LOCUS       NM_025553               2882 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L11 (Mrpl11), mRNA.
ACCESSION   NM_025553
VERSION     NM_025553.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2882)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   2  (bases 1 to 2882)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 2882)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   4  (bases 1 to 2882)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of an upstream ORF in this gene, and
            shows that it functions to reduce protein levels by ~67%.
REFERENCE   5  (bases 1 to 2882)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ168778.1, AK167247.1 and AC124502.4.
            
            On May 6, 2010 this sequence version replaced NM_025553.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.96741.1,
                                           SRR7974084.2278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            regulatory uORF                    :: PMID: 19372376
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CJ168778.1         161-193
            34-831              AK167247.1         2-799
            832-2882            AC124502.4         156593-158643       c
FEATURES             Location/Qualifiers
     source          1..2882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.19 cM"
     gene            1..2882
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /note="mitochondrial ribosomal protein L11"
                     /db_xref="GeneID:66419"
                     /db_xref="MGI:MGI:2137215"
     exon            1..210
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      24..44
                     /regulatory_class="uORF"
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19372376]"
                     /note="this uORF is predicted to encode a 6 aa peptide
                     (PMID:19372376)"
     CDS             88..666
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /note="39S ribosomal protein L11, mitochondrial"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL11m"
                     /protein_id="NP_079829.1"
                     /db_xref="CCDS:CCDS29444.1"
                     /db_xref="GeneID:66419"
                     /db_xref="MGI:MGI:2137215"
                     /translation="MSKLSRATRTLKKPEAGGVIRSIVRAGQAIPGPPLGPILGQRGV
                     SINQFCKEFNEKTKDIKEGIPLPTKIFIKPDRTFELKIGQPTVSYFLKAAAGIEKGAR
                     HTGKEVAGLVSLKHVYEIACVKAKDDAFAMQDVPLSSVVRSIIGSARSLGIRVVKDLS
                     AEELEAFQKERAVFLAAQKEADLAAQAEAAKK"
     exon            211..306
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /inference="alignment:Splign:2.1.0"
     exon            307..400
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /inference="alignment:Splign:2.1.0"
     exon            401..560
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /inference="alignment:Splign:2.1.0"
     exon            561..2882
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      814..819
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /note="hexamer: AATAAA"
     polyA_site      835
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /note="major polyA site"
     regulatory      2277..2282
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /note="hexamer: AGTAAA"
     polyA_site      2296
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
                     /note="hexamer: ATTAAA"
     polyA_site      2881
                     /gene="Mrpl11"
                     /gene_synonym="2410001P07Rik; L11mt"
ORIGIN      
        1 gggcccttca cctctgaccc aaaatggccg cgcccagagc gtagttcttt gcttctccga
