LOCUS       NM_026154               1686 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus mitochondrial ribosomal protein L10 (Mrpl10),
            transcript variant 1, mRNA.
ACCESSION   NM_026154
VERSION     NM_026154.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Cheong,A., Lingutla,R. and Mager,J.
  TITLE     Expression analysis of mammalian mitochondrial ribosomal protein
            genes
  JOURNAL   Gene Expr Patterns 38, 119147 (2020)
   PUBMED   32987154
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Yang,Y., Cimen,H., Han,M.J., Shi,T., Deng,J.H., Koc,H.,
            Palacios,O.M., Montier,L., Bai,Y., Tong,Q. and Koc,E.C.
  TITLE     NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein
            synthesis by deacetylation of the ribosomal protein MRPL10
  JOURNAL   J Biol Chem 285 (10), 7417-7429 (2010)
   PUBMED   20042612
  REMARK    GeneRIF: Data describe the regulation of mitochondrial protein
            synthesis by the reversible acetylation of the mitochondrial
            ribosome and characterize MRPL10 as a novel substrate of the
            NAD(+)-dependent deacetylase, SIRT3.
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Mu,X., Zhao,S., Pershad,R., Hsieh,T.F., Scarpa,A., Wang,S.W.,
            White,R.A., Beremand,P.D., Thomas,T.L., Gan,L. and Klein,W.H.
  TITLE     Gene expression in the developing mouse retina by EST sequencing
            and microarray analysis
  JOURNAL   Nucleic Acids Res 29 (24), 4983-4993 (2001)
   PUBMED   11812828
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Goldschmidt-Reisin,S., Kitakawa,M., Herfurth,E.,
            Wittmann-Liebold,B., Grohmann,L. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins. N-terminal amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 273 (52), 34828-34836 (1998)
   PUBMED   9857009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD561609.1, AK150774.1 and BF458354.1.
            
            On May 17, 2018 this sequence version replaced NM_026154.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002865.1, AK078463.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                CD561609.1         23-35
            14-1681             AK150774.1         2-1669
            1682-1686           BF458354.1         19-23               c
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.69 cM"
     gene            1..1686
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /note="mitochondrial ribosomal protein L10"
                     /db_xref="GeneID:107732"
                     /db_xref="MGI:MGI:1333801"
     exon            1..71
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..808
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /EC_number="3.6.5.3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; 39S ribosomal protein L10, mitochondrial; large
                     ribosomal subunit protein uL10m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL10m isoform 1
                     precursor"
                     /protein_id="NP_080430.1"
                     /db_xref="CCDS:CCDS25312.1"
                     /db_xref="GeneID:107732"
                     /db_xref="MGI:MGI:1333801"
                     /translation="MAAAVAGILRGGLPPRAAWLPTLQTVRHGSKAVTRHWRVMHFQR
                     QKLMAITEYIPPKPAINPRCLPPPPKPPKEESGLVRLLRQDIVAVFRDNRMIAVCQNV
                     ALSAEDKLLLRHQLRKHKIFIKVFPSQVLKPFLENSKYRNLLPLFVGHNLLLVSEEPK
                     VKEMVRVLKSVPFLPLLGGCVDDTILSRQGLVDYAKLPSLDQLQGQLVGGLTHLMAQT
                     RYLLQHQPVQLTSLLDQYVKEQNEGDCATSANEKLHPPDPAPDA"
     exon            72..241
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /inference="alignment:Splign:2.1.0"
     exon            242..406
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /inference="alignment:Splign:2.1.0"
     exon            407..551
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /inference="alignment:Splign:2.1.0"
     exon            552..1686
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /note="hexamer: AATAAA"
     polyA_site      1686
                     /gene="Mrpl10"
                     /gene_synonym="0610040E02Rik; L10mt; MRP-L8; Rpml8"
                     /note="major polyA site"
ORIGIN      
        1 atgggaactt cctgtagcga tggctgcggc ggtggccggg atcctccgtg gaggtctccc
       61 gccccgggcg gcttggctgc ccaccctcca gactgtgcgc catggctcca aggctgtgac
      121 ccgccactgg cgagtcatgc acttccagcg gcagaagctg atggctataa ctgagtatat
      181 tcctcccaaa cctgccatca acccgagatg cctgccacct cctcccaagc cccccaagga
      241 ggagtcaggc ctcgtccggc tcctgcgtca agatatagta gcagtttttc gggacaaccg
      301 aatgatagct gtctgccaga acgtggccct gagtgcagag gacaagcttc tcctgagaca
      361 ccagctgcgg aaacacaaga tcttcataaa agtcttcccc agccaggtcc taaagccttt
      421 tctagaaaat tccaaatacc gaaacctgct accccttttt gtcggacaca acctgctgct
      481 ggtcagtgag gagcccaagg tcaaggaaat ggtgcgggtc ttaaagagcg ttcctttcct
      541 gccgctgctg ggtggctgcg ttgatgacac catcctcagc aggcagggac tcgtagacta
      601 tgccaagctg cccagcctgg atcagctaca ggggcagctg gtaggagggc ttactcacct
      661 catggcccag acccgctacc tgcttcagca ccagcctgtc cagctgactt ccctgttgga
      721 tcagtatgtc aaagagcaaa acgagggaga ttgtgccacg tcagccaatg agaagctaca
      781 tcctcccgat cctgctccag atgcctagcc ggcctgtttt acccagctct gcccataaac
      841 acactctgtc cctgttgtct gtctcgttgt ctggcagaga tctaaaagaa tttggagtgg
      901 ggagtggcct tgtgtgactt ggctctcatt cacaatgacc tccttgggga caggcctctt
      961 gatgatacag agaaattcca ttccagactg aggctgccca ttgtccttgg tttcactgat
     1021 cactgtcttt agttgttcca actagggacc cgataggagc agtctccttg agttctccct
     1081 gcacaaggca gggagaacag agactcttgc ccagcctcct cacccactac cccatgctgt
     1141 tttcccagtc cacattctca gtgctcgtgc catggtggac cggctaggaa gacttgtgaa
     1201 tggcacctcc tgggtcttgt gccaagcact ctacagacac agatgccagc tcctttagtc
     1261 ctcaccattc aggaaacagc agagaagcct gagttctgga taaggtcttg aattcggttc
     1321 tctgaagcct caaattctca aagtagaaca cgagtgggtc ctggtgggct gacgttggcg
     1381 ttccaccctt cgggtgtgct gggctgtgga aagaataggg aaactgcttc gtgataaaaa
     1441 taaaataaat tttattgcct tttttatttt ttaagaatta ttttatgtgt aaaactgtgc
     1501 ttacggggct gtagagatgg ctcagcagtt aacagcactg actgctcttc cagaggtcct
     1561 gagttcaatt cccagcaacc acatggtgac tcccaagcat ctgtaatgaa ctggtgacct
     1621 cttctggtgt gtctgaagac agctacagtg tactcataaa taaaataaat aatattttta
     1681 aaagcc
//
