LOCUS       NM_001177658            4216 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus mitochondrial ribosomal protein L15 (Mrpl15),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001177658
VERSION     NM_001177658.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4216)
  AUTHORS   Cheong A, Lingutla R and Mager J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 4216)
  AUTHORS   Greber BJ and Ban N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 4216)
  AUTHORS   Brown A, Amunts A, Bai XC, Sugimoto Y, Edwards PC, Murshudov G,
            Scheres SHW and Ramakrishnan V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 4216)
  AUTHORS   Tarantino C, Paolella G, Cozzuto L, Minopoli G, Pastore L, Parisi S
            and Russo T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   5  (bases 1 to 4216)
  AUTHORS   Sansom SN, Griffiths DS, Faedo A, Kleinjan DJ, Ruan Y, Smith J, van
            Heyningen V, Rubenstein JL and Livesey FJ.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   6  (bases 1 to 4216)
  AUTHORS   Tamplin OJ, Kinzel D, Cox BJ, Bell CE, Rossant J and Lickert H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4216)
  AUTHORS   Mootha VK, Bunkenborg J, Olsen JV, Hjerrild M, Wisniewski JR, Stahl
            E, Bolouri MS, Ray HN, Sihag S, Kamal M, Patterson N, Lander ES and
            Mann M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 4216)
  AUTHORS   O'Brien TW, Fiesler SE, Denslow ND, Thiede B, Wittmann-Liebold B,
            Mougey EB, Sylvester JE and Graack HR.
  TITLE     Mammalian mitochondrial ribosomal proteins (2). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 274 (51), 36043-36051 (1999)
   PUBMED   10593885
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY083200.1, AK003367.1, BC068230.1, CX563035.1, AK017824.1 and
            AI836668.1.
            
            [WARNING] On May 5, 2023 this sequence was replaced by
            NM_001177658.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC068230.1, AK150880.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-230               BY083200.1         15-244
            231-1020            AK003367.1         215-1004
            1021-1374           BC068230.1         1004-1357
            1375-1782           CX563035.1         290-697
            1783-3125           BC068230.1         1766-3108
            3126-3467           AK017824.1         804-1145
            3468-4192           BC068230.1         3450-4174
            4193-4216           AI836668.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..4216
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1"
     gene            1..4216
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
                     /note="mitochondrial ribosomal protein L15"
                     /db_xref="GeneID:27395"
                     /db_xref="MGI:MGI:1351639"
     exon            1..154
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..937
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
                     /EC_number="3.6.5.3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 39S ribosomal protein L15, mitochondrial;
                     L15mt; MRP-L15; ribosomal protein, mitochondrial, L7"
                     /codon_start=1