       61 ggcgagctaa gattaaaatc ctacatcatg tccaagctaa gccgggccac tcggaccctc
      121 aagaagcccg aggccggcgg cgtgatccgg tccatcgtgc gagcaggcca agctattcct
      181 gggcctccac taggtcccat cttgggtcag cgaggtgtct ctatcaacca gttctgcaaa
      241 gagttcaacg agaagacaaa ggacatcaaa gaaggcattc ccctgcctac aaaaattttt
      301 ataaagcccg acaggacatt tgagctcaag attgggcagc ccactgtttc ttactttttg
      361 aaggcagctg ctgggatcga gaagggggcc cggcatacag ggaaagaggt ggcaggcctg
      421 gtgagtttga agcacgtata tgagattgcc tgtgtcaaag ctaaggatga tgcttttgcc
      481 atgcaagatg tgcccctgtc ttctgtggtc cgttccatca ttggctctgc ccgttccctg
      541 ggcattcgag tggtgaagga cctcagtgca gaagaactgg aggctttcca gaaggaacga
      601 gctgtgtttt tggctgctca gaaagaggca gatttggcag cccaggcaga agctgccaag
      661 aagtgacccc aactttctac actctgagaa tttgaagtga gaggctgaga aagggggcca
      721 cagaggaagc tgagccaaag gacttcatgg caacccgatt tctagtttcc tgacatgttt
      781 ctgtacattt gctgtgccag gggatcaagc ctgaataaat atcctttgtc atcaactctc
      841 agcttctctc ctgagacccc agagatgggg accaatactg acagttccca gccttcacag
      901 gtgtgagctg ccctacaggt gaacgcagcc tcaaccaagc aaattatcat gcccagtgcc
      961 ttggtcagcc ttgtattata tcaaaataac caaagcttgg tgctttataa agaaaaggta
     1021 ttgatttggc ttctgattca tggtgctgga gtatggcaag gctcacttgc tgtatgacag
     1081 catggtacag tggaaacagt cacatacata gggccatctg tgtgaggtag cctcacctgg
     1141 accagtcccc gccttaaggc caacattagt gaaggttgga ctcccagacc cctccgccag
     1201 accacacttt gatttattca ttttatatgt gactgttttg cctgcatata tgtgagtgca
     1261 ctgtgtgcat gcttggtgtc tgtcagaaga gggtattgga tcccctggag ctggatttat
     1321 gggtagttgt gaaccagtat gtggatcctg gagttgaacc tgggttctct gtaagagcaa
     1381 caaacaagtg ctcttacctc ctgagccatc tctctactct atcccccttt tttgagatag
     1441 gatctctgga tatccttgaa ctcacggaga tccacctgcc tctgccttcc acattgctgg
     1501 gactaaagct tgcaccacca tacagggcat agcccccact tcttaaggat tccaccacct
     1561 tccacactgg gaagcaagcc ttcagcccat gagcctccgg ggcacgtgtc gtaacattca
     1621 ggctctgagt aggtacaagt ggagtagagc ccagggagaa atcctatgtt cagggttgaa
     1681 gatgttgttt cctgatggag ctgctcctta cacaaagcct caacttctat tcccaacact
     1741 tcagagcaca taagcctgtg ctcttccctc ggggatgaga gaaggcacag tcgatggggt
     1801 ccacagacac taaggcttgg ctgtgttgct tgtcttttct tagtataact gttggggagt
     1861 ttgtatctga gaagcaggag cctgacagag aattcagacc acagataggg ttatccttta
     1921 tccaggggca gcttcaggcc tccctgctga gttgacatga ttgtttctga ggcagaatct
     1981 cattatttag ccttggctgg cctgaaactg gctggctagg ctacagcctg acctctcagt
     2041 gctccagtta aaggtgtgca ttaccccacc cggctcctta ctaagtttgg ttatttgctt
     2101 ttttaaaact tgccatttgg ggctggagag atggctcaga ggttaagagc actagctgct
     2161 cttccagagg tcctgtgttc agttcccagc aaccacatgg tagctcatca ccatatatag
     2221 tgagatctgg tgccctcctc tggcttgcag gtatacatgc aggcaaaaca ctacgtagta
     2281 aatctataaa acaaaacttg ctggtttttt tgtttttgtt ttgttttgtt ttgttttaat
     2341 gctgttggag atgaaaccca gggcctcatt cagccagagc caggactgtg tccctctcag
     2401 ctctgcctct gccaagcttg tgaatctacc ctgggtcagg gagaacagcc gaatcacagc
     2461 ccagacctac ataagtgaaa ttccagtaga cacctgcctg agaagtcctt gtggaccctt
     2521 gacctgcctg agaagtcctt ggggaccctt ggtctgcctg agaagtcctt ggggaccctt
     2581 ggtctgcctg agaagtcctt ggggaccctt ggtctgcctg aaaagtcctt gggggccctt
     2641 gacctgcctg agaagtcctt gggggccctt gacctcctgt tttcccattc tacaaaacat
     2701 caagtgttct ctcagaagag aggcagaatt gacaggaaag atgaagtctg tgtttgccgt
     2761 gtgttgcatg ctgggcatta ttttttgctt gttaacattc tgaacaattt agtcaaattt
     2821 tcacatagta ttaatagttc aacattgttt actaatacaa ttaaaacttt tattacgtgt
     2881 at
//
