta
      841 ggatttatgg aaagtaagag gcatccagat gctcagcctc ctaagacagt aaattcacaa
      901 cttaggttct aaattctagg tctagttttg cttgtttgtt ggaggggagg ggatcttgct
      961 gtgtaatcca gactatatcc accatgcagc agtcctcctg tccctgtgtt cccaagtgtt
     1021 caccaccaca cagtgccagt ttgctttggt tttgtttttt ctgagacagt ttctttgact
     1081 gtcttagaac tctgtttgta gaccaggttg gccttgaact aagcgatcca cctgcctctg
     1141 cctcctcagt actaggatta aaggtatggg gcactacctc ctggctcagt ttgcttatct
     1201 caacactaat ttagatgggc cctgtacctc ttgattccaa accatcttcc tatggtgact
     1261 ggctgacgtc cagcatagag acccaccgtt ggaattcctt ttttgctttt ataagttata
     1321 catgagaatc tttatgaatc ctatgagact aggtttcacc ttggcatctt catacatatc
     1381 taccaatgtc ttttgaccat gcttaccacc acatgcatgc accctattgt cctgcctatt
     1441 tcaactagtc ccccttccac ttgatgtctt tttatgtgtg tgattatgtc ctggcgagtt
     1501 tcattagtcc tgcttacagg agcatgtgtg tgtcttacca atggctgtac cactgtctgt
     1561 ccatccacaa aggagggtgc agccgcctga gcttctaacc cccttcttaa caggattttg
     1621 acaggctact atgagagcaa gcattcagtc ccaagagatt gcttcctgat aactagctgt
     1681 gtgagcctct gtacaggaat cttcaaataa catggtaccc ctaaaactga gaattgtttc
     1741 taggcaaggt cacatttgtt tcactcaatg tctgaatggg ttttgaatgt ggactcaaat
     1801 agatgtatca ccaccctgat catagatagg gctgtaggca tctgccagga tgttggcctt
     1861 ccggataagt tccttcctct tagagggtgt gaagaggaag gttgatagag agtgatgcat
     1921 tagaaagtta agcctgctgg gaatttcctg gaagcttttg ttgccaaaag tggacctctg
     1981 tgggaaccca gaaagaggaa atcctgtttc agaatggcca gggtatgtga gaagcatgga
     2041 gcttatttat atccactaaa tatgggatat gacccatcct ggctgctgtt ctgtatgttc
     2101 agagacttga ccagggagtc atggaaagaa gttctcctga acaattagtg cagcacctga
     2161 aggtagaagg tcactgtgga agcagaaaga cattagcttc agtgacacta ttctaagact
     2221 ctttgcccta cagctgctta cactaaatca cctggtcccg gcagagctgt cactcttcct
     2281 tctgcataga acttgacatg ttttttgtaa atctttatcc cttttcctat cttttgagca
     2341 tttacaagtt agatgcctga gtcatgactt gttctaggaa aagcccttcc cttaaaacca
     2401 aatcttggaa gactttgcaa caggtaaaat atgaaagggc tctcagattt ttttttgaac
     2461 acccaccatt tggagcttta atatttccct aaatgtttta tacttcttta ttgagtaggg
     2521 agggtacatg catctcagaa tgcagataga ggccagagga cagctttccc aagttcttcc
     2581 aacctgtggt tcctaggtat ggaagacagg tcatcagact tagtagcaag tgccttctga
     2641 gctgtatctc taccccttct attagaagca tccgaatctc cagcatcacc ttacatacta
     2701 gagattgcat acttcaagca tatttgcagt aaatctgacc ctggctaaaa gtgaagcatc
     2761 agcagtcaag gagctcacag ttgtacaggg cactacatat ctaataatct ggccccccaa
     2821 agttgacaaa tcctaagaca tctactgaag gctttgttaa tctgcctgta tttgtaaata
     2881 actgcctttg agtagacatt gcctaaatac caagccaagc ccttctcatc gcttcgaaag
     2941 agtggttctc cacatcgagt tccagatttt gatctacaca aacatggatc ctctgtgtag
     3001 tcttggctgt cctggaactc actctgtagg ctaggctggc cttgaactta gagatcttcc
     3061 tgcctctgcc tcccttgtgc tgagattgaa ggtacatatt gccatactca tggtaaggat
     3121 tgggggggag ggtttcaatt ctttacaata aggttgacaa actaatgtcc ctcacccacc
     3181 caaaaaacct aacacactta cttaaaagtt tagcactatg aacccaatac ctacctatca
     3241 tttttaaacc gagtaactgt atccctgtat cttaagtgga gtcatgtcct gctttatctc
     3301 cattagcaaa tatgcaattg ttcctagtgg gatgtcccag gcacaaagtt gtcatgatag
     3361 gaatgtggtc atcttaattg cctgatagat ttccagtttt ttatgggaca aagtccagat
     3421 ttcttacact gcctactaat caagcatctg cttgatgctc cactacgtgg tgcctctcaa
     3481 gctcatgctg tagaagcata gaacacacct tatttgggtg gtttttctgg cacaggtccc
     3541 tttacacttt gttcacacag tccctgtcat ccagaggctc cactttgacc tacataactt
     3601 gtacacaaac tttcacgtgg ctcttctgat catccccatt cctaaactca taactttgtc
     3661 acacaagata tgcctgctgt gtttatgtag tacactgaaa tacaacattg ctttatagtt
     3721 ccctatggta tagggcatta gactgaagac aacaatgaaa atagattaaa aactaacaag