                     /product="39S ribosomal protein L15, mitochondrial isoform
                     1 precursor"
                     /protein_id="NP_001171129.1"
                     /db_xref="CCDS:CCDS48211.1"
                     /db_xref="GeneID:27395"
                     /db_xref="MGI:MGI:1351639"
                     /translation="MAGTARGCGTSLDLLRSLPRVSLANLKPSPNSRKRERRPRDRRR
                     GRKCGRGHKGERQRGTRPRLGFEGGQTPFYIRIPKYGFNEGHSFRHQYQPLSLRRLQY
                     LIDLGRVDPTQPIDLTQLVNGRGVTIQPLKRDYGVQLVEEGADTFQAKINIEVQLASE
                     LAIAAIEKNGGVVTTAFYDPRSLEILCKPIPFFLRGQPIPKRMLPPESLVPYYTDAKN
                     RGYLADPAKFPEARLELAMKFGYVLPDITKDELFRMLSARKDPRQIFFGLAPGWVVNM
                     ADKKILKPTDENLLKYYSS"
     exon            155..309
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     exon            310..475
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     exon            476..599
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     exon            600..4203
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4169..4174
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
     polyA_site      4203
                     /gene="Mrpl15"
                     /gene_synonym="HSPC145; MRP-L7; Rpml7"
ORIGIN      
        1 aacgcggagt ctacgccgct tcctgggcgc ccttgaagca ccgcgggtca tggctggcac
       61 ggcgcgcggc tgcgggacca gcctggacct gctgcggtcc ttgccgagag tgagcctggc
      121 caacctgaag cccagtccta actccagaaa acgggaaaga cgtccaagag atcggagaag
      181 aggtaggaag tgtggcagag gccataaagg agaaaggcag agaggaaccc ggccaaggct
      241 gggctttgag ggagggcaga ctccatttta catacgaatc ccaaaatatg gatttaatga
      301 aggacatagt ttcaggcacc agtatcagcc tttgagtctc aggagactac agtatctcat
      361 tgatttaggt cgagttgatc caactcaacc tattgaccta acccagcttg tgaatgggag
      421 aggtgtgacc atccagccgc ttaagaggga ttatggagtc cagctggttg aagagggtgc
      481 tgatactttt caagcaaaaa ttaatattga agtgcagctg gcttcagaat tagccattgc
      541 tgccattgaa aaaaatggcg gtgttgttac tacagccttc tatgacccaa gaagtctaga
      601 aattctgtgc aagcctattc cattctttct gcggggacaa ccaattccga aaagaatgct
      661 tccccctgag tcactggtgc cctattacac cgatgcaaaa aaccggggct acctggctga
      721 ccctgccaag tttcctgaag caagacttga actcgccatg aagtttggct acgtccttcc
      781 tgatattacg aaagatgaac tcttcagaat gctcagcgct cggaaggatc cgaggcagat
      841 tttctttggt cttgctcctg gctgggtagt gaatatggca gataagaaaa ttctaaaacc
      901 tacagatgag aatcttctca agtattacag ctcctgaact gccttctact aaatcagact
      961 tgtgagccag acgggctgca catggattct tgtgggtatt aaagctttgg gtctgttacc
     1021 agccttcact gctcaggtct tttgttcttt ttccatctta aatagcagac agcaaaagct
     1081 gcacgagcga ctgagccttt gagggtgtgt gcttgaaaat ctgaacagtg gcaggcttta
     1141 gaaaggggat taaaaagaaa aaaacctact taaaattacc tttcttttgg ggggtgggga
     1201 gactgtgttt tgatacatgg tttctctgtg tagccctggc tgtcctggaa cttgttctgt
     1261 agaccaggct ggctttgaac tcacacagtt ccgcctgctt ctgttgggat tcaaggcatg
     1321 taccgccact gcccagcctg actaagtagt ttaaaacatt tctttactgt ccatcttttc
     1381 atggactttt cttacctaca ttttctgttt tgtcagagtg cagggcagag attgattagt
     1441 aggcctggaa gcctttactg ttcggggact taaactgggc cctcttggtc ttctgttgtt
     1501 taagacatca gacaagtcct ttagctgaag tacagtgtca gtctgcagca ataggaggag
     1561 agactgtaga gtcgctttcc taccatgtct ttgcagttta gaggttggac ctgtgctgta
     1621 catactgagt gacactgccc tttggctcca gcttctgggg ggcccctgaa tgacacatgc
     1681 ttccttgatc tgaggagaac tttgaccata gcctgtctgc atagaaatca atttccttaa
     1741 atgaacacgt cctgtattgt aactgtatcg ggtgtgcaca catcctgtaa tgtaactgta
     1801 tggggtgtgc tgtagcccta ggaaagctat tgccttgccg cctagttgtg caggaggctt
     1861 tcctttggta ctgcagtgta catttgcagg tctcagagcc cctgccttcc caggaagact
     1921 tcttcatggg aagtgagagg aaattagtca tctgaaggga gaacacattg cggccttcca
     1981 tctcagaatg tactttgcgg gttcttggag tctcctcccc catcccttca agcagagtgg
     2041 ctacctcaca tagaagaact gacagccaaa catgggcttt cttcattttg gttgtctgtg
     2101 gtggcataca ggtggaagga aattggcata gagtgataaa gggaagaata aaaacaggaa
     2161 acagatgtct ggtgaagtag aatgctggcc agtgtttatt tggtgacagg gactttgtca
     2221 caaacagctg tatccgggtt gagagactat ccctacagct cattctcagc caaaatagcg
     2281 ccttccatgg aattcacgtg gtccactcta gcccttgtgc cagtcacaag gcgtggagcg
     2341 ctccagtgga ggtggtagca gtttgtatcc cttgagactc taccttaaaa agcaataagt
     2401 cttgagtgta ggtctgtcct tcctggaatg tggcctcagc tttcggtgtg cacacatcct
     2461 gtaatgtaac tatggggtgt gctgtagccc aaggaaagct attgccttgc ctcgtgcagg
     2521 aggctttggt gaccaaactc taaaaacact tgagttagtg ttttaaaaca atttttagtg
     2581 ccaggcatag ttagttgtac actactttaa tcccagctcc cagaaggcag agaggcaggt
     2641 atatctctga gcttaaggcc aacctgctct ataaagtgag accctgtctc caaaagccaa
     2701 agcaaacagc agacagttct agagttcgga gacagatggg caaagggttg aagtttaaac
     2761 tttaaagcgt ttgtgagcca cacagaagct tgggcatcag aagactggtc agatacctcc
     2821 aggctcagtg gccagccagt ttagctgcat ggtagctcac aaccatctgt tttcccaatt
     2881 ccagggcact tgatgcactc ttctgacttc catggatttt cggcaagata ctcaatacac
     2941 ataaaataat aaaaaagcca ttgagaaaag acatctgacc agcatctggc ctccatgtgt
     3001 gcctgcatct ggtctccatg tgtgcctgca tctggcctcc atgtgtgcct gcatctgccc
     3061 ccacatccca tttctaaagt aagagggaaa cttttgttat gatctgagtc cctggtcttt
     3121 ttttttaatt gtaagtcttt acaattttct ttgggaagta gaaggtcctt cttagggtgg
     3181 ggagtgtcag acgggaccag tactcgtttc acttagggtg gaggagagag ctctgatgtt
     3241 agtgtgagtc ccatgacggt tgtctttcgt gataacttgc tgtaggcaga ccactacact
     3301 ctagcttgct cgttacatgc ttggagctgc acagccatct gggtgaaaca cttgagtagg
     3361 actttaagca agactagatt tgggactttg gcatgcaatt tattctctgc ctcagtttca
     3421 ccatctgcca aatggagggt aaaataaaaa tttggttatt ataaaataca aattctctta
     3481 gggattttac tgctataacc agcaccatga ccaaaagcca gttgggaagg aagattattt
     3541 tgcttacacg tccgtaacac tgttcatcaa ggaaggaagc caggataaga actcaaacag
     3601 ggcagcagct catgtagaga ccatggagca tgctgcttac tgacttgctc ctcatggctt
     3661 gctcagcctg cttccttata aaacccgaga tcaccagccc acagatggca ccacccacaa
     3721 tgggctgggt ccttccccat taatcattaa gaaaatgccc tacaggtttg cctacagctg
     3781 gattgtacag aggcattttc ttaattgaga ttccttcatt tcagatgact gtcaagttga
     3841 cataaaatta gaacagttat tatgcaagtc gctagtgttt gtaaagcatg tagcacatgc
     3901 ctgtttcgta ggcctctaga gttagtgtct cttctgatcc ttaggtaact gccaccctgt
     3961 ggattctact tccttccctc ttaggattta catatagtct gtaaagcact cttgagtctc
     4021 actaatgaga agaaaatgca tgatagactt tatattgttt ttagcaggag ctaaaaaata
     4081 cattttgaag aagcagcata gcagaggcag aaacatagca cccaagtctg aaacaattgg
     4141 caccagtctt cccttctgca gtttgttcaa taaacagaat tcctaaatct aataacctta
     4201 aaaaaaaaaa aaaaaa
//