     3781 ttaaagtgct tccaaactgc aatccaagtt gtaatgaagt gtgtttgaga gagattactg
     3841 ccatttgaga ctgtcatttc ttcttattgc taccaaaagc agtctaaaac atcaagcttt
     3901 gtactactaa aattagtgtt ccttccccca cccccaaaaa aaattttttt ttaactagga
     3961 ttcagataaa gataaaaaag cattttgcat cagaacatgt ggcggtcaat atgtatataa
     4021 attgcatatc ctcacaagac attttccttc acatttgcat tacctttaac aatgctgctt
     4081 ccagaaccgg cggaatgact cgataaaatg cccacctctt gagcatcagg tcctgaagtg
     4141 acatcccaag ccacacaaaa agctaggtgt ggggccagga agatggttca ttccgtaaag
     4201 atggtgccaa gcctgataac ttgactccta gaatccacat agtagaaaaa aaataacccc
     4261 cacaactgac tacacatgct gtggcacaca ctactgatag aaatttaaac aaacaaaaac
     4321 agaagccagg tgtgatggta tatcctgtta tcccagtgct gggcattcag ggtagagata
     4381 tgcagatctt agaagctcac tggccagcca acttagccaa actggtaaat tctaggctca
     4441 ggaagaaatc ctatctcaaa aaatcctgag gaggctgacc tctagcctcc acatgcatgt
     4501 gcactcaccc acgggaacat acaatcatac atacacacac acaatgctga tccccatcca
     4561 ctaagttgat tttacaacct aggaatgaat tacaacctgc ttttactggg tttactcagc
     4621 ctttcagtgc ctaagcattg cctttgctgg ataaaatcca gacattacat tgacagcctg
     4681 gtccagccac atctcaagcc tgccatattc aaccctggcc gaagtttatg aaacaactgt
     4741 gctttgtgtg gaaatgctaa ggcatttcag tatccaagac caaaaaaaaa aaaaaaaaaa
     4801 aatcctctac cgggccttaa atgctgatag tgattgtcaa gagtataaac atatgtctaa
     4861 ttaatttccc acacatttta catattccaa catcctggaa tatttctaac caatgccaca
     4921 gacagaaaat acctatatat ttctacactg gcaaaaccag aaatgatgca tcttttatga
     4981 aaaagtcact gaattcctca agtgaagctc agcgttatta cagtggccca gactcttcat
     5041 ttgatctttt aaccacatag aagaccaccc atactgtata ttagatctga gacttgttca
     5101 tcctacaaag caaaaaagtt tggccccagg gctggggtgg agctctgtgg taacgtgtgc
     5161 ttagcattca tcaagtcctg agttcagtcc ccagcacaac acacaaccag ctagaaagaa
     5221 agttgccact tcctcaagcc cttaaggcca aggccacccc atttcctgga gcccttagac
     5281 actgacagcc aagctttgtt tctataagtc ttacaaggtc cttatatatt ttaaatttca
     5341 gtcttttatc agatacatgg acggcaaata ttctatctcc tgcaggttac cttttcacgt
     5401 tcagattgct tgtttgatgt ttaaaacccg cttggttcaa tatcatccca ttgactgact
     5461 ttctattctt tactgttcta tgcagaatgt atcactaggg tcagtggaga cgcttctccc
     5521 tgtgttctct tctagctgtt atactggtct tcccagaact aggaccctca tccgtctggg
     5581 acttctattt gtctttaata cattttgtgc taattatgta gggttccgaa tctagctaag
     5641 ggatagagca tgtgactgaa aagtatgagg cctcagtttc aattcctaga accagaacgg
     5701 ggcaggggaa tggagaaaat caagttaatt ttgagtctgg tataaaacaa gggttctgat
     5761 tttcccccct tggcttgagg atatatggtt tctcaacaac agtttttgga gtgatttcct
     5821 ccagtgtata ctcatttggc aaaaatcagt tgactctgcg tgcttgtgtt tatttctggg
     5881 ctctatcctg tgccatggcc tgtgtctgtt atgccgcaca gccgcatttg cttactatag
     5941 gtttgtgata cagcctgcag ttggggaaga tgatgccttt ttctttatga cattattttg
     6001 gctatatgga attttttgta cttacaaact ttgtctttgg tgtttttttt tttttaattt
     6061 ttgttttttt ttaaaggtca ttggtatttt tatagggatt gcatgaactc tatagattac
     6121 tttgagttct gtgaacattt taataatttt cattcttcca atcttgagag caaggcagtg
     6181 ttccacttat cagtgttatt ttcaatgtct tttatcggtg ctaataattt tgagcacaag
     6241 ggtttttttg gcattttgtc ttgttttgtg ttgttttttg agttctctgt agccttggat
     6301 gccttgtcct gaagcttgct ctgttaacca gtctggcctc aaactcacag agatccacct
     6361 gtttctgctc caacacacta gaattaaaag cgtgtcccac cactgcccag ctgggtacaa
     6421 atcttttaca ttcttagtta tatttattcc tatgtctttt aggctgtgga ttgggcccag
     6481 gctctagcac atactaggca aatactctag aactgaacca cagctccagc cctgatagtt
     6541 ccacaaatgg aagcatttcc tttactttct ttaccagtgg gccagtttca cactgtacat
     6601 cttttattat agtgactgaa taactctact tttaaaaccc ttcactaaat agtgagttcc
     6661 tcgagaaaac acatctaatt catttctccc accacccaat aaagaacatg ag
//
